Format for course curriculum

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Annexure ‘CD – 01’



FORMAT FOR COURSE CURRICULUM

L

T

P/S

SW/FW

TOTAL CREDIT UNITS

3

1

4

-

6



Course Title: RESEARCH METHODOLOGY AND PHARMACOLOGICAL SCREENING

Credit Units:

Course Level: Post-graduate Course Code:
Course Objectives The purpose of this curriculum is to provide knowledge on writing research proposal/thesis/manuscripts. In addition, students will be informed of animal handling and the guidelines to follow. They will also be informed of basic techniques involved in screening of drugs for various activities using animal models
Pre-requisites: Basic Understating of Drug Discovery Process
Student Learning Outcomes:

  1. Understanding of basics concepts of drug discovery process.

  2. Concept of preclinical and clinical drug development with humane use of animals / subjects.

  3. Students will get in-depth knowledge of

    1. Animal handling and usage guidelines

    2. Experimental pharmacology Tools/techniques

    3. Animal models and screening methodology

    4. Project proposal and paper writing

    5. Methods of Literature Survey




  1. Students will get in-depth knowledge of writing research proposal/thesis/manuscripts.

  2. In addition, students will be informed of animal handling and the guidelines to follow.

  3. They will also be informed of basic techniques involved in screening of drugs for various activities using animal models.


Course Contents/Syllabus:




Weightage (%)

Module I

20

Methods of Literature Survey

Research-Meaning, purpose, Types, (Educational, Clinical, Experimental, Historical descriptive, Basic applied and Patent oriented Research) objective of Research.

Literature survey-How to collect literature - Use of Library, books (using appendices) and journals – Medlines - Internet, chemical & biological abstracts, Patent Search, and reprints of articles as a source for Literature survey.



Module II

20

Project proposal and paper writing

Essentials of medical writing. The Research Report Paper writing/ thesis writing. What is Impact factor, Citation index. Different parts of the Research paper/Thesis/Proposal

Title, Abstract, Key Words, Methodology, Results, Discussion, Conclusion, Acknowledgements, References, Errata, Importance of Spell check for entire project, Uses of footnotes


Module III

20

Animal handling and usage guidelines

General Animal handling and animal care guidelines (CPCSEA). Common laboratory animals, breeding methods, anesthesia & euthanasia of experimental animals.




Module IV

20

Experimental pharmacology Tools/techniques

Techniques used in experimental pharmacology (Bioassay, in-vitro and in-vivo techniques), their advantages and disadvantages. Alternatives to animal use in pharmacology lab . Acute, sub-acute and chronic toxicity studies, Determination of LD50 , LD99 and ED 50 of a drug.




Module V

20

Animal models and screening methodology

Drug screening methods involved in the evaluation of Antidiabetics, Antieplileptics, Antihypertensives, Antiinflammatory, Analgesics and Anticancer drugs.




Pedagogy for Course Delivery: Power point presentations and Whiteboard based class learning

Lab/ Practicals details, if applicable:
List of Experiments:
1. Screening of Antidiabetic agents.

2. Screening of Antiepileptic and Anticonvulsant drugs.

3. Screening of Antihypertensive agents.

4. Screening of Anti-inflammatory agents.

5. Screening of Analgesics drugs (Opioids/Non-opioids)

6. Screening of Anticancer agents.



7. Toxicity studies as per ICMR guidelines (Acute, sub-acute and chronic toxicity studies)

Assessment/ Examination Scheme:



Theory L/T (%)

Lab/Practical/Studio (%)

End Term Examination

50/17

33


100

Theory Assessment (L&T):

Continuous Assessment/Internal Assessment

End Term Examination

Components (Drop down)














Weightage (%)

10

10

5

5

70

Lab/ Practical/ Studio Assessment:





Continuous Assessment/Internal Assessment

End Term Examination

Components (Drop down













PR

V

Weightage (%)

5

15

5

5

40

30




Text Reading and References:


  • CPCSEA, FDA and INSA guidelines

  • Ghosh, MN, Fundamentals of Experimental Pharmacology, Scientific Book Agency, Calcutta

  • W L M Perry. Pharmacological experiments on isolated preparations. Edinburgh [u.a.] : E. & S. Livingstone

  • S K Gupta. Drug Screening Methods. Jaypee Brothers medical Publishers.

  • S S Agrawal & M Paridhavi Swamy. Herbal Drug Technology, Orient Longman Publishers.

  • The UFAW Handbook on the care and management of laboratory and other Research animals by UFAW. 8th ed.,2010, Wiley-Blackwell

  • S K Gupta. Drug discovery and Clinical Research. Jaypee Publications


Additional Reading:

Any other Study Material:

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