Electronic Posters: Molecular

4228. Ultrasmall Particle of Iron Oxide – RGD Peptidomimetic Conjugate as Novel MRI Contrast Agent

Sophie Laurent¹, Carmen Burtéa¹, Vincent Rerat², Jacqueline Marchand-Brynaert², Luce Vander Elst¹, Robert N. Muller<sup>1

1</sup>Université de Mons, Mons, Belgium; ²Université catholique de Louvain, Louvain-la-Neuve , Belgium

In this work, we describe the grafting of a home-made RGD peptidomimetic on ultrasmall particles of iron oxide (USPIO) coated with 3,3’-bis(phosphonate)propionic acid, and the determination of the grafting rates by X-ray photoelectron spectroscopy (XPS). The USPIO-g-Mimic have been characterized by photon correlation spectroscopy (PCS); their magnetometric and relaxometric profiles, and their capacity to target leukemic cells were also analyzed.

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