2011 YÜksek lisans tez özetleri

Synthesıs Of The New Schıff Bases By Condensatıon Of 2-Amıno-5-Merkapto-1,3,4-Thıadıazole Wıth Aldehyde Derıvatıves

Schiff bases are typically formed by the condensation of a primer amine and carbonyl compounds.

Schiff bases are very important compounds which are able to bond with reversible oxygen and have anticancer, antibacterial, antifungal, antiviral, catalytic, photocromic, thermocromic characteristic features. With all these benefits, working with Schiff bases is very common in divisions of biology, pharmacology and analitical chemistry. Also it is known that Schiff bases have been used as a dye stuff.

The Schiff bases used to as a ligand and connected central atoms with (by) donor atoms. Azomethine or imine bonds are very interesting bonds and they effect the spectral characteristics of the compound.

In this study, the new Schiff bases were synthesized by condensation of 2-amino-5-mercapto- 1,3,4,-thiadiazole with aldehyde derivatives. The structure of new ligands were elucidated on the basis of elemental analyses, IR, ¹H-NMR, and MS spectroscopic techniques. The most important indicator of Schiff bases which is azomethine bond (-HC =N-) were identified and were confirmed to occur via IR and NMR spectrums. Besides, in IR spectrums, the C=N vibrations around 1600 cm^-1 have been identified. OH and SH groups in many compounds have been identified via ¹H-NMR spectrums as well. The effects of the substituents and hydrogen bridges on the compounds were investigated spectroscopically.
  

ŞEN Musa

Danışman : Prof. Dr. Refiye YANARDAĞ

Anabilim Dalı : Kimya

Programı : Biyokimya

Mezuniyet Yılı : 2011

Tez Savunma Jürisi : Prof. Dr. Refiye YANARDAĞ

Prof. Dr. Ayşen YARAT

Prof. Dr. İnci ARISAN ATAÇ

Prof. Dr. Ayşe YUSUFOĞLU

Doç. Dr. Özlem SAÇAN