Evaluation of protection by sunscreens in laboratory model of skin toxicity by UV rays.
Ecotoxicity evaluation in various water samples viz; BOD , COD, Total solids ,pH, acidity etc.
Honorary Lecturer in Toxicology department from 2003- February 2009.
Junior Research Fellow (October 2002-June2005) in Chemoprevention laboratory in the Department of Medical Elementology & Toxicology, Jamia Hamdard New Delhi India.
Senior Research Fellow, (June2005-June2006) Research work at Chemoprevention Lab, Department of Medical Elementology & Toxicology, Jamia Hamdard, and New-Delhi. (Topic: Role of herbal anti-proliferative agents in renal carcinogenesis: A Mechanistic approach).
Senior Research Fellow, (June 2006-December2006) in a project funded by Indian Council of Medical Research (ICMR) Government of India and carried out at Chemoprevention Lab, Department of Medical Elementology & Toxicology, Jamia Hamdard, India.
University Tabulator 2006-2007and 2007-2008.
Awarded Hamdard National Foundation Scholarship for 2.5 years2003-2005
Senior Research fellowship (SRF) awarded from Indian Council of Medical Research (ICMR, Government of India, (in June 2006-December 2006)
Research Associateship (RA) awarded from Indian Council of Medical Research (ICMR, Government of India in 2006-2008.
Young scientist award from Department of Science and Technology (Fast track) Govt. of India to carry out work on “Chemoprevention by Plant polyphenols: Possible Role of NFb, TNF alpha, IFN gamma, caspases?? From June2008 for three years.
Travel award at the International Conference of Society for Free Radical Research held at Lonavala, Mumbai-India January 2007.
One paper was presented at the XIth International congress of Toxicology held in July 2007 at Montreal, Canada.
Travel Award from Indian Academy of Science, Department of Science and Technology and CSIR in 2003 to attend XIth International congress of Toxicology held in July 2007 at Montreal, Canada. Abstract is selected to compete under Young achievers award category and oral presentation at TOXCON 2010 to be held in September 2010 at SLOVAKIA.
Travel award including full airfare and registration fees is approved by DST Govt. of India to attend TOXCON 2010. at SLOVAKIA.
CST Uttar Pradesh honored with young scientist award in 2010 for work in cancer chemoprevention Toxicology
Underwent summer training from June 2002 to September 2002 in Central Pollution Control Board, NewDelhi-India.
Life membership of Society of Toxicology (SOT) of India.
Annual member of INSA.
Research area working at present
Current Research: The goal of present study is to elucidate the basic mechanisms underlying two stage hepatic cancers induced by Solt and Farber protocol with highlighting preventive interventions that can modulate the mechanism involved. Several reports indicate that polyamines are involved in regulating cellular differentiation and growth. Chemopreventive tools bring about many of their effects by interacting with nuclear receptors. These nuclear receptors are trans-activating factors that can regulate the expression of specific genes involved in differentiation, proliferation, and apoptosis. As mentioned earlier, it has become clear in the past few years that apoptosis and mitogenesis are equally important in maintaining cell number homeostasis; thus, in addition to cell proliferation, apoptosis has emerged as a critical target for prevention. Targeting NF-B by agents could be a promising strategy to enhance the anti-tumor activity of agents.
Given the fact that cancer development can be roughly divided into three stages of initiation, promotion and progression, control over this disease may only be achieved if molecular changes underlying each stage can be well characterized and recapitulated in animal models of carcinogenesis. Hence, animal models are significantly important and play a major role in recognition of new agents.
Experience in conducting various surgeries, neurobehavioral tests including traction test, sleeping time, catalepsy, conditioned and unconditioned avoidance response, partial hepatectomy and handling of Mouse, Rat, Rabbit, Guinea Pig and fish.
Proficiency in using analytical instruments like Spectrophotometer, Ultracentrifuge, Beta Scintillation Counter (Pharmacia)
ELISA PLATE Reader
Experienced in estimation of enzymatic and non-enzymatic antioxidants such as Xanthine Oxidase, Catalase, Glutathione Reductase, Peroxidase and Glutathione-S-Transferase, Acetylcholine Esterase, Monoamine Oxidase, various ATPase's, reduced glutathione, thiol profile, ascorbic acid, etc. Analysis and interpretation of the antioxidant status of normal and diseased tissues.
Area of specialization Oxidative Stress Biomarkers in carcinogenesis with emphasis on renal and hepatic cancer.
Rat- Induction of chemically induced liver and kidney cancer, Induction of chemically induced oxidative stress, Induction of genotoxicity
Mice-Induction of chemically induced skin cancer, Induction of genotoxicity, Induction of chemically induced oxidative stress
Experience in data acquisition, analysis and presentation.
Handling of computers and proficiency in various software packages (MS office, Chem. Draw, Multivariate statistics.
Presented poster, delivered oral presentations at various national and international conferences.
Full Length Published Papers/Book chapter
Sarwat Sultana, Salahuddin Ahmed, Sonia Sharma and Tamanna Jahangir.
Emblica officinalis reverses thioacetoamide induced oxidative stress and
early promotional events of primary hepatocarcinogenesis.Journal of
Pharmacy and Pharmacology 56(12), 1573-1579, (2004). Impact Factor-1.718
Sarwat Sultana, Salahuddin Ahmed, Tamanna Jahangir and Sonia Sharma Inhibitory effect of celery seeds extract on chemically induced hepatocarcinogenesis: Modulation of cell proliferation, metabolism and altered hepaticfoci development. Cancer Letters 221(1): 11-20(2005) Impact Factor-3.3
Tamanna Jahangir, Tajdar Husain Khan, Lakshmi Prasad & Sarwat Sultana. Pluchea lanceolata attenuates CdCl2 induced oxidative stress and genotoxicity in Swiss albino mice. Journal of Pharmacy and Pharmacology,Sep; 57(9): 1199-204 (2005) Impact Factor-1.718
Tamanna Jahangir, Tajdar Husain Khan, Lakshmi Prasad and Sarwat Sultana. Alleviation of free radical mediated oxidative and genotoxic effects of cadmium by farnesol in Swiss albino mice. Redox Report, 10(6):303-10(2005). Impact Factor-1.6
Sarwat Sultana, Salahuddin Ahmad, Naghma Khan, Tamanna Jahangir.
Effect of Emblica officinalis (Gaertn) on CCl4 induced hepatic toxicity and DNA synthesis in
Wistar rats. Indian Journal of Experimental Biology, 43(5), 430-6, (2005). Impact Factor-
Tamanna Jahangir, Tajdar Husain Khan, Lakshmi Prasad and Sarwat Sultana. Farnesol prevents Fe-NTA mediated renal oxidative stress and early tumor promotion markers in rats. Human and Experimental Toxicology, 25(5): 235-42(2006). Impact Factor-1.33
Tamanna Jahangir, Tajdar Husain Khan, Lakshmi Prasad and Sarwat Sultana. Adhatoda vasica extract reverses cadmium chloride induced oxidative stress and genotoxicity in Swiss albino mice. Biological Trace Element Research, 111(1-3):217-28(2006).Impact Factor-1
Tamanna Jahangir & Sarwat Sultana*
Modulatory effects of Pluchea lanceolata against chemically induced oxidative damage, hyperproliferation and two-stage renal carcinogenesis in Wistar rats. Molecular and Cellular Biochemistry Oct; 291(1-2):175-85. (2006).Impact Factor-1.7
Lakshmi Prasad, Tajdar Husain Khan, Tamanna Jahangir and Sarwat Sultana* Acorus calamus extracts and nickel chloride: Prevention of oxidative damage and hyperproliferation response in rat kidney. Biological Trace Element Research. Oct; 113(1):77-92(2006). Impact Factor-1
Lakshmi Prasad, Tajdar Husain Khan, Tamanna Jahangir and Sarwat Sultana* Effect of gallic acid on renal biochemical alterations in male Wistar rats induced by ferric nitriloacetic acid. Human & Experimental Toxicology25(5): 235-42(2006) Impact Factor-1.33
Lakshmi Prasad, Tajdar husain khan, Tamanna Jahangir and Sarwat sultana* Chemomodulatory effects of terminalia chebula against nickel chloride induced oxidative stress and tumor promotion response in male Wistar rats. Journal of Trace Element in Medicine and Biology, 20(4):233-9. (2006) Impact Factor-2.4
Khan TH, Tamanna Jahangir, Prasad L and Sultana S. Inhibitory effect of Apigenin on benzo(a)pyrene-mediated genotoxicity in Swiss albino mice. Journal of Pharmacy and Pharmacology ,58(12):1655-60(2006).Impact Factor-1.718
Tamanna Jahangir & Sarwat Sultana
Tumor promotion and oxidative stress in ferric nitrilotriacetate (Fe-NTA) mediated renal carcinogenesis: protection by Adhatoda vasica” Toxicology Mechanisms and Methods17:421–430, (2007) Impact Factor-0.8
Tamanna Jahangir& Sarwat Sultana Perillyl alcohol protects against Fe-NTA induced nephrotoxicity and early tumor promotional events in rat experimental model. Evidenced Based Complimentary and Alternative Medicine4(4): 439-45. (2007) Impact Factor-2.9
Lakshmi Prasad, Tajdar Husain Khan, Tamanna Jahangir and Sarwat Sultana* Effect of Luteolin on Nickel chloride Induced Renal Hyperproliferation and Biotransformation Parameters in Wistar Rats. Pharmaceutical Biology(Formerly International Journal of Pharmacognosy), 45, 2, 116-123(8) (2007)Impact Factor-0.4
Lakshmi Prasad, Tajdar husain khan, Tamanna Jahangir and Sarwat sultana* Abrogation of DEN/Fe-NTA induced carcinogenic response, oxidative damage and subsequent cell proliferation response by Terminalia chebula in kidney of Wistar rats’, Die Pharmazie. ,62(10):790-7(2007)Impact Factor-0.8
Sarwat Sultana Salahuddin Ahmed and Tamanna Jahangir. Emblica officinalis andhepatocarcinogenesis: A chemopreventive study in Wistar rats. Journal of Ethnopharmacology 7, 00, (2007).Impact Factor -2.049
Tamanna Jahangir and Sarwat sultana ‘B (a) P induced genotoxicity: attenuation by Farnesol in mouse experimental model’ Journal of Enzyme Inhibition and Medicinal Chemistry. 23(6): 888-94 (2008) Impact Factor-1.343
Sarwat Sultana, Lakshmi Prasad and Tamanna Jahangir. Luteolin ameliorates ferric nitrilotriacetic acid induced renal toxicity and tumor promotional response in rat. Indian Journal of Experimental Biology 47(5):355-60(2009). Impact Factor-0.551
Sayeed Ahmad, Shabana Rehman, M. Aftab Ahmad, Khalid M. Siddiqui, Seemin Shaukat, Masood Shah Khan, Kamal Y. T., Tamanna Jahangir. Khamiras, a natural cardiac tonic: An overview Journal of Pharmacy & Bio Allied Sciences; (2010),2:93-9
Sayeed Ahmad and Tamanna Jahangir. Protective effects of Punica granatum in experimentally induced gastric ulcers Toxicology Mechanisms and Methods. (Accepted ahead of print, 2010)
Effect of Nigella sativa and bee honey on pulmonary, hepatic and renal function in Sudanese in Khartoum state. Journal of Medicinal Plants Research (2011)Vol. 5(xx), pp. Book Chapter:
Sarwat Sultana& Tamanna Jahangir:Cancer Chemoprevention: Possible role of Phytochemicals In; Herbal drugs: A Cancer Chemopreventive & Therapeutic perspective (ed. Rajesh Arora) Jaypee Brothers, Medical Publishers, New Delhi