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Genetic diversity and natural selection in the rhoptry-associated protein 1 (RAP-1) of recent Plasmodium knowlesi clinical isolates from Malaysia



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Genetic diversity and natural selection in the rhoptry-associated protein 1 (RAP-1) of recent Plasmodium knowlesi clinical isolates from Malaysia


The Plasmodium rhoptry-associated protein 1 (RAP-1) plays a role in the formation of the parasitophorous vacuole following the parasite’s invasion of red blood cells. Although there is some evidence that the prot...

Mira Syahfriena Amir Rawa, Mun-Yik Fong and Yee-Ling Lau

Malaria Journal 2016 15:62

Acquired immune responses to three malaria vaccine candidates and their relationship to invasion inhibition in two populations naturally exposed to malaria


Malaria still represents a major cause of morbidity and mortality predominantly in several developing countries, and remains a priority in many public health programmes. Despite the enormous gains made in cont...

Otchere Addai-Mensah, Melanie Seidel, Nafiu Amidu, Dominika J. Maskus, Stephanie Kapelski, Gudrun Breuer, Carmen Franken, Ellis Owusu-Dabo, Margaret Frempong, Raphaël Rakotozandrindrainy, Helga Schinkel, Andreas Reimann, Torsten Klockenbring, Stefan Barth, Rainer Fischer and Rolf Fendel

Malaria Journal 2016 15:65

Malaria in pregnancy: a passive surveillance study of pregnant women in low transmission areas of Colombia, Latin America


Malaria causes a significant burden in highly endemic areas where children and pregnant women are more susceptible to severe disease and death, however, in low transmission settings malaria in pregnant women i...

Mary Lopez-Perez, M. Andreína Pacheco, Lucía Buriticá, Ananias A. Escalante, Sócrates Herrera and Myriam Arévalo-Herrera

Malaria Journal 2016 15:66

The complexities of simple technologies: re-imagining the role of rapid diagnostic tests in malaria control efforts


Malaria rapid diagnostic tests (RDTs) are assumed to be simple-to-use and mobile technologies that have the capacity to standardize parasitological diagnosis for malaria across a variety of clinical settings. ...

Uli Beisel, René Umlauf, Eleanor Hutchinson and Clare I. R. Chandler

Malaria Journal 2016 15:64

Mutations of pvdhfr and pvdhps genes in vivax endemic-malaria areas in Kota Marudu and Kalabakan, Sabah


Malaria cases persist in some remote areas in Sabah and Sarawak despite the ongoing and largely successful malaria control programme conducted by the Vector Borne Disease Control Programme, Ministry Of Health,...

Umi Rubiah Sastu, Noor Rain Abdullah, Nor Azrina Norahmad, Muhammad Nor Farhan Saat, Prem Kumar Muniandy, Jenarun Jelip, Moizin Tikuson, Norsalleh Yusof and Hasidah Mohd Sidek

Malaria Journal 2016 15:63

Partitioning the contributions of alternative malaria vector species


In many locations malaria is transmitted by more than one vector species. Some vector control interventions, in particular those using genetic approaches, are likely to be targeted against a single species or ...

Anne Deredec, Samantha M. O’Loughlin, Tin-Yu J. Hui and Austin Burt

Malaria Journal 2016 15:60

Application of mosquito repellent coils and associated self-reported health issues in Ghana


The use of mosquito coils has gained widespread patronage in malaria-endemic countries, even though it is not a recommended preventive measure for avoiding mosquitoes. Mosquito coils contain insecticides, whic...

Jonathan N. Hogarh, Philip Antwi-Agyei and Kwasi Obiri-Danso

Malaria Journal 2016 15:61

Erratum to: Therapeutic assessment of chloroquine–primaquine combined regimen in adult cohort of Plasmodium vivax malaria from a tertiary care hospital in southwestern India


Kumar Rishikesh, Asha Kamath, Manjunatha H. Hande, Sudha Vidyasagar, Raviraja V. Acharya, Vasudeva Acharya, Jayaprakash Belle, Ananthakrishna B. Shastry and Kavitha Saravu

Malaria Journal 2016 15:59


Multi-country comparison of delivery strategies for mass campaigns to achieve universal coverage with insecticide-treated nets: what works best?


The use of insecticide-treated nets (ITNs) is widely recognized as one of the main interventions to prevent malaria. High ITN coverage is needed to reduce transmission. Mass distribution campaigns are the fast...

Celine Zegers de Beyl, Hannah Koenker, Angela Acosta, Emmanuel Obi Onyefunafoa, Emmanuel Adegbe, Anna McCartney-Melstad, Richmond Ato Selby and Albert Kilian

Malaria Journal 2016 15:58

Multiple causes of an unexpected malaria outbreak in a high-transmission area in Madagascar


The malaria burden in Madagascar dropped down last decade, largely due to scale-up of control measures. Nevertheless, a significant rise of malaria cases occurred in 2011–2012 in two regions of the rainy South...

Thomas Kesteman, Solofoniaina A. Rafalimanantsoa, Harimahefa Razafimandimby, Heriniaina H. Rasamimanana, Vaomalala Raharimanga, Benjamin Ramarosandratana, Arsene Ratsimbasoa, Jocelyn Ratovonjato, Nohal Elissa, Laurence Randrianasolo, Alyssa Finlay, Christophe Rogier and Milijaona Randrianarivelojosia

Malaria Journal 2016 15:57

Endothelial activation, haemostasis and thrombosis biomarkers in Ugandan children with severe malaria participating in a clinical trial


Malaria is a major cause of morbidity and mortality in sub-Saharan Africa, and poor outcomes have been associated with endothelial activation. In this study, biomarkers of endothelial activation, haemostasis, ...

Susan M. Graham, Junmei Chen, Dominic W. Chung, Kevin R. Barker, Andrea L. Conroy, Michael T. Hawkes, Sophie Namasopo, Kevin C. Kain, José A. López and W. Conrad Liles

Malaria Journal 2016 15:56

Increased adhesion of Plasmodium falciparum infected erythrocytes to ICAM-1 in children with acute intestinal injury


Children with severe malaria are at increased risk of invasive bacterial disease particularly infection with enteric gram-negative organisms. These organisms are likely to originate from the gut, however, how ...

James A. Church, Lydia Nyamako, Peter Olupot-Olupot, Kathryn Maitland and Britta C. Urban

Malaria Journal 2016 15:54


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