Electronic Posters: Cardiovascular

Molecular Imaging in Cardiovascular Disease & Cancer

Hall B Monday 14:00-16:00 Computer 40

14:00 3741. A DNA-Targeted Gadolinium Chelate to Selectively Enhance Acutely Injured Myocardium

Shuning Huang¹, Hushan Yuan², Howard Chen³, Guangping Dai¹, Lee Josephson², David E. Sosnovik<sup>1,3

1</sup>Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States; ²Center for Translation Nuclear and Molecular Imaging, Massachusetts General Hospital, Charlestown, MA, United States; ³Center for Molecular Imaging Research, Massachusetts General Hospital, Charlestown, MA, United States

Delayed enhancement of gadolinium cannot discriminate acute and chronic injury since both produce similar changes in the pharmacokinetics of small gadolinium chelates, such as Gd-DTPA. Here, we demonstrated that the acute myocardial infarction can be distinguished from both subacute and chronic myocardial injury by utilizing a DNA-targeted gadolinium chelate (Gd-TO).

14:30 3742. 21 Tesla Rat Heart Magnetic Resonance Microimaging by Paramagnetic Anti-Troponin Bound Polyethylene Based Iron-Oxide Nanoparticles and Image Processing

Rakesh Sharma^1,2, Kiran Shetty, <sup>3

1</sup>FAMU-FSU College of Engineering,, CIMAR, National High Magnetic Field Laboratory, Tallahassee, FL, United States; ²Center of Nanomagnetics and Biotechnology, Florida State University & TCC, Tallahassee, FL, United States; ³NHMFL, Florida State University, Tallahassee, FL, United States

The 21T MR microimaging by using first time troponin nanoparticles enhances the visualization of cardiac muscles fiber and offers technical advancement in future. Diffusion weighting offers the fiber tracking and functional analysis. Image processing offers heart probabilistic atlas and maps.

15:00 3743. Optimization of Ultrashort TE Imaging for Angiography and Molecular Imaging of Iron-Oxide Nanoparticles

Ravi Teja Seethamraju¹, Sonia Nielles-Vallespin², Shuning Huang³, David E. Sosnovik<sup>3,4

1</sup>MR R and D, Siemens Medical Solutions, USA Inc., Charlestown, MA, United States; ²Cardiovascular MR, Royal Brompton Hospital, London, United Kingdom; ³Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States; ⁴Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States

Iron oxide based USPIOs inherently exhibit T1 shortening apart from their traditional T2 properties. This property is best utilized at ultrashort echo times. We demonstrate how a single UTE sequence can produce both angiographic images as well as molecular quantitation.

15:30 3744. PEGylated Nano-Peaches: A Novel Multimodality Platform for Imaging of Atherosclerosis

Andrei Maiseyeu¹, Georgeta Mihai¹, Marcus A. Badgeley¹, Orlando P. Simonetti¹, Jeffrey A. Deiuliis¹, Chandan K. Sen¹, Sampath Parthasarathy¹, Sanjay Rajagopalan<sup>1

1</sup>Heart and Lung Research Institute, The Ohio State University, Columbus, OH, United States

Novel "peach-like" nanoparticle (NP) contrast agents were manufactured, characterized and tested. In-vitro studies showed preferential uptake of NPs by macrophages while in-vivo studies in ApoE-deficient mice revealed protracted signal enhancement of atherosclerotic plaque. Proper design and ease of fabrication of these nanostructures makes them very versatile as either T1 or T2 MRI contrast agents. These NPs loaded with fluorescein or near-infrared emitting quantum dots represent attractive tools for multimodality imaging of atherosclerosis.