Electronic Posters: Cardiovascular

Thursday 13:30-15:30 Computer 38

13:30 3724. Myocardial Infarction Segmentation by GMM Clustering Method with Free-Breathing 3D Navigator-Gated DE-MRI

Yonggang Lu^1,2, Thanh D. Nguyen³, Noel C. F. Codella³, Dorinna D. Mendoza⁴, Jonathan Weinsaft⁴, Bruce B. Lerman⁵, Yi Wang<sup>3

1</sup>Wiscom Intelligent System Co.,Ltd., Nanjing, Jiangsu, China; ²Department of Radiology , Weill Medical College of Cornell University, New York, NY, United States; ³Department of Radiology, Weill Medical College of Cornell University, New York, NY, United States; ⁴Department of Medicine, Division of Cardiology, Weill Medical College of Cornell University, New York, NY, United States; ⁵Department of Medicine, Weill Medical College of Cornell University, New York, NY, United States

A GMM clustering method with a free-breathing 3D Navigator-Gated DE-MRI was proposed for myocardial infarction segmentation in this study. Compared to commonly used methods, the novel method has a superior performance of more accuracy and operator-independence in assessing myocardial infarction as demonstrated by preliminary experiments with in vivo human data.

14:00 3725. Interstrain Comparisons of Murine Global Cardiac Mechanical Function Using MRI

Christakis Constantinides¹, Nikolas Aristokleous¹, Konstantinos Fokianos², Jeff Brandenburg³, Dimitrios Perperidis<sup>1

1</sup>Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus; ²Mathematics and Statistics, University of Cyprus, Nicosia, Cyprus; ³Radiology, Duke University Medical Center, Durham, NC, United States

Quantitative characterization of ventricular function has become important for the assessment of cardiac performance in heart disease. As the manipulation of the mammalian genome becomes routine, it is now possible to generate animal models to study cardiovascular function and dysfunction. Critical to successful phenotypic screening of mouse models of the cardiovascular system using MRI are highly efficient four-dimensional (4D) acquisition protocols, and reduction of the computational image processing complexity for accurate quantification. The -goal of this study is the efficient, quantitative assessment of interstrain cardiac performance in C57BL/6J and DBA/2J mouse hearts under anesthesia, using MRI.

14:30 3726. Feasibility of Myocardial T1 Mapping from Cine-IR Images by Image Warping

Vincenzo Positano¹, Matteo Milanesi¹, Piergiorgio Masci¹, Thomas KIng Foo², J C. Hardy², Luca Marinelli², Andrea Barison, ^1,3, Daniele De Marchi¹, Massimo Lombardi¹, Luigi Landini<sup>4

1</sup>MRI Laboratory, "G- Monasterio" Foundation and Istitute of Clinical Physiology, Pisa, Italy; ²Global Research Center, General Electric, Niskayuna, NY, United States; ³Scuola Sant'Anna, Pisa, Italy; ⁴Department of Information Engineering, University of Pisa, Italy

Myocardial T1 mapping from Cine-IR images is feasible by warping the myocardium signal in each frame on a standardized model, evaluating the pixel-by-pixel T1 distribution on the model, and finally warping back the resulting T1 map on each frame.

15:00 3727. Myocardial Motion Estimation from Cardiac Cine-MRI with a Phase-Based Optical Flow Method

Marie Xavier¹, Alain Lalande¹, Paul Michael Walker¹, Jean-Christophe Eicher², Jean-Eric Wolf, ^1,2, François Brunotte¹, Louis Legrand<sup>1

1</sup>LE2I, University of Burgundy, Dijon, France; ²Department of Cardiology, University Hospital, Dijon, France

Generally, the evaluation of myocardial motion from cine-MRI sequences requires a visual evaluation of the regional contractile function and depends on the experience of the reader. To automatically detect local myocardial wall motion abnormalities from cine-MRI sequence, an optical flow technique based on phase information was used. First, the robustness of the technique with regards to Rician noise and to brightness variations was evaluated on synthetic images. Then, in the context of cardiac cine-MRI, a segmental decomposition of the myocardium allowed us to study the mean velocity along the cardiac cycle and gave similar values to those obtained by echocardiography.