2011 YÜksek lisans tez özetleri

Synthesis of Some Amino Substitue Triazine Compounds Containing Sulphur

It was aimed to synthesis of new 1,3,4-thiadiazolo-1,2,4-triazine derivatives and new Schiff bases in this study. The heterocyclic compounds which contain nitrogen and sulfur atoms are very important because of their biological and pharmacological effects. This compounds and their derivatives have significant impacts as anticancer, antiproliferative, antihypertensive, antiviral, antimalarial, antifungal and herbicide.

In this study firstly thiocarbohydrazide, which is one of the starting compounds, was synthesized by the reaction of carbon disulfide and hydrazine hydrate. As for starting compounds 4-amino-3-merkapto-1,2,4-triazine-5(4H)-on was obtained from the reaction of thiocarbohydrazide and glioxylic acid monohydrate. Also 4-amino-3-methylthio-1,2,4-triazine-5(4H)-on was synthesized from the reaction of 4-amino-3-mercapto-1,2,4-triazine-5(4H)-on with methyl iodide. Then, the new five cyclisation products were synthesized from the reaction of synthesized 4-amino-3-mercapto-1,2,4-triazine-5(4H)-on with 4-chloro-2,5-difluorobenzoic acid, 2-chloro-4,5-difluorobenzoic acid, 2-bromo-4-chlorobenzoic acid, 3-bromo-4-methylbenzoic acid and 4-bromo-2-methylbenzoic acid. Also, one new Schiff base was synthesized from the reaction of 4-amino-3-mercapto-1,2,4-triazine-5(4H)-on with 4-(methylthio)benzaldehyde.

The structures of all these synthesized compounds were characterized by UV, FT-IR, ¹H-NMR, ¹³C-NMR, MS and elemental analysis methods after they were purified by chromotographic or crystalization methods.