Bio-data of

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  Disaster Management System relating to Medical Emergencies. Seminar on Disaster Management, ITR, Chandipur, 02-03 November 2010.
  
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  Management of Accidents: Chemical Transportation. Foundation Programme for Assistant Directors, Industrial Safety & Health, Labour Department, Haryana, HIPA, 28th October 2010
  
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  Emergency Preparedness: Medical Response for Chemical Disaster Management. Foundation Programme for Assistant Directors, Industrial Safety & Health, Labour Department, Haryana, HIPA, 28th October 2010
  
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  Security and Safety aspects of CBRN Agents SPG Course. INMAS, Delhi. 28 September 2010
  
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  Issues in CBRN Disaster Management. Raising Preparedness of QRTs/ Co-opted Troops. INMAS, Delhi, 20 September 2010
  
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  Training Initiatives in CBRN Emergency Management. Specialised Training Course on Management of CBRN Emergencies: Raising Preparedness of QRTs and Co-opted Troops. INMAS, Delhi, 20 September 2010.
  
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  CBRN Threat Perception. Specialised Training Course on Management of CBRN Emergencies: Raising Preparedness of QRTs and Co-opted Troops INMAS, Delhi, 20 September 2010
  
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  NBCD activities at INMAS. NBCD Specialisation course. INMAS, Delhi, 17 September 2010.
  
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  Nuclear Decontamination of Men and Equipment. Training on Preparedness for Emergency Medical Response to CBRN Casualties. JPN Apex Trauma Centre, AIIMS, New Delhi, 16 September 2010
  
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  CBRN Emergency Management. Raising Preparedness of QRTs/ Co-opted Troops. INMAS, Delhi, 13 September 2010
  
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  An overview of CBRN Emergency Management: Raising Preparedness of Response Teams. Raising Preparedness of QRMTs/RAMT. INMAS, Delhi, 6 September 2010
  
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  Emergency Preparedness & Planning for Safe Transportation through Road, Rail and Pipelines. Conference on “Emergency Planning in Industries Including HWM and Transportation of Petroleum, Petroleum Products, Natural Gas by Pipelines & POL Tankers”. 30-31 August 2010, New Delhi.
  
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  CBRN Disaster Management. Workshop on Chemical (industrial) Disaster Risk Management. Agartala, 28 August 2010.
  
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  CBRN Disaster Management. CEP on Preparedness and Response for Management of CBRN Disaster, INMAS, Delhi, 16 August 2010
  
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  Critical Issues in Management of CBRN Emergencies: An Overview. Preparing National Security Guards for Common Wealth Games. INMAS, Delhi, 2 August 2010
  
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  CBRN Threats and Mitigation. Conference on Science & Technology for Homeland Security -2010, New Delhi, 29 July 2010.
  
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  Basic issues in CBRN Disaster Management. Orientation Course for Medical/Nursing Officers, Paramedics - Army Hospital R & R, 15 June 2010
  
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  CBRN Disaster: An overview. NBCD Specialisation Course (Nuclear Disaster Management), INMAS, Delhi, 30^th April 2010
  
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  Nuclear Decontamination of Men and Equipment. Training on ‘Preparedness for Emergency Medical Response to CBRN Casualties’, for Medical Officers of GNCT of Delhi; JPN Apex Trauma Centre, AIIMS, New Delhi, 29^th April 2010
  
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  CBRN Mock Exercises- Testing of Emergency Management Plans. Seminar on ‘New Advancements in NBC Defence and Radiological Safety practiced onboard Ships and Submarines’, NBCD School, INS, Shivaji, Lonavla, 23^rd March 2010
  
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  Management of CBRN Disasters: Role Pharmacist can play. Indian Pharmaceutical Association Convention 2010, Chennai, 13th March 2010
  
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   National Guidelines and formulation of Action Plan. Conference on Chemical (Industrial) Disaster Management (CIDM-2010): Global Perspective. Convention Centre, Renaissance, Powai, Mumbai, February 15-16, 2010
  
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  Nuclear Disasters (Accidental/Intentional). Workshop/Seminar on Climate Change and Disaster Management. MGICCC, Delhi, 22nd January 2010.
  
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  National Guidelines and Regulatory Framework: Preventive Approach. Plenary Lecture during Conference on Chemical (Industrial) Disaster Management Pipelines, Storages and Medical Preparedness, FICCI, New Delhi, 11-13 Feb’2009.
  
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  Chemical Disaster Action Plan: Salient inputs from NDMA. Plenary Lecture during Conference on Chemical (Industrial) Disaster Management Pipelines, Storages and Medical Preparedness, FICCI, New Delhi, 11-13 Feb’2009.
  
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  Nuclear and Radiological Emergency Preparedness: Decontaminatrion Issuues. Plenary Lecture during 28th IARP Conference with focal theme of Management of Nuclear and Radiological Emergencies (IARP NC-2008), Jodhpur.
  
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  Medical Preparedness for Radiation Disaster Management. Plenary Lecture during International Conference on Radiation Biology & Translational Research in Radiation Oncology (ICRB 2008), Jaipur 10^th November 2008.
  
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  Chemical Disaster Management. KEY NOTE ADDRESS during ICC-CCPS Seminar on Process Safety in Chemical Industry, Mumbai, 7^th December 2007
  
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  Disaster related technical education in Pharmacy Curricula: Present status and perspectives with special reference to CBRN Disaster. Plenary Lecture during 12^th Annual Convention of APTI, Chandigarh, 26^th October 2007
  
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  Nano-particulate carriers for drug delivery. Invited Lecture in Symposia on Medical Sciences (including Physiology) 92^nd Indian Science Congress, Ahmedabad (7^th January 2005)
  
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  Radioprotection by Plants of the Himalayan High Altitude Region. Plenary Lecture 7 at 56^th Indian Pharmaceutical Congress. Kolkata (3^rd December 2004)
  
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  MR Spectroscopy for rapid evaluation of metabolic modulation approaches for improving radiotherapy of tumours. Plenary Lecture during Symposium on ‘Biomarkers of Ecotoxicity, Cancer Monitoring and Prevention’, Jamia Hamdard, New Delhi , 29^th August 2004
  
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  Nuclear Medicine Imaging: A development tool in Pharmaceutical research. Invited Lecture in Symposium 2: Drug Discovery, 55^th Indian Pharmaceutical Congress, Chennai, (19^th December 2003)
  

	Selective enhancement of glucose uptake in tumors by Photosan-3: implications for improving radiotherapy of cancer. Invited Lecture in Symposium 15: Novel approaches in Cancer Therapy, 54^th Indian Pharmaceutical Congress, Pune (15^th December 2002) MRS-a cost effective modality for rapid pre-pharmacological screening of promising drug candidates in post-CPC SEA era. Symposium of Biomedical Magnetic Resonance, Plenary Lecture during Annual meeting of National Magnetic Resonance Society, Lucknow (22^nd January 2002) Rapid evaluation of metabolic modulators by MRS. Plenary Lecture 11 during 53^rd Indian Pharmaceutical Congress Association, New Delhi, (23^rd December 2001) ‘Medical Informatics: Challenges and Opportunities’ KEY NOTE ADDRESS during Conference of the Indian Association for Medical Informatics (IAMI-2001), YMCA, New Delhi (^3rd March 2001) _____________________________________________________________________ Other Interactions _____________________________________________________________________ Interacting with leading R & D Centres, academia and Industry like  NCL, IISc, IITG, CDRI, RRLJ, IHBT, ACBR, AIIMS, MAMC, NEHU, Bharathiar Univerity, CCS University, MSU, Vadodera, Jamia Hamdard University, University of Delhi, Ranbaxy Research Laboratory, Nicholas Piramal, Sun Pharma Advance Research Centre and Lupin Laboratories; Co-ordination and liaisoning with NDMA, MoH&FW, IPC, ICMR, IPC, CSIR and DST on various official assignments
INVITED TALKS/SEMINARS/PRESENTATIONS (ABROAD)
	‘Spread & Severity of Novel H1N1 flu (Swine Flu) Pandemic in India: A revisit of the Mitigation Strategies adopted’. Canada-India Workshop on Frontiers in Science and Engineering, York University, Toronto, 12^th October, 2011 ‘Indian Approach to CBRN Defence’. XIVth International CBRN Symposium, Defence Academy of the United Kingdom, Shrivenham, 5th October 2011 Exploring Technical and Practical Cooperation: Response and Crisis Management. IISS workshop "Avenues for Cooperation on Nuclear and Radiological Security", London, UK, 21 January 2011 Demystifying novel H1N1 Pandemic Flu. Department of Chemistry and Biochemistry, Medical Faculty, Trakia University, Stara Zagora, Bulgaria, 3^rd December 2009 Biomarkers, South Africa-India Workshop on Biotechnolgy and Health, Pretoria, South Africa, 30th March 2009 Herbal Radioprotectors, Institutional mechanisms and Policies for Disaster Management, Swedish Rescue Services Agency, Karlstad, Sweden, 4th December 2008. Disaster Management in India: Recent initiative, Training School of Swedish Rescue Services Agency, Skovde, Sweden, 8th December 2008. An overview of MR Contrast Agents: Part II, Max-Planck Institute of Biological Cybernetics, Tuebingen, Germany, 3rd September 2002 Enhancement of glucose uptake in tumors by Haematoporphyrin derivative: Implications for improving radiochemotherapy of Brain tumor. Wallace Kettering Neurosciences Institute, Kettering, USA, 27th August 2002 Attended Society for Molecular Biology Meeting at Boston, USA (August 2002) An overview of MR Contrast Agents: Part I, Max-Planck Institute of Biological Cybernetics, Tuebingen, Germany, 22nd August 2002 Basics of MR Contrast and relaxation, Max-Planck Institute of Biological Cybernetics, Tuebingen, Germany, 6th August 2002 MRS of Intact Cancer Cells for Design, Development and High-throughput Screening of Promising Drug Candidates as Adjuvant to Radiotherapy. Max-Planck Institute of Biological Cybernetics, Tuebingen, Germany, 11th July 2002 Concepts of 2-deoxy-D-glucose in Radiotherapy. Radiopharmazeutisches Seminar, PET Center, Radiopharmacy, Eberhard Karls Universitaet, Tuebingen, Germany, 4th July 2002 Pre-pharmacological evaluation of Promising metabolic concepts using NMR spectroscopy Radiopharmazeutisches Seminar, PET Center Radiopharmacy, Eberhard Karls Universitaet, Tuebingen, Germany, 27th June 2002 Rationale and Experimental Design of Photsan-3 and FDG–PET study. Center for PET/ Clinic of Nuclear Medicine and Dept. of Pulmonary Diseases, Central Clinic, Bad Berka, Germany, 8th May 2000
	Prepharmacological Drug Screening through a consideration of Pharmacokinetics and Bioenergetics as monitored by P-31 MRS. Dept. of Biomedical Engineering, University of Applied Sciences, Jena, Germany, 4th May 2000 Metabolic modulation of 2-deoxy-D-glucose for increasing its efficacy and selectivity. Center for PET/Clinic of Nuclear Medicine, Central Clinic, Bad Berka, Germany, 20th April 2000 MRS of intact tumor cells for developing energy-linked radiomodifiers. INSERM U438-RMN Bioclinique, Centre Hospitalier Universitaire, Grenoble, Cedex, France, 30th March 2000. MRS technique for simulating micro-environmental conditions of the tumour, Institute of Biophysics, University of Frankfurt, Germany, 28^th November 1991

LECTURES DELIVERED AT INDUSTRIAL/EDUCATIONAL INSTITUTIONS AND PROFESSIONAL FORUM An overview of Chemical Disaster Management. Training course on Role of Police in Disaster Management, 30^th September 2009, NIDM, New Delhi Management of CBRN Disasters, Pharmacy Department, Faculty of Technology & Engineering, The Maharaja Sayajirao University of Baroda, 25^th September 2009 Vadodara. CBRN Disaster Management. NIDM Training Programme on Chemical, Biological, Radiological And Nuclear (CBRN) Disasters; 9^th September 2009, Delhi Salient Features of NDMA- Chemical (Inudstrial) Disaster Management Guidelines Defining Safety Parameter on Pipelines, Containrerisation, Storages and Ports. Conference on Safety and Security of Chemicals, Petroleum, Petroleum Products & Natural Gas at Storages, Waregouses, Ports and Transportation through Pipelines & Containers, August 12-13, 2009 Chennai. Nuclear Decontamination of Man and Equipment Training Course on Preparedness for Emergency Medical Response to CBRN Casualties for Medical Officers of GNCT of Delhi, JPN Apex Trauma Center, AIIMS 29-31 July 2009 Disaster Management: Current Status and Perspectives. Quality Improvement Programme on “A New Pharmacy Era: Quality Initiatives and New Technologies”, Jadavpur University, Kolkata, 23^rd July, 2009. Disaster Management: Role Pharmacist can play. Quality Improvement Programme on “A New Pharmacy Era: Quality Initiatives and New Technologies”, Jadavpur University, Kolkata, 22^nd July, 2009. Medical Preparedness for CBRN Disasters. Quality Improvement Programme on “A New Pharmacy Era: Quality Initiatives and New Technologies”, Jadavpur University, Kolkata, 22^nd July, 2009. Medical Preparedness for CBRN Disasters. Training programme on ‘Disaster Health Care Management’, NIDM, New Delhi, 19th June 2009 Disaster Management in India with special reference to CBRN Disasters. 2nd Structured Workshop, INMAS, Delhi, 18th June 2009
Historical Overview of Disaster Management in India. Seminar on Disaster Management. Central Command’s Commanders Conference, Nainital, 11th June 2009 Case Studies of Important Natural Disasters, Lessons learnt and National Programmes on Disaster Mitigation. Seminar on Disaster Management. Central Command’s Commanders Conference, Nainital, 11th June 2009. Evaluation of Brain Drug Delivery Approaches by Pharmacoscintigraphy Technique. Quality Improvement Programme on Advances in Targeted Drug Delivery Systems, Birla Institute of Technology, Ranchi, 1 June 2009. Nuclear Decontamination of Man and Equipment. Training Course on Preparedness for Emergency Medical Response to CBRN Casualties for Medical Officers of GNCT of Delhi, JPN Apex Trauma Center, AIIMS 22 May 2009 Salient Inputs from NDMA conference on Chemical (Industrial) Disaster Management Pipelines, Storages and Medical Preparedness, FICCI, New Delhi, 11-13 Feb, 2009 Chemo-surveillance and Risk Management Strategies to enhance Industry-Community linkages. NDMA-FICCI-MoEF National Conference, Hyderabad, 28th February 2008 Emergency Medical Preparedness and Response to Chemical Disasters. National Level Training Programme on On-Site & Off-Site Emergency Management Planning, Guwahati, 23rd December 2008 Salient Features of NG on Medical Preparedness & Mass Casualty Mgmt. Programme on Mass Casualty Management, NIDM, Delhi, 17 November 2008 Salient features of Chemical & Biological Disaster Management Guidelines. Training Programme on Disaster Management for Revenue Officers, HIPA, Gurgaon, 6th November 2008 District Chemical & Industrial Disaster Management Plan. Training Programme on Disaster Management for Revenue Officers, HIPA, Gurgaon, 6th November 2008 Management of Hazchem Transportation Emergencies: Challenges and Perspective. World Congress on Disaster Management (WCDM,-2008) Hyderabad, October 23, 2008. Perspectives of Emergency Management System in National Disaster Management Guidelines for Pipelines Carrying HAZCHEM. National Conference on Safeguarding Pipelines, Isolated Storages and Ports Handling Hazardous Chemicals. Goa,  October 16, 2008 Management of Nuclear and Radiological Emergencies. Indian Red Cross Society. New Delhi. September 26, 2008. Biological Disaster Management. Indian Red Cross Society. New Delhi. September 26, 2008. Emergency Preparedness: Medical Response to Chemical Disaster Management. Training Program on “Industrial & Chemical Disasters, Haryana Institute of Public Administration. August 29, 2008 Management of Chemical Transportation Emergencies. Training Program on “Industrial & Chemical Disasters, Haryana Institute of Public Administration. August 29, 2008 Creating Awareness, Raising Preparedness and Honing Radiological Emergency Response: A Glimpse into the Future. Indo-US Workshop on “Medical countermeasures for radiation injury: current and evolving technologies” 17-20 Aug’ 2008
On-Site Planning & Emergency Planning for Transportation & Pipelines. FICCI-NDMA National Conference on On-Site Planning of the Industry including Medical Preparedness & Management of Casualties. Chennai. July 24-25, 2008 Prevention and Preparedness for Chemical (Industrial) Disasters- Emerging Concepts. FICCI-NDMA National Conference on Industrial (Chemical) Disaster Management. Kolkata, 27th March 2008 General Methods of Phytochemical & Biological Screening, Isolation and Purification of Plant Constituents. Faculty of Pharmacy, Jamia Hamdard, Delhi, 17th March 2008 Prevention and Preparedness for Chemical (Industrial) Disasters-Emerging Concepts. NDMA-FICCI-MoEF National Conference, Hyderabad, 28th February 2008 An Introduction to National Disaster Management Guideline. National Consultation Workshop on Health Sector Disaster Management. Organised by MoH&FW at INSA, New Delhi, 17^th December 2007 An Overview of Chemical Disasters. Medical Preparedness and Mass Casualties Management, PMI, NTPC Ltd., Noida, 23rd November 2007 Introduction to National Guideline on Chemical (Industrial) Disaster Management. FICCI-NDMA National Conference on Industrial (Chemical) Disaster Management Awareness, Goa, 15^th November 2007 Creating Disaster Resilient Communities. FICCI-NDMA National Conference on Industrial (Chemical) Disaster Management Awareness, Goa, 15th November 2007 Biological and Nuclear Disaster Management. Indian Red Cross Society, 29th October 2007, New Delhi Creating Disaster Resilient Communities: Industry & Community Initiative. FICCI-NDMA National Conference on Chemical (Industrial) Disaster Management Awareness. Vadodara, 8th August 2007 Chemical Disasters. Training Programme on NBC Disasters. National Institute of Disaster Management, New Delhi, 6th August 2007 Safety and Security in Handling commonly used Toxic Industrial Chemicals/Materials. National Conference on Chemical (Industrial) Disaster Management Awareness. FICCI, Mumbai, 2nd June 2007 Nuclear Medicine for Pharmaceutical Research, SPARC, Vadodara, 5th January 2005 Pharmacoscintigraphy in DrugResearch, Pharmacy Department, Faculty of Technology and Engineering, MSU, Vadodera, 4th January 2005 Chemical (Industrial) Disaster Management in India: NDMA’s initiatives. Training Programme on Management of Hazardous Chemicals/Wastes and Industrial (Chemical) Accidents/Disasters. FICCI, Chandigarh, 28th March 2007 Biological and Chemical (Terrorism) Disasters: Documentation and R&D issues; National Workshop on Biological and Chemical Disasters, NDMA, New Delhi; 23rd February 2007 Chemical Disaster Management: Present Status and Context. National Workshop on CDM, Disaster Management Institute, Bhopal, 7the September 2006 Techno-legal regimes for Chemica l Disasters. Workshop on Chemical Industrial Disaster Management, NDMA, New Delhi, 17^th February 2006
Emerging NMR techniques for Drug Research, Quality Improvement program entitled Recent Advances in Analytical Techniques, College of Pharmacy, New Delhi, 7^th March 2002 Nuclear Magnetic Resonance Spectroscopic techniques for pre-pharmacological evaluation of promising drug candidates, Department of Pharmacology, AIIMS, New Delhi, 16^th February 2002 Applications in Biomedicine Course. Dr. BR Ambedkar Centre for Biomedical Research, University of Delhi, Delhi, 22nd September 2000 In vivo Magnetic Resonance Spectroscopy. Magnetic Resonance: Applications in Biomedicine Course. Dr. BR Ambedkar Center for Biomedical Research, University of Delhi, Delhi, 15th September 2000
	Quality Assurance of Radiopharmaceuticals. DRM PG Course, Faculty of Medical Sciences, University of Delhi, Delhi, 17th August 2000 MR Spectroscopy for rapid evaluation of potential drugs. Ranbaxy Research Laboratories, Gurgaon, 3rd August 2000 Studies of Cellular Metabolism by FT-NMR. The Pharmaceutical Discussion Group, New Delhi, 24th June 1997
INTERNATIONAL CONFERENCES/WORKSHOPS/SYMPOSIA ORGANISED _____________________________________________________________________________ Indian Co-ordinator, Indo-UK Conference on CBRN Disaster Management and Security, FICCI, New Delhi (16- 17 February 2012) Indian Co-ordinator, Indo Taiwan Workshop on Drug Development for Cancer and Infectious Disease: From Basics to Industry, Moga, Punjab (14- 15 December 2011) Organising Secretary, Workshop for Partnership Development Activities between Canada & India on Photonic Sensor Technologies for Environmental Monitoring and Homeland Security, Delhi, India (1-2 March 2011) Indian Co-ordinator, 2^nd Indo South Africa Workshop on Biotechnology and Health., INMAS, Delhi India (23-24 November 2009) Indian Co-ordinator, 1^st Indo-South Africa Workshop on Biotechnology and Health, Pretoria, South Africa (30 March- 1 April 2009) Indian Co-ordinator, Indo-German Workshop on Recent Trends in Development of PET Pharmaceuticals, INMAS, Delhi (15-17 November 2005) Organising Secretary, Indo-Tunisian Workshop on Biotechnology in Medicine, INMAS, Delhi (28-30 June 2004) Joint Secretary, Annual Meeting of Society of Nuclear Medicine (India) and Indo-American Symposium on Nuclear Medicine, INMAS. Delhi (12-15 December 2001) Organising Secretary, Satellite meeting and Exposition of Marketable Health Care Technologies developed in India and Cuba, INMAS, Delhi (5^th October 2000) Organising Secretary, Indo-Cuban Workshop on Biotechnology in Healthcare: Institution Industry Interaction, Hotel Le Meridien, New Delhi (3-4 October 2000) Organising Secretary, Indo-Cuban Symposium on Immunotechnology in the Management of Cancer, INMAS, Delhi (7^th November 1998) Organising Secretary, Application of Photodynamic Technology in Healthcare, INMAS, Delhi (1-3 December 1997) Joint Secretary, Indo-German Workshop on Improving Tumor Radiotherapy INMAS, Delhi (5^th February 1997) Joint Secretary, Training Course and Indo-German Workshop on Applications of Flow-cytometry in Cellular and Molecular Biology, INMAS, Delhi (14-25 March 1994) Joint Secretary, Indo-Dutch Symposium on Biomedical Aspects of Photosensitization, INSA, New Delhi (15-16 May 1992) Joint Secretary, Indo-Japanese Symposium on Radiomodifiers in the Management of Cancer, JNU, New Delhi (2-6 December 1991) Joint Secretary, International Symposium on Photophysiology & Photomedicine, Jamia Hamdard Convention Center, New Delhi (14-18 February 1990) Joint Secretary, Indo-German Symposium on Recent Advances in Radiation Oncology, INMAS, Delhi (15-19 March 1989) Joint Secretary, International Seminar on Recent Trends in Non-invasive Organ Imaging, Vigyan Bhawan, New Delhi (6-8 January 1986)
OVERSEAS ASSIGNMENTS
Visited a number of Universities, Research Institutes and Hospitals in USA in 6-20 October 2003 to assess Positron Emission Technologies Deputed for about one and a half year in Germany (University of Frankfurt, Central Clinic, Bad Berka, Max-Planck Institute of Biol Kybernetics, Tuebingen), CIMAB, Cuba and on various scientific assignments during 1990-2003. I visited Swedish Rescue Services Agency, Sweden for a period of 15 days in Nov-Dec 2008 as  International Fellow (Senior Biomedical Scientist) of Indian Council of Medical Research, New Delhi. In March-April 2009, I visited Trakia University Stara Zagora, Bulgaria twice (during 15-25 March 2009 and 27 Nov-12th December 2009), to carry outcollaborative research studies on Electron Paramagnetic Resonance. I visited DST, Pretoria, South Africa (29th March -1st April 2009) as a part of Indian delegation to attend a Symposium on Biotechnology and Healthcare and develop collaborative research projects. I visited Bali, Indonesia (18-19 October 2010) as a part of DST, India delegation to attend 2nd Indonesia –India Joint Science and Technology meeting. I visited International Institute of Strategic Studies (IISS), London, UK, to participate in a workshop on “Avenues for Cooperation on Nuclear and Radiological Security” on 21 January 2011 and spoke on “Exploring Technical and Practical Cooperation: Response and Crisis Management Visited National Police CBRN Centre, Ryton, attended meeting at the Office of the Security and Counter Terrorism, Home Office, London & HART, NARU, UK, Participated in the deliberation of the workshop “ XIVth International CBRN Symposium” at Carnfield University, Shrivenham, UK (3-5 October 2011) Participated in Multi-Agency Gold (Strategic) CBRN Command (26-29 March 2012) at National Police CBRN Centre, Ryton, Coventry, UK. Visited Defence CBRN Centre, Winterbourne Gunner, UK to witness large scale CBRN Mock Drill
INTERNATIONAL SCIENTIFIC COLLABORATIONS I have played a pivotal role and acted as a crucial link both in Business Development and R&D for the following International Collaborations: Indo German collaborative project entitled, ‘Improving Cancer Radiotherapy with 2-deoxy-D-glucose’ (1990-94) Indo Cuban collaborative project entitled, ‘Development of radiopharmaceuticals for improvinf radioimmunodiagnosis & therapy’ (2000-2001) Indo-Italian collaboration between Pavia University and Radiopharmaceutical Department, INMAS on Infection Scintigraphy with special reference to Tuberculosis (Project MH-9 of Indo-Italian POC in S&T 2002-2004) Indo-Bulgarian collaboration between Trakia University, Stara Zagora and INMAS on Studies on Antioxidants against Oxidative Stress induced by Drugs and Radiation (Project B-57 of Indo-Bulgarian POC in S&T 2008-11)
MEMORANDUM OF UNDERSTANDING (MoU) _____________________________________________________________________________ Entered Memorandum of Understanding with following 5 national scientific/academic institutions and Industries to foster R&D activities: Bhabha Atomic Research Centre (Development of Systems, Training and Testing of Emergency Plans, 8^th July 2010) Ranbaxy Laboratories, New Delhi (Screening and Evaluation of formulations and New Drug Delivery Systems 22^nd January 2004) Jamia Hamdard University (collaborative activities with Life Sciences Laboratories of DRDO, 12^th May 2004) Institute of Himalayan Bioresource Technology, Palampur (Phytochemical studies, 16^th April 2004) Regional Research Laboratory (now known as Institute of Integrative Medicine), Jammu (Phytochemical studies, 18^th March 2004)

bRIEF Summary of Doctoral Thesis
Radiomodifiers are used as an adjuvant to radiotherapy for increasing the damaging effects in tumor cells and to minimize the adverse effects in normal surrounding tissues that are included in the irradiated volume. Analyses of the cytogenetic damage, DNA damage & repair, and survival have been traditionally used in radiation oncology for developing more effective and safe radiomodifiers. We have developed a quick, non-destructive and reliable method for rapid evaluation of promising agents/therapeutic modalities.

Biological NMR or MR Spectroscopy (MRS) offers unmatched possibilities for non-invasive examination of cellular biochemistry, energetics and metabolism. Utilizing MRS techniques the dynamic changes in the metabolically available concentrations and distributions of the biochemicals could be measured at different levels of organization of the living organisms. With 31P MRS, the bioenergetic changes reflecting the tumor energetics, phospholipid metabolism, intracellular pH, and other phosphorylated metabolites could be non-invasively measured in vivo. The purpose of undertaking the present study had been two-fold. First, to develop a method for obtaining NMR data from perfused intact cell system simulating the milieu of tumor. Secondly, it was our goal to compare and evaluate the metabolic effects of 2-deoxy-D-glucose (2-DG), a promising energy-linked radiomodifier administered as a single agent and in combination with agents that could modify the pharmacokinetics of 2-DG in the desired direction.

The design of assemblies for perfused agarose gel-cell thread technique for MRS was modified keeping in view the ease of operations, reliability and the intended applications. The MRS technique for studies on perfused cell populations was standardized for utilization as an experimental tumor model for radiation oncology studies. The cell-gel threads matrix could be considered as a simple model of tumor tissue (cells and interstitium) and the inlet tygon tubing for supply of perfusate could be contemplated as blood vessel. Thus, the drug treatment by this technique could be considered comparable to intra-tumoral injection.

Using this technique, dynamic information on the metabolic state of cells under well-controlled cellular environmental conditions was obtained for exploring the effects of therapeutic interventions by following the biotransformation of drug(s) and monitoring the induced therapeutic response. This method allowed dynamic monitoring of the cellular metabolic changes in the cell population under different environmental conditions with or without therapeutic interventions. The influence of various drugs and treatment modalities for cancer therapy individually or as multitherapy protocol applied by appropriate physicochemical manipulations, could be measured before, during and after the treatment. It was possible to follow the fate of the drug in situ under the normal and simulated tumor-like situations. Understanding of the spectral changes following therapeutic interventions can provide a basis for designing better treatment modalities for optimizing cancer therapy.

Preliminary studies were carried out on photodynamic (HP-PDT) effects in yeast as a model of cancer cells for standardization and to test the utility of this technique as an experimental model. Ehrlich ascites tumor cell, F-5 strain has been used for the main set of experiments since these cells can be easily passaged in suspension cultures in vitro and in the ascites fluid of mouse in vivo, and even solid tumors of the cells can be grown in the leg muscles of mouse. The usefulness of this technique to simulate tumor heterogeneity has been established. The reproducibility of the measurement was demonstrated and the ability to detect dynamic changes subsequent to physicochemical manipulations was confirmed. Investigations of the rate and extent of changes of cellular bioenergetics induced by metabolic modulators and the reversibility profile upon removal of treatment was feasible as time course studies. The modulating effects of the energy-linked on the phosphorous metabolites could be readily determined by comparing the bioenergetic status and changes in other phosphorylated metabolites with pretreatment controls. Accumulation of the phosphorylated metabolic intermediates due to inhibition of selective enzyme(s) could also be monitored as a function of time.

MRS of perfused cells had been usefully employed for rapid screening of four promising metabolic modulators, which could potentiate the effects of 2-DG. Important conclusions that could be drawn are summarized below:

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  Upon 2-DG treatment, the rate and extent of accumulation of 2-DG-6-Phosphate downfield in the PME region and the changes in the bioenergetic profile of cells, have been found to be dependent on molar concentration ratio of 2-DG to glucose, and on the flow rate of perfusion. In presence of 2-DG, utilization of C-13 enriched glucose and production of labelled lactate reduced as compared to control. These studies provided vital information on glycolytic flux in presence of 2-DG.
  
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  Our observation about the adequacy of utilizing phospholipids as a biomarker of radiation induced therapeutic response in 31P MRS studies on perfused cells, was validated in solid tumors also. PC/GPC ratio could be employed as a reliable indicator for radiotherapeutic response as it reflects the rate of turnover (synthesis versus breakdown) of membrane phospholipids.
  
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  Certain unique signals have been observed upon treatment with 2-deoxy-D-galactose, and 6-amino-nicotinamide, which could throw some light on their mechanism of action. The assignments and monitoring of 2-deoxy-D-galactose-1-phosphate peak in the studies with 2-deoxy-D-galactose and 6-phosphogluconate in the studies with 6-amino-nicotinamide helped in understanding their metabolic role and the probable mode of action.
  
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  Amongst a number of potential metabolic modulators evaluated as adjuvant to 2-DG in increasing the extent and duration of its effects on tumor cell bioenergetics, 6-aminonicotinamide and haematoporphyrin derivative (Hpd) appear promising. Energy deficiency induced by these combinations was more pronounced and sustained (irreversible). Energy status did not recover implying that the combinations could be more useful as adjuvant to radiotherapy. The effects of these combinations were more prominent in studies carried out under simulated hypoxic conditions of tumors.
  
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  Hpd, a well-accepted drug for PDT, and 2-DG combination was considered most potential combination in perfused cell MRS. The usefulness of Hpd in increasing the bioavailability of 2-DG was proved even in solid Ehrlich ascites tumors, as predicted on the basis of MRS studies on perfused EAT cells. Variance in the results on bioenergetic status in the perfusion and in vivo tumor models observed in many experiments with Hpd and 2-DG combination could be explained on the basis of several variables in the two systems. MR spectral variations with perfused cells and murine tumor need further investigation to understand their pharmacological significance. Effects of Hpd and 2-DG combination on the radiotherapeutic response in animal tumor model indicate the utility of the approach in improving tumor therapy. Acid shift in pH in addition to remarkable increase in GPC and Pi levels upon Hpd + 2-DG treatment followed by irradiation could be justified as expected in tumors undergoing slow acidosis. The increase in therapeutic advantage observed in MRS studies of perfused cells needs validation using conventional techniques in various other models before clinical applications.
  

Rapid screening of potential drugs/therapies, forecasting the probable mode of action of effective therapies and designing better approaches of therapeutic interventions is some of the contemplated applications of this technique in drug research. By this non-invasive pre-pharmacological screening, a number of systematic invasive experimentation on animals could be avoided/minimized. Actual clinical experiment could thus be reduced without compromising the pharmacological relevance.

SUMMARY OF PUBLISHED WORK OF DR. RAKESH KUMAR SHARMA

Journals (Accepted/published = 216)
		Papers accepted / published in international journals	101
		Papers accepted/published in national journals	46
		Short papers published in national/international journals	69
Chapter in books			32
Chapter in monographs			14
Books/monograph edited			13
Guidelines prepared			08
Patents granted/filed/applied			07
Popular Articles in Hindi			17
Invited seminars/talks			~100
	Paper presented in Conferences = Presenting author/co-author of ~200presentations

TOTAL NUMBER OF PUBLICATIONS/BOOK CHAPTERS = 216 + 32 + 14 = 262

Dr. Rakesh Kumar Sharma’s research group papers have been published in the various peer reviewed journals as described below:

PAPERS PUBLISHED IN NATIONAL JOURNALS WITH IMPACT

FACTORS = 8

Name of Journal	I.F.	Paper(s)	Total I.F.
Ind. J. Biochem. Biophys	0.574	3	1.722
Ind. J. Exp. Biol.	0.55	1	0.55
Ind. J. Chem (A)	0.617	1	0.617
Ind. J Med Res	1.516	1	1.516
Ind J Pharmacol	0.267	1	0.267
J. Sci Ind Res	0.359	1	0.359
TOTAL		8	5.031
Average impact factor of 8 Papers published in national journals = 0.6288 PAPERS PUBLISHED IN INTERNATIONAL JOURNALS WITH IMPACT FACTORS = 75 Name of Journal I.F. No. of Papers Total I.F. AAPS Journal 3.54 3 10.62 AAPS PharmSciTech 1.19 3 3.57 Apoptosis 4.066 1 4.066 Bioorg Med Chem Lett 2.65 1 2.65 Biotech Applied Biochem 1.239 2 2.478 Cancer Bio Therapy 2.711 2 5.422 Cellular Immunology 2.698 1 2.698 Chem Pharm Bull 1.698 1 1.698 Crit Rev Ther Drug Carrier Sys 3.308 1 3.308 Drug Deliv 1.413 1 1.413 Drugs R & D 1.354 1 1.354 Envi Mol Mutagenesis 2.868 1 2.868 Environ Toxicol Pharmacol 1.293 2 2.586 Euro J Med Res 1.13 1 1.13 Euro J Pharm Biopharm 3.151 1 3.151 Euro J Pharm Sci 2.608 1 2.608 Evid-Based Compl Alt Med 2.064 4 8.256 Expert Opinion on Drug Delivery 4.482 1 4.482 FEBS Letters 3.541 1 3.541 Hell J Nucl Med 0.705 1 0.705 Heterocycles 1.165 1 1.165 Int J Pharm 2.962 2 5.924 Integr Cancer Ther 1.508 2 3.016 J Biotech 2.881 1 2.881 Journal of Biotechnology & Biotechnological Equipment 0.503 2 1.006 J Controlled Release 5.949 1 5.949 J Drug Target 2.885 6 17.31 J Environ Pathol Toxicol Oncol 1.066 1 1.066 J Med Food 1.39 1 1.39 J Pharm Pharmacol 1.742 2 3.484 J Pharm Sci 2.906 1 2.906 Journal of Renewable and Sustainable Energy 0.855 1 0.855 Method find Exp Clin Pharmacol 1.136 1 1.136 Mol Cell Biochem 1.896 4 7.584 Nanomedicine-Nanotech Biol Med 5.44 1 5.44 New J Chem 3.006 1 3.006 Nucl Med Biol 2.456 2 4.912 Pharmacol Biochem Behavior 2.967 2 5.934 Phytomedicine 2.174 1 2.174 Phytotherapy Reserch 1.746 2 3.492 Planta Medica 2.037 1 2.037 Stem Cells and development 4.146 4 16.584 Strahlenther Oncol 3.776 2 7.552 Z. Naturforsch 'C' 0.776 3 2.328 TOTAL 75 177.735 Average impact factor of 75 Papers published in international journals 2.3698 Total impact factor of 83 papers published in SCI Journals (with impact factors) is 182.766. Average Impact factor is 2.202. PAPERS PUBLISHED IN NATIONAL JOURNALS WITHOUT IMPACT FACTORS Name of Journal Paper(s) Bioinformatics India 1 Biomedicine 2 Chemical Industry Digest 2 Chemical News 1 Defence Security Alert 2 Der Pharmacia Lettre 1 DESIDOC Bull Info Technol 1 Heralds Liby Sci 1 Ind J Hosp Pharm 8 Ind J Nuc Med 8 Ind J Pharm Edu 1 Ind J Physiol Pharmacol 2 Ind J Radiat Res 3 Mediquest 1 Pharma Methods 1 Pharma Rainmaker 1 The Phama Review 2 TOTAL 38 PAPERS PUBLISHED IN INTERNATIONAL JOURNALS WITHOUT IMPACT FACTORS Name of Journal Paper(s) Acta Pharma 1 Alasbmin J 2 Amer Journal of Drug Delivery 1 Central European Journal of Agriculture 1 Elixir Pharmacy 1 Journal of Global Infectious Diseases 1 Inter J Cosm Sci 1 J. Dietary Supplement 2

SUMMARY OF CITATIONS OF 10 IMPORTANT ARTICLES (till March 2012)

Research Manuscript	Citations
Int J Pharm 243: 93-105 (2002)	151
Phytotherapy Research 19: 1-22 (2005)	142
J Pharm Sci 95(3): 570-580 (2006)	72
J Biotech 122(4), 494-510 (2006)	51
AAPS Journal. Oct 7, 6(3), e23 (2004)	46
AAPS Pharm Sci Tech 7(1), Article 8 (2006)	41
Ind J Med Res 80: 541-545 (1984)	39
J Controlled Release 105: 185-198 (2005)	36
Mol Cell Biochem 273, 209-223.(2005)	33
Mol Cell Biochem 273, 193-208 (2005)	33
TOTAL CITATIONS	644

CONCLUSION:
I have applied for 7 patents and have 216 publications to my credit besides contributing 35 chapters in books. Total impact factor of 75 papers published in international journals is 177.735 (Average impact factor= 2.3698). Total impact factor of 83 papers published in SCI Journals (with impact factors) is 182.766. Average Impact factor is 2.202.
Maximum citations received by a paper (published by my first graduate student in 2002), is 151 and highest Impact Factor of any of my publication= 5.949. Ten of my best papers have received a total of 644 citations till now (Average citations 64.4). I have edited 13 books.

In addition, I have Edited Special issue of Journal of Pharmacy and Bioallied Sciences on CBRN Disaster Management published as Vol 2 No. 3. (2010).