This deliverable summarised the main objectives of the WP proposing an approach of building the framework for INTEGRATE VPH predictive modelling development. The clinically relevant questions that have been defined so far with concern the development of scenario-driven prediction models that given a set of characteristics will be able to predict in an accurate way the response to a drug and/or the response/resistance to a specific preoperative drug. This deliverable highlighted the main techniques that will be exploited giving emphasis to multi-kernel techniques that will allow the integration of multi-level heterogeneous data and subsequently the development of predictive models beyond the sate-of-the-art.
