Electronic Posters: Molecular

Thursday 13:30-15:30 Computer 70

13:30 4226. Positive Contrast and Quantitative Imaging of Magnetic Nanoparticles and Cancer Cells with Biomarker Targeted RGD-Nanoparticle Conjugates Using T₁ Weighted Ultrashort Echo Time (UTE) Imaging

Xiaodong Zhong¹, Longjiang Zhang^2,3, Liya Wang², Hongwei Chen², Julie Yeh², Andrew Wang⁴, Hui Mao<sup>2

1</sup>MR R&D Collaborations, Siemens Healthcare, Atlanta, GA, United States; ²Department of Radiology, Center for Systems Imaging, Emory University, Atlanta, GA, United States; ³Department of Radiology, Jinling Hospital, Nanjing University College of Clinical Medicine, Nanjing, Jiangsu, China; ⁴Ocean NanoTech, LLC, Springdale, AR, United States

Negative contrast of magnetic nanoparticles (MNPs) on conventional T₂ weighted images may suffer from poor contrast to noise ratio (CNR). This study demonstrated that positive T₁ contrast from MNPs can be obtained using ultrashort echo time (UTE) imaging, resulting higher CNR than that of conventional T₂ weighted imaging. Signal intensity of MNPs in UTE images has a linear correlation with core size and concentration of MNPs used in this study. Cell imaging with the UTE method also demonstrated potential applications of UTE imaging of biomarker targeted MNPs with contrast enhancement associated to the binding of cell targeted MNP.

14:00