Course Title:RESEARCH METHODOLOGY AND PHARMACOLOGICAL SCREENING
Course Level: Post-graduate Course Code: Course Objectives The purpose of this curriculum is to provide knowledge on writing research proposal/thesis/manuscripts. In addition, students will be informed of animal handling and the guidelines to follow. They will also be informed of basic techniques involved in screening of drugs for various activities using animal models
Pre-requisites: Basic Understating of Drug Discovery Process Student Learning Outcomes:
Understanding of basics concepts of drug discovery process.
Concept of preclinical and clinical drug development with humane use of animals / subjects.
Students will get in-depth knowledge of writing research proposal/thesis/manuscripts.
In addition, students will be informed of animal handling and the guidelines to follow.
They will also be informed of basic techniques involved in screening of drugs for various activities using animal models.
Methods of Literature Survey
Research-Meaning, purpose, Types, (Educational, Clinical, Experimental, Historical descriptive, Basic applied and Patent oriented Research) objective of Research.
Literature survey-How to collect literature - Use of Library, books (using appendices) and journals – Medlines - Internet, chemical & biological abstracts, Patent Search, and reprints of articles as a source for Literature survey.
General Animal handling and animal care guidelines (CPCSEA). Common laboratory animals, breeding methods, anesthesia & euthanasia of experimental animals.
Experimental pharmacology Tools/techniques
Techniques used in experimental pharmacology (Bioassay, in-vitro and in-vivo techniques), their advantages and disadvantages. Alternatives to animal use in pharmacology lab . Acute, sub-acute and chronic toxicity studies, Determination of LD50 , LD99 and ED 50 of a drug.