Electronic Posters: Cardiovascular

Myocardial Function: Experimental & Human Studies II

Hall B Monday 14:00-16:00 Computer 30

14:00 3584. Left Ventricular Dyssynchrony: Effect of Age, Ejection Fraction, Mass and Cardiovascular Disease

Daniela Foell¹, Bernd Jung², Elfriede Schilli³, Felix Staehle², Christoph Bode³, Michael Markl<sup>2

1</sup>Cardiology , University Hospital , Freiburg, Germany; ²Diagnostic Radiology, Medical Physics, University Hospital, Freiburg, Germany; ³Cardiology, University Hospital, Freiburg, Germany

MR tissue phase mapping (TPM) was employed to study the relationships of age, heart rate, left ventricular (LV) ejection fraction (EF), and LV-mass with myocardial dyssynchrony among 95 subjects with normal and pathological cardiac function. Compared to age-matched controls significantly (p<0.01) enhanced myocardial dyssynchrony was found in patients with hypertensive heart disease (n=18) and dilated cardiomyopathy (n=12) with most prominent changes if left bundle branch block was present (n=7). Multiple regressions revealed significant relationships of dyssynchrony with LV-EF, LV-mass, and age. As sensitive markers for LV dysfunction, both radial systolic and long-axis diastolic dyssynchrony were superior to systolic long-axis dyssynchrony.

14:30 3585. MR Assessment of Left Ventricular Strain After Repair of Tetralogy of Fallot

Karen G. Ordovas¹, Marcus Carlsson², Elyse Foster³, Alison Meadows⁴, Alastair Martin⁴, Michael Hope⁴, Loi Do⁴, Charles Higgins⁴, Maythem Saeed<sup>4

1</sup>Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States; ²Clinical Physiology, Lund University, Lund, Sweden; ³Cariology, UCSF, San Francisco, CA, United States; ⁴Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States

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15:00 3586. Assessment of Cardiac Function and Infarct Size Following Myocardial Infarction in Mitochondrial Cyclophilin-D Knockout Mice

Anthony N. Price¹, Shiang Y. Lim², Johannes Riegler¹, Derek M. Yellon², Derek J. Hausenloy², Mark F. Lythgoe<sup>1

1</sup>Centre for Advanced Biomedical Imaging, Department of Medicine and UCL Institute of Child Health, University College London, London, United Kingdom; ²The Hatter Cardiovascular Institute, University College London Hospital and Medical School, London, United Kingdom

Coronary heart disease (CHD) remains one of the leading causes of morbidity and mortality worldwide. A principal symptom of CHD is myocardial infarction (MI), which leads to a complex process of ventricular remodelling and ultimately heart failure. Novel treatment strategies which are capable of limiting myocardial infarct size, preventing LV remodelling and preserving cardiac function are needed to improve clinical outcomes. The inhibition of mitochondrial cyclophilin-D (CypD), has been reported to reduce infarct size in pre-clinical studies. Here we present the first MRI assessment of cardiac function and infarct size in CypD^-/- mice at 48 hours following myocardial infarction.

15:30 3587. Healthy Ageing in Females Is Associated with Altered Cardiac Energetics Related to Both Systolic and Diastolic Function: A Comparison of MRS, Cardiac Tagging and Cine Imaging

Kieren Grant Hollingsworth¹, David Emerys Jones², Julia Lindsay Newton³, Bernard D. Keavney⁴, Guy A. MacGowan⁵, Andrew Mark Blamire<sup>1

1</sup>Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom; ²Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom; ³Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom; ⁴Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom; ⁵Cardiology, Freeman Hospital, Newcastle upon Tyne, Tyne and Wear, United Kingdom

It is unclear whether there are relationships between cardiac energetics and age-related decline of systolic and diastolic function. 25 healthy females with no previous history of cardiac disease were recruited, covering the age range 18-65. Phosphorus spectroscopy, cine imaging and cardiac tagging were carried out. PCr/ATP ratio was found to decline significantly with age, most strongly in the over 60 group. E/A ratio, peak circumferential strain and torsion recoil rates declined with age, with the first two significantly associated with the PCr/ATP ratio. This suggests that both systolic and diastolic function are associated with energetic changes in ageing.