Electronic Posters: Cardiovascular

Thursday 13:30-15:30 Computer 28

13:30 3564. MRI of Longitudinal Myocardial Strain Using Multislice Cine DENSE with Through-Plane Displacement Encoding

Xiao Chen¹, Xiaodong Zhong, ^1,2, Frederick H. Epstein<sup>3

1</sup>Biomedical Engineering, University of Virginia, Charlottesville, VA, United States; ²MR R&D Collaboration, Siemens Healthcare, Atlanta, GA, United States; ³Radiology, University of Virginia, Charlottesville, VA, United States

The purpose of the present study was to develop a cine DENSE pulse sequence for quantitative imaging of longitudinal motion, where two adjacent short-axis slices are encoded for through-plane (longitudinal) displacement and are simultaneously acquired. Displacement trajectories measured from the two slices are used to calculate longitudinal strain. By acquiring both slices within a single breathhold, a fixed and consistent distance between the slices is maintained, which enables the accurate calculation of longitudinal strain from the measured longitudinal displacement fields. The sequence and theory were evaluated and demonstrated in normal volunteers.

14:00 3565. Feasibility of CINE Myocardial T₂^* Mapping Using Susceptibility Weighted Gradient-Echo Imaging at 7.0 T

Fabian Hezel¹, Tobias Frauenrath¹, Wolfgang Renz², Jeanette Schulz-Menger^1,3, Thoralf Niendorf<sup>1,3

1</sup>Berlin Ultrahigh Field Facility, Max-Delbrueck Center for Molecular Medicine, Berlin, Germany; ²Siemens Healthcare, Erlangen, Germany; ³Experimental and Clinical Research Center (ECRC), Charité Campus Buch, Humboldt-University, Berlin, Germany

This study is designed to demonstrate the promise of susceptibility weighted 2D CINE FLASH and T2* Mapping of the heart at 7T.

14:30 3566. Longitudinal Functional and Structural Characterization of Inducible Heart Specific SOD2 Knock-Out Mice by Cardiac MRI

Thomas Kaulisch¹, Heiko G. Niessen¹, David Kind¹, Michael Neumaier¹, Julia Tillmanns¹, Lothar Kussmaul², Simon Melov³, Detlef Stiller<sup>1

1</sup>In-Vivo Imaging Unit, Dept. of Drug Discovery Support, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, BW, Germany; ²Dept. of CNS Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, BW, Germany; ³Buck Institute for Age Research, Novato, CA, United States

Oxidative stress induced by reactive oxygen species (ROS) plays an important role in heart diseases. Because fatty acid oxidation is carried out in the mitochondria, their dysfunction will have a severe impact on cardiac function. Because ROS are usually reduced by SOD2, a new mouse model (Fsod2H) with inducible knock-down of SOD2 gene was generated. In-vivo imaging was performed from week 32 to 57 of animal age. A significant reduction of heart contractibility and an increase in heart volume were measured for tgSOD2 mice. Overall, MRI allows for longitudinal quantitative assessment of functional and structural changes in the mouse heart.

15:00 3567. Quantitative Assessment of Left Ventricular Function Using Cardiac Phase-Contrast and Cine Magnetic Resonance Imaging Comparison with Pressure-Volume Loops Analysis: In Vivo Validation on a Swine Model

Hung-Yu Lin¹, Fei Wang², Waiel Almoustadi³, Bo Xiang², Trevor Lee³, Rakesh Arora³, Scott B. King², Boguslaw Tomanek², Darren Freed³, Ganghong Tian<sup>2

1</sup>Institute for Biodiagnostics, National Research Council of Canada, Winnipeg, Manitoba, Canada; ²Institute for Biodiagnostics, National Research Coincil of Canada; ³Saint Boniface General Hospital, Winnipeg, Manitoba, Canada

Noninvasive PC-MRI and cine MRI have been recognized as a valuable and accurate technique to evaluate hemodynamics and heart function. Previous clinical studies suggest that evaluation of the passive relaxation properties serves as a useful indicator of quantitative contractility and function without the influence of relative ventricular load. To our knowledge, the correlation of LV function obtained from noninvasive PC-MRI, cine MRI and invasive P-V loops relation has not been investigated and reported. The aim of the present study was to determine the validity of PC-MRI, cine MRI in the assessment of LV function comparing with dynamic P-V loops analysis.