Israel state records י"ג בשבט התשס"ח January 20, 2008

תרכובות והרכבים להעברת גורמים פעילים ושיטה להכנת ההרכבים	COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS AND METHOD OF PREPARING SUCH COMPOSITIONS
[54]
	18.03.1997					[22]
	US	[33]	29.03.1996	[32]	60/017902	[31]
Int. Cl.8 C07C 229/00						[51]
	DIVISION FROM 126318					[62]
			EMISPHERE TECHNOLOGIES, INC., U.S.A.			[71]
	WO/1997/036480					[87]
סנפורד ט. קולב ושות', שער הגיא 4, מרמורק , ת.ד. 2273, רחובות			SANFORD T.COLB & CO., P.O.B. 2273, REHOVOT 76122			[74]

[57] A compound selected from

the group consisting of:

or salts thereof.

__________

143558			[21][11]
שיטה להגברת הפעילות הביולוגית של ליגנדים			METHOD OF ENHANCING THE BIOLOGICAL ACTIVITY OF LIGANDS			[54]
	23.12.1999					[22]
	US	[33]	23.12.1998	[32]	60/113387	[31]
Int. Cl.8 A61K 038/17, A61P 025/28, C07K 014/515, 014/52, 014/705, C12N 001/21, 005/10, 015/12, 015/62, C12P 021/02						[51]
			REGENERON PHARMACEUTICALS, INC., U.S.A.			[71]
	WO/2000/037642					[87]
לוצאטו את לוצאטו, גן תעשייה, עומר , ת.ד. 5352, באר שבע			LUZZATTO & LUZZATTO, INDUSTRIAL PARK, OMER, P.O.B. 5352, BEER-SHEVA 84152			[74]

[57] A nucleic acid encoding a fusion polypeptide, wherein the fusion polypeptide comprises a first subunit comprising at least one copy of a fibrinogen domain of angiopoeitin-1 or angiopoeitin-2, the first subunit being fused to the N-terminal end of a multimerizing component, said multimerizing component being fused at its C-terminal end to a second subunit comprising at least one copy of the same fibrinogen domain of angiopoeitin-1 or a angiopoeitin-2.

__________

144107			[21][11]
מלח אשלגן של ( S ) – אומפראזול			POTASSIUM SALT OF (S)-OMEPRAZOLE			[54]
	18.01.2000					[22]
	SE	[33]	28.01.1999	[32]	9900274-3	[31]
Int. Cl.8 A61K 031/4184, A61P 001/00, C07D 401/00						[51]
			ASTRAZENECA AB, SWEDEN			[71]
			MATHS NILSSON			[72]
	WO/2000/044744					[87]
לוצאטו את לוצאטו, גן תעשייה, עומר , ת.ד. 5352, באר שבע			LUZZATTO & LUZZATTO, INDUSTRIAL PARK, OMER, P.O.B. 5352, BEER-SHEVA 84152			[74]

[57] The postassium salt of (S)-omeprazole form B, characterized in being a hydrate form.

__________

144126			[21][11]
שיטה לשינוי ספציפיות של תרכובות המעכבים ציקלואוקסיגנאז			METHOD OF ALTERING THE SPECIFICITY OF CYCLOOXYGENASE-INHIBITING COMPOUNDS			[54]
	16.12.1999					[22]
	US	[33]	07.01.1999	[32]	60/115090	[31]
Int. Cl.8 A61K 031/40, 045/00, 045/06, A61P 029/00						[51]
			VANDERBILT UNIVERSITY, U.S.A.			[71]
	WO/2000/040087					[87]
וולף, ברגמן וגולר, רחוב קרן היסוד 19ב' , ת.ד. 1352, ירושלים			WOLFF, BREGMAN AND GOLLER, 19B KEREN HAYESOD ST., P.O.B. 1352, JERUSALEM 91013			[74]

[57] A method of altering specificity of a cyclooxygenase-inhibiting compound, the method comprising the steps of:

(a) providing a compound having cyclooxygenase inhibitory activity, the compound having a carboxylic acid moiety or pharmaceutically acceptable salt thereof associated with the cyclooxygenase inhibitory activity but lacking specificity for cyclooxygenase-2 inhibitory activity; and

(b) altering the specificity of the compound in step (a) from lacking specificity for cyclooxygenase-2 inhibitory activity to having specificity for cyclooxygenase-2 inhibitory activity by converting the compound having the carboxylic acid moiety or pharmaceutically acceptable salt thereof into a derivative having an ester moiety or a secondary amide moiety.

__________

144204		[21][11]
מכשיר לכוונון רב–מיתרים נגינות צבטניים		DEVICE FOR TUNING STRINGS OF MULTI-STRINGED MUSICAL INSTRUMENTS PLAYED BY PLUCKING	[54]
	09.07.2001		[22]
Int. Cl.8 G10D 003/14, 013/04			[51]
ולדימיר מילוב, בית-שמש		VLADIMIR MILOV	[71]
פרל כהן צדק לצר, מרכז גב-ים 1, רח' שנקר 5 , ת.ד. 12704, הרצליה		PEARL COHEN ZEDEK LATZER, 5 SHENKAR STREET, P.O.B. 12704 HERZLIYA 46733	[74]

[57] Device for tuning of stringed instruments played by plucking, containing: an oblong guide including means for its setting on the fingerboard in the direction perpendicular to the longitudinal axis of the fingerboard, said oblong guide being capable of moving along the fingerboard, said means for setting of the guide containing two carrier elements intended to be set on opposite sides of the fingerboard and leaning against the fingerboard surface, at that one of said carrier elements is capable of moving along the guide, a pinch unit clamping down any string to the fingerboard, said pinch unit capable of moving along the guide, said pinch unit having an eccentric shape and being capable of turning around the guide, a band to be connected with one of the carrier elements and being capable of connection with the second carrier element, said band ensuring the location of the device on the fingerboard and the leaning of the string against the fingerboard surface by the pinch unit.

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144710			[21][11]
הרכבים ביישומי הזלפה			COMPOSITIONS FOR PERFUSION APPLICATIONS			[54]
	24.01.2000					[22]
	US	[33]	03.02.1999	[32]	09/243921	[31]
Int. Cl.8 A61K 035/00						[51]
			BIOTIME, INC., U.S.A.			[71]
	WO/2000/045873					[87]
סנפורד ט. קולב ושות', שער הגיא 4, מרמורק , ת.ד. 2273, רחובות			SANFORD T.COLB & CO., P.O.B. 2273, REHOVOT 76122			[74]

[57] Use of a conventional biological buffer free non-naturally occurring plasma-like solution comprising:

(i) electrolytes,

(ii) an oncotic agent, and

(iii) and a dynamic buffering system

in the preparation of a medicament which is suitable for simultaneous or sequential administration with a fluid blood composition to treat hypovolemia.

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145051			[21][11]
תולדות 4 –חומצה סולפנית – פירידין – 2 [6 – מתוקסי – 5 – (2 – מתוקסי – פנוקסי) – 2 – פירידין – 4 – איל פירימידין – 4 – איל] אמידו השימוש בהן להכנת תרכובות רפואיות			PYRIDINE - 2 - SULFONIC ACID [6 - METHOXY - 5 - (2 - METHOXY - PHENOXY) - 2 - PYRIDIN - 4 - YL - PYRIMIDIN - 4 - YL] - AMIDE DERIVATIVES AND THEIR USE FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS			[54]
	28.02.2000					[22]
	EP	[33]	03.03.1999	[32]	99104306.8	[31]
Int. Cl.8 A61K 031/505, A61P 043/00, C07D 401/14						[51]
			F. HOFFMANN-LA ROCHE AG, SWITZERLAND			[71]
	WO/2000/052007					[87]
ריינהולד כהן ושותפיו, רחוב אחד העם 21 , ת.ד. 4060, תל אביב			REINHOLD COHN AND PARTNERS, 21 AHAD HA'AM ST., P.O.B. 4060, TEL AVIV 61040			[74]

[57] The compound 5-methyl-pyridine-2-sulfonic acid [6-methoxy-5-(2-methoxy-phenoxy)-2-pyridin-4-yl-pyrimidin-4-yl]-amide or a pharmaceutically acceptable salt thereof.

__________

145185			[21][11]