Israel state records י"ג בשבט התשס"ח January 20, 2008

ננוחלקיקים מסיסים במים של חומרים הידרופילים והידרופוביים פעילים	WATER SOLUBLE NANOPARTICLES OF HYDROPHILIC AND HYDROPHOBIC ACTIVE MATERIALS
[54]
	18.03.2004					[22]
	US	[33]	28.09.2001	[32]	09/966847	[31]
	US		26.09.2002		10/256023
Int. Cl.8 A61K 009/00, 009/51, 038/00, 045/00, 047/06						[51]
סולובסט בע"מ, נס-ציונה			SOLUBEST LTD.			[71]
	WO/2003/028700					[87]
פאולינה בן-עמי , בן עמי ושות', ת.ד. 94, רחובות			PAULINA BEN-AMI, BEN-AMI & ASSOCIATES, P.O.B. 94, REHOVOT 76100			[74]

[57] A hydrophilic dispersion comprising a water-insoluble or water soluble active compound and an amphiphilic polymer which wraps said active compound to form a water-soluble nano-sized molecular entity in which non-valent bonds are formed between said active compound and said amphiphilic polymer such that said bonds fixate said active compound within said polymer, in which nano-sized molecular entity the active compound is in the amorphous or partially crystalline state and wherein said amphiphilic polymer does not form rigid matrices or cross-linked polymers.

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161443			[21][11]
תהליך להכנת b14–הדרוקסי–בקאטין III 14,1––קרבונאט			PROCESS FOR THE PREPARATION OF 14BETA-HYDROXY-BACCATIN III -1,14-CARBONATE			[54]
	18.07.2002					[22]
	IT	[33]	19.10.2001	[32]	MI2001A002186	[31]
Int. Cl.8 C07D 305/00, 305/14, C07F 007/18						[51]
			INDENA S.P.A., ITALY			[71]
	WO/2003/035633					[87]
ריינהולד כהן ושותפיו, רחוב אחד העם 21 , ת.ד. 4060, תל אביב			REINHOLD COHN AND PARTNERS, 21 AHAD HA'AM ST., P.O.B. 4060, TEL AVIV 61040			[74]

[57] A process of the preparation 14β-hydroxy-1,14-carbonate-baccatin III, which comprises:

(a) treatment of 7-triethylsilyl-13-ketobaccatin III of the formula

with suitable bases and oxidizing agents, to give 7-triethylsilyl-13-keto-14-hydroxy-baccatin III:

(b) carbonation of the 1 and 14 hydroxyls to give 14.beta.-hydroxy-7-TES-13-keto-baccatin III-1,14-carbonate:

(c) reduction of the ketone at the 13-position and cleavage of the protective group in 7.

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161641			[21][11]
שיטה להקטנת קצב הפעפוע דרך פולימרים של חומרים בעלי שחרור איטי ותהליך להכנת התקני השקיה בטפטוף בעלי בקרה ארוכת טווח של גידול שורשים			METHOD OF REDUCING THE RATE OF DIFFUSION OF SLOW-RELEASE MATERIALS THROUGH POLYMERS AND PROCESS FOR MAKING DRIP IRRIGATION DEVICES WITH LONG-TERM CONTROL OF ROOT GROWTH			[54]
	01.11.2002					[22]
	US	[33]	06.11.2001	[32]	60/332952	[31]
Int. Cl.8 A01G 025/02, A01N 025/08						[51]
			RODNEY RUSKIN, U.S.A.			[71]
	WO/2003/039251					[87]
סנפורד ט. קולב ושות', שער הגיא 4, מרמורק , ת.ד. 2273, רחובות			SANFORD T.COLB & CO., P.O.B. 2273, REHOVOT 76122			[74]

[57] A slow-release product comprising a thermoplastic polymeric carrier, a slow-release active material which has been absorbed in a fine particulate material and dispersed in the thermoplastic polymeric carrier, and an intercalation material in fine particulate form dispersed in the carrier, the intercalation material comprising an

inert inorganic material with a layered structure, in which molecules of the slow-release active material released from the particulate absorbing material are contained within spaces between the layers of the dispersed particulate intercalation material, the dispersed particulate

intercalation material reducing the diffusion rate of the slow-release active material from the polymeric carrier.

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161887			[21][11]
מתקן שטיפה למיכל הדחה, במיוחד מיכל הדחה דו–כמותי			FLUSH DEVICE FOR A FLUSH TANK, IN PARTICULAR A DUAL-FLUSH TANK			[54]
	09.05.2004					[22]
	IT	[33]	09.05.2003	[32]	MI2003A000937	[31]
Int. Cl.8 E03B 011/00						[51]
			OLIVEIRA & IRMAO, S.A., PORTUGAL			[71]
לוצאטו את לוצאטו, גן תעשייה, עומר , ת.ד. 5352, באר שבע			LUZZATTO & LUZZATTO, INDUSTRIAL PARK, OMER, P.O.B. 5352, BEER-SHEVA 84152			[74]

[57] A flush device (1) for a flush tank, in particular a dual-flush tank, comprising a supporting structure (2), a valve (3) controlled by a slide (4) movable along an axis (A) inside the structure, and an actuating mechanism for activating the slide; the device being characterized in that the slide comprises inner and outer tubular members inserted one inside the other and connected to slide axially with respect to each other along said axis with a predetermined axial clearance.

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162384			[21][11]
תכשיר המעכב מטריקס–מטאלפרוטיאזות לטיפול במחלות גידוליות			COMPOSITION INHIBITING MATRIX-METALLOPROTEINASES FOR THE TREATMENT OF NEOPLASTIC DISEASES			[54]
	31.01.2002					[22]
	US	[33]	08.01.2002	[32]	041427	[31]
Int. Cl.8 A61K 031/198, 031/355, 031/375, 031/401, 031/525, 033/04, 038/05, 045/00, A61P 001/00, 009/00, 035/00, C07D 311/00, 311/28						[51]
			MATTHIAS RATH, THE NETHERLANDS			[71]
	WO/2003/057211					[87]
ריינהולד כהן ושותפיו, רחוב אחד העם 21 , ת.ד. 4060, תל אביב			REINHOLD COHN AND PARTNERS, 21 AHAD HA'AM ST., P.O.B. 4060, TEL AVIV 61040			[74]

[57] A pharmaceutical composition of biochemical substances for use in treating a neoplastic disease in a human, comprising: an anti-neoplastic disease therapeutically effective amount of a catechin compound selected from the group consisting of epicatechins, epigallocatechin, epicatechin gallate, and epigallocatechin gallate; an anti-oxidant; a proline; and a lysine, wherein the anti-oxidant, proline and lysine are in amounts sufficient to produce a synergistic effect in combination with the catechin compound that is therapeutically effective in inhibiting the activity of a matrix-metalloproteinase.

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162553			[21][11]
תהליך למיצוי שמן והתקן לכך			OIL EXTRACTION PROCESS AND APPARATUS THEREFOR			[54]
	17.01.2002					[22]
	EP	[33]	08.01.2002	[32]	02000484.2	[31]
Int. Cl.8 B01D 011/02						[51]
			EXTRACTIS HOLDINGS LIMITED, BRITISH VIRGIN ISLANDS			[71]
	WO/2003/057342					[87]
ריינהולד כהן ושותפיו, רחוב אחד העם 21 , ת.ד. 4060, תל אביב			REINHOLD COHN AND PARTNERS, 21 AHAD HA'AM ST., P.O.B. 4060, TEL AVIV 61040			[74]

[57] Process for solvent extraction of oils in oil bearing material, in an extraction chamber comprising the formation of a solvent mist with significant adiabatic cooling, whereby a pressure difference between an inlet and an outlet of the extraction chamber drives the mist through the oil bearing material, the outlet being subjected to the action of a vacuum.

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162777			[21][11]
שיטה לייצור תרכובות גריניאר			METHOD FOR THE PRODUCTION OF GRIGNARD COMPOUNDS			[54]
	28.12.2002					[22]
	DE	[33]	04.01.2002	[32]	10200149.9	[31]
Int. Cl.8 C07F 003/00, 003/02						[51]
			GRUNENTHAL GMBH, GERMANY			[71]
	WO/2003/055894					[87]
ריינהולד כהן ושותפיו, רחוב אחד העם 21 , ת.ד. 4060, תל אביב			REINHOLD COHN AND PARTNERS, 21 AHAD HA'AM ST., P.O.B. 4060, TEL AVIV 61040			[74]

[57] A process for the production of at least one Grignard compound, characterized in that magnesium is reacted in a suitable liquid reaction medium under a protective gas atmosphere with at least one halosubstituted organic compound with microwave irradiation.

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163466			[21][11]