Course descriptions courses in english

PHR208	Pathophysiology
This course involves transferring knowledge about the mechanisms of alterations in human physiologic function and their effects on bodily functions throughout the lifespan Core Textbook: Hammer, G.D., McPhee, S.J. (2014). Pathophysiology of Disease : An Introduction to Clinical Medicine, 7th Edition, Lange, ISBN-13: 978-0071806008

PHR209

Physiology

Anatomy, physiology and diseases of systems are covered mainly of respiratory system, gastrointestinal system, endocrine system, female and male genital systems, renal system, sensory organs, hearing and balance disorders, visual impairments, skin disorders, important infectious diseases and neoplasias. Core Textbook: Paulsen, F., Waschke, J. (2013), Sobotta Atlas of Human Anatomy, Vol 1,2 and 3, 15th Edition, Elsevier, ISBN: 978072343732

PHR210

Plant Biology

An interest in plants will be developed by demonstrating their role and importance in the prevention and treatment of diseases. This will be achieved by describing the diversity of plants and their classification. The anatomy and morphology of the plants used in the prevention and treatment of diseases will be the main focus. Core Textbook: Mauseth, J. (2012), Botany: An Introduction to Plant Biology, 5th Edition, Jones & Bartlett, ISBN-10: 1449665802

PHR211	Public Health
The relationship between health and social sciences; social, cultural and biological factors affecting health; population; understanding society structure; and structure of health systems will form the knowledge content of this course. Core Textbook: Carter, J, Slack, M. (2009), Pharmacy in Public Health: Basics and Beyond, ASPH, ISBN-10: 1585281727

PHR212

Pharmaceutical Botany

The aim of the course is to give knowledge on medicinal, useful and poisonous plants in a systematical order. The scientific names, distinguished charateristics, distributions, usages and economical values will be covered and rich flora and medicinal plants of Cyprus and Turkey will be introduced. Pharmaceutical Botany Lab. Information will be given on plant nomenclature, descriptions of plants, preparation of the herbal materials and their storage, general concepts on the identification of the medicinal plants, examination of roots, stems, methamorphosis, leaves, flowers, fruits, identification of Coniferae and Angiospermae plants and Cyprus and Turkish flora will be examined. Core Textbook: Upton, R., Graff, A., Jolliffe, G., Länger, R., Williamson, E. (2011). American Herbal Pharmacopoeia: Botanical Pharmacognosy - Microscopic Characterization of Botanical Medicines, CRC Press, ISBN: 978-1420073263 Supplementary Textbook: Heywood, V., Brummitt, R., Culham, A. (2007). Flowering Plant Families of the World, Firely Books, ISBN-13: 978-1554072064

PHR213

Immunology

Introduction to immunology, antigen and antibody, cellular and humoral immunity, immünoprophylaxis, hypersensitivity reactions are the main topics. Core Textbook: Doan, T., Melvold, R., Viselli, S., Wallenbaugh, C. (2012), Immunology (Lippincott Illustrated Reviews Series), 2nd Edition, LWW, ISBN-13: 978-1451109375 Supplementary Textbook: Owen, J., Punt, J., Stranford, J. (2013), Kuby Immunology, 7th Edition, Macmilan, ISBN-13: 978-1464137846

PHR215	Computer Program Applications into the Pharmacy
This course is designed to inform pharmacy students about computer program applications to pharmacy practice, namely the programs used by the social security systems (Emekli Sandığı, Bağ-Kur, SSK) and pharmacy in use (farmakom, byte). Core Textbook: Course package

PHR217	Introduction to Pharmaceutical Technology
Pharmaceutical dosage forms, drug research and legislation, patent, pharmacokinetic, bioavailability, stability, and incompatibility will be discussed and information on prescription and abbreviations used in prescription will be given. Core Textbook: Course package

PHR300

Training II (in Summer)

Hospital and /or Community Pharmacy Training: Determination of the drug requirements of the hospital pharmacy, purchasing drugs for the hospital pharmacy, organisation and placement of the pharmacy, meeting the drug requirements of outpatient and inpatient, obtaining knowledge about drug information studies and keeping the records in the pharmacy as well as evaluation of hospital pharmacy’s relationship with the official and unofficial units are included in the content of this course

PHR301

Pharmacognosy I

This course comprises the biological origin of crude drugs, cultivation, collection, drying, stabilization of medicinal plants, chemistry of drugs of biological origin, inorganic compounds, organic acids, plant enzymes, lipids, carbohydrates, monosaccaride derivatives, isolation and identification of sugars in the plant material, homogeneus and heterogenous polysaccarides, tannins, classification, isolation and identification of glycosides, and drugs of biological origin containing the above constituents as well as their pharmacological actions and uses. Pharmacognosy I Lab. Demonstration on microscope, microscopial examinations in theory, quantitative microscopy (measurement in microscope plant cells and tissues, microscopical examination of powdered vegetable drugs, chemical identification of active constituents of saponins, antraquinids, cyanogenetic and cardiac glycogides, tannins, proteins and their chromatographic applications will be performed. Core Textbook: Evans, W.C., (2009), Trease and Evans Pharmacognosy, 16th Edition, Saunders Elsevier, ISBN-13: 978-0702029332 Supplementary Textbook: Heinrich, M. Barnes, J., Gibbons, S., Williamson, E. M. (2012), Fundamentals of pharmacognosy and phytotherapy, 2nd Edition, Churchill Livingstone, ISBN-13: 978-0702033889

PHR302

Pharmacognosy II

The aim of the course is to train a pharmacist with knowledge of physico-chemical properties, sources, classification and detection of alkaloids and volatile oils belonging to different classes as well as the isolation from natural sources, pharmacologial activity, uses and biosynthesis and alkaloid containing drugs of biological origin. Pharmacognosy II Lab. The isolation techniques, quantitative and qualitative analysis, classification of volatile and fixed oils, quantitative analysis of volatile oils by volumetric and gravimetric methods, indice determinations and, TLC analysis of fixed oils, determination reactions of alkaloids, quantitative colorimetric analysis of Solanaceae alkaloids, quantitative analysis of total alkaloids of Cinchona, chromatographic analysis of alkaloids in medicine, isolation of caffeine from black tea and its pharmacopeal analysis, total qualitative analysis of herbal teas, project presentation will be carried out. Core Textbook: Evans, W.C., (2009), Trease and Evans Pharmacognosy, 16th Edition, Saunders Elsevier, ISBN-13: 978-0702029332 Supplementary Textbook: Heinrich, M. Barnes, J., Gibbons, S., Williamson, E. M. (2012), Fundamentals of pharmacognosy and phytotherapy, 2nd Edition, Churchill Livingstone, ISBN-13: 978-0702033889

PHR303

Pharmaceutical Chemistry II

Adrenergic agents, adrenergic blocking agents, cholinergic agents, cholinergic blocking agents, cardiac glycosides, antiarrhythmics, antianginal and vasodilator agents, antihypertensives, antihyperlipidemics, coagulant and anticoagulant agents, antianemic drugs, trombolytics, antiaggregeting agents and diuretics are the main topics. Pharmaceutical Chemistry II Lab. Paper, thin layer, column and high pressure liquid chromatography techniques and their applications in drug analysis, separation of solid-solid and liquid-liquid mixtures, determination of some physical parameters such as density, boiling point and melting point, measurement of refraction index and determination of specific rotation, drug metabolism and pharmacopoeia analysis will be performed Core Textbook: Williams, D. A., Lemke, T. L. (2012), Foye's Principle of Medicinal Chemistry, 7th edition, Lippincott, Williams & Wilkins, ISBN-13: 978-1609133450 Supplementary Textbook: Cairns, D. (2012) Essentials of Pharmaceutical Chemistry, 4th Edition, , Pharmaceutical Press, ISBN-13: 978-0853699798

PHR304

Pharmaceutical Chemistry III

The main topics are introduction to chemotherapy, antiseptics, disinfectans, antiprotozoal, antimalarial, antiaemobic, antileishmanial, antitricomonal, antihelmintic, ectoparasiter, antifungal, antiviral, antineoplastic, antibacterial antimycobacterial, sulfonamides, oxazolidindiones quinolones, antibiotics, digestive carminatives, antiemetics, antiacides and antiulcer drugs, laxative-purgatives, antidiarhetics, antiallergics, local anesthetics, vitamines, diagnostic compounds and hormones. Pharmaceutical Chemistry III Lab. Basic principles of quantitative analysis covering titrimetric methods such as neutralisation, oxido-reduction, complexometry, nitritometry and their application in drug analysis. Also spectrophotometric methods, derivative spectroscopy, quantitative analysis in drug mixture, the principles and applications of the chemical and instrumental techniques such as ultraviolet, infrared, nuclear magnetic resonance and mass spectroscopy of qualitative analysis and structural elucidation of drugs will be covered. Core Textbook: Williams, D. A., Lemke, T. L. (2012), Foye's Principle of medicinal Chemistry, 7th edition, Lippincott, Williams & Wilkins, ISBN-13: 978-1609133450 Supplementary Textbook: Cairns, D. (2012) Essentials of Pharmaceutical Chemistry, 4th Edition, Pharmaceutical Press, ISBN-13: 978-0853699798

PHR305

Pharmaceutical Technology II

Rheology, colloidal dispersions, aerosols, suspensions and technological properties of emulsions, ointments transdermal drug carrier systems, suppositories and cosmetics are the main topics. Pharmaceutical Technology II Lab. Suspensions, sedimentation volume, redispersibility and particle size distribution analysis in suspensions, emulsions, liniments, viscosity of intravenous emulsions, HLB, ternary phase diagrams, ointments and drug release form ointments, suppositories and drug release form suppositories, vaginal suppositories’ formulations and properties of semi-solid systems will be covered all through the course. Core Textbook: Aulton, M. E., Taylor, K. M.G (2013). Aulton’s Pharmaceutics, 4th Edition, Churchill Livingstone, ISBN: 978-0-7020-4291-1 Supplementary Textbook: Sinko, P. (2010), Martin’s Physical Pharmacy and Pharmaceutical Sciences, 6th Edition, Wolters Kluwer/Lippincott Williams &Wilkins, ISBN 978-0-7817-9766-5 Rowe, C. R., Sheskey, P. J., Cook, W. G., Fenton, M. E. (2012). Handbook of Pharmaceutical Experiments, 7th Edition, Pharmaceutical Press, ISBN 978-085711027594

PHR306

Pharmaceutical Technology III

New drug delivery systems, parenteral solutions, water for injection, pyrogenity tests, parenteral preparations, contamination, GMP and quality assurance, ophthalmic, nasal and ear preparations, grinding theories and sampling methods, and methods of the particle size determination, the general properties of the powders, definition of preformulation importance and investigation of the organoleptic properties, excipients used in the tablet formulation, compression methods and applications, coating methods, gelatin capsules, stability, packing materials are the main topics. Pharmaceutical Technology III Lab. At the completion of this course, the student will have skills in sterilization techniques (aseptic technique, thermal sterilization), compounding sterile preparations, performing end-product sterilization using a filtration method, calculate the millimoles, milliequivalents, and milliosmoles of selected sterile solutions, calculate the quantities of materials needed to compound selected sterile preparations (including the ability to use E-values to prepare isotonic solutions), select proper drug containers and administration sets for sterile products, prepare labels for sterile drug preparations that fulfill legal requirements and help promote the proper use of the medication. Core Textbook: Aulton, M. E., Taylor, K. M.G (2013). Aulton’s Pharmaceutics, 4th Edition, Churchill Livingstone, ISBN: 978-0-7020-4291-1 Supplementary Textbook: Sinko, P. (2010), Martin’s Physical Pharmacy and Pharmaceutical Sciences, 6th Edition, Wolters Kluwer/Lippincott Williams &Wilkins, ISBN 978-0-7817-9766-5 Rowe, C. R., Sheskey, P. J., Cook, W. G., Fenton, M. E. (2012). Handbook of Pharmaceutical Experiments, 7th Edition, Pharmaceutical Press, ISBN 978-085711027594

PHR307	Pharmacology II
Drugs affecting autonomic nervous system, cardiovascular system, and renal conservation of water will be covered Core Textbook: Whalen K. (2014), Lippincott Illustrated Reviews: Pharmacology, 6th Edition, Wolters Kluwer, ISBN-13: 978-1451191776 Supplementary Textbook: Katzung BG, Masters SB, Trevor AJ (2014), Basic&Clinical Pharmacology, 12th Edition, McGraw Hill, ISBN 978-0-07-176401-8.

PHR308

Pharmacotherapy

Introduces the clinical use of medication in the prevention and treatment of disease and serves as a foundation for the delivery of pharmaceutical care. Rational use of available drugs, pharmacoecomics and pay-back system, pharmacogenetics, drugs adverse reactions, effects of drugs on biochemical parameters will be discussed. Core Textbook: Dipiro, J. T., Talbert, R. L., Yee, G. C., Wells, B. G. (2014), Pharmacotherapy: A pathophysiological approach, 9th Edition, McGraw-Hill Medical, ISBN-10: 0071800530

PHR309

Clinical Biochemistry

Introduction to biochemical analysis, biochemistry of the circulatory system, bilirubin metabolism, liver functions and jaundice, and related disorders, biochemistry and disorders of immune system, blood biochemistry, coagulation, hematological disorders, biochemistry of the digestive system and its disorders, digestion of lipids and phospholipids and disorders of lipid metabolism, structure and functions of kidney, kidney function tests, renal diseases and the related biochemical data, renin-angiotensin-aldosterone system, hypertension and coronary heart diseases and the related biochemical tests, biochemistry and the disorders of endocrine system, biochemistry and the complications of diabetes mellitus, cancer biochemistry are the main topics. Clinical Biochemistry Lab. Basic techniques in biochemical analysis, hematological tests, quantitative tests for carbohydrates, proteins and total lipids in blood and urine, determination of cholesterol and lipoproteins in plasma, liver and kidney function tests, determination of keton bodies and their metabolites in urine, enzymatic tests will be performed. Core Textbook: Crook, M. A. (2012), Clinical Chemistry and Metabolic Medicine, 8th edition, Hodder Arnold, ISBN-13: 978-1444144147 Marshall, W. J. and Bangert, S. K. (2012). Clinical chemistry, 7th edition, Edinburgh : Mosby, ISBN-13: 978-0723437031

PHR310

Pharmacology III

Drugs used to treat diseases of central nervous system, autacoids, drugs affecting respiratory, gastrointestinal and endocrine systems will be covered. Core Textbook: Whalen K. (2014), Lippincott Illustrated Reviews: Pharmacology, 6th Edition, Wolters Kluwer, ISBN-13: 978-1451191776 Supplementary Textbook: Katzung BG, Masters SB, Trevor AJ (2014), Basic & Clinical Pharmacology, 12th Edition, McGraw Hill, ISBN 978-0-07-176401-8.

PHR311	Health and Drug Economy
Information on general management human resources management, general accounting, pharmacoeconomics will be covered. Core Textbook: Rascati, K. (2013), Essentials of Pharmacoeconomics Point, Lippincott Williams & Witkins, ISBN-10; 1451175930

PHR312	First Aid
Structure and functions of human body, definition and principles of first aid, basic first aid applications, evaluation of accident environment, transport of casualty, choking, coma, artificial respiration and heart massage, first aid in bleeding, shock, heat stroke, cold exposure epilepsy, bites, fractures, bandage and atelles, first aid legislation will be covered. Core Textbook: Course Package

PHR314	History of Pharmacy and Deontology
The main topics are origins and evolution of pharmacy through the ages, pharmacy in Turkey, famous pharmacists in the world, discovery of medicines, also notion and rules of deontology, its history and evolution will be covered in the second part of the course. Core Textbook: Course Package

PHR400	Trainning III (in Summer)
Industry Training: Formulation designing studies, quality control and quality assurance studies of raw materials and products, manufacturing studies of different dosage forms, the studies of sales and marketing units, studies of approval file preparation for licensed and generic products, studies concerned with GMP/GLP will be performed in the pharmaceutical industry. {[CD]\>*_C:Q_3:7}

PHR401

Pharmaceutical Biotechnology

Applications of recombinant DNA in the pharmaceutical sciences biotechnology derived protein products, vaccines, monoclonal antibodies and pharmaceutical applications, formulation of pharmaceutical biotechnology products, gene therapy, and viral and non-viral gene therapeutics, cell culture, fermentation and bioreactor systems, usage of transgenic plants and animals for production of biopharmaceuticals, analytical methods used in pharmaceutical biotechnology, role of the pharmacists in dispensing and application of biotechnology products will be covered. Core Textbook: Groves, M. J. (2006). Pharmaceutical Biotechnology, Second Edition, CRC Press Taylor & Francis Group, ISBN-13: 978-0849318733

PHR402

Biopharmaceutics Pharmacokinetics

Absorption mechanisms, physiological and pharmaceutical factors effecting bioavailability and bioequivalence and their calculations, in vivo correlations, compartment models and importance, definition and history of clinical pharmacokinetics, importance of pharmacokinetic models, absorption kinetics, first past effect, estimation methods of bioavailability and bioequivalence, distribution and elimination kinetics, distribution volume, estimation of total clearance, the effect of pathological situations on the pharmakokinetic parameters will be covered. Core Text: Shargel, L, Wu-Pong, Yu, A. (2012), Applied Biopharmaceutics and Pharmacokinetics, 6th Edition, McGraw-Hill Education