Electronic Posters: Cardiovascular

Wednesday 13:30-15:30 Computer 28

13:30 3560. Interventricular Synchrony in Chronic Thrombo-Embolic Pulmonary Hypertension Recovers After Endarterectomy

Gert Jan Mauritz¹, J. Tim Marcus¹, Jochem Bosboom¹, Anton Vonk Noordegraaf<sup>1

1</sup>VU University Medical Center, Amsterdam, Netherlands

The aim of this study is to assess whether the Left-Right (L-R) mechanical synchrony in Chronic Thrombo-Embolic Pulmonary Hypertension recovers after pulmonary endarterectomy. Nine patients were included, and underwent MRI myocardial tagging at baseline before, and 1 year after endarterectomy. The L-R delay in peak myocardial circumferential shortening decreased from 95 ± 61 ms at baseline, to 2 ± 47 ms after endarterectomy (p < 0.05). Cardiac output increased from 3.7 ± 0.9 lit/min, to 4.8 ± 0.6 lit/min (p<0.01). The L-R resynchronization and functional RV recovery are in line with reverse RV remodeling after endarterectomy.

14:00 3561. Effect of Physiological Variation of Heart Rate on Quantitative Cardiac T2 Mapping

Marion de Roquefeuil^1,2, Anne Menini^1,2, Jean-Marie Escanyé³, Pierre-Yves Marie³, Jacques Felblinger<sup>1,2

1</sup>U947, INSERM, Vandoeuvre-lès-Nancy, France, France; ²IADI, Nancy-Université, Nancy, France, France; ³Department of Nuclear Medicine, CHU, Nancy, France

Heart Rate (HR) variation is around 30 % during healthy subject breath-holds necessary for cardiac MR acquisition. As MR system is synchronized with R peaks, image contrast depends on HR evolution. Especially, cardiac T2 mapping used in heart transplantations and pathologies follow up is biased by HR variation. We propose a method to compensate this systematic error and to improve diagnostic quality: a RR-adjusted corrective factor applied on SE signal in k-space.

14:30 3562. Cardiac Torsion and Strain in Fatigued Primary Biliary Cirrhosis Patients Investigated by 3T Cardiac Tagging Show Evidence of Accelerated Ageing Processes

Kieren Grant Hollingsworth¹, David Emerys Jones², Roy Taylor¹, Guy A. MacGowan³, Julia Lindsay Newton⁴, Andrew Mark Blamire<sup>1

1</sup>Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom; ²Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom; ³Cardiology, Freeman Hospital, Newcastle upon Tyne, Tyne and Wear, United Kingdom; ⁴Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom

Primary biliary cirrhosis (PBC) is an autoimmune liver disease affecting females from middle age. After our previous observation that PBC patients have impaired cardiac energetics compared to matched controls while preserving normal cardiac morphology, the same cohort was studied with cardiac tagging at 3T to assess cardiac torsion and strain. Those PBC patients with severe fatigue were found to have significant increases in myocardial peak torsion and reduction in peak strain which have previously been seen to be typical of healthy ageing. This suggests that cardiac changes in fatigued PBC patients may reflect an accelerated ageing process.

15:00 3563. Magnetic Resonance Imaging (Mri) Characterization of the Functional and Morphological Changes in Heart and Lung After Myocardial Infarction in Mice

Hasan Alsaid¹, Weike Bao¹, Mary V. Rambo¹, Gregory A. Logan¹, David J. Figueroa¹, Stephen C. Lenhard¹, Charles J. Kotzer¹, Mark E. Burgert¹, Beat M. Jucker<sup>1

1</sup>GlaxoSmithKline, 709 Swedeland Rd, King of Prussia, PA, 19406, United States

In this study, MRI was used for the first time to non-invasively and serially assess cardiac dysfunction and lung congestion in a chronic heart failure model, myocardial infarction (MI), in mice. Cardiac and lung MRI were performed at baseline then every three days up to 13 days post-MI. MRI results revealed that MI induced significant pulmonary congestion/edema as detected by increased MRI signal intensity and was associated with increased lung volume and decreased cardiac function. Additionally, significant correlations were observed between lung signal intensity, lung volume, ejection fraction, left ventricular mass and lung wet weight/body weight ratio.