Mechanical Ventilation & Weaning
Research studies
Ely EW, Baker AM, Dunagan DP, Burke HL, Smith AC, Kelly PT, et al. Effect on the duration of mechanical ventilation of identifying patients capable of breathing spontaneously. N Engl J Med 1996;335:1864-9 free full text
Kollef MH, Shapiro SD, Silver P, St John RE, Prentice D, Sauer S, et al. A randomized, controlled trial of protocol directed versus physician- directed weaning from mechanical ventilation. Crit Care Med 1997;25:567-74.
Cheung AM, Tansey CM, Tomlinson G, Diaz-Granados N, Matté A, Barr A, Mehta S, Mazer CD, Guest CB, Stewart TE, Al-Saidi F, Cooper AB, Cook D, Slutsky AS, Herridge MS. Two-year outcomes, health care use, and costs of survivors of acute respiratory distress syndrome. Am J Respir Crit Care Med. 2006 Sep 1;174(5):538-44
Girard TD,Kress JP, Fuchs BD: Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (a wakening and breathing controlled trial): a randomised controlled trial. Lancet 2008 371:126–134.
Jackson JC, Girard TD, Gordon SM et al. Long-term cognitive and psychological outcomes in the Awakening and Breathing controlled Trial. AJRCCM 2010; 182:183-191
Wunsch H, Linde-Zwirble WT, Angus DC, Hartman ME, Milbrandt EB, Kahn JM. The epidemiology of mechanical ventilation use in the United States. Crit Care Med. 2010 Oct;38(10):1947-53
Martin AD, Smith BK, Davenport PD, Harman E, Gonzalez-Rothi RJ, Baz M, Layon AJ, Banner MJ, Caruso LJ, Deoghare H, Huang TT, Gabrielli A. Inspiratory muscle strength training improves weaning outcome in failure to wean patients: a randomized trial. Critical Care 2011, 15:R84
Moisey LL, Mourtzakis M, Cotton BA, Premji T, Heyland DK, Wade CE, Bulger E, Kozar RA; Nutrition and Rehabilitation Investigators Consortium (NUTRIC). Skeletal muscle predicts ventilator-free days, ICU-free days, and mortality in elderly ICU patients. Crit Care. 2013 Sep 19;17(5):R206.
Files DC, Xiao K, Zhang T, Liu C, Qian J, Zhao W, Morris PE, Delbono O, Feng X. The posterior cricoarytenoid muscle is spared from MuRF1-mediated muscle atrophy in mice with acute lung injury. PLoS One. 2014 Jan 31;9(1):e87587.
Thomas P, Paratz J, Lipman J. Seated and semi-recumbent positioning of the ventilated intensive care patient - effect on gas exchange, respiratory mechanics and hemodynamics. Heart Lung. 2014 Mar-Apr;43(2):105-11.
Schmidt M, Pellegrino V, Combes A, Scheinkestel C, Cooper DJ, Hodgson C. Mechanical ventilation during extracorporeal membrane oxygenation. Crit Care. 2014 Jan 21;18(1):203
Needham DM, Yang T, Dinglas VD, Mendez-Tellez PA, Shanholtz C, Sevransky JE, Brower RG, Pronovost PJ, Colantuoni E. Timing of Low Tidal Volume Ventilation and ICU Mortality in ARDS: A Prospective Cohort Study. Am J Respir Crit Care Med. 2014 Dec 5
Files DC, Sanchez MA, Morris PE. A conceptual framework: the early and late phases of skeletal muscle dysfunction in the acute respiratory distress syndrome. Crit Care. 2015 Jul 2;19:266.
Chlan LL, Tracy MF, Guttormson J, Savik K. Peripheral Muscle Strength and Correlates of Muscle Weakness in Patients Receiving Mechanical Ventilation. Am J Crit Care. 2015 Nov;24(6):e91-8.
Klompas M, Li L, Szumita P, Kleinman K, Murphy MV; CDC Prevention Epicenters Program. Associations between different sedatives and ventilator-associated events, length-of-stay, and mortality in mechanically ventilated patients. Chest. 2015 Oct 22.
Jeon K, Jeong BH, Ko MG, Nam J, Yoo H, Chung CR, Suh GY. Impact of delirium on weaning from mechanical ventilation in medical patients. Respirology. 2015 Nov 4.
Sansone GR, Frengley JD, Vecchione JJ, Manogaram MG, Kaner RJ. Relationship of the Duration of Ventilator Support to Successful Weaning and Other Clinical Outcomes in 437 Prolonged Mechanical Ventilation Patients. J Intensive Care Med. 2016 Jan 20.
Chan KS, Aronson Friedman L, Dinglas VD, Hough CL, Morris PE, Mendez-Tellez PA, Jackson JC, Ely EW, Hopkins RO, Needham DM. Evaluating Physical Outcomes in Acute Respiratory Distress Syndrome Survivors: Validity, Responsiveness, and Minimal Important Difference of 4-Meter Gait Speed Test. Crit Care Med. 2016 May;44(5):859-68.
Zambon M, Beccaria P, Matsuno J, Gemma M, Frati E, Colombo S, Cabrini L, Landoni G, Zangrillo A. Mechanical Ventilation and Diaphragmatic Atrophy in Critically Ill Patients: An Ultrasound Study. Crit Care Med. 2016 Jul;44(7):1347-52.
Dres M, Dubé BP, Mayaux J, Delemazure J, Reuter D, Brochard L, Similowski T, Demoule A. Coexistence and Impact of Limb Muscle and Diaphragm Weakness at Time of Liberation From Mechanical Ventilation in Medical ICU Patients. Am J Respir Crit Care Med. 2016 Jun 16
Fernández Carmona A, Esquinas AM, Ubeda Iglesias A, Díaz Castellanos MÁ. Return of Voice for Tracheostomized Patients in ICU, Not Only Psychologic Advantages. Crit Care Med. 2017 Jan;45(1):e118-e119.
Dubé BP, Dres M, Mayaux J, Demiri S, Similowski T, Demoule A. Ultrasound evaluation of diaphragm function in mechanically ventilated patients: comparison to phrenic stimulation and prognostic implications. Thorax. 2017 Mar 30.
Thomas S, Sauter W, Starrost U, Pohl M, Mehrholz J. Time to decannulation and associated risk factors in the postacute rehabilitation of critically ill patients with intensive care unit-acquired weakness: a cohort study. Eur J Phys Rehabil Med. 2017 Aug;53(4):501-507.
Khemani RG, Sekayan T, Hotz J, Flink RC, Rafferty GF, Iyer N, Newth CJL. Risk Factors for Pediatric Extubation Failure: The Importance of Respiratory Muscle Strength. Crit Care Med. 2017 Aug;45(8):e798-e805.
Kutchak FM, Rieder MM, Victorino JA, Meneguzzi C, Poersch K, Forgiarini LA Junior, Bianchin MM. Simple motor tasks independently predict extubation failure in critically ill neurological patients. J Bras Pneumol. 2017 May-Jun;43(3):183-189.
Sandoval Moreno LM, Casas Quiroga IC, Wilches Luna EC, García AF. Efficacy of respiratory muscle training in weaning of mechanical ventilation in patients with mechanical ventilation for 48hours or more: A Randomized Controlled Clinical Trial. Med Intensiva. 2018 Feb 2. pii: S0210-5691(17)30341-8
Zeng H, Zhang Z, Gong Y, Chen M. Effect of chest physiotherapy in patients undergoing mechanical ventilation: a prospective randomized controlled trial].Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017 May;29(5):403-406
Reviews
Boles JM, Bion J, Connors A, Herridge M, Marsh B, Melote C, Pearl R, Silverman H, Stanchina M, Vieillard-Baron A, Welte T.: Weaning from mechanical ventilation. Eur Respir J 2007; 29: 1033–1056 free full text
Blackwood B, Alderdice F, Burns K, Cardwell C, Lavery G, O'Halloran P. Use of weaning protocols for reducing duration of mechanical ventilation in critically ill adult patients: Cochrane systematic review and meta-analysis. BMJ. 2011 Jan 13;342:c7237. doi: 10.1136/bmj.c7237. free full text
Hsieh SJ, Soto GJ, Hope AA, Ponea A, Gong MN. The Association between Acute Respiratory Distress Syndrome, Delirium, and In-Hospital Mortality in Intensive Care Unit Patients. Am J Respir Crit Care Med. 2015 Jan 1;191(1):71-8.
Rose L, Dainty KN, Jordan J, Blackwood B. Weaning from mechanical ventilation: a scoping review of qualitative studies. Am J Crit Care. 2014 Sep;23(5):e54-70.
Goligher EC, Douflé G, Fan E. Update in Mechanical Ventilation, Sedation, and Outcomes 2014. Am J Respir Crit Care Med. 2015 Jun 15;191(12):1367-73.
Wang L, Li X, Yang Z, Tang X, Yuan Q, Deng L, Sun X. Semi-recumbent position versus supine position for the prevention of ventilator-associated pneumonia in adults requiring mechanical ventilation. Cochrane Database Syst Rev. 2016 Jan 8;1:CD009946.
Zambon M, Greco M, Bocchino S, Cabrini L, Beccaria PF, Zangrillo A. Assessment of diaphragmatic dysfunction in the critically ill patient with ultrasound: a systematic review. Intensive Care Med. 2017 Jan;43(1):29-38.
Bui KL, Nyberg A, Maltais F, Saey D. Functional Tests in Chronic Obstructive Pulmonary Disease Part 1: Clinical Relevance and Links to the International Classification of Functioning, Disability and Health. Ann Am Thorac Soc. 2017 Feb 28
Bui KL, Nyberg A, Maltais F, Saey D. Functional Tests in Chronic Obstructive Pulmonary Disease Part 2: Measurement Properties. Ann Am Thorac Soc. 2017 Feb 28
Lu Z, Xu Q, Yuan Y, Zhang G, Guo F, Ge H. Diaphragmatic Dysfunction Is Characterized by Increased Duration of Mechanical Ventilation in Subjects With Prolonged Weaning. Respir Care. 2016 Oct;61(10):1316-22.
Bissett BM, Leditschke IA, Neeman T, Boots R, Paratz J. Inspiratory muscle training to enhance recovery from mechanical ventilation: a randomised trial. Thorax. 2016 Sep;71(9):812-9.
Latronico N, Minelli C, Eikermann M. Prediction of long-term outcome subtypes in ARDS: first steps towards personalised medicine in critical care. Thorax. 2017 Dec;72(12):1067-1068
Guidelines
Girard TD, Alhazzani W, Kress JP, Ouellette DR, Schmidt GA, Truwit JD, Burns SM, Epstein SK, Esteban A, Fan E, Ferrer M, Fraser GL, Gong MN, Hough CL, Mehta S, Nanchal R, Patel S, Pawlik AJ, Sessler CN, Strøm T, Schweickert W, Wilson KC, Morris PE. An Official American Thoracic Society/American College of Chest Physicians Clinical Practice Guideline: Liberation from Mechanical Ventilation in Critically Ill Adults. Rehabilitation Protocols, Ventilator Liberation Protocols, and Cuff Leak Tests. Am J Respir Crit Care Med. 2016 Oct 20.
Schmidt GA, Girard TD, Kress JP, Morris PE, Ouellette DR, Alhazzani W, Burns SM, Epstein SK, Esteban A, Fan E, Ferrer M, Fraser GL, Gong MN, Hough CL, Mehta S, Nanchal R, Patel S, Pawlik AJ, Sessler CN, Strøm T, Schweickert W, Wilson KC, Truwit JD. Official Executive Summary of an American Thoracic Society/American College of Chest Physicians Clinical Practice Guideline: Liberation from Mechanical Ventilation in Critically Ill Adults. Am J Respir Crit Care Med. 2016 Oct 20.
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