Publication type
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Randomised trials, cohort studies, case series or systematic reviews of these study designs
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Search period
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1990 – May 2014 or inception of the database, if later than 1990
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Language
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Non-English language articles were excluded unless they provided a higher level of evidence than the English language articles identified
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Safety of NAAT
No studies were identified that reported on the safety of NAAT (plus AFB microscopy and/or culture) compared with current testing (AFB microscopy, tissue biopsy and/or culture). As NAAT is usually conducted on the same samples used for other testing, no AEs were expected.
To date, NAAT has been widely used without any safety concerns. However, more patients will receive a false-positive NAAT than a false-positive AFB result. Therefore, more patients will receive treatment for a disease they do not have and will possibly have an adverse reaction to the anti-TB drugs until clinical unresponsiveness is noted or culture results become available.
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