Curriculum Vitae

2. Research As Collaborator

2010–	Cell tracking in vivo using iron nanoparticle labelling for cellular therapy of osteoarthritic joints Principal Investigator: Ben Webster, Macquarie University, Sydne, Australia
2009–	Long term followup MRI of the neuraxis of patients with neurofibromatosis Type 1 Principal Innvestigator: Kathryn North, Paediatric Neurology, Childrens’ Hospital at Westmead, Sydney, Australia
2008–	Multicentre pilot comparison study of magnetic resonance angiography (MRA) with the blood pool contrast agent Vasovist and intra-arterial digital subtraction angiography (IA-DSA) in patients with below-knee peripheral artery disease Principal Investigator: Sudakhar Venkatesh, Diagnostic Radiology, National University of Singapore This study is investigating the performance of a new intravascular MRI contrast medium for evaluating small vessels in patients with severe peripheral vascular disease
2006–2008	Development of Ultrawideband Microwave Imaging for Detection and Diagnosis of Breast Malignancies Principal Investigator: Soh Cheong Boon, Electrical Engineering, Nanyang Technological University, Singapore This project aims to develop algorithms for ultrawideband energy propagation and received signal decoding for diagnosis of breast tumours.
2006–2008	MMedWeb – Multimedia Medical Conceptual Web for Intelligent Information Access Principal Investigator: Leow Wee Kheng, School of Computing, National University of Singapore This project aims to use data mining of hospital PACS and RIS and other medical informatics databases to create a new way of visualizing patient data and clinical history through integration, intelligent classification and clustering of events and investigations.
2005–2007	Nanoparticles of biodegradable polymers for new-concept chemotherapy Principal Investigator: Feng Si-shen, Chemical & Biomolecular Engineering, NUS This project involves development of drug-loaded biodegradable polymeric nanoparticles to treat animal tumour models, with simultaneous incorporation of commercial clinically approved iron oxide nanoparticles to provide MR imaging localization of the particles in vivo.
2005–2007	Use of Diffusion MRI for evaluation of treatment response of liver tumours undergoing image-guide ablation therapy Principal Investigator: Sudhakar Venkatesh, Diagnostic Radiology, NUS This clinical project is aimed at prospectively determining whether diffusion MRI is useful for depiction of tumour viability in the liver before and after locoregional image-guided therapy
2004-2007	Use of Multidetector CT Scan in the Management of Patients with Acute Lower Gastrointestinal Haemorrhage Principal Investigator: Goh Poh Sun, Diagnostic Radiology, NUS This clinical project is aimed at prospectively evaluating the role and performance of multidetector multiphase contrast enhanced CT scan of the abdomen for detection and localization of acute lower bowel bleeding, with the aim of facilitating and directing treatment.
2004–2006	MRI Findings in Patients with Acute Hip Pain Principal Investigator: Yvonne YW Ho, Diagnostic Imaging, National University Hospital This project surveyed the range of diagnostic findings in patients who present to Accident and Emergency with acute hip pain and a suspected radiographically occult femoral neck fracture.
2003–	Evaluation of Autologous Cartilage Repair in the Knee using Contrast-Enhanced MR Arthrography Principal Investigator: James HP Hui, Orthopaedics, National University of Singapore The project evaluates the MRI findings before and after autologous cell-based arthroscopic repair of articular cartilage ulcers using 3D MRI with and without intra-articular injection of dilute MR contrast agent.
2003–2006	Virtual Spine Workstation Principal Investigator: Teoh Swee Hin, Mechanical Engineering, National University of Singapore This project aims to develop computer-based models of the human spine using a combination of clinical-level CT and MRI and micro-CT to develop meshing models of bone, to develop computer simulations of bone architectural strength and behaviour. These meshing models will be used to model and simulate response of osteoporotic bone to the addition of bone cement used during the procedure of vertebroplasty. They will also be used to simulate mechanical changes of the spine during various motions, and to develop a simulator for surgical training. This was a broadly multidisciplinary program involving Engineering, Radiology and Orthopaedic Surgery. I am co-supervising one PhD student who is working on meshing models and cement vertebroplasty simulations.
2002-2003	Brain MRI volumetry in early dementia patients. Principal Investigator: Martha Chiu, Psychological Medicine, National University of Singapore The project aims to develop a psychometric scoring system relevant to Asians to test for the development of dementia, and to compare this with 3D MRI scans processed using manual and semiautomated volumetric evaluation of whole brain and hippocampal volumes.
2002-2003	3D models of ancient pre-Angkorian skeletons with computerised skeletal reconstruction and anthropomorphic measurements using high-resolution 3D CT imaging. Principal investigator: Rethy Chhem, Diagnostic Radiology, National University of Singapore The project aims to develop expertise in NUS across the Faculty of Medicine and between Medicine and Arts in evaluation of skeletal remains from Southeast Asia using a unique imaging tool, multi-detector CT, to acquire high resolution scans of the entire skeleton.
2002-2008	Multidetector CT for pulmonary embolisation assessment. Principal investigator: Dr Sudhakar K Venkatesh, Department of Diagnostic Radiology, National University of Singapore The project aims to determine best visualization methods to detect pulmonary embolism & pulmonary artery anatomy.
2002-2004	Imaging of Ossification and Incorporation of Synthetic Biodegradable Bone Scaffolds for Cranioplasty Burr Hole Defects Principal Investigator: Dr. TC Lim, Department of Surgery, National University of Singapore This project was a collaboration between Department of Surgery, the Division of Bioengineering and the Department of Diagnostic Radiology at National University of Singapore to demonstrate progressive ossification of a novel polycaprolactone biodegradable burr hole plug cover, after seeding of with autologous marrow cells and surgical implantation, using CT scanning.
2002-2003	3D modeling and tissue extraction of the orbital soft tissues using MR data Principal Investigator: Dr Shantha Amrith, Ophthalmology, National University Hospital The project aims to use MRI data to collect imaging data of the orbits to enable 3D model development for volumetric analysis of orbital components.
2001	Efficacy of an abbreviated MRI scan protocol for assessment of acute stroke Principal investigator: J. Chong, Dept. of Diagnostic Radiology, NUS This study evaluates the efficacy and accuracy of a new brain MRI protocol used for acute stroke patients who are moving and uncooperative.
2001	Fine needle aspiration of the lung: effect of immediate cytologic review on accuracy and safety Principal Investigator: K.Y. Seto, Dept. of Diagnostic Imaging, NUH Collaborative research into the accuracy, efficacy and safety of fine needle biopsy of lung lesions performed at NUH from 1997 to 2000.
1998-	Outcomes of radiofrequency ablation for treatment of malignant liver neoplasms Principal Investigator: S.C. Wang, Diagnostic Radiology, NUS Clinical programme to determine efficacy and safety of percutaneous CT guided RF ablation for inoperable primary and secondary liver malignancies.
2000-	Efficacy of Yttrium-90 microsphere embolisation for the treatment of malignant liver neoplasms Principal Investigators: C.K. Leow, Dept.of Surgery, NUS to 2004. and S.C. Wang, Dept. of Diagnostic Radiology, NUS Clinical programme to determine effectiveness of intra-arterial radioactive embolotherapy for inoperable liver tumours.
2000-2001	Fine needle aspiration of the lung: cytological subclassification of bronchogenic carcinomas and diagnosis of tuberculosis Principal Investigator: M. Salto-Tellez, Dept. of Anatomical Pathology, NUS Collaborative research into the cytological diagnostic accuracy of fine needle biopsy of lung lesions performed at NUH from 1997 to 2000.
1994	Value of the 7-day chest radiograph for prediction of severity of chronic lung disease in premature neonates Principal Investigator: Dr. M.R. Hariram, Neonatology Unit, Royal North Shore Hospital Blinded scoring of 6 and 7-day chest radiographs to assess severity of lung involvement and correlation with follow-up assessment of lung function
1992-1994	The role of the zygapophysial joint in chronic low back pain. Principal investigator: A. Schwarzer, Dept. of Anatomy, University of Newcastle Investigation of the utility of facet joint injections in treating patients with chronic low back pain and no neurological signs, using CT, SPECT bone scan, X-ray and MRI correlation.
1991, 1996	A double-blind, placebo-controlled 12-month study of the effect of Misoprostil on cartilage in patients with early osteoarthritis. Primary investigator: Prof. Peter Brooks, Dept. of Rheumatology, RNSH. Performance and review of knee MRI scans to evaluate severity of cartilage loss before and after treatment with new anti-arthritic agent Misoprostil.