Israel state records י"ג בשבט התשס"ח January 20, 2008

עיבוד אבקה באמצעות נוזלים גזיים דחוסים	POWDER PROCESSING WITH PRESSURIZED GASEOUS FLUIDS
[54]
	10.10.2002					[22]
	US	[33]	10.10.2001	[32]	60/328301	[31]
Int. Cl.8 A61K 009/00, 009/14, 009/16, 009/28, 009/48, 009/51						[51]
			BOEHRINGER INGELHEIM PHARMACEUTICALS, INC., U.S.A.			[71]
	WO/2003/030871					[87]
ריינהולד כהן ושותפיו, רחוב אחד העם 21 , ת.ד. 4060, תל אביב			REINHOLD COHN AND PARTNERS, 21 AHAD HA'AM ST., P.O.B. 4060, TEL AVIV 61040			[74]

[57] A method for particle precipitation and retention in carrier material comprising the steps of:

(a)(1) dissolving a solid or semi-solid material in a pressurized gaseous fluid, thereby forming a solution comprising a gaseous fluid solvent and a dissolved solute of solid or semi-solid material or

(a)(2) dissolving solid or semi-solid material in a liquid solvent, thereby forming a liquid solution comprising a liquid solvent and a dissolved solute of solid or semi-solid material;

(b)(1) precipitating particles of the solid or semi-solid material out of the gaseous fluid solution produced in step (a)(1) by introducing the solution into a region of lower pressure or into a region containing an inert gas or

(b)(2) precipitating particles of the solid or semi-solid material out of the liquid solution produced in step (a)(2) by introducing the solution into either:

(1) a region containing a pressurized gaseous fluid in which said liquid solvent is substantially soluble but said solid or semi-solid material is substantially insoluble, or (2) a region into which said pressurized gaseous fluid is subsequently introduced to cause the solubilization of the liquid solvent into the pressurized gaseous fluid and the precipitation of the particle of the solid or semi-solid material;

(c) directing the introduced solution and resulting precipitated particles produced in step (b) (1) or (b)(2) onto or into a mixed bed of carrier material; and

(d) retaining and dispersing at least some of the precipitated particles in the carrier material to produce a blend of the solid or semi-solid material particles and carrier material, a granulation of the solid or semi-solid material particles with carrier material, carrier material partially or fully coated with the solid or semi-solid material particles, or mixtures thereof; and wherein the carrier material in the mixed bed is maintained in the mixed state at least during steps (c) and (d).

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160957			[21][11]