Educational qualification

CURRICULUM VITAE

Rizwan Hasan Khan

Interdisciplinary Biotechnology Unit

Aligarh Muslim University

Aligarh 202 002 India

[e-mail] [e-mail]

[e-mail]

EDUCATIONAL QUALIFICATION

Ph.D. From Interdisciplinary Biotechnology Unit, A.M.U., Aligarh, India in 1996.

Thesis: "Purification and some properties of Pigeon Pea lectin."

M.Phil. From Interdisciplinary Biotechnology Unit, A.M. U., Aligarh, India in 1992.

Dissertation: “Isolation and characterization of rhizobial polysaccharide receptor."

M.Sc. From Interdisciplinary Biotechnology Unit, A.M.U., Aligarh, India in 1989.

B. Sc From Lucknow University, Lucknow, India in 1985.
POSITION HELD

1. 
   Present Position: Professor (27/4/2011 - till date)
   
2. 
   Associate Professor (April 2008-26April 2011)
   
3. 
   Reader, Interdisciplinary Biotechnology Unit, AMU, Aligarh, India from April 2005 –March 2008.
   
4. 
   Lecturer, Interdisciplinary Biotechnology Unit, AMU, Aligarh, India from October 1997-March 2005.
   
5. 
   Project Associate, worked on "Cloning, Expression and Purification of Ovine Growth Hormone" DBT sponsored project at National Institute of lmmunology, New Delhi, India from October 1996-October 1997.
   
6. 
   Lecturer, Interdisciplinary Biotechnology Unit, AMU, Aligarh, India from March 1993- September 1995.
   
7. 
   Visiting fellow:
   

1. 
   University of Michigan, Ann Arbor, U.S.A. (2000)
   
2. 
   University College of London, U.K. (2011)
   
3. 
   Visiting Professor, King Saud University, Riyadh, Saudi Arabia (19^th -23^rd May 2013).
   

ACADEMIC HONOURS/AWARDS/SCHOLARSHIPS

1. Junior Research Fellowship awarded from the Council of Scientific and Industrial Research, Govt. of India (1989-1991)

2. Senior Research Fellowship awarded from the Council of Scientific and Industrial Research, Govt. of India (1992-1993)

3. Qualified Graduate Aptitude Test in Engineering with a percentile of 92.48 (1989)

4. Best Poster award at 38th Annual Meeting of the Association of Microbiologists of India & Conference on Microbes in Sustainable Development held at Jamia Mi1lia Islamia Campus, New Delhi, 12-14 December, 1997 for the Poster entitled" Recombinant ovine growth hormone expression in high cell density fed-batch culture of E.coli".

5. Awarded BOYSCAST Fellowship for the year 2000, to work at University of Michigan, Ann Arbor, USA with Prof. I. J. Goldstein.

6. 
   Awarded INSA Visiting Fellowship 2001, to work at A.I.I.M.S, New Delhi with Prof. T.P. Singh.
   
7. 
   Awarded SERC Visiting Fellowship 2002 to work at I.I.Sc, Bangalore with Prof. A. Surolia.
   
8. 
   Awarded the Young Muslim Scientist Award (YMSA)-2002 by the Muslim Association for the Advancement of Science (MAAS), Aligarh.
   
9. 
   Best Poster award at National Syposium on Biophysics “Biophysics in Medicine and Biology” under the aegis of Indian Biophysical society, organized by ‘The Department of Biophysics’; Punjab University Chandigarh, November 15-17, 2007.
   

10 Awarded Commonwealth Fellowship for the year 2011, to work at University College of London, U.K.

11. Received “Best Researcher Award of the University” for the year 2015.

PAPER Reviewing experience

Reviewed papers submitted for publication to the following journals:

1. 
   Biochemistry (USA)
   
2. 
   Archives of Biochemistry and Biophysics
   
3. 
   Biochimica et Biophysica Acta
   
4. 
   The International Journal of Biochemistry & Cell Biology
   
5. 
   Comparative Biochemistry and Physiology
   
6. 
   Indian Journal of Clinical Biochemistry
   
7. 
   International Journal of Biological Macromolecules
   

In the panel of Editorial Board members:

1. 
   PLoS One (Academic Editor)
   
2. 
   Current Protein Peptide Science
   
3. 
   Journal of Biophysics
   
4. 
   Protein Peptide Letters
   
5. 
   Journal of Biomedicine & Biotechnology
   
6. 
   Journal of Biophysical Chemistry
   
7. 
   Journal of Protein & Proteomics
   
8. 
   Journal of Proteomics & Bioinformatics
   

Contribution of chapter to a book OR BOOK:

1. 
   A few studies done in solvent mediated unfolding of serum albumins: Folding intermediates, Aggregation and unfolding. (http://www.amazon.com/studies-solvent-mediated-unfolding-albumins/dp/3659127051).
   
2. 
   Recombinant polypeptides in Therapeutics in “Specialty Polymers” by I.K. International Publishing house Pvt. Ltd. (2007). Chapter contribution. (http://www.abebooks.co.uk/book-search/isbn/8188237655/page-1/).
   
3. 
   Chapter contributed to e- series of book titled “Advances in Protein and Peptide Sciences, Vol.1, 2013, 833-867”. (http://ebooks.benthamscience.com/book/9781608054879/chapter/117205/)
   
4. 
   Chapter “Protein folding and aggregation: a revisit of basic concept” contributed in e-book entitled Proteostasis and Chaperone Surveillance by Singh RL, Springer India 2015 (http://www.springer.com/in/book/9788132224662)
   

PROFESSIONAL SOCIETY MEMBERSHIP

1. Indian Biophysical Society, India (Life member)

2. Society of Biological Chemists, India

RESEARCH EXPRIENCE

1. Pre-doctoral

The work of my Ph.D. thesis deals with the isolation, purification and physico-chemical study on pigeon pea lectin. The lectin was purified by salt precipitation followed by affinity chromatography. The purity and molecular weight of the lectin was determined by gel filtration and SDS-PAGE. The UV-CD spectra of lectin suggest that the predominant secondary structure is β- pleated sheet. The saccharide binding specificity was investigated by hapten-inhibition of hemagglutination or glycoconjugate precipitation. The presence of various ionizable groups was determined by hydrogen-ion titration. Numbers of phenoxyl groups present in lectin were also determined by spectrophotometric method. The effect of metal ions on carbohydrate binding activity of lectin was investigated in detail.

2. Post-doctoral

This involves the scale up of biological processes for the production of recombinant proteins from E.coli, process optimization, downstream operation for protein purification. Also, optimization of solubilization process for recombinant proteins was made in order to refold them to their native structure.

3. PRESENT WORK

Currently involved in the following aspects of Structural Biology:

1. 
   Protein stability, Structure and Function
   
2. 
   Amyloid induction and inhibition
   
3. 
   Characterization of folding intermediates of proteins at low pH.
   
4. 
   Interaction of lectin with rhizobia.
   
5. 
   Purification and physico-chemical characterization of lectin from different sources.
   
6. 
   Protein aggregation and misfolding