| 4.2.3 Important considerations in biological monitoring
(a) In choosing a test to meet the above objectives, it is important to have an understanding of the relationship between environmental exposure and the concentration of an HCS in biological samples. This includes an understanding of the principles of absorption, biotransformation, distribution and excretion of an HCS.
(b) In addition, there should be analytical methods available of sufficient sensitivity and specificity to detect concentrations of the substance in urine, blood or exhaled air in the range likely to be encountered in industry.
(c) The HCSs listed in Table 3 of Annexure 1 are those for which the above criteria have a reasonable chance of being met.
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