The accuracy of NAAT at determining the presence of MTB or NTM in a specimen will be determined using culture as the reference standard. The diagnostic accuracy of NAAT in determining the presence of rifampicin-resistant MTB in a specimen will also be determined using DST as the reference standard.
It is important to note that culture is an imperfect reference standard for the diagnosis of MTB and NTM. Not all patients who are clinically diagnosed as having TB or NTM infections (on the basis of histopathology, symptoms and response to drug therapy, as well as culture) will have received a positive culture result.
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