An assessment of nucleic acid amplification testing for active mycobacterial infection

Outputs from the economic evaluation

The results of the economic evaluation are presented for four scenarios:

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  TB mixed scenario: patients with true TB are spread across treatment populations based on high or low clinical suspicion of TB (best reflective of current practice)
  

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  TB low-suspicion scenario: all patients (including all with true TB) are treated as though they have a low clinical suspicion of TB—that is, clinical judgment is not used as a basis to initiate treatment but, rather, treatment decisions are based on AFB ± NAAT
  
• 
  Perfect clinical judgment scenario: all patients with true TB are treated as per high clinical suspicion—that is, clinical judgement has 100% sensitivity and specificity in identifying TB; and all patients without TB are treated as per low clinical suspicion—that is, treatment decisions are based on AFB ± NAAT
  
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  TB high-suspicion scenario: all patients are treated as though they have a high clinical suspicion of TB—that is, treatment is initiated in all patients on the basis of clinical judgment.
  

The following summarises the results of the economic evaluation that will be presented:

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  disaggregated by decision tree probabilities, incremental costs and incremental outcomes (TB mixed scenario only); the disaggregated results for additional scenarios are presented in Appendix
  
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  for the TB mixed scenario, the incremental cost-effectiveness is presented incorporating costs in a stepped manner (additional scenarios in Appendix )
  
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  incremental cost-effectiveness of each of the three additional scenarios
  
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  sensitivity analyses.