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CURRICULUM VITAE 1. Name: Anwar Bishara Bikhazi Marital Status: Married to Samia Habib Hourani, Three gents 2. Nationality: Lebanese, and holder of British Passport., Born 17/12/1941. 3. Education: a. High School Education. “International College”, High School Certificate, and Seventh Secondary Class Certificate, Math-Major, 1960, Honorable Mention. b. University Education: “American University of Beirut”, Bachelor of Science in Pharmacy, 1965, With Distinction. *Elected/Served as “Secretary” of the “Pharmacy Students Society”, Academic Year 1963-1964. *Elected/Served as “President” of the “Pharmacy Students Society”, Academic Year 1964-1965. c. Graduate Education. 1. Master of Science in Pharmacy, 1967, American University of Beirut, Lebanon. 2. Doctor of Philosophy, 1970, Pharmaceutical Chemistry, University of Michigan, Ann Arbor, Michigan, U.S.A. d. Granted the Eli Lilly Endowment and General University Scholarship, at the University of Michigan, during preparation for the Doctor of Philosophy Degree. 4. Post Doctoral Training: From July 1970 through September 1971 did his Post-Doctoral training at the University of Michigan, under contract PH-43-68-1284 with Chemotherapy, National Cancer Institute, NIH, Bethesda, Maryland. 5. Citations, Prizes, and Awards:
6. Professional Experience:
b. Joined the faculty of the School of Medicine, the American University of Beirut, Department of Physiology, July 1977, as an Assistant Professor. Then promoted to the rank Associate Professor (July 1979) and to the rank Full Professor (July 1984). c. Joined the Faculties of Medical Sciences, Director, School of Pharmacy, The Lebanese University, 1986-1993. d. Teaching Experience: I. Undergraduate Courses.
II. Graduate Courses.
Dissertations.
7. Research Experience:
8. Research Support:
9. Membership in Scientific Societies: a. Rho Chi Honor Society b. Sigma Xi Chapter, University of Michigan c. Sigma Xi Club, A.U.B. d. Lebanese Order of Pharmacists e. American Physiological Society (Associate Member) f. The New York Academy of Sciences, N.Y., USA g. American Pharmaceutical Association (Currently American Pharmacists Association). h. American Association of Pharmaceutical Scientists 10. Academic & Scholarship Committees: Served as a member of the following committees: a. Faculty of Medicine (A.U.B.)
b. Medical Board (A.U.B., Medical Center) 1. Pharmacy and Therapeutics Committee, Chairman 2. Accreditation Committee c. University Committees, A.U.B. 1. Interfaculty Graduate Nutrition Committee 2. University Admissions Committee, Chairman 3. University Commencement Committee 4. University Graduate Board 5. Ad Hoc Committee to the Board of Trustees on University Planning
(Saudi Arabia) a School of Pharmacy.
with A.U.B. in performing a feasibility to establish a model “Reference University” including a College of Medicine with Medical Center, a College of Pharmacy, a College of Nursing, and a College of Health Sciences, in Jeddah, Kingdom of Saudi Arabia. d. The Nadim Andraos Foundation - AUB Scholarship Committee (Chairman) 1986-1994. 11. Governments' Committees:
Fund.
Practice in Lebanon".
12. Publication Editorial Board: a. Local Journals
b. International Journals
URL: www.bentham.org/ . 5. Invited by Editorial Board of the “Heart and Vessels” journal to peer review an article, November 2007. 6. Invited by Michael Williams, Regional Editor of the journal “Biochemical Pharmacology” to review a commentary manuscript, April 2010. 7. Invited by Lynn LeCount, CMA, Managing Editor, “Biochemical Pharmacology” to review a scientific manuscript, August 2010.
Scientific and Regulatory Aspects of Dissolution and Bioequivalence”, June 3-5, 2005, Athens, GREECE. 13. Graduate Supervision: Advised, supervised, and primarily mentored (as principal investigator) the work of 66 (65 Master of Science + 1 Doctor of Philosophy) graduate students within my research laboratories at A.U.B. The following are their names and theses titles. School of Pharmacy, American University of Beirut. 1. Quantitative Estimate of Particulate Matter in Pharmaceutical Prepations Intended for Intravenous Adminstration. Joannis A.Shiatis, 1975. 2. Calcium-Prostaglandin Aggregation and its Effect on Prostaglandin Uptake by the Isolated Rabbit Intestine. Nabil S. Nader, 1976. 3. Kinetics Aggregation of Human Platelets. Ghassan E. Ayyub, 1976. 4. Kinetics of Degradation of a Novel Antimitogenic and Antiviral Palladium (II) Coordination Compound. Sarkis M. Aghazarian, 1976. Faculty of Medicine, Department of Physiology, American University of Beirut. Liver related Research. 1. Interface Transport of Prostaglandin E1 and F2 through Normal and Diabetic Rat Hepatocytes. Ghassan M. Baasiri, 1979. 2. Agglutination Kinetics of Normal and Diabetic Rat Hepatocytes. Ilyas H. Abbud, 1979. 3. Role of Insulin and Prostaglandin E2 on the Uptake of Sugars by Normal and Diabetic Rat Hepatocytes. Hasan M. Nubani, 1980. 4. Agglutination Kinetics of Enzymatically Treated Normal and Diabetic Adult Rat Hepatocytes. Lutfiyyah H. Turyaki, 1980. 5. Effect of Colchicine, Phospholipase and ß Galactosidase on the Cytoskeleton of normal adult Rat Hepatocytes. Antun Abbas-Ghaleb, 1983. 6. Effect of Phospholipase A2, Colchicine and ß Galactosidase on the Cytoskeleton of Streptozocin Treated Diabetic Adult Rat Hepatocytes. Sami H. Saad, 1984. 7. Role of Sodium and Ouabain on the Uptake of Amino Acids by Normal Hepatocytes. Hiba U. Muhtasib, 1986. 8. Role of Insulin on the Uptake of Amino Acids: Alanine and Phenylalanine by Normal Rat Hepatocytes. Sawsan R. Skafi, 1986. 9. Role of Glucagon on the Uptake of D-Glucose and 3-0-Methyl-D-Glucose by Normal Rat Hepatocytes. George E. Haddad, 1987. 10. Role of Sodium and Ouabain on the Uptake of Alanine by Normal and Diabetic Rat Hepatocytes. Rula A. Abbud, 1987. 11. The Effect of Insulin on Alanine Uptake by Normal and Streptozotocin-induced Diabetic Rat Hepatocytes. Habib M. Alloush, 1987. 12. A System Approach for Measuring Na+-K+ ATPase Receptor Sites by Employing Tracer Ouabain-Adsorption Isotherm in Normal and Diabetic Rat Hepatocytes. Eman K. Shaaban, 1991. 13. Adsorption of Acetyl-Concanavalin A on Viable Hepatocytes Isolated from Normal & Steptozotocin-Induced Diabetic Rat. Nashwa M. Mrad, 1992. 14. Mechanism of Calcium Transport Across Isolated Viable Rat Liver Parenchymal Cells. Eva T. Choueiri, 1994. 15. Handling of Tracer Verapamil Isradipine & Azidopine in Perfused Rat Liver. Rima S. Saleh, 1995. Kidney related Research. 1. Effect of Ouabain on Sodium and Potassium Retention in Perfused Rat Kidney. Haytham H. Zantut, 1980. 2. Role of Diuretics on Sodium, Potassium and Chloride Retention in Perfused Rat Kidney. Nicholas J. Maarrawi, 1981. 3. Effect of Elevated Blood Pressure, Renin and Aldosterone on Renal Sodium Retention in the Two Kidney Goldblatt Hypertensive Rats. Jamil N. Bitar, 1982. 4. Effect of Diabetes on Natriuresis in the Presence of Ouabain and Ethacrynic Acid in Perfused Rat Kidney. Roy Peter Z. Shukri, 1983. 5. Effect of Dexamethasone on Sodium Retention in Perfused Rat Kidney. Sany T. Khabbaz, 1984. 6. Sodium Retention in Cortex and Medulla of Perfused Rat Kidneys. Joseph E. Abi Ra'd, 1985. 7. A Modified Kidney Perfusion Technique in situ. Joe M. Kuraya-Ziyadah, 1985. 8. Effect of Changing pH on Sodium Retention by the Perfused Rat Kidney. Rita A. Abbud, 1985. 9. Effect of Ethacrynic Acid and Ouabain on Sodium Retention at Different pHs by the Perfused Rat Kidney. Alexander G. Ziadeh, 1986. 10. The effect of Amiloride, ethacrynic Acid and Ouabain on Sodium Retention by the Perfused Rat Kidney Tubule Cells at Different pHs. Suad I. Nabhan, 1986. 11. Effect of Xanthines on Sodium Retention in Perfused rat Kidney. Ilyas Y. Bu-Abbud, 1987. 12. Effect of Prednisone on Sodium retention in Perfused Rat Kidney. Muna M. El-Kasti, 1987. 13. Sodium handling in Rat Kidney Tubules After Corticosterone Administration. Raed J. Hawwa, 1988. 14. Effect of Verapamil Ouabain and Ethacrynic Acid on Calcium Retention in Perfused Rat Kidneys. Myrna H. Medlej. 1990. 15. Effect of Cis Platinum Cis-Palladium and Cis-Rhodium on Calcium and Sodium Retention in Perfused Rat Kidneys. Rola A. Awar, 1991. 16. Effect of Ouabain, Amiloride, Ethacrynic Acid, & Furosemide on Chloride Retention in Perfused Normal and Diabetic Rat Kidney. Nesrine M. El-Bizri, 1992. Gastro-intestinal related Research. 1. Role of Bile Salts on Linoleic Acid Uptake by Rat Columnar Intestinal Epithelial Cells. Maria M. Jundi, 1981. 2. Transcellular Mechanisms of L-Alanine Uptake by Distal Rat Ileum in situ. Michel N. Abu Salbi, 1983. 3. System Approach to the Trans-epithelial Transport of Butyric and Linoleic Acids Across Rat Jejunal Enterocytes. Sawsan I. Kuraydiyyah, 1984. (Doctor of Philosophy Thesis). 4. Transcellular Mechanisms of PGE1 Uptake by Distal Rat Ileum in situ. Liliane Y. Yakub, 1984. 5. Role of the Cytoskeleton in the Absorption and Intracellular Transport of Vitamin D3. Jean-Jacques Rafie, 1985. 6. Role of Bile Salts on Linoleic Acid Absorption by Proximal Rat Jejunum in vitro. Antoine F. Abu Fadel, 1986. 7. Transcellular Mechanisms of PGE2 and PGF2 Uptake by Distal Rat Ileum in situ. Nasir M. Lakkis, 1986. 8. The Differential Absorption of Vitamin D3 and its Active Metabolite 1,25-dihydroxycholecalciferol in the Intestinal cells of the rat. Abdel Salam R. Hasbini, 1986. 9. Transcellular Mechanisms of PGE1 Uptake by Distal Rat Ileum in situ. Maher A.S. Khattab, 1987. 10. Effect of Na and pH on PGE1 Absorption by Distal Ileum in situ. Muhammad Ali A. Zaydan, 1987. 11. Effect of Sodium and Tetrodotoxin on Prostaglandin Distal Ileal Transport in Rats. Kassem D. Abouchehade, 1989. 12. Calcium Transport Via Membrane-Bound Proteins Across the Gastrointestinal Epithelium of Rats. Doris E. Jaalouk, 1993. 13. Kinetics of Absorption of Glycyl-Sarcosine Across the Rat Jejunum. Ghada S. Kurban, 2001. 14. Effects of Diabetes Mellitus and Insulin on the Regulation of the Jejunal PEPT1 Symporter in a Rat Model. May M. Skoury, 2003. 15. Pept-1 Regulation by Insulin in the Rat Jejunum. Nadim W. El Majzoub, 2004. 16. Role of Insulin on Jejunal PEPT-1 Expression: Supportive Data correlating Glycyl-Sarcosine Uptake and mRNA Expression. Asdghig H. Der-Boghosian, 2006. 17. Effect of Insulin on the Expression of Jejunal Oligopeptide Transporter PEPT-1 Through Transcription Factors JUNB and CDX2 in Type One Diabetes Mellitus in the Rat. Sara R. Saad, 2008.
Angiotensin II with Endothelium and Myocytes in Myocardial Perfused Rat Hearts. Khaled Aref Hassan, 1999.
in a Normal and Diabetic Rat Heart Model. Dima N. El-Khechen, 2002.
Special Topics. 1. Electrochemical Studies of Calcium in Human Erythrocytes. Samia S. Aboul-Husn, 1981.
Sickle Cell Disease with Parents' Findings. Muna A. Buhazza, 1982. 14. Invited Lecturer: 1. The University of Michigan, College of Pharmacy, 1991 2. The University of Utah, College of Pharmacy, 1992 3. The University of Sherbrooke, Faculty of Medicine, Department of Physiology and Biophysics, 1994, 1995 and 1996.
and 1996. 5. “International Symposium on Scientific and Regulatory Aspects of Dissolution and Bioequivalence”, Athens, 12-14 April, 2002. 6. Satellite Symposium Speaker in the “ 1er Congres Ordinal Franco-Libanais”, Organise Conjointement par Le Conseil National de L’Ordre des Medecins de France et L’Ordre des Medecins du Liban, Beirut, Lebanon, 21-24 April, 2005.
3. Workshop on "Oral Drug Delivery", U. of Michigan, USA, 1993. 4. Workshop on "Rational Use of Essential Drugs", WHO, Tehran, 1995. 16. Papers and/or Poster Presentations at Scholarly Conferences: 1. Attended on a yearly basis the "Federation of the American Societies of Experimental Biology" from 1981 to 1993. Since then and to-date is attending the “Experimental Biology" meetings. All meetings were held in the USA. 2. Attended on a yearly basis the “American Association of Pharmaceutical Scientists” meetings since its establishment in 1986. All meetings were held in the USA. 3. Attended the annual meetings of the "American Pharmaceutical Association", 1969, 1970, 1971, 1973, 1975, 1977 and 1993. 4. Attended the "Comparative Aspects of Translocating ATPases" conference in Leura, NSW, Australia, 1995. 5. Attended the "International Endotoxin Society" meeting in Nagoya, Japan, 1996.
January 27-30, 1999, Monte-Carlo, Monaco. 7. Attended the 3rd “International Symposium on Angiotensin II Antagonism,” February 28-March 2nd 2000, London, U.K. 8. Attended the “2nd International Forum on Angiotensin II Receptor Antagonism”, January 24-26, 2001, Monte-Carlo, Monaco.
10. Attended and presented a lecture at the “International Symposium on Scientific and Regulatory Aspects of Dissolution and Bioequivalence”, Athens, Greece, April 12-14, 2002. 11. Moderator of the Biopharmaceutics Classification System during the “2nd International Symposium on Scientific and Regulatory Aspects of Dissolution and Bioequivalence”, Athens, Greece, June 3-5, 2005. 12. Attended and presented a poster at the “Ninth International Conference on Endothelin”, September 11-14, 2005, Park City, Utah. U.S.A.
a. Anwar B. Bikhazi, "Solute Transport via the Chorio-Amnion Membranes of Human Placentae", M.Sc. Thesis, A.U.B., Beirut, Lebanon (1967). b. Anwar B. Bikhazi, "Interfacial Barrier Limited Transport of some Organic Solutes in the Aqueous Polysorbate 80-Hexadecane System", Ph.D. Dissertation, University of Michigan, Ann Arbor, Michigan (1970). II. Abstracts and Scientific Papers 1. A. Bikhazi and W.I. Higuchi, "An Interfacial Barrier Limited Transport of Cholesterol from An Aqueous Polysorbate 80 Solution to Hexadecane." Abstract No.87, page 64, presented to the Basic Pharmaceutics Section of the American Pharmaceutical Association Conference, May 19-23, 1969. 2. A.B. Bikhazi and W.I. Higuchi, "Interfacial Barrier Limited Transport of some Organic Solutes in the Aqueous Polysorbate 80-Hexadecane System." Abstract No. 33, page 52, presented to the Basic Pharmaceutics Section of the American Pharmaceutical Association Conference, April 12-17, 1970, Washington D.C., U.S.A. 3. A.B. Bikhazi and W.I. Higuchi, "Interfacial Barrier Limited Interphase Transport of Cholesterol in the Aqueous Polysorbate 80-Hexadecane System," J. Pharma. Sci., 59, 744-748, 1970. 4. W.I. Higuchi, A. Ghanem and A.B. Bikhazi, "Mechanistic Studies of Solute Transport at Oil-water Interface," Federation Proceedings, 29, 1327-1334, 1970.
Transport of Sterols and other Organic Compounds at the Aqueous Polysorbate 80-Hexadecane Interface," Biochim. Biophys. Acta, 233, 676-687, 1970. 6. A.P. Simonelli, S.C. Mehta, A.B. Bikhazi, and W.I. HHHHiguchi, "Dissolution Rates of High Energy Polyethylene Glycol (PEG)-Drug Coprecipitates." Abstract No. 55, page 69, presented to the Basic Pharmaceutics Section of the American Pharmaceutical Association Conference, March 27-April 2, 1971, San Francisco, U.S.A. 7. Anwar B. Bikhazi and Anthony P. Simonelli, "Dissolution Rates of High Energy Sodium Cholate-Drug Coprecipitates." Abstract No. 68, page 69, Ibid. 8. A.P. Simonelli and A.B. Bikhazi, "Dissolution Rate of High Energy Ternary Coprecipitates of Drug: Polyvinylpyrrolidone (PVP): Sodium Cholate." Abstract No. 69, page 69, Ibid. 9. A.P. Simonelli and A.B. Bikhazi, "Dissolution Rate of High Energy Ternary Coprecipitates." Abstract, page 130-131, The Lebanese Association for the Advancement of Science, Third Science Meeting, December 17-18, 1971, Beirut, Lebanon. 10. A.B. Bikhazi and J.J. Hajjar, "A Probable Role of Micelle Solubilization in Solute Transport through the Isolated Rabbit's Intestine." Abstract, pages 169-171, The Lebanese Association for the Advancement of Science, Fourth Science Meeting, December 14-16, 1972, Beirut, Lebanon. 11. A.B. Bikhazi and J.J. Hajjar, "Mechanistic Studies on the Effect of Cholate Concentration on Cholesterol Transport through Isolated Rabbit's Intestine." Abstract No. 54, page 67, presented to the Basic Pharmaceutics Section of the APhA Academy of Pharmaceutical Section Meeting, November 11-14, 1973, San Diego, U.S.A. 12. H.A. Tayim, A.H. Malakian and A.B. Bikhazi, "Synthesis and Physicochemical, Antimitogenic, and Antiviral Properties of a Novel Palladium (II) Coordination Compound," J. Pharm. Sci., 63, 1469-1471, 1974.
Cholate Concentration on Cholesterol Uptake by Isolated Rabbit Intestine," J. Pharm. Sci., 63, 1703, 1974.
Lipid/Water Partition Coefficient of PGE1 and PGF2. Explanation of this Effect on Prostaglandin Uptake by Rabbit's Intestine." Abstract, 19th National Meeting of Academy of Pharmaceutical Sciences, November 1975, Atlanta, Georgia, U.S.A. 15. A.B. Bikhazi, S.M. Aghazarian, H.A. Tayim and A.H. Malakian, "Kinetics of Degradation of a Novel Antimitogenic and Antiviral Palladium (II) Coordination Compound," Ibid. 16. J.J. Hajjar, R.N. Khuri, and A.B. Bikhazi, "Effect of Bile Salts on Amino Acid Transport by Rabbit Intestine," Am J. Physiol., 229(2), 518, 1975. 17. A.B. Bikhazi Bikhazi and G.E. Ayyub, "Kinetics of Aggregation of Human Platelets," Abstract, 124th American Pharmaceutical Association Meeting, May 14-20, 1977, New York, U.S.A 18. H. Tayim, A. Vassilian and A. Bikhazi, "Synthesis and Antimitogenic Properties of some Palladium, Platinum, and Rhodium Coordination Compounds." Abstract, 8th International Conference on Organo-Metallic Chemistry, Sept. 12-16, 1977, Kyoto, Japan. 19. A.B. Bikhazi, J.A. Shiatis and A.F. Haddad, "Quantitative Estimation of Particulate Matter in Pharmaceutical Preparations intended for Intravenous Administration," J. Pharm. Sci., 66, 181, 1977. 20. A.B. Bikhazi, N.S. Nadir and J.J. Hajjar, "Calcium-Prostaglandin Aggregation and its Effect on Prostaglandin Uptake by the Isolated Rabbit Intestine," J. Pharm. Sci., 66, 1308, 1977. 21. A.B. Bikhazi, S.M. Aghazarian and H.A. Tayim, “Kinetics of Degradation of a Novel Antimitogenic and Antiviral Palladium (II) Coordination Compound”, J. Pharm. Sci., 66, 1515, 1977. 22. Jean-Jacques Hajjar, Kamil Nassar and Anwar Bikhazi,"Effect of Vitamin A on In Vitro Alanine Transport in Isolated Rabbit Ileum," Comp. Biochem. Physiol., 58A, 281, 1977. 23. A.B. Bikhazi and G.E. Ayyub, "Kinetics of Aggregation of Human Platelets," J. Pharm. Sci., 67, 939, 1978. 24. A.B. Bikhazi, G.M. Baasiri, C.F. Nassar and N.Z. Boulos, "Prostaglandin Uptake by Hepatocytes from Normal and Diabetic Rats." Abstract, Fourth International Prostaglandin Conference, May 27-31, 1979, Washington D.C. 25. A. Vasilian, A.B. Bikhazi and H.A. Tayim, "Synthesis and Antimitogenic Activity of some Coordination Compounds of Platinum (II), Palladium (II) and Rhodium (III), “J. Inorg. Nucl. Chem., 41, 775-778, 1979. 26. A.M. Abdelnoor, H. Kassem, A.B. Bikhazi and A. Nowotny, “Effect of Gram-Negative Bacterial Lipopolysaccharide-Derived Polysaccarides, Glycolipids, and Lipopolysaccharides on Rabbit and Human Platelets in Vitro,” Immunobiol., 157, 145-153, 1980. 27. A.B. Bikhazi, E.H. Abboud, S.K. Agulian and C.F. Nassar, “Agglutination Kinetics of Normal and Diabetic Adult Rat Hepatocytes,” Pflugers Arch., 386, 245-250, 1980. 28. A.B. Bikhazi, N.J. Maarawi and S.K. Agulian, “Effect of Mg and Ethacrynic Acid on Na Retention in Perfused Rat Kidney,” Federation Proc., 40, 394, 1981. 29. A.B. Bikhazi, M. Jundi-Tamer, E.L. Coe and A.R. Jurjus, "Role of Bile Salts on Linoleic Acid Uptake by Isolated Rat Columnar Intestinal Cells," Federation Proc., 41, 1683, 1982. 30. A.B. Bikhazi, G.M. Baasiri, N.Z. Boulos and R.N. Khuri, "Transport of Prostaglandins Through Normal and Diabetic Rat Hepatocytes." J Pharm. Sci., 72, 296-299, 1983. 31. A.B. Bikhazi, H.M. Nubani and E.L. Coe, "Effect of Insulin and Dinoprostone on D-Glucose and 2-Deoxy-D-Glucose Uptake by Normal and diabetic Rat Hepatocytes," J. Pharm. Sci., 72, 116-118, 1983. 32. A.B. Bikhazi and K.M. Bitar, "Adsorption of Concanavalin A on Human Platelets," Ann. Biomed. Eng., 10, 219-229, 1982. 33. A.B. Bikhazi, L.H. Turyaki, "Agglutination Kinetics of Enzymatically Treated Normal and Diabetic Rat Hepatocytes," J. Pharm. Sci., 73, 628-630, 1984. 34. A.B. Bikhazi, H. Zantut, N. Maarawi and K. Sayyid, "Role of Ouabain and Diuretics on Sodium, Potassium and Chloride Retention in Perfused Rat Kidney," Comp. Biochem. Physiol., 77A, 507-511, 1984. 35. A.B. Bikhazi, M.N. Abu Salbi and J.H. Itani, “Transcellular Mechanisms of Amino Acid Uptake by Distal Rat Ileum In Situ," Comp.Biochem. Physiol., 80A, 5-9, 1985.
some Haematologic Findings of Fifty Bahraini Patients with Sickle Cell Disease with Parent's Findings," J. Med. Genetics, 22, 293-295, 1985. 37. A.B. Bikhazi, S.I. Kuraydiyyah and K.M. Bitar, "System Approach to Transepithelial Transport of Butyric and Linoleic Acids Across Rat Jejunal Enterocytes," Federation Proceedings, 44, 445, 1985. 38. L.Y. Yakub and A.B. Bikhazi, "Transcellular Mechanism of PGE1 Uptake by Distal Rat Ileum In Situ," Federation Proceedings, 44, 1822, 1985.
of Vitamin D3 and 1,25-Dihydroxyvitamin D3 by Intestinal Jejunal Cells of the Rat," J. Pharm. Sci., 78(1), 17-20, 1989. 44. A.B. Bikhazi, S.H. Saad and T.A. Ghaleb, "Effect of Treatment with Phospholipase A2, Colchicine and ß-Galactosidase on Agglutination of Rat Hepatocytes," J. Pharm. Sci., 78(3), 1-3, 1989.
47. A.B. Bikhazi, N.M. Lakkis and K. Abu-Shehadeh, "Intestinal Retention of Prostaglandins in Rat Ileum," The FASEB Journal, 4, A985, 1990.
dependent Retention of Prostaglandins in Rat Ileum," J. Pharm. Sci., 80, 1110-1113, 1991. 49. S.I. Kreydiyyeh and A.B. Bikhazi, "Effect of Cytochalasin, Colchicine and Ethylenediaminetetra-acetic Acid on Linoleic Acid Transport Across Rat Jejunal Enterocytes," J. Pharm. Sci., 81, 441-443, 1992. 50. A.B. Bikhazi, Myrna Medlej-Hashim and Muna El-Kasti, Effect of Verapamil, Ouabain and Ethacrynic Acid on Calcium Retention in Perfused Rat Kidneys," J. Pharm., Sci., 81, 1178-1180, 1992. 51. A.B. Bikhazi, "Narrow Window Drugs," The Lebanese University Drug Letter, 1, 1-4, 1992. 52. A.B. Bikhazi, "Transdermal Drug Delivery: Mechanisms and Relevance," The Lebanese University Drug Letter, 2, 1-5, 1993. 53. A.B. Bikhazi, K.M. Bitar, E.K. Shaaban and M. El-Kasti, "Adsorption Isotherms of Ouabain on Hepatocytes from Normal and Streptozotocin-induced Diabetic Rats," J. Pharm. Sci., 83, 1758-1761, 1994. 54 A.B. Bikhazi, M. El-Kasti, R.A. Abbud, A.G. Ziadeh and S. Nabhan, "Effect of Changes in pH on Renal Sodium Handling in Perfused Rat Kidneys," The FASEB Journal, 8, A834, 1994. 55. A.B. Bikhazi, E.T. Chouerie and M.M. El-Kasti, "Mechanisms of Calcium Transport Across Dispersed Viable Rat Hepatocytes," The FASEB Journal 9, A553, 1995. 56. A.B. Bikhazi, A. Salameh, M.M. Al-Kasti and R.A. Awar, “Comparative Nephrotoxic Effects of Cis-Platinum (II), Cis-Palladium (II), and Cis-Rhodium (III) Metal Coordination Compounds," Comp. Biochem. Physiol., 111C, 423-427, 1995. 57. A.B. Bikhazi and D.E. Jaalouk, "Role of Membrane- Bound Proteins on Calcium Transport Across Gastro-intestinal Epithelium in Rats, "Satellite Symposium, 7th FAOBMB Congress, POS 3-8, October 1995, Leura, Australia. 58. A.B. Bikhazi, K.M. Bitar, S.I. Kreydiyyeh, R.S. Saleh, M.M. El-Kasti, M.Z.M. Ibrahim and O.R. Abul-Khoudoud, "Binding and Distribution of some Prototype Calcium Channel Blockers in Perfused Rat Liver," The FASEB Journal, 10, A138, 1996.
63. R.E. Haddad, A.R. Jurjus, M.Z.M. Ibrahim, Z.A. Nahlé, M.M. El-Kasti K.M. Bitar, S.I. Kreydiyyeh, F.A. Saadeh, and A.B. Bikhazi, "Binding of 125I-Insulin on Capillary Endothelial and Myofiber Cell Membranes in Normal and Streptozotocin-Induced Diabetic Perfused Rat Hearts," Comp. Biochem. Physiol., 117A, 523-530, 1997. 64. A. Bikhazi, Z. Nahlé, S. Kreydiyyeh, R. Haddad, K. Bitar, G. Haddad, A. Abdelnoor, "Endotoxin Binding on Capillary Endothelium and Myocyte Plasma Membranes in Perfused Rat Heart," J. Endotox. Res., 4/1, 45-51, 1997. 65. A.B. Bikhazi, Z.A. Nahlé, M.F. Abou Fares, R.E. Haddad and K.M. Bitar, “Polypeptide Delivery at Myocyte-Surfaces in a Perfused Rat Heart Preparation. Conference on Formulations and Drug Delivery II,” Abstract # 84, p. 84, 1997. 66. A. Bikhazi, Z. Nahlé, R. Haddad and K. Bitar, “Comparative Binding of Angiotensin II and DUP753 on Capillary Endothelium and Myofibers in Perfused Rat Hearts,” FASEB J., 12, A408, 1998. 67. G. Haddad, F. Saadeh, L. Sharaf, Z. Nahlé, M. Abou Fares, K. Bitar and A. Bikhazi, “Kinetics of IGF-1 Binding on Cardiac Myofibers and Capillary Endothelium During Chronic Eccentric Hypertrophy,” FASEB J., 12, A709, 1998. 68. A.B. Bikhazi, F.A. Saadeh, R.E. Haddad, Z.A. Nahlé, M.F. Abou Fares, K.M. Bitar, A.E. Birbari, “Insulin Receptor Binding Characteristics in Perfused SHR and WKY Rat Hearts,” Comp.
and Cardiac Myocyte Surfaces in Perfused Rat Hearts,” J. Pharm. Sci., 87, 1363-1367, 1998. 70. A.B. Bikhazi, A.G. Ziadeh, R.A. Abbud, S.I. Nabhan and G.E. Haddad, “Two Uncompetitive Titrated Sites of the Na+/H+ Exchanger in Perfused Rat Kidney,” J. Pharm. Sci., 1, S-391, 1998. 71. A.B. Bikhazi, K.A. Hassan, J.H. Gebrael and K.M. Bitar, “Angiotensin II-AT1-Subtype Receptor Binding with Antagonist and Potential Activation of AT2-Subtype Receptor,” International Forum on Angiotensin II Receptor Antagonism, Abstract 1.1, page 15, 1999. 72. G.E. Haddad, L. Sharaf, Z. Nahlé, K. Bitar and A.B. Bikhazi, “IGF-1 Receptor Kinetics during Regression of Cardiac Hypertrophy following ACE-inhibitor or AT1-antagonist Treatment,” FASEB J., 13, A438, 1999. 73. A.B. Bikhazi and K.M. Bitar, “Effect of Diabetes Mellitus in Endothelin Binding on Capillary Endothelium and Cardiac Myocytes in Perfused Rat Heart,” FASEB J., 13, A767, 1999.
75. A.B. Bikhazi, A.G. Ziadeh, R.A. Abbud, S.I. Nabhan, and G.E. Haddad, “Two Uncompetitive, Activated, and Transport sites of the Na+/H+ Exchanger for pH Regulation in Perfused Rat Kidney,” Comp. Biochem. Physiol., 123/4, 417-422, 1999. 76. A.B. Bikhazi, M.E. El-Sabban, G.N. El-Zein, and K.A. Hassan. “Angiotensin II Binding, Fibroblast and Collagen Alterations in Myocardial Infarcted Rat Hearts,” jraas, 1, 78, 2000. 77. A.B. Bikhazi, K.A. Hassan, M.E. El-Sabban, and K.M. Bitar, “Kinetics of Angiotensin II Binding on Endothelium and Myocytes in Myocardial Infarcted Rat Hearts,” FASEB J., 14, A423, 2000. 78. A.B. Bikhazi, S.T. Azar, A.E. Birbari, G.N. El-Zein, G.E. Haddad, R.E. Haddad, and K.M. Bitar, “Characterization of Insulin-Resistance: Role of Receptor Alteration in Insulin-Dependent Diabetes Mellitus, Essential Hypertension, and Cardiac Hypertrophy,” Eur. J. Pharm. Sci., 11(4), 299-306, 2000. 79. A.B. Bikhazi, “Kinetics of Glycyl-Sarcosine Absorption in the Rat Jejunum. Pharm. Sci., Supplement 2 (4), 2173, 2000. 80. M.E. El-Sabban, K.A. Hassan, A.E. Birbari, K.M. Bitar, and A.B. Bikhazi, “Angiotensin II Binding and Extracellular Matrix Remodeling in a Rat Model of Myocardial Infarction,” Journal of the Renin-Angiotensin-Aldosterone System (jraas), 1(4), 369-378,2000. 81. A.B. Bikhazi, K.A. Hassan, C.I.N. Ochoa Chaar, N.E. Abou Zeid, K.M. Bitar, “Effect of AT1-R and AT2-R Antagonists on Angiotensin II Binding at Endothelial and Cardiac Myocytes in Perfused Rat Hearts,” 2nd International Forum on Angiotensin II Receptor Antagonism, Abstract 5.60, page 35, 2001. 82. A.B. Bikhazi, A.R. Jurjus, M.T. Kamal, A.M. Al-Housseini, R.N. Saab, W.A. Jaroudi, K.M. Bitar, “Kinetics of Lipopolysaccharide (endotoxin) Clearance by Kupffer and Parenchyma Cells in Perfused Rat Liver,” Comp. Biochem. Physiol., 129, 339-348, 2001. 83. A.B. Bikhazi, W.A. Jaroudi, N.E. Abou Zeid, and K.M.Bitar. “Differential Location of Angiotensin II Receptor Subtypes and Potential Effects of their Antagonists on Cardioprotection in a Rat Heart Model.” Trends Comp. Biochem. Physiol. 8, 91-97, 2001. 84. A.B. Bikhazi, D.N. El-Khechen, M.E. El-Sabban, E.H. Baydoun, K.M. Bitar. Endothelin-1 binding and receptor subtypes localization and alteration in a normal and diabetic rat heart model. FASEB J., 16, A848, 2002. 85. A.B. Bikhazi, M.Khalifeh, A.Al Kutoubi, J. Abbas, F. Mourad, A. Chehal, M-Z. Habbal, A. Shamseddine. Comparative Pharmacokinetics between Intravenous and Intra-arterial Delivery of Gemcitabine in Unresectable Pancreatic Cancer Patients. AAPSPharmSci, 4, Abstract W5224, 2002. 86. G.E. Haddad, K. Blackwell, and A.B. Bikhazi. “Regulation of IGF-1 by RAS during Regression of Eccentric Hypertrophy through ACE-Inhibitor and AT1-Antagonist,”Canad.J.Physiol.Pharmacol. 81 (Number 2), 142-149,2003. 87. W.A. Jaroudi, A.R. Jurjus, M.E. El-Sabban, M.T. Kamal, K.M.Bitar, and A.B. Bikhazi. “Endothelium/Myocyte Cellular Insulin Receptor Alterations in a Rat Model of Myocardial Infarction,” Canad.J.Physiol.Pharmacol. 81 (Number 3), 1-7, 2003. 88. A.B. Bikhazi, A.M. Khalifeh, W.A. Jaroudi, R.E. Saadeddine, A.R. Jurjus, M.E. El Sabban, and K.M. Bitar. “Endothelin-1 receptor subtypes expression and binding in a perfused rat model of myocardial infarction,” Comp. Biochem. Physiol. Part C 134, 35-43, 2003. 89. A.B. Bikhazi, M.N. Skoury, A.R. Jurjus, D. Jacques. “Insulin-Regulation of the Jejunal PEPT1 Symporter in a diabetic Rat Model”. 3rd International Research Conference, PharmaConference, Transporters & Drugs, page 62, abstract P35, 2003. 90. A.B. Bikhazi, C.N. Karam, K. M. Bitar, N.N. Salti, J.A. Usta, D.Z. Zwainy, and R.E. Abrahamian. Role of insulin and angiotensin II receptor subtype I antagonist on endothelin 1 binding in diabetic rat hearts. FASEB Journal, volume 18 (4), A635, 2004. (Abstract). 91. A.B. Bikhazi, M.M. Skouri, D.S. Zwainy, A.R. Jurjus, S.I. Kreydiyyeh, D.A. Smith, K. Audette, D. Jacques. “Effect of Diabetes-Mellitus and Insulin on the Regulation of PepT 1 Symporter in Rat Jejunum”. Molecular Pharmaceutics, vol 1(4), 300-308, 2004. 92. W.A. Jaroudi, N. Nuwayri- Salti, J.A.Usta, D.S. Zwainy, C.N. Karam, K.M. Bitar A.B. Bikhazi. “Effect of Insulin and Angiotensin II Receptor Subtype-1 Antagonist on Myocardial Remodeling in Rats with Insulin-Dependent-Diabetes-Mellitus”. Journal of Hypertension, vol. 23(2), 381-392, 2005. 93. A.I. Shameseddine, M.J.Khalifeh, F.H. Mourad, A.A. Chehal, A. Al Kutoubi, J. Abass, M.Z. Habbal, L.A. Malaeb, A.B. Bikhazi. “Comparative Pharmacokinetics andMetabolic Pathways of Gemcitabine during Intravenous and Intra-arterial Delivery in Unresectable Pancreatic Cancer Patients with Early Clinical Data”. Clinical Pharmacokinetics, 44(9), 957-967, 2005. 94. A. Bikhazi, C. Karam, D. Zwainy, N. Nuwayri-Salti, J. Usta, K.Bitar, W.Jaroudi. Role of Insulin, Endothelin-1, and Angiotensin II Subtype-1 Antagonist on Myocardial Remodeling in Insulin-Dependent-Diabetic Rat Hearts. The AAPS Journal. Abstract, Volume 6, Issue S1, October 2004. ISSN 1551-1081 / ISBN 0-9711767-1-X. 95. N. Karam, N. Nuwayri-Salti, J. A. Usta, D. S. Zwainy, R E Abrahamian, W. A. Al Jaroudi, M. J. Baasiri, S. A. Abdallah, K. M. Bitar, A. B. Bikhazi. Effect of Systemic Insulin and Angiotensin II Receptor Subtype-1-Antagonist on Endothelin-1 Receptor Subtype(s) regulation and Binding in Diabetic Rat Hearts. ENDOTHELIUM, 12(5-6), 225-231, 2005. 96. A.B.Bikhazi, W.M.Maharsy, K.M.Bitar, D.S. Zwaini, N.S. Issa. Angiotensin II Receptor Regulation and Affinity Changes in Treated IDDM Rat Hearts. The FASEB Journal, Abstract, March 7, Volume 20, No.5, page A1195, 2006. 97. N. Nuwayri-Salti, C.N. Karam, W.A. Al Jaroudi, J.A. Usta, W. M. Maharsy, K.M. Bitar, A.B. Bikhazi. Effect of type-1-diabetes mellitus on the regulation of insulin and endothelin-1 receptors in rat hearts. Canadian Journal of Physiology and Pharmacology (CJPP). Volume 85, Number 2, 215-224, 2007. 98. Anwar B. Bikhazi, Asdghig H. Der Boghossian, Lina N. Kadi. Effective role of dietary restriction on jejunal PepT-1 function. The FASEB Journal, Abstract, Volume 21, page 602.5, 2007. 99. Wael M. Maharsy, Lina N. Kadi, Nahla G. Issa, Khalil M. Bitar, Asdghig H. Der-Boghossian, Roy Abrahamian, and Anwar B. Bikhazi. Cross-talk related to Insulin and Angiotensin II binding on myocardial remodeling in diabetic rat hearts. Journal of the Renin-Angiotensin-Aldosterone System., Volume 8, pages 59-65, 2007. 100. Anwar B. Bikhazi, Wael M. Maharsy, Lina N. Kadi, Nahla G. Issa, Ghinwa M. Barakat, George K. Karam, Omar A. Batal, Nuha Nuwayri-Salti and Khalil M. Bitar. Effect of Insulin and Losartan on Modulation of Insulin-Like-Growth Factor 1 Receptor at Heart Level in Diabetic Rats. The Open Drug Delivery Journal, Volume 1, pages 1-6, 2007.
Mounir Y. Obeid, Lina N. Kadi, Asdghig H. Der-Boghossian, and Anwar B.Bikhazi. Role of Glucagon-Like Peptide-1 (GLP-1) analogues on Insulin regulation in diabetic rat hearts. Canadian Journal of
102. Asdghig H. Der-Boghossian, Sara R. Saad, Claudine Perrault, Chantale Provost, Danielle Jacques, Lina N. Kadi, Nahla G. Issa, Abla Sibai, Nadim El-Majzoub, and Anwar B. Bikhazi. Role of insulin on jejuna PepT 1 expression and function regulation in diabetic male and female rats. Canadian Journal of Physiology and Pharmacology, 88, 753-759, 2010. 103. Ghinwa M. Barakat, Nuha-Nuwayri-Salti, Lina N. Kadi, Khalil M. Bitar, Wael Al-Jaroudi, and Anwar B. Bikhazi. Role of Glucagon-Like-Peptde-1 and its agonists on early prevention of cardiac remodeling in type 1 diabetic rat hearts. General Physiology and Biophysics, 30, 34-44, 2011. 104. Shushan B. Artinian, Sawsan M. Al Lafi, Suzan S. Boutary, Khalil M. Bitar, Nadine S. Zwainy and Anwar B. Bikhazi. Assessment of Glucagon-Like Peptide-1 Analogue and Renin Inhibitor on the Binding and Regulation of GLP-1 Receptor in Type 1 Diabetic Rat Hearts. Experimental Diabetes Research. vol. 2011, Article ID 489708, 7 pages, 2011. doi:10.1155/2011/489708. 105. Ghinwa M. Barakat, Mohamad E. Moustafa, and Anwar B. Bikhazi. Effects of selenium and exendin-4 on glucagon-like peptide-1 receptor, IRS-1, and Raf-1 in the liver of diabetic rats. Biochemical Genetics, DOI 10. 1007/s10528-012-9532-2. 50, 922-935, 2012. 106. Anwar B. Bikhazi, Mohamad I. Al Chami, Nadine S. Zwainy, and Asdghig Der-Boghossian. Conference: Experimental Biology Meeting, San Diego, California, April 21-25, 2012. Source: FASEB JOURNAL, Volume 26, Published April 2012. 107. Sawsan M. Al Lafi, Shushan B. Artinian, Suzan S. Boutary, Nadine S. Zwainy, Khalil M. Bitar, and Anwar B. Bikhazi. Aliskiren, Exendin-4 and Insulin: Impact on Endothelin Receptor Subtype(s) Regulation/Binding in Type 1 Diabetic Rat Hearts. Canadian Journal of Physiology and Pharmacology, 10-1139/cjpp-2013-0095, 2013. 108. Suzan S. Boutary, Shushan B. Artinian, Sawsan M. Al Lafi, Nadine S. Zwainy, Khalil M. Bitar, and Anwar B. Bikhazi. Role of Insulin, Glucagon-Like Peptide-1 Analogue and Vitamin D In The Regulation of Endothelin-1 Receptor Subtypes In Type-1 Diabetic Rat Hearts. General Physiology and Biophysics. Submitted for publication, March 17, 2014. III. Minireviews, Reviews and Chapters 1. A.B. Bikhazi, G.E. Haddad, H.M. Alloush,F.H. Uthman, N.A. Fakhruddin and M. El-Kasti. In: Membrane Pathophysiology "Effect of Insulin and Glucagon on Hepatocellular Alanine Uptake in Normal and Streptozocin-induced Diabetic Rats." G. Bkaily (Editor), Kluwer Academic Publishers, Norwell, Mass., USA, pp. 271-289, 1994. 2. A.B. Bikhazi,“Formulations and Drug Delivery. II,” Investigational Drugs Weekly Highlights, Week 47, 46-49, 1997.
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