Israel state records י"ג בשבט התשס"ח January 20, 2008

בטא–ספוגנין–5 ונגזרות פסיודוספוגנין ושימושן בטיפול בשגעון	5-BETA-SAPOGENIN AND PSEUDOSAPOGENIN DERIVATIVES AND THEIR USE IN THE TREATMENT OF DEMENTIA
[54]
	29.09.2000					[22]
	GB	[33]	29.09.1999	[32]	9923076.5	[31]
Int. Cl.8 A61K 031/58, A61P 025/00, C07J 071/00						[51]
			PHYTOPHARM PLC, UNITED KINGDOM			[71]
			PAUL BARRACLOUGH, JIM HANSON, PHIL GUNNING, DARYL REES, ZONGQIN XIA, YAER HU			[72]
	WO/2001/023406					[87]
ד"ר מרק פרידמן בע"מ, מגדל משה אביב, ק.54 , רח ז'בוטינסקי 7, רמת- גן			DR. MARK FRIEDMAN LTD., MOSHE AVIV TOWER, 54TH FLOOR, 7 JABOTINSKY ST., RAMAT GAN 52520			[74]

[57] The use of compounds of the formula



and their pharmaceutically acceptable salts, wherein

in the formula (I):

R₁, R₂, R₄, R₅, R₆, R_7, R_8, R₁₀, are independently of each other, either H, OH, =O or OR where R = optionally substituted alkyl, optionally substituted acyl, optionally substituted carbamoyl, alkoxycarbonyl; R₃ is either H, -O or OR where R= optionally substituted alkyl, optionally substituted acyl, optionally substituted carbamoyl, alkoxycarbonyl;

R₉, R₁₂, R₁₁, R₁₃ can be either H, OH or OR where R = optionally substituted alkyl, optionally substituted acyl, optionally substituted carbamoyl, alkoxycarbonyl; R₁₄ = optionally substituted alkyl group; …… represents an optional double bond,

and wherein in the formula (II):

R_1, R₂, R₄, R₅, R₆, R₇, R₈, R₁₀, are, independently of each other, either H, OH, =O or OR where R= optionally substituted alkyl, optionally substituted acyl, optionally substituted carbamoyl, alkoxycarbonyl; R₃ is either H, -O or OR where R=optionally substituted alkyl, optionally substituted acyl, optionally substituted carbamoyl, alkoxycarbonyl;

R₉, R₁₂, R₁₁, R_13, can be either H, OH or OR where R = optionally substituted alkyl, optionally subsituted acyl, optionally substituted carbamoyl, alkoxycarbonyl; R₁₄ = optionally substituted alkyl group; R₁₅ = H, optionally substituted alkyl, optionally substituted acyl, or glucosyl; ……. represents an optional double bond; in the manufacture of a medicament for enhancing cognitive function or for treating cognitive dysfunction.

בקשות חלוקה מבקשה זו שטרם פורסמו.

180972,

The applications for division from this application have not yet been published

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148995			[21][11]