Curriculum vitae professor ramendra k. Singh

Research experience

1982-1986 Junior & Senior Research Fellow, Department of Science &

Technology (DST), New Delhi

1986-1989 Scientist, Council of Scientific & Industrial Research (CSIR),

New Delhi. Under Scientists’ Pool Scheme

1990-1991 Research Associate, CSIR, New Delhi.

1991 (June-Sept) Visiting Scientist, Indian National Science Academy (INSA) New Delhi. Visited Tata Institute of Fundamental Research, Mumbai and worked with Prof. G. Govil on Application of 2D NMR and its related techniques like NOESY & COSY in DNA / RNA structural analysis.
1991-1992 UNESCO Fellow, at Tokyo Institute of Technology, Tokyo, in the laboratory of late Prof. T. Hata and worked on Development of a new chlorinating reagent. The suitably modified nucleosides were easily converted to 5'-chloro- and 3'-chloro-dideoxy nucleosides, the highly useful synthons.
1992-1995 Scientist, DST, New Delhi under Young Scientists Program. The work done under this project was; i) introduction of a new thiocarbamate linkage as internucleoside bond, and, ii) synthesis of some fluorescent and anti-fungal nucleoside analogues.

1994(Jan-April) Visiting Scientist, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India. Visited ASTRA Research Centre India, Bangalore and worked on Development of Non-radioactive Diagnostic kit for Malaria Detection using biotinylated Oligonucleotides. It was a highly sensitive technique in comparison to the traditionally used one.

1995-1997 Post Doctoral Fellow, at Chiba Institute of Technology, Japan in the laboratory of Prof. H. Takaku, and worked on Synthesis and Biological properties of 5'-2' oligonucleotides. Studies were done on duplex and triplex formation using DNA/RNA fragments and duplexes as well using Tm measurement and gel retardation studies. The 5'-2' oligonucleotides were indigenously prepared by introducing modifications at sugar level, on Gene Synthesizer following the normal protocol.

Post-Doctoral Research
UNESCO Fellowship 1991 - 1992, UNESCO Fellow

Tokyo Institute of Technology, Tokyo

UNESCO & Ministry of Education, Science and Culture, Govt of Japan
Post-Doc Fellowship 1995 - 1997, Post-Doc Fellow

Chiba Institute of Technology, Chiba, Japan

Ministry of Education, Science and culture, Govt of Japan
INSA International 2010 - 2011, Institute of Biochemistry and Biophysics

Exchange Fellowship Polish Academy of Sciences, Warsaw, Poland

Indian National Science Academy, New Delhi

Fulbright - Nehru 2013 – 2014, School of Pharmacy, Chapman University, CA,

Senior USA

Research Fellowship J W Fulbright Foreign Scholarship Board, Washington DC, USA
Techniques learnt Solution and solid phase synthesis of oligonucleotides and peptides and various techniques like TLC, Flash column chromatography, hplc, gel electrophoresis, UV, IR and NMR. In addition to these, techniques used in anti-sense and antigene approaches in gene expression including duplex and triplex formation, sequencing, PCR, Drug designing and development, Microbial Testing, etc also are the integral part of my research interest.
Teaching Experience *Department of Chemistry, University of Allahabad

At Undergraduate and Postgraduate levels

From 1986-1991, 1992-1995, 1997- onwards

Topics: General Chemistry, Stereochemistry

Spectroscopy and Biomolecules

*Centre of Biotechnology, University of Allahabad

At PG level from 2000 - 2009

Topics: Biomolecules, Oligonucleotide Synthesis

Purification and Applications

Ph. D. students *Ph. D. awarded 10

*Working at present 09 (PDF 01; JRF/SRF 08)

Invited talks/others

• 
  Science Forum, Chapman University, CA, USA
  
• 
  At Chemistry Department, IIT Bombay, Mumbai
  
• 
  Inspire Programme, DST, New Delhi at Degree College, Upardaha, Baraut, Allahabad
  
• 
  Resource Person, Hands-on Training in Chemistry, DST Inspire Internship Science Camp, Botany Dept, Univ of Allahabad
  
• 
  At various national/International symposia/conferences.
  
• 
  In Refresher Courses for Degree and P.G. College & Univ. teachers
  
• 
  On All India Radio, Allahabad
  
• 
  Judge, 23^rd National Children’s Science Congress – 2015
  

Kendriya Vidyalaya, New Cantt, Allahabad

• 
  Judge, Science Congress/Exhibition
  

St. Joseph’s College, Allahabad

• 
  Judge, National Children’s Science Congress (District level)
  

MPVM Ganga Gurukulam, Allahabad

*Member, Research Fund Recommending Authority, DBT, DST, ICMR, CST, etc

*Member, Expert Committee, Interview Board Civil Services, Jharkhand Public Service Commission, 2015

*Expert, Chemistry, appointed by Hon’ble High Court, Allahabad on disputed questions of Chemistry, UP Public Service Commission, 2016

Professional training *Orientation Course 01

*Refresher Courses 04 with “A” grade

Seminars/ Conferences organized
*Coordinator, Organized a 4-day Workshop on Training Program on Academic leadership and Education Management for VCs, Pro VCs, Deans, Directors, Deans and Heads of the Departments, sponsored by MHRD, New Delhi
* Member, Organizing Committee: 2^nd International Conference on HIV/AIDS, STDs & STIs. Las Vegas, USA, Oct 27-29, 2014
*Co-convener & Organizing Secretary: National Symposium on Chemistry at the Interface of Innovative Researches in Science & Technology, Department of Chemistry, Univ. of Allahabad, Feb 27-28, 2014.

Patents

1. 
   Ramendra K. Singh & G. Kumari
   

Isoindolinedione derivatives as anti-HIV and antibacterial agents

Submitted to the Govt of India, Application No. 663/DEL/2014

Published in The Patent Office Journal, 18/09/2015, p 53430

2. 
   Nucleoside mimetics as anti-JEV agents
   

In preparation

Research projects

Completed

1. 
   Development of folate receptor-mediated system for targeted delivery of curcumin in cancer cells, Agency – DBT, New Delhi, Year – 2010, Duration – 3Y 9M Amount – Rs 58.02 lacs
   

Prof. B. C. Das, PI, ACBR, Delhi University (North campus), Delhi

Dr. Ramendra K. Singh, Co-PI, Univ. of Allahabad, Allahabad

2. 
   Design and development of antiviral compounds as inhibitors of HIV replication. PI, Agency- DBT-ICMR, New Delhi, Year – 2007, Duration – 4 years, Amount - Rs 57.32 lacs.
   

3. 
   Design and Synthesis of SAM/SAH analogues as antiviral agents. PI
   

Year-2004, Duration- 3 Years, Agency- UGC, New Delhi

Amount - Rs 6,47,300

4. 
   Modified nucleosides, nucleotides and oligonucleotides of biological and therapeutic importance, PI, Year – 2002, Duration - 3.5 Years
   

Agency- DST, New Delhi, Amount- Rs. 16,02,698

5. 
   Design & Synthesis of Nucleoside Analogs of Therapeutic use. PI
   

Agency- DST, New Delhi, Year –1993, Duration- 3 Years

Amount - Rs 4.00 lacs.

5. 
   Interaction of some important azo dyes with specific sequences of DNA/RNA. Co-PI, Agency – UGC, New Delhi, Year - 1999, Duration - 3 years, Amount - Rs 3.516 lacs.
   

5. 
   Development of new chlorinated agents for industrial use. Co-PI
   

Agency -NVS Chemicals, Moradabad, Year – 1998

Duration - 2 years, Amount - Rs 3.50 lacs.

5. 
   Design and development of oligonucleotides of therapeutic value. Co-PI, Agency- DST, New Delhi, Year - 1997, Duration- 3.5 years
   

Amount - Rs 20.00 lacs.

5. 
   Improved routes for the synthesis of modified oligonucleotides. Co-PI, Year - 1991, Agency - DBT, New Delhi, Duration - 3 years
   

Amount- Rs 25.89 lacs

Research Collaborators

• 
  Dr. S. K. Gupta, Emeritus Scientist, National Institute of Immunology, New Delhi.
  
• 
  Dr. S. S. Kulkarni, Scientist, National AIDS Research Institute, Pune
  
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  Prof E. De Clercq, Rega Institute for Medical Research, Katholieke Universiteit. Leuven, Belgium
  
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  Prof. C. Pannecouque, Rega Institute for Medical Research, Katholieke Universiteit. Leuven, Belgium
  
• 
  Prof. Raymond F. Schinazi, Director, Center for AIDS Research, Emory University, USA
  
• 
  Prof. Paolo La Colla, Department of Biomedical Technology, University of Cagliari, Italy
  
• 
  Prof. K. Parang, School of Pharmacy, Chapman University, California, USA