Electronic Posters: Cardiovascular

Thursday 13:30-15:30 Computer 34

13:30 3660. Monitoring Iron Chelation Effect in Hearts of Thalassaemia Patients with Improved Sensitivity Using Reduced Transverse Relaxation Rate (RR2)

Jerry S. Cheung^1,2, Wing-Yan Au³, Shau-Yin Ha⁴, Jens H. Jensen⁵, Dan Kim⁵, Abby Y. Ding^1,2, Iris Y. Zhou^1,2, Hua Guo⁵, Truman R. Brown⁶, Winnie C.W. Chu⁷, Darshana D. Rasalkar⁷, Pek-Lan Khong⁸, Gary M. Brittenham⁹, Ed X. Wu<sup>1,2

1</sup>Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Pokfulam, Hong Kong SAR, China; ²Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam, Hong Kong SAR, China; ³Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China; ⁴Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China; ⁵Department of Radiology, New York University School of Medicine, New York, United States; ⁶Department of Radiology, Columbia University, New York, United States; ⁷Department of Diagnostic Radiology and Organ Imaging, The Chinese University of Hong Kong, Hong Kong SAR, China; ⁸Department of Diagnostic Radiology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China; ⁹Department of Pediatrics, Columbia University, New York, United States

Accurate MRI characterization of myocardial iron is needed to improve the diagnosis and management of thalassaemia patients with transfusional iron overload. This study aimed to demonstrate that a new transverse relaxation index, the reduced R2 (RR2) that is estimated from non-monoexponential multi-echo CPMG signal decay and sensitive to ferritin iron, could detect the myocardial iron changes immediately following 1-week iron chelation suspension in thalassaemia patients at 3T.

14:00 3661. Quantitative T1 and T2 Measurements of Tissue Characteristics in Myocardial Infarction – Pilot Results at 3T

Stefan K. Piechnik¹, Erica Dall'Armellina¹, Vanessa M. Ferreira¹, Lowri E. Cochlin², Jürgen E. Schneider¹, Stefan Neubauer¹, Matthew D. Robson<sup>1

1</sup>Cardiovascular Medicine, OCMR, Oxford University , Oxford, Oxfordshire, United Kingdom; ²Dept of Physiology, Anatomy and Genetics, Oxford University, Oxford, Oxfordshire, United Kingdom

We present preliminary results of T1- and T2-mapping at 3T in sub-acute myocardial infarction to demonstrate the ability of quantitative CMR in delineating myocardial tissue changes following an ischemic event.

14:30 3662. Free-Breathing, Single Shot Fat-Water Separated Cardiac Imaging with Motion Corrected Averaging

Peter Kellman¹, Diego Hernando², Saurabh Shah³, Christophe Chefd'hotel⁴, Z-P Liang², Andrew E. Arai<sup>1

1</sup>National Institutes of Health, Bethesda, MD, United States; ²University of Illinois, Urbana, IL, United States; ³Siemens Medical Solutions, Chicago, IL, United States; ⁴Siemens Corporate Research, Princeton, NJ, United States

A rapid fat/water separated imaging protocol has been developed for free-breathing cardiac applications for cases where patients have difficulty breath-holding or have significant arrhythmias. The method combines a 2 echo GRE acquisition and parallel imaging, and may be used with repeated measurements and motion corrected averaging to further improve image quality. The method has been applied to both pre-contrast and late enhancement imaging.

15:00 3663. Navigator Guided High-Resolution Single-Shot Black-Blood TSE Images Using ZOOM and Sensitivity Encoding (SENSE) on a 32 Channel RF System

Raja Muthupillai¹, Amol Pednekar², Claudio Arena¹, Scott D. Flamm¹, Benjamin Y. Cheong<sup>1

1</sup>Diagnostic and Interventional Radiology, St. Luke's Episcopal Hospital, Houston, TX, United States; ²Philips Healthcare

We demonstrate that by using a judicious combination of reduced FOV imaging (ZOOM), Sensitivity Encoding (SENSE), and half-scan, it is feasible to obtain diagnostic quality single-shot (SSH) dual-inversion recovery prepared black blood(BB) turbo spin echo(TSE) images with minimal image blurring during normal respiration. The results of the study, performed on 8 asymptomatic subjects, show that SSH T2-TSE images acquired using ZOOM+SENSE under navigator triggering, yield images with quality that is comparable to conventional multi-shot BB-TSE images acquired over a 14-16 heart beat breathhold.