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Annex 3.2. Damian Labuda’s CV



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Annex 3.2. Damian Labuda’s CV


CURRICULUM VITAE

DAMIAN LABUDA

Professor

Department of Pediatrics

University of Montreal

CHU Sainte-Justine

3175, chemin de la Côte-Sainte-Catherine

Montreal, Quebec H3T 1C5

Tel. (514) 345-4931 ext. 3586

E-mail: damian.labuda@umontreal.ca

STUDIES AND DEGREES
1967-1971 M.Sc. Biology/Biochemistry (Supervisor: Jacek Augustyniak)

Adam Mickiewicz University (UAM), Poznan.

Thesis: Studies of iodination and tritiation of the ACTH molecule.

1976 Ph.D., Biochemistry (Supervisor: Jacek Augustyniak) (UAM)

Thesis: Studies of phenylalanine-specific tRNA from barley.

1982 D.Sc. ("Habilitacja") (UAM)

"Code RNA: RNA. Mechanism of codon recognition by tRNA". (UAM editions, 1983, biology series, vol. 22).
PRE AND POST-DOCTORAL TRAININGS
1971 Service of Biochemistry, Centre d'Énergie Nucléaire,

Saclay, France


1972-1973 Institute of Plant Physiology,

Hungarian Academy of Sciences, Szeged, Hungary

1978-1982 (3 full years) Max-Planck Institute of Biophysical Chemistry,

Göttingen, Germany



POSITIONS

1972-1976 Research Assistant

1976-1981 Adjunct Department of Biochemistry,

Institute of Biology, UAM, Poznan.


1982-1984 Research Associate Department of Biochemistry,

Université de Montréal.

1984-1988 Research Assistant Department of Pediatrics,

Professor Université de Montréal.


1988-1990 Research Associate Professor Department of Pediatrics,

Université de Montréal.


1990-1994 Associate Professor Department of Pediatrics,

Université de Montréal.


1994-Present Professor Department of Pediatrics,

Université de Montréal.



AFFILIATIONS
Molecular Biology Program/University of Montreal
Chercheur titulaire de l’IREP (Institut Interuniversitaire de Recherche sur des Populations until 2001)
Comité de direction du RMGA (Réseau de Médecine Génétique Appliquée of FRSQ)
Scientific Advisor (Molecular Biology Diagnostic Laboratory at Hôpital Sainte-Justine)


FELLOWSHIPS
1971 Commissariat d'Énergie Atomique, France.
1972/1973 Hungarian Academy of Sciences, Hungary.
1978/1982 Max-Planck Gesellschaft, Germany.

(3 full years)


1986-1992 Fonds de la recherche en santé du Québec, (FRSQ).

Scholarship - Sénior I/II


1992 Prize of Excellence - Conseil des Clubs de Service.

Published Refereed Papers (2003-present)


  1. Xu L, Pan-Hammarstrom Q, Forsti A, Hemminki K, Hammarstrom L, Labuda D, Gustafsson JA and Dahlman-Wright K (2003) Human estrogen receptor Beta 548 is not a common variant in three distinct populations. Endocrinology 144:3541-3546.




  1. Bortolini M-C, Salzano FM, Thomas MG, Stuart S, Nasanen SPK, Bau CHD, Hutz MH, Layrisse Z, Petzl-Erler ML, Tsuneto LT, Hill K, Hurtado AM, Castro-de-Guerra D, Torres MM, Groot H, Michalski R, Nymadawa P, Bedoya G, Bradman N, Labuda D and Ruiz-Linares A (2003) Y-chromosome evidence for differing ancient demographic histories in the americas. Am J Hum Genet. 73:524-539.




  1. Zietkiewicz E, Yotova V, Gehl D, Wambach T, Arrieta I, Batzer M, Cole DEC, Hechtman P, Kaplan F, Modiano D, Moisan J-P, Michalski R and Labuda D (2003) Haplotypes in the dystrophin DNA segment point to a mosaic origin of modern humans’ diversity. Am J Hum Genet. 73:994-1015.




  1. Mathonnet G, Krajinovic M, Labuda D and Sinnett D (2003) Role of DNA mismatch-repair genetic polymorphisms in the risk of childhood acute lymphoblastic leukemia. Br J Haematol. 123:45-48.




  1. Fleury I, Beaulieu P, Primeau M, Labuda D, Sinnett D and Krajinovic M (2003) Characterization of BCL-1 polymorphism in the glucocorticoid receptor gene. Clin Chem. 49:1528-1531.




  1. Mathonnet G, Labuda D (corresponding athor) Meloche C, Wambach T, Krajinovic M and Sinnett D (2003) Variable continental distribution of polymorphisms in the coding regions of DNA-repair genes. J Hum Genet. 48: 659-64.




  1. Brockstedt U, Uzarowska A, Montpetit A, Pfau W and Labuda D (2004) In vitro evolution of RNA aptamers recognizing carcinogenic aromatic amines. Biochem Biophys Res Commun. 313: 1004-8




  1. Krajinovic M, Lamothe S, Labuda D, Lemieux-Blanchard E, Théorêt Y and Sinnett D (2004) Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Blood. 103:252-7




  1. Xiao F-X, Yotova V, Zietkiewicz E, Lovell A, Gehl D, Bourgeois S, Moreau C, Spanaki C, Plaitakis A, Moisan J-P and Labuda D (2004) Human X-chromosomal lineages in Europe reveal Middle Eastern and Asiatic contacts. Eur J Hum Genet. 12: 301-11




  1. Pastinen T, Sladek R, Gurd S, Ge B, Lepage P, Sammak A, Laverge K, Villeneuve A, Gudin T, Forgetta V, Beck A, Zotti C, Bourgoin S, Verner A, Harmsen E, Labuda D, Morgan K, Dewar K, Vohl M-C, Naumova AK, Sinnett D and Hudson TJ (2004) A survey of genetic and epigenetic variation affecting human gene expression. Physiol Genomics 16: 184-93


Published Refereed Papers (2003-present) (continued)


  1. Le Jossec M, Wambach T, Labuda D (corresponding author), Sinnett D and Levy E (2004) Genetic diversity patterns in the SR-BI/II locus can be explained by a recent selective sweep. Mol Biol Evol. 21: 760-9.




  1. Bourgeois S and Labuda D (2004) Dynamic allele-specific oligonucleotide hybridization on solid support. Anal Biochem 324:309-311.




  1. El-Mabrouk N and Labuda D (2004) Haplotypes histories as pathways of recombinations. Bioinformatics 20:1836-41.




  1. Lovell AD, Yotova V, Xian F-X, Batzer MA and Labuda D (2004) Polymorphisms within a polymorphism: SNPs in and around a polymorphic Alu insertion in intron 44 of the human dystrophin gene, detected by SSCP and dHPLC. J Hum Genet 49:269-72.




  1. Brukner I, Paquin B, Belouchi M, Labuda D and Krajinovic M (2005) Decrease of self-priming by modified random oligonucleotides incresase the performance of whole genome amplification. Anal Biochem. 339:345-347.




  1. Duquette A, Roddier K, McNabb-Baltar J, Gosselin I, St-Denis A, Dicaire MJ, Loisel L, Labuda D, Marchand L, Mathieu J, Bouchard JP and Brais B (2005) Mutations in senataxin responsible for Quebec cluster of ataxia with neuropathy. Ann Neurol. 57: 408-414.




  1. Laberge AM, Jomphe M, Houde L, Vézina H, Tremblay M, Desjardins B, Labuda D, St-Hilaire M, Macmillan C, Shoubridge EA and Brais B (2005) A “Fille du Roy” introduced the T14484C Leber hereditary optic neuropathy mutation in French Canadians. Am J Hum Genet. 77:313-317.




  1. Lovell A, Moreau C, Yotova V, Xiao F, Bourgeois S, Gehl D, Bertranpetit J, Schurr E and Labuda D (2005) Ethiopia: between Sub-Saharan Africa and western Eurasia. Ann Hum Genet. 69:275-287.




  1. Yotova V, Labuda D (corresponding author), Zietkiewicz E, Gehl D, Lovell A, Lefebvre J-F, Bourgeois S, Lemieux-Blanchard É, Labuda M, Vézina H, Houde L, Tremblay M, Toupance B, Heyer E, J.Hudson T, Laberge C (2005) Anatomy of a founder effect: myotonic dystrophy in Northeastern Quebec. Hum Genet. 117: 177-187.




  1. Bélanger H, Beaulieu P, Moreau C, Labuda D, Hudson TJ and Sinnett D (2005) Functional promoter SNPs in cell cycle checkpoint genes. Hum Mol Genet. 14:2641-2648.




  1. Sinnett D, Labuda D and Krajinovic M (2005) MTHFR genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukemia. Blood 106:2590-2591.

Published Refereed Papers (2003-present) (continued)



  1. Bedoya G, Montoya P, Garcia J, Soto I, Bourgeois S, Carvajal L, Labuda D, Alvarez V, Ospina J, Hedrick PW and Ruiz-Linares A (2006) Admixture dynamics in Hispanics: a shift in the nuclear genetic ancestry of a South American population isolate. Proc Natl Acad Sci USA 103:7234-7239.




  1. Brukner I, Labuda D and Krajinovic M (2006) Phi29-based amplification of small genomes. Anal Biochem. 354:154-156.




  1. Sinnett D, Beaulieu P, Bélanger H, Lefebvre JF, Langlois S, Théberge MC, Drouin S, Zotti C, Hudson TJ and Labuda D (2006) Detection and characterization of DNA variants in the promoter regions of hundreds of human disease candidate genes. Genomics 87:704-710.




  1. Durocher F, Labrie Y, Soucy P, Sinilnikova O, Labuda D, Bessette P, Chiquette J, Laframboise R, Lepine J, Lesperance B, Pichette R, Plante M, Tavtigian SV and Simard J (2006) Mutation analysis and characterization of ATR sequence variants in breast cancer cases from high risk French Canadian breast/ovarian cancer families. BMC Cancer 6:230-251.




  1. Healy J, Bélanger H, Beaulieu P, Larivière M, Labuda D and Sinnett D (2007) Promoter SNPs in G1/S checkpoint regulators and their impact on the susceptibility to childhood leukemia. Blood 109:683-92.




  1. Fuselli S, Gilman RH, Chanock SJ, Bonatto SL, De StefanoG, Evans CA, Labuda D, Luiselli D, Salzano FM, Soto G, Vallejo G, Sajantila A, Pettener D and Tarazona-Santos E (2007) Analysis of nucleotide diversity of NAT2 coding region reveals homogeneityacross native American populations and high intra-populations diversity. Pharmacogenomics J. 7: 144-152.




  1. Labuda D, Labbé C, Langlois S, Lefebvre J-F, Freytag V, Moreau C, Sawicki J, Beaulieu P, Pastinen T, Hudson TJ and Sinnett D (2007) Patterns of variation in DNA segments upstream of transcription start sites. Hum Mutat. 28: 441-450.




  1. Brukner I, El-Ramahi R, Gorska-Flipot I, Krajinovic M and Labuda D (2007a) Generation of oligonucleotide probes to discriminate between closely related DNA sequences. Nucleic Acids Res. 35: e66.




  1. Brukner I, Krajinovic M, Dascal A and Labuda D (2007) A protocol for the in vitro selection of specific oligonucleotide probes for high-resolution DNA typing. Nat Protoc. 11:2807-14.




  1. Brukner I, El-Ramahi R, Sawicki J, Gorska-Flipot I, Krajinovic M and Labuda D (2007b) Hybridization probes for 39 different types of Human Papillomaviruses. J Clin Virol. 39: 113-118.

Published Refereed Papers (2003-present) (continued)



  1. Pshezhetsky AV, Fedjaev M, Ashmarina L, Mazur A, Budman L, Sinnett D, Labuda D, Beaulieu JF, Ménard D, Nifant’ev I and Levy E (2007) Subcellular proteomics of cell differentiation: quantitative analysis of the plasma membrane proteome of Caco-2 cells. Proteomics. July:7 (13): 2201-2215.




  1. Witsch-Baumgartner M, Braun I, Gruber M, Andria G, Bertranpetit J, Bieth E, Clusellas N, Estivill X, Gasparini G, Giros M, Krajewska-Walasek M, Menzel J, Miettinen T, Ogorelkova M, Rossi M, Schinzel A, Schmidt K, Schõnitzer D, Seemanova E, Sperling K, Syrrou M, Talmud Philippa J, Wollnik B, Krawczak M, Labuda D, Utermann G (2007) Age and origin of major Smith-Lemli-Opitz syndrome (SLOS) mutations in European populations. J Med Gen. 45(4): 200-9.



  1. Moreau C, Vézina H and Labuda D (2007) Effets fondateurs et variabilité génétique au Québec. Médecine Sciences 11 :1008-13.



  1. Yotova V, Lefebvre JF, Kohany O, Jurka J, Michalski R, Modiano D, Utermann G, Williams SM and Labuda D (2007) Tracing genetic history of modern humans using X-chromosomes lineages. Hum Genet. 122(5): 431-43.




  1. Wang S, Lewis CM, Jakobsson M, Ramachandran S, Ray N, Bedoya G, Rojas W, Parrra MV, Molina JA, Gallo C, Mazzotti G, Poletti G, Hill K, Hurtado AM, Labuda D, Klitz W, Barrantes R, Bortolini MC, Salzano FM, Petzl-Erler ML, Tsuneto LT, Llop E, Rothhamner F, Excoffier L, Feldman MW, Rosenberg NA and Ruiz-Linares A (2007) Genetic variation and population structure in Native Americans. Plos Genetics. 3(11): e185.




  1. Dulucq S, St-Onge G, Gagné V, Ansari M, Sinnett D, Labuda D, Moghrabi A and Krajinovic M (2007) DNA variants in dihydrofolate reductase gene and outcome in childhood ALL. Blood. 111(7):3692-700.




  1. Gorska-Flipot I, Sawicki J, Gaboury LA, Krajinovic M, Labuda D, Brukner I, Rouleau D, Ghattas G, Franco EL, Coutlée F (2008) Newly isolated HPV97, related to HPV18 and 45 is frequently detected in HIV-positive men from the Montreal area. Int J Cancer. 122(5) :1195-7.




  1. Lefebvre JF and Labuda D (2008) Fraction of Informative Recombinations: a Heuristic Approach to Analyse Recombination Densities. Genetics. 178(4):2069-79.




  1. Gokcumen O, Dulik MC, Pai AA, Zhadanov SI, Rubinstein S, Osipova LP, Andreenkov OV, Tabikhanova LE, Gubina MA, Labuda D and Schurr TG (2008)Genetic variation in the enigmatic Altaian Kazakhs of South-Central Russia: insights into Turkic population history. Am J Phys Anthropol. 136(3):278-93.




  1. Sirois F, Gbeha E, Sanni A, Labuda D et Mbikay M (2008) Ethnic Differences in the Frequency of the Cardioprotective C679X PCSK9 Mutation in a West African Population. Genet Test 12(3):377-80.

Published Refereed Papers (2003-present) (continued)


  1. Cruciani F, Trombetta B, Labuda D, Modiano D, Torroni A, Costa R and Scozzari R (2008) Genetic diversity patterns at the human clock gene period 2 (PER2) are suggestive of population-specific positive selection. Eur J Hum Genet (epub ahead of print – 25 June)



Accepted or in press refereed papers (2003-present)


  1. Moreau C, Vézina H, Yotova V, Hamon R, de Knijff P, Sinnett D and Labuda D (2008) Genetic Heterogeneity in Regional Populations of Quebec - Parental Lineages in the Gaspe Peninsula. Am J Phys Anthropol (in revision)


Submitted refereed papers


  1. Bourgeois S, Yotova V, Bourtoumieu S, Moreau C, Michalski R, Moisan JP, Hill K, Hurtado AM, Ruiz-Linares A and Labuda D (2008) X-chromosome lineages reveal strong founder effect in the colonization of the Americas. (submitted – Am J Phys Anthropol)




  1. Healy J, Dionne J, Bélanger H, Larivière M, Moreau C, Labuda D and Sinnett D (2008) Functional variation of the promoter region of TGFβ1 and its impact on childhood leukemia. (submitted)




  1. N’Diaye N, Pastinen T, Paterson A, Larivière M, Labuda D, Hudson TJ and Sinnett D (2008) A Naurally Occuring Regulatory Haplotype Enhances BTN3A2 Expression. (submitted)


Published Contributions to a Collective Work/Book Chapters/Reviews (2003-present)

  1. Krajinovic M, Labuda D and Sinnett D (2003) Pharmacogenetics of childhood acute lymphoblastic leukemia. Curr Pharmacogenetics 1:87-100.



  1. Simard J, Dumont M, Labuda D, Sinnett D, Meloche C, El-Alfy M, Berger L, Lees E, Labrie F and Tavtigian SV (2003) Prostate cancer susceptibility genes: lessons learned and challenges posed. Endocr Relat Cancer 10:225-259.



  1. Cardinal G, Deschênes M, Knoppers BM, Hudson T, Labuda D, Bouchard G, Racine É, Fecteau C, Truong S and Laberge C (2003) Statement of principles on the ethical conduct of human genetic research involving populations. RMGA http://rmga.qc.ca/index.html.



  1. Labuda D, Krajinovic M and Bourgeois S (2004) Allele specific oligonucleotide hybridization (ASO). Encyclopedia of Diagnostic Genomics and Proteomics – Marcel Dekker. pp. 38-41.



  1. Sinnett D, Mathonnet G, Meloche G, Moghrabi A, Labuda D and Krajinovic M (2004) Genetic determinants to childhood acute lymphoblastic leukemia. In: Pandalai SG (ed) Recent Research Developments in Haematology. Vol 1 India. Transworld Research Network 1:135-154.

Published Contributions to a Collective Work/Book Chapters/Reviews (2003-present) (continued)

  1. Sinnett, D, Meloche C, Labuda D, Mathonnet G, Moghrabi A, Sabbagh A, Infante-Rivard C and Krajinovic M (2004) Genetic susceptibility to childhood acute lymphoblastic leukemia. Nova Science Publishers, Inc. pp. 1-31.



  1. Sinnett D, Labuda D and Krajinovic M (2006) Challenges identifying genetic determinants of pediatric cancers – the childhood leukemia experience. Fam Cancer 5:35-47.



  1. Sinnett D, N’Diaye N, Labuda D and Krajinovic M (2006) Genetic determinants of childhood leukemia. Bulletin du cancer. Sept, 93:857-865.



  1. Brais B, Desjardins B, Labuda D, St-Hilaire M, Tremblay M and Vézina H (2007) The Genetics of French Canadians. IN: Cavalli-Sforza LL, Feldman M (eds.) Henry Stewart Talks; Biomedical and Life Sciences – Human Population Genetics (CD-ROM) Londres, Angleterre: Henry Stewart Group of Companies <http://www.hstalks.com/index.htm>

Oral presentations/Seminars (2003-present)

  1. Labuda D (2003) Genetic information: What it can tell us about our ancestry? 61st Annual Meeting of the Polish Institute of Arts and Sciences of America, McGill University, June 7th, McGill University, Montreal, Qc. (invited speaker)



  1. Labuda D (2003) Malaises autour de gènes mutés ; conference on : Génomique et pluralisme au Canada échanges pour approfondir le dialogue. Bioethics Across Borders, Joint Meeting of the Canadian Bioethics Society and the American Society for Bioethics and Humanities, October 22-26, Montréal, Qc (invited presentation)



  1. Labuda D, (2003) Variabilité d’ADN – leçons sur notre histoire, le présent et le futur. Les biotechnologies 50 ans après la découverte de l’ADN, 28e Congrès annuel de l’Association des biologistes du Québec, December 4-5 (invited conference)



  1. Labuda D (2004) What genetics can tell us about our ancestry, our present and future. MUHC Research Seminar, Montreal Children’s Hospital Centenial Seminar, March 1st, Montreal, Qc. (invited conference)



  1. Labuda D, Yotova V, Piché C, Gehl D, Moreau C, Jurka J, Kohany O, Michalski R, Moisan JP, Schurr E, Utermann G, Williams S (2004) X-linked marker tracing history of human populations. HUGO: Human Genome Meeting, April 4, Berlin, Germany. (oral presentation and poster)



  1. Labuda D, Langlois S, Gehl D, Beaulieu P, Lefebvre JF, Vasquez H, Moreau C, Labbé C, Théberge MC, Bourgoin S, Zotti C, Pastinien T, Lepage P, Hudson T, Dewar K, Sinnett D. (2004) Genetic variability in gene segments upstream of coding regions. Human Genome Variation Society Scientific Meeting, April 4, Berlin, Germany (oral presentation)

Oral presentations/Seminars (2003-present) (continued)

  1. Labuda D, (2004) X Chromosome Markers & Human Population History. Population genetics symposium, Human Genetic Student Society, April 22, Montreal, Quebec. (conference)



  1. Labuda D, Yotova V, Zietkiewicz E, Gehl D, Lovell A, Lefebvre JF, Bourgeois S, Lemieux-Blanchard E, Labuda M, Vézina H, Houde L, Tremblay M, Toupance B, Heyer E, Fortin J, Lepage P, Hudson TJ, Lescault A, Laberge C (2004) Founder effect in North-Eastern Quebec and the extent of the genetic signature associated with the myotonic dystrophy mutation. « Qui fait quoi » ; 5e Journées Génétiques, RMGA, May 17, Montreal, QC. (oral presentation)



  1. Labbé C, Labuda D (2004) Diversité des régions promotrices des gènes du métabolisme du glutathion. XIXe Congrès Annuel de la recherche des étudiants gradués et post-gradués, Centre de recherche de l’Hôpital Sainte-Justine, Université de Montreal. June 4, Montreal, QC. (oral presentation)



  1. Labuda D (2004) X-linked markers tracing history of human populations, LMS Durham Symposiums on Mathematical Genetics, University of Durham, July 5, United Kingdom. (invited presentation)



  1. Labuda D, Lefebvre J, Moreau C, Labbé C, Langlois S, Beaulieu P, Theberge MC, Bélanger H, Sinnett D and the Genome Quebec Regulatory Genetics Consortium (2005) Contribution of gene conversions to the genetic diversity of DNA segments. European Human Genetics Conference, May 7-10, Prague, Czech Republic. (oral presentation)



  1. Labuda D (2006) Natural selection in the promoter regions: genetic diversity upstream of transcription start sites. Genes and Populations in Health and Disease, Portugaliae Genetica, 9th edition, March 6-8, Porto, Portugal. (invited presentation)



  1. Labuda D (2006) Reading history of human populations from genetic diversity of chromosome Xp21. Genes and Populations in Health and Disease, Portugaliae Genetica, 9th edition, March 6-8, Porto, Portugal. (invited presentation)



  1. Labuda D, Yotova V, Lefebvre J-F, Kohany O, Jurka J, Michalski R, Modiano D, Utermann G and Williams S (2007) Structure complexe de la population ancestrale humaine - une histoire génétique retracée par les lignages du chromosome Xp21, GALF, 31 mai, 1-2 juin, Genève, Suisse. (oral presentation)



  1. Labuda D, Moreau C, Yotova V, Hamon R, de Knijff P, Sinnett D and Vézina H. (2008) Genetic heterogeneity in regional populations of Quebec – parental lineages in the Gaspé Peninsula. 7ème Journées génétique RMGA. May 14-16, 2008, Québec, Canada. (oral presentation)

International Conference Abstracts/posters (2003-present)

  1. Drouin S, Beaulieu P, Labuda D and Sinnett D (2003) Comparative genomic approach to human transcription factor binding site validation. Oncogenomics 2003, January 28-February 2, Phoenix, AZ.



  1. El-Mabrouk N and Labuda D (2003) Haplotypes histories as networks of recombinations. Recomb 2003, April 10-13, Berlin.



  1. Witsch-Baumgartner M, Labuda D and Utermann G (2003) Origins of the common DHCR7 mutations: IVS8-1G>C and W151X causing the Smith-Lemli-Opitz syndrome. European Human Genetics Conference 2003, European Society of Human Genetics, May 3-6, Birmingham, England.



  1. Vézina H, Bélanger J, Heyer E, Houde L, Tremblay M, Sinnett D and Labuda D (2003) Patrimoine génétique des Gaspésiens. 71e congrès de l’ACFAS « Savoirs partagés », May 19-23, Rimouski, Qc.



  1. Labuda D (2003) Genetic information: what it can tell us about our ancestry. 61st Annual Meeting of the Polish Institute of Arts and Sciences of America, McGill University, June 6-7, Montreal.



  1. Bélanger H, ThébergeM-C, Langlois S, Bourgoin S, Beaulieu P, Gehl D, Labuda D and Sinnett D (2003) High-throughput detection of polymorphisms in regulatory regions of candidate genes related to common genetic diseases. AACR, 94th Annual Meeting, July 11-15, Washington D.C., USA.



  1. Meloche C, Drouin S, Labuda D and Sinnett D (2003) Detection of putative regulatory SNPs in DNA repair genes. AACR, 94th Annual Meeting, July 11-15, Washington D.C., USA.



  1. Hudson TJ, Pastinen T, Sladek R, Gurd S, Sammak A, Ge B, Brandstrom H, Lepage P, Lavergne K, Villeneuve A, Gaudin T, Zotti C, Bourgoin S, Verner A, Harmsen E, Vohl M-C, Naumova AK, Labuda D and Sinnett D (2003) Linking haplotypes with gene regulation. AACR Special Conference in Cancer Research, September 13-17, Key Biscayne, Florida.



  1. Krajinovic M, Lamothe S, Labuda D, Lemieux-Blanchard, Théorêt Y and Sinnett D (2003) Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. AACR Special Conference in Cancer Research, September 13-17, Key Biscayne, Florida.



  1. Birkett NJ, Maziak DE, Ambrosone C, Darling G, Inculet R, Labuda D, Mckeown-Eussen G, Sinha R, Sinnnett D, Young E, Ghadirian P and Duranceau A (2004) Dietary heterocyclic amines and risk of adenocarcinoma of the esophagus. AACR, 95th Anuual Meeting, March 27-31, Orlando, FL.

International Conference Abstracts/posters (2003-present) (continued)

  1. Witsch-Baumgartner M, Rossi M, Giros M, Kelley I, Clayton P, Lechner S, Labuda D (2004) A mosaic pattern of common recurrent and founder DHCR7 mutations causing the Smith-Lemli-Opitz Syndrome in Europeans. European Human Genetics Conference, June 12-15, Munich, Germany.



  1. Bélanger H, Beaulieu P, Larivière M, Moreau C, Langlois S, Labuda D, Sinnett D (2004) Functional ploymorphisms in the regulatory region of genes implicated in G1/S checkpoint. Oncogenetics: achievement and challenges, October 7-8, Montreal, Canada.



  1. Gahier-Rudolf A, Doreau A, Labuda D, Sinnett D, Moghrabi A, Krajinovic M (2004) Glucocorticoïd receptor gene polymorphisms:frequencies and impact on ALL outcome. Annual Meeting of the American Society of Human Genetics, October 26-30, Toronto, Canada.



  1. Sanchez R, Vasquez H, Labuda D, Yotova V, Costea F, Levy E, Sinnett D (2004) Haplotype diversity and genetic determinants of the therapetic response. Annual Meeting of the American Society of Human Genetics, October 26-30, Toronto, Canada.



  1. Labbé C, Moreau C, Yotova V, Gehl D, Lefebvre J-F, Beaulieu P, Langlois S, Théberge M-C, Bélanger H, Zotti C, Sinnett D, Labuda D (2004) Polymorphisms in genes of glutathione metabolism: promoter regions. Annual Meeting of the American Society of Human Genetics, October 26-30, Toronto, Canada.



  1. Beaulieu P, Théberge M-C, Bélanger H, Langlois S, Larivière M, Lefebvre J-F, Gehl D, Labuda D, Sinnett D (2004) In-silico assesment of the impact of single nucleotide polymorphismsin the regulatory regions of human genes. Annual Meeting of the American Society of Human Genetics, October 26-30, Toronto, Canada.



  1. Théberge M-C, Bourgoin S, Beaulieu P, Langlois S, Bélanger H, Gehl D, Labuda D, Sinnett, D (2004) High-throughput detection of regulatory polymorphisms in candidate genes relevant to common diseases. Annual Meeting of the American Society of Human Genetics, October 26-30, Toronto, Canada.



  1. Bélanger H, Beaulieu P, Larivière M, Moreau C, Langlois S, Labuda D, Sinnett D (2004) Functional ploymorphisms in the regulatory region of genes implicated in G1/S checkpoint. Annual Meeting of the American Society of Human Genetics, October 26-30, Toronto, Canada.



  1. Labrie Y, Durocher F, Soucy P, Labuda D, Simard J (2004) Characterization of sequence variants in high-risk non-BRCA1/2 French Canadian families. Annual Meeting of the American Society of Human Genetics, October 26-30, Toronto, Canada.



  1. Yotova V, Lovell A, Moreau C, Bourgeois S, Xiao F, Gehl D, Bertranpetit J, Schurr E, Labuda D (2004) Ethiopia: between Sub-Saharan Africa and Western Eurasia. Annual Meeting of the American Society of Human Genetics, October 26-30, Toronto, Canada.

International Conference Abstracts/posters (2003-present) (continued)

  1. Leger C, Simoneau M, Théberge M-C, Vasquez H, Lefebvre J-F, Levy E, Sinnett D, Labuda D (2004) Genetic diversity in the coding regions of three members of the glutathione peroxidase family. Annual Meeting of the American Society of Human Genetics, October 26-30, Toronto, Canada.



  1. Bourgeois S, Yotova V, Lovell A, Xiao F, Pich C, Moreau C, Bourthoumieu S, Zietkiewicz E, Michalski R, Ruiz-Linares A, Labuda D (2004) X-chromosome polymorphisms and the genetic structure of Amerindian populations. Annual Meeting of the American Society of Human Genetics, October 26-30, Toronto, Canada.



  1. Moreau C, Yotova V, Gehl D, Cauvier C, Sinnett D, De Knijff P, Vezina H, Labuda D (2004) Genetic diversity among European settlers of the Gaspe Peninsula (Quebec). Annual Meeting of the American Society of Human Genetics, October 26-30, Toronto, Canada.



  1. Labuda D, Moreau C, Langlois S, Gehl D, Beaulieu P, Lefebvre J-F, Vasquez H, Labbe C, Théberge M-C, Bélanger H, Zotti C, Sinnett D (2004) Population genetics of bona fides regulatory regions. Annual Meeting of the American Society of Human Genetics, October 26-30, Toronto, Canada.



  1. Labuda D (2005) Diversity in DNA segments upstream of the transcription start sites. HUGO Mutation Detection 2005: VIII International Symposium on Mutations in the Genome, May 31-June 4, Santorini, Greece.



  1. Labuda D and Lefebvre J-F (2006) Heuristic approach for analysis of the recombination density along DNA sequence. HGM 2006, HUGO’s 11th Human Genome Meeting, May 31-June 3, Helsinki, Finland.



  1. Sawicki J, Gaboury LA, Krajinovic M, Labuda D, Brukner I, Coutlée F, Gorska I (2006) Cloning strategy of a new type of Human Papilloma Virus from a clinical sample with mixed HPV infection. 23 International Papillomavirus Conference and Workshop, Prague.



  1. Dionne J, Ouimet M, Gagné V, Larivière M, Labuda D and Sinnett D (2007) Functional impact of regulatory polymorphisms (rSNP) in G1/S cell cycle checkpoint genes. AACR Annual Meeting, April 14-18, Los Angeles, CA.



  1. Gerbault P, Moreau C, Vézina H and Labuda D (2007) Regionalization of the founder effect in Quebec. HGM2007, May 21-24, Montreal, Qc.



  1. Dionne J, Ouimet M, Gagné V, Larivière M, Labuda D and Sinnett D (2007) Functional impact of regulatory polymorphisms (rSNP) in G1/S cell cycle checkpoint genes. HGM2007, May 21-24, Montreal, Qc.



  1. Gerbeault P, Moreau C, Vézina H and Labuda D (2007) Régionalisation de l'Effet Fondateur au Québec. GALF 2007, 31 mai, 1-2 juin, Genève, Suisse.

International Conference Abstracts/posters (2003-present) (continued)

  1. Bherer C, Labuda D, Houde L, Tremblay M and Vézina H (2007) Contribution génétique différentielle des immigrants fondateurs aux pools géniques régionaux du Québec. GALF 2007, 31 mai, 1-2 juin, Genève, Suisse.



  1. Roy-Gagnon MH, Moreau C, Sinnett D, Laprise C, Vézina H and Labuda D (2008) Regional Genetic Variation and Linkage Disequilibrium in Quebec. 3rd Annual Canadian Genetic Epidemiology and Statistical Genetics Meeting, Institute of Genetics, April 29-May 1, 2008, Toronto, ON.



  1. Hussin J, Nadeau P, Lefebvre JF and Labuda D. (2008) Haplotype Allelic Classes In The Lactase Persistence Locus. The Biology of Genomes, Cold Spring Harbour. May 6-10, 2008, New York, USA.



  1. Nadeau P, Hussin J, Lefebvre JF and Labuda D. (2008) Testing Haplotype Allelic Classes By Coalescence Simulations. The Biology of Genomes, Cold Spring Harbour. May 6-10, 2008, New York, USA.



  1. Lefebvre JF and Labuda D. (2008) InfRec: A Heuristic Tool To Analyze Recombination Rate At The Sequence Level. The Biology of Genomes, Cold Spring Harbour. May 6-10, 2008, New York, USA.

Local Conference Abstracts/posters (2003-present)

  1. Bourgeois S, Zietkiewicz E, Yotova V, Michalski R, Ruiz-Linares A and Labuda D (2003) Effets fondateurs et colonisation de l’Amérique. IXe journée scientifique des programmes de biologie moléculaire, IRCM, April 25, Montreal.



  1. Bélanger H, Théberge M-C, Langlois S, Bourgoin S, Beaulieu P, Gehl D, Zotti C, Labuda D and Sinnett D (2003) Détection de variants d’ADN dans les régions régulatrices de gènes candidats pour des maladies complexes. XVIIIe congrès annuel de la recherche des étudiants gradués et post-gradués de l’Hôpital Sainte-Justine, June 6, Montreal. (1st prize, poster presentation, M.Sc. category)



  1. Sinnett D, Lamothe S, Labuda D, Lemieux-Blanchard E, Théorêt Y, Moghrabi A and Krajinovic M (2004) Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. “Qui fait quoi” ; 5e Journées Génétiques, RMGA, May 17, Montreal, QC.



  1. Krajinovic M, Primeau M, Chiasson S, Costea I, Bournissen FG, Moghrabi A, Robaey P, Labuda D and Sinnett D (2004) Genetic polymorphisms in predicting disease outcome. « Qui fait quoi ? » ; 5e Journées Génétiques, RMGA, May 17, Montreal, QC.

Local Conference Abstracts/posters (2003-present)

  1. Vézina H, Cauvier C, Moreau C, Yotova V, Bélanger J, Houde L, Sinnett D, Tremblay M, Labuda D (2004) Étude généalogique et moléculaire du patrimoine génétique des gaspésiens. « Qui fait quoi ? » ; 5e Journées Génétiques, RMGA, May 17, Montreal, QC.



  1. Labuda D (2006) Les Québécois – des chasseurs-cueilleurs? Qui fait quoi? 6èmes journées génétiques, RMGA, May 1-2, Montreal, Qc.



  1. Gerbault P, Moreau C, Yotova V and Labuda D (2006) Régionalisation de l’effet fondateur au Québec. XXIe Congrès annuel de la recherche des étudiants gradués et post-gradués, Centre de recherche CHU Sainte-Justine, June 2, Montreal, Qc.



  1. Bourgeois S, Yotova V, Lovell A, Piché C and Labuda D (2006) Structure génétique des populations amérindiennes. XXIe Congrès annuel de la recherche des étudiants gradués et post-gradués, Centre de recherche CHU Sainte-Justine, June 2, Montreal, Qc.



  1. Bherer C, Labuda D, Houde L, Tremblay M and Vézina H (2007) Contribution génétique différentielle des immigrants fondateurs aux pools géniques régionaux du Québec. XXIIe Congrès annuel de la recherche des étudiants gradués et post-gradués, Centre de recherche CHU Sainte-Justine, May 15-16, Montreal, QC.



  1. Gerbault P, Moreau C, Vézina H and Labuda D (2007) Régionalisation de l’effet fondateur au Québec. XXIIe Congrès annuel de la recherche des étudiants gradués et post-gradués, Centre de recherche CHU Sainte-Justine, May 15-16, Montreal, QC.



  1. Dionne J, Ouimet M, Gagné V, Larivière M, Labuda D and Sinnett D (2007) Caractérisation fonctionnelle des variants génétiques de la région régulatrice des gènes du point de contrôle G1/S. XXIIe Congrès annuel de la recherche des étudiants gradués et post-gradués, Centre de recherche CHU Sainte-Justine, May 15-16, Montreal, QC.



  1. Roy-Gagnon MH, Moreau C, Sinnett D, Laprise C, Vézina H and Labuda D. (2008) Génome québécois : variabilité régionale et déséquilibre de liaison. Qui fait quoi? 7ème Journées génétiques RMGA. May 14-16, 2008, Québec, Canada.



  1. N’Diaye N, Pastinen T, Paterson A, Larivière M, Labuda D, Hudson TJ and Sinnett D. (2008) A naturally occurring regulatory Haplotype enhances BTN2A2 expression. Qui fait quoi? 7ème Journées génétiques RMGA. May 14-16, 2008, Québec, Canada.



  1. Gbeha E, Yotova V, Moreau C, Sanni A and Labuda D. Variabilité Génétique des Populations Ouest-africaines. Qui fait quoi? 7ème Journées génétiques RMGA. May 14-16, 2008, Québec, Canada.



  1. Bherer C, Vézina H and Labuda D. Conséquences des histoires démographiques régionales du Québec sur le spectre de fréquences alléliques. Qui fait quoi? 7ème Journées génétiques RMGA. May 14-16, 2008, Québec, Canada.

Local Conference Abstracts/posters (2003-present)

  1. Hussin J, Nadeau P, Lefebvre JF and Labuda D. Haplotype allelic classes in the lactase persistence locus. Qui fait quoi? 7ème Journées génétiques RMGA. May 14-16, 2008, Québec, Canada.



  1. Nadeau P, Hussin J, Lefebvre JF and Labuda D. Testing haplotype allelic classes by coalescence simulations. Qui fait quoi? 7ème Journées génétiques RMGA. May 14-16, 2008, Québec, Canada.



  1. Healy J, Dionne J, Larivière M, Ouimet M, Beaulieu P, Labuda D and Sinnett D. Regulatory genetics in cancer research – the childhood leukemia story. Qui fait quoi? 7ème Journées Génétiques RMGA. May 14-16 , 2008, Québec, Canada.

SOURCE OF FUNDING


ORGANISM

TITLE
INVESTIGATOR
AMOUNT / YEAR

PERIOD

FRSQ

Échantillon de référence pour la recherche en épidémiologie génétique et en génétique des populations humaines au Québec - RMGA

D. Labuda

41,127$

04/2008-

03/2009


FRSQ

Étude de la diversité de la population québécoise contemporaine - RMGA

D. Labuda

47,372$

04/2008-

03/2009


CIHR

Montreal Spring School of Population Genomics and Genetic Epidemiology

D. Labuda

7,000$

04/2008-

05/2008


FRSQ

Montreal Spring School of Population Genomics and Genetic Epidemiology

D. Labuda

7,000$

04/2008-

05/2008


NSERC

Genetic history of human populations

D. Labuda

24,625$

04/2008-

03/2009


CIHR (Pop)

Optimization and validation of Human Papillomavirus probes obtained through in vitro molecular evolution

M.Krajinovic

D. Labuda

I. G-Flipot


150,000$


03/2007-

04/2008


CIHR (NPE-80218)

Genetic models of complex conditions and population structure of Quebec.

D. Labuda et al.

99,980$

04/2006-03/2009

Génome Québec / Génome Canada

The GRID project: gene regulators in disease.

T. Hudson et al.


72,000$

01/2006-

03/2009


FQRNT

Méthodes formelles pour l’inférence de relations d’évolution entre les séquences génomiques.

N. El-Mabrouk et al.

75,000$

04/2005-03/2008

FRSQ/RMGA

Études des populations régionales du Québec.

G. Rouleau, H. Vézina et al.

44,000$

04/2004-03/2008

CIHR (MOP-67150)

Variability in genomic sequences : patterns of genetic events in the human populations

D. Labuda

152,000$

04/2004-03/2007

CIHR (NTA-71859)

Developing diagnostic tools through in vitro molecular evolution

D. Labuda, M. Krajinovic, I. Gorska-Flipot

197,326 $

07/2004

06/2006


VRQ (VRQ 2201-146)

Cellule épithéliale de l’intestin : identification de gènes de susceptibilité et de nouvelles cibles thérapeutiques.

E.Levy et al.

~450,000 $

09/2002-03/2006

Génome Québec / Génome Canada

Regulatory genetics – high throughput screening of gene targets related to common genetic diseases.

T. Hudson et al.

Total of $11,600,000

04/2001-09/2005

ORGANISM

TITLE
INVESTIGATOR
AMOUNT / YEAR

PERIOD

CIHR (MOP-12782)

Variability in genomic sequences : patterns of genetic events in human population

D. Labuda

13,434$

10/2003-03/2004

NSERC

(170180-02)
Modèles génétiques et l’histoire de la population du Québec dans le contexte de données moléculaires

D. Labuda

E. Heyer


H. Vézina

$21,000

04/2002 03/2004

NSERC

(170180-99)
Modèles génétiques et l’histoire de la population du Québec dans le contexte de données moléculaires.

D. Labuda and

E. Heyer


$21,000

04/1999-04/2002

FRSQ/RMGA


Axe démogénétique

D. Labuda

(C. Laberge et al.)
$30,000

budget HSJ
2001-2004

FRSQ/RMGA

Identification of SNPs for a marker haplotype of myotonic dystrophy in Quebec.

D. Labuda

(C. Laberge et al.)
$19,000


2001-2004

CIHR (MOP-12782)


Variability in genomic sequences: Patterns of genetic events in the human populations.

D. Labuda

$107,469

10/2000-09/2003

MRC

(MT-12782)
Variability in human genomic sequences: Patterns of genetic events in the human populations.

D. Labuda

$97,027

$89,285


$91,071

10/1997-09/2000

MRC

(MOP-37951)
Environment and genetic polymorphisms in childhood acute lymphoblastic leukemia

C. Infante-Rivard, D. Labuda, D. Sinnett, M. Bernstein

$69,716


04/2000-03/2003

Ecogenix Inc. (Research Contract)

Genetic polymorphisms in cancer susceptibility genes

D. Labuda and D. Sinnett

$500,000

2000-2002

CRC

Nutritional factors and gene-environment interactions in the etiology of adenocarcinoma of

The esophagus.
N. Birkett, et al.

$85,000

09/1999-08/2002

CGDN

(Center of Excellence)
Genetic susceptibility factors in complex diseases and therapeutic response.

D. Sinnett and D. Labuda

$50,000

1999-2001




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