Cv lioara restier english version

Academic Resume

Lioara RESTIER MIRON

PhD, MSc

Coordinator CRA

HCL – GHE

Hôpital Cardiologique de Lyon

Center for Clinical Investigations - CPMH

Clinical Research (Pr. Michel OVIZE)

Etage TM

28, av Doyen Lépine

69677 BRON Cedex

Fax: [phone]

Phone: +33 (4 ) 27 86 92 02

Personal Data
Business Address …………………… HCL – GHE - Hôpital Cardiologique de Lyon

Center for Clinical Investigations – CPMH; Clinical Research - Etage TM ; 28, av Doyen Lépine ; 69677 BRON Cedex, FRANCE

Phone …………………………………[phone]

Fax ……………………………………[phone]

E-Mail ………………………………[e-mail]
Residence …………………………….298, route de Bordenoud

38110 Dolomieu, France

Phone …………………………………[phone]

E-Mail ………………………………[e-mail]

Born …………………………………..24 December 1967 in Romania

Citizenship ……………………………French and Romanian

Education
Ph.D. – Bioengineering – 2007, Université Lyon I, France
M.Sc. – Physico-chemistry and Quality of Bio products - 1998, INA-PG, Paris, France
M.S.E. – Chemistry - 1993, Polytechnic Institute, Iasi, Romania

Details
2007 to 2008…...Post doctoral training in cellular electrophysiology

→ Research project: “Effect of the mutated S140 and V141 mutated KCNQ1 residues in the gating function of the IKs potassium channel”

→ Laboratory: Ion channels laboratory – Nora Eccles Harrison Cardiovascular Research and Training Institute – University of UTAH, Salt Lake City (USA)

→ Supervisor: Pr. Michael Sanguinetti

2002 to 2007….. PhD student in Bioengineering, Université Lyon I

→ Research project: “Genotype phenotype characterization of patients with a risk of ventricular arrhythmia and their identification by quantitative electrocardiological methods”

→ Laboratory: INSERM ERM107, Laboratoire MTIC, Hôpital Louis Pradel

→ Supervisors: Pr. Philippe Chevalier, Dr. Jocelyne Fayn, Pr. Paul Rubel

1998 ………….. Master in Phisicochemistry and Quality of Bio products

→ Research project: Study of the photosensitive incidence of the Maillard advanced products on the human crystalline lens AA; Effect of the UVA factor on the genesis of the protein aggregates in the human crystalline lens”

→ Laboratory: INRA, Analytical Chemistry Laboratory, Agronomic National Institute, Paris

→ Supervisor: Dr. Inès Birluez Aragon

1993 …………. Master Engineer Degree in Chemistry

→ Research project: “Comparison tests between actual and XVI century vegetal tannins, by analytical chemistry methods”

→ Laboratory: Analytical Chemistry Laboratory, Polytechnic Institute of Iasi, Romania
Experience
Clinical trials:
Since March 2008 → Coordinator CRA at Cardiologic Hospital of Lyon – Non Invasive Cardiology Department: clinical trials phase III and IV

2002 to 2006 → Clinical Research Associate at Cardiologic Hospital of Lyon – Biochemistry Department: Clinical trial (phase III) on “Genetic diagnosis of Congenital Long QT Syndrome”

Rhythmology Department: clinical trials phase III and IV

Non Invasive Cardiology Department: clinical trials phase III

2000 → Medical representative in dermatology – Setting up and monitoring of a clinical trial (phase IV) on “Tazaroten ® in the treatment of psoriasis”
Scientific cooperation:
2002 → Participated in a research project on: “Negative modulation of the Hsp27 protein expression in protons radio-resistant cells SQ20B and characterization of the molecular mechanism”

→ Laboratory: INSERM , Laboratoire de radiobiologie, Hôpital Lyon Sud

→ Supervisors: Pr. Claire Rodriguez, Pr. Robert Rousson

1998 → Participated in a research project on: “Polymers-proteins interactions on the

coagulation stream – Study of the initiation role of different heparins at the level of coagulation contact phase”
Administrative Experience:

1998. 
      → Quality Engineer at Hutchison Telecom France – Implementation of a documentation management system for Information Technology (IT) software
      

1993 to 1995 → Business Engineer at SC “CREATOR” SRL – Quality control for imported-exported products and contracts management
Commissions:

2005. 
      → Member of the local organizing committee for the IEEE Computers in Cardiology conference, 25-28 September 2005, Lyon, France
      

2004 → Participated in the evaluation phase of the European EPI-MEDICS project
Diverse:
Since 2003 → Judicial Expert nearby Grenoble Judicial Court as interpreter in Romanian

1992 to 1993 → Technical editor at “Bursa de Est” Magazine (Romania)

Information technology
→ MS Office (Word, Excel, Power Point, Access), Internet, Windows, SQL

→ Statistics: SPSS (12.0), BMDP New System (2.0), Answer Tree, Clampfit (9.0), Origin (7.0)

Spoken Languages

• 
  Romanian (native)
  
• 
  French (fluent)
  
• 
  English (good level)
  

References

• 
  Michael Sanguinetti, PhD, Professor of Physiology – University of Utah – Department of Physiology – Nora Eccles Harrison Cardiovascular Research and Training Institute; 95 South 2000 East, Salt lake City, UTAH 84108, USA. Tel : [phone], Fax : [phone], Email : [e-mail]
  
• 
  Jocelyne FAYN, PhD, INSERM ERM107, Hôpital Cardiologique Louis Pradel, 28, Avenue du Doyen Lépine 69677 BRON Cedex, France. Tel : [phone] , Fax : [phone], Email : [e-mail]
  
• 
  Paul RUBEL, PhD, Director of INSERM ERM107, Professor in Informatics at INSA de Lyon. INSERM ERM107, Hôpital Cardiologique Louis Pradel, 28, Avenue du Doyen Lépine 69677 BRON Cedex, France. Tel : [phone] , Fax : [phone], Email : Paul. [e-mail]
  

Publications

Journals

1. 
   Restier-Miron L, Fayn J, Millat G, Li B, Rodriguez-Lafrase C, Chevalier P, Rubel P. Identification of the potential LQT2 carriers by using the CAVIAR method. IEEE Computers in Cardiology 2004;31:789-92.
   
2. 
   Rubel P, Fayn J, Arod S, Atoui H, Télisson D, Simon-Chautemps L, Forlini MC, Placide J, Restier L, Li B, Chevalier P. Intelligence ambiante et systèmes pervasifs en Télémédecine. Exemples d'application en télécardiologie. La Revue des SAMU 2004;26:521-6.
   
3. 
   Christe G, Restier L, Chahine M, et al. Effects of a persistent sodium current through mutated hNav1.5 sodium channels on intracellular ionic homeostasis in a ventricular cell model. IEEE Computers in Cardiology 2005;32:997-1000.
   
4. 
   Chevalier P, Tabib A, Meyronnet D, Chalabreysse L, Restier L, Ludman V, Alies A, Adeleine P, Thivolet F, Burri H, Loire R, Francois L, Fanton L. Quantitative study of nerves of the human left atrium. Heart Rhythm. 2005;2(5):518-22.
   
5. 
   Rubel P, Fayn J, Nollo G, Assanelli D, Li B, Restier L, Adami S, Arod S, Atoui H, Ohlsson M, Simon-Chautemps L, Telisson D, Malossi C, Ziliani GL, Galassi A, Edenbrandt L, Chevalier P. Toward personal eHealth in cardiology. Results from the EPI-MEDICS telemedicine project. J Electrocardiol. 2005;38(4 Suppl):100-6.
   
6. 
   Chevalier P, Cottraux J, Mollard E, Sai N, Brun S, Burri H, Restier L, Adeleine P. Prevention of implantable defibrillator shocks by cognitive behavioral therapy: a pilot trial. Am Heart J. 2006;151(1):191.
   

7. 
   Millat G, Chevalier P, Restier-Miron L, Da Costa A, Bouvagnet P, Kugener B, Fayol L, Gonzalez Armengod C, Oddou B, Chanavat V, Froidefond E, Perraudin R, Rousson R, Rodriguez-Lafrasse C. Spectrum of pathogenic mutations and associated polymorphisms in a cohort of 44 unrelated patients with long QT syndrome. Clin Genet. 2006;70(3):214-27.
   
8. 
   Restier-Miron L, Fayn J, Millat G, Denjoy I, Rodriguez-Lafrasse C, Rubel P, Chevalier P. Spatiotemporal electrocardiographic characterization of ventricular depolarization and repolarization abnormalities in long QT syndrome. J Electrocardiol. 2007;40(4):368-74.
   
9. 
   Restier L, Cheng L, Sanguinetti MC. Atrial fibrillation-associated mutations in the S1 domain of KCNQ1 slow deactivation of IKs channels. J Physiology. 2008 (submitted)
   

Proceedings, Seminars, Conferences

10. 
    Restier L, Fayn J, Rubel P, et al. Abnormal 3D ECG in long-QT syndrome patients: A new phenotypic marker for HERG mutations. 77th Scientific Meeting of the American-Heart-Association, Nov 07-10, 2004. Circulation 2004;110 (17 Suppl.): 2891.
    
11. 
    Restier L, Fayn J, Rodriguez C, et al. 3D analysis of a standard ECG shows depolarization abnormalities LQT2, but not in LQT1 carriers. 78th Annual Scientific Session of the American-Heart-Association, Nov 13-16, 2005. Circulation 2005;112(17 Suppl.):3286.
    
12. 
    Restier L, Li B, Denjoy I, Millat G, Rodriguez C, Fayn J, Rubel P, Chevalier P. Anomalies éléctriques spatio-temporelles dans le syndrome du QT long congénital – Nouveaux marqueurs dans le diagnostic précoce des porteurs d’une mutation HERG. Journées Nationales de la Société Française de Cardiologie. 2-4 Juin 2005, Lyon, France.
    
13. 
    Li B, Restier L, Rubel P, Fayn J, Arod S, Placide J, Chevalier P. Utilisation d’un appareil ECG personnel portable en ambulatoire chez le patient cardiaque: Etude préliminaire Lyonnaise. Journées Nationales de la Société Française de Cardiologie. 2-4 Juin 2005, Lyon, France.
    
14. 
    Restier L, Fayn J, Millat G, Rodriguez C, Denjoy I, Rubel P, Chevalier  P. Spatiotemporal caracterisation of long QT syndromes using CAVIAR. 6th Staff Studies Symposium. 28-30 Septembre 2005, Lyon, France.
    
15. 
    Fayn J, Restier L, Li B, Chevalier P, Rubel P. Assessment of the benefit of pervasive self-care ECG recording in arrhythmogenic patients. World Congress of Cardiology, Sep 02-06, 2006. Eur. Heart J. 2006;27 Suppl. 1:140.
    
16. 
    Restier-Miron L, Fayn J, Probst V, et al. Arrhythmogenic right ventricular dysplasia and Brugada syndrome: 3D ECG similarities and differences.79th Annual Scientific Session of the American-Heart-Association, Nov 12-15, 2006. Circulation 2006;114(18 Suppl.): 469-470.
    

LRM Academic Resume