PHR403
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Pharmaceutical Technology IV
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Methods of particle size, reduction, grinding theories and sampling methods, the importance of particle size, determination methods of the particle size, the general properties of the powders, definition of preformulation importance and investigation of the organoleptic properties, excipients used in the tablet formulation, compression methods and applications, coating methods, gelatin capsules, stability, packing materials will be covered. Pharmaceutical Technology IV Lab. Boric acid tablet, aspirin tablet by direct compression, aspirin tablet by dry granulation, sodium phenobarbital tablet, aspirin-phenacetine-cafeine tablet, ascorbic acid tablet by dry granulation, acetaminophen tablet, ascorbic acid tablet by wet granulation, effervescent bath tablet, effervescent antiacid tablet, antiacid chewing tablet, sustained release aspirin tablet, tablet dissolution test, stability test of aspirin tablet, sugar coating and film coating of solid dosage forms and capsules, formulation designs will be performed. Core Textbook: Aulton, M. E., Taylor, K. M.G (2013). Aulton’s Pharmaceutics, 4th Edition, Churchill Livingstone, ISBN: 978-0-7020-4291-1 Supplementary Textbook: Sinko, P. (2010), Martin’s Physical Pharmacy and Pharmaceutical Sciences, 6th Edition, Wolters Kluwer/Lippincott Williams &Wilkins, ISBN 978-0-7817-9766-5 Rowe, C. R., Sheskey, P. J., Cook, W. G., Fenton, M. E. (2012). Handbook of Pharmaceutical Experiments, 7th Edition, Pharmaceutical Press, ISBN 978-085711027594
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PHR404
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Research Methods and Skills
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Research techniques, preparing research aim, presentation of research subjects, literature survey, evaluation of the literature will be presented. Core Textbook: Course package
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PHR405
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Pharmaceutical Toxicology
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History and principles of toxicology, toxicity tests, and absorption, distribution, and excretion and biotransformation of toxicants, classification mechanisms of toxic effects, mutagenesis and mutagenic agents, teratogenesis and teratogenic agents, carcinogenesis, carcinogenic agents, allergic reactions and immunotoxic effects, toxicological assessment of drug-drug interactions, hypersensitivity reactions of toxicants and idiosyncratic reactions, general approach to emergency management of poisoning will be covered. Pharmaceutical Toxicology Lab. Classification of poisons, qualitative and quantitative analysis methods of toxicant, isolation characterization and toxicity determinations of acidic and alkali drugs from biological samples, qualitative and quantitative analysis and assessment of their toxicities of non-steroidal anti-inflammatory drugs, cardiovascular drugs and drugs with low therapeutic index in biological samples will be performed. Also knowledge about poison information centers in Cyprus and Turkey will be given. Core Textbook: Hayes, A. W., Kruger, G. L. (2014), Hayes’ Principles and Methods of Toxicology, 6th Edition, CRC Press, ISBN-13: 978-1842145364 Supplementary Textbook: Lodola, A., Stadler, J. (2013), Pharmaceutical Toxicology in Practice: A Guide to Non-clinical Development, Wiley, ISBN-13: 978-0470371374
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PHR406
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Law, Ethics and Proffesionalism in Pharmacy Practice
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Turkish pharmacy laws and regulations, business ethics, good pharmacy practice, pharmaceutical industry, hospital, pharmacy and patient interactions will be covered. Also, pharmacy legislation, recent acts and regulations, definition of social pharmacy, definitions of health, consumer behavior in prescreption and nonprescription drug choice, patient-physician-pharmacist communication, drug noncompliance and consequences will be covered. Core Textbook: Kosergarten, D. C., Pissano, D. J., (2006). Pharmacy and Federal Drug Law, McGraw-hill Global Educational Holdings, ISBN: 0-07-146809-9
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PHR407
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Pharmacognosy III
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This course is continuation of pharmacognosy II. Core Textbook: Evans, W.C., (2009), Trease and Evans Pharmacognosy, 16th Edition, Saunders Elsevier, ISBN-13: 978-0702029332 Supplementary Textbook: Heinrich, M. Barnes, J., Gibbons, S., Williamson, E. M. (2012), Fundamentals of pharmacognosy and phytotherapy, 2nd Edition, Churchill Livingstone, ISBN-13: 978-0702033889
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PHR408
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Clinical Pharmacy and Pharmaceutical Care II
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Respiratory system disorders cardiovascular system disorders, rheumatological disorders, infectious diseases, neurological-psychological disorders, geriatric disorders and the role of pharmacist on these disorders will be covered. Core Textbook: Walker, R., Whittlesea, C. (2011), Clinical Pharmacy and Therapeutics, 5th Edition, Churchill Livingstone, ISBN-13: 978-0702042935 Supplementary Textbook: Alldredge, B. (2012), Koda-Kimble and Young's Applied Therapeutics: The Clinical Use of Drug, 10th Edition, LWW, ISBN-13: 978-1609137137
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PHR409
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Clinical Pharmacy and Pharmaceutical Care I
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Basics and principles of clinical pharmacy, drug usage in risk group patients and the role of pharmacist in, gastrointestinal system disorders and the role of pharmacist in hepatic disorders, renal disorders, endocrine system disorders will be covered. Core Textbook: Walker, R., Whittlesea, C. (2011), Clinical Pharmacy and Therapeutics, 5th Edition, Churchill Livingstone, ISBN-13: 978-0702042935
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PHR410
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Cosmetology
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Production technologies, properties of dermatolological products, cosmetics which contain active substances, types of products, stability and effectivity tests performed in cosmetic products at standard basis (GMP, GLP etc.) of international regulations, and adverse effects of cosmeceutics will be covered. Core Textbook: Course package Supplementary Textbook: Swarbrick, J. (2006) Encyclopedia of Pharmaceutical Technology, 3rd Edition, Informa Healthcare
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PHR411
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Pharmacy Management
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This course covers business management and accounting in addition to cost minimization, cost benefit, cost effectiveness and cost utility analysis of pharmaceutical products in medical field. Core Textbook: Rascati, K. L. (2013), Essentials of Pharmacoeconomics, 2nd Edition, Lippincott, Williams, & Wilkins. Philadelphia PA, ISBN-13: 978-1451175936 Dessella, S. P., Zgarrick, D. P. (2005), Pharmacy Management; Essentials for All Practice Settings, New York, NY, the Mcgraw-Hill companies, IP No. 0-07-141869-5
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PHR413
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Drug Information in Clinical Pharmacy Practice
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Information sources in drug information, clinical pharmacists' counselling and monitoring, oral contraceptive use, clinical use of nonsteroidal antiinflammatory drugs, drug information on anticoagulants, iron preparations, vitamins and minerals, determination and prevention of drug interactions by the clinical pharmacist, drug information in pregnancy and lactation, clinical use of antifungal drugs, pharmacist counselıng in oral hygiene and care, drug-induced nephrotoxicity, drug-induced hepatotoxicity, drug allergy are the main topics. Core Textbook: Malone, P. M., Kier, K. L., Stanovich, J. E. (2011), Drug information: a guide to Pharmacists, 4th Edition, IP no. 212 .175.119.58
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PHR415
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Patients Safety and Medical Error
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Introduction to rational drug use, role of pharmacists in rational drug use, drug dispensing, patient education, compliance, case studies are the main topics. Core Textbook: Warholak, T. E., Nau, D. P. (2010). Quality and Safety in Pharmacy Practice, McGraw-Hill Global Educational Holdings, ISBN: 978-0-07-160385-0
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PHR416
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Good Manufacturing Practice
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The main topics are quality assurance, quality control, organization and personelles, environment buildings and equipment manufacturing and process controls, packaging and labeleng controls, laboratory controls, storage and distribution, documentation, product saving and recalling, validation, and calibration Core Textbook: Course package
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PHR417
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Principles of Pharmaceutical Care
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Patient oriented concepts, pharmaceutical care processes like, pharmaceutical care in hyperlipidemia, in gastrointestinal disorders, in diabetes, in upper respiratory tract infections, in rational antibiotic use, problems in antibiotic use in pain and muscle spasms, in hypertension, and clinical pharmacist's role in herbal drug use, common skin disorders with clinical pharmacist's approach are the main topics. Core Textbook: Cipolle, R. J., Strand, L. M., Morley, P. C. (2012). Pharmaceutical Care Practice; the patient-centered Approach to medication management Services, 3rd Edition, McGraw-Hill Global Educational Holdings, ISBN: 978-0-07-175638-9
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PHR418
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Industrial Pharmacy
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Personel, building and enviroment, supplying units, equipment, quality assurance, GMP, quality control, documentation, validation are the main topics. Core Textbook: Hiremath, S. R. (2008).Textbook of industrial Pharmacy: Drug delivery Systems, Cosmetics and Herbal Drug Technology, Orient Longman, ISBN-13: 978-8125033097
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PHR419
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Nutrimental Plants
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The main topics are role and value of the plant sources in human nutrition, vegetable products pertaining nutrition. Also various nutrimental plants in alphabetical order according to their Latin names will be presented. Core Textbook: Course package
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PHR420
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Manufacturing and Quality Control of Active Pharmaceuticals
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Importance of R&D in API manufacture, importance of patent search in API manufacture, design and installation of an API, working safety, reactions utilized in organic synthesis, arrangement of reaction conditions, determination of the synthetic methods, separation and purification techniques after synthesis, sources, monitorisation and removal of impurities, quality controls applied to the APIs, methods for the production of aspirin, and acetaminophen, methods for the production of semi-synthetic penicillins, production methods of some newly developed APIs, pormation of salts of the APIs and salt selection, crystal polymorphism in APIs and hydrates will be covered. Core Textbook: Course package
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PHR421
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Pharmacovigilance and Drug Interactions
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The main topics are introduction to adverse drug reactions and spontaneous reporting, history and importance of pharmacovigilance, the safety of medicines in public health programmes, necessity of national pharmacovigilance systems, establishment of pharmacovigilance system in Turkey (TUFAM), national reporting, PSUR, international pharmacovigilance data sources.Drug interactions introduction to pharmacokinetics and pharmacodynamics (ADME), drug interactions with antibacterial agents, antiviral and antineoplastic agents, anticoagulants, antihypertansives, antiplatelet and other drugs used in cardiovascular diseases, drugs acting in CNS, With drugs acting in endocrine system, drugs used to treat gastrointestinal disorders, drug interactions with muscle relaxants and antitussive drugs will be covered in the second part of the course. Core Textbook: Course package
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PHR422
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Protein Production by Recombinant Dna Technology
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Recombinant DNA technology production flow chart, cell bank and general information about the preparation techniques, expression systems, fermentation techniques, fermentors and bioreactors, up and downstream processes, separation and purification techniques for expressed proteins and production related problems will be covered. Core Textbook: Zhu, J. (2013), Protein Production by Recombinant DNA Technology textbook, Smithers Rapra Technology, ISBN:978-1847359766
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PHR424
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Cell Culture Techniques
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Introduction of cell culture, cell culture laboratory layout and equipment used in cell culture types and origins, cell bank systems, cell bank system applications, cell freezing and storage methods, cell bank system applications, cell viability and toxicity tests, tissue engineering are the main topics Core Textbook: Mather, J. P., Roberts, P. E. (2013). Introduction to Cell and Tissue Culture: Theory and Technique (Introductory Cell and Molecular Biology Techniques), Springer, ISBN-13: 978-0306458590
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PHR500
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Training IV
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Industry Training: Formulation designing studies, quality control and quality assurance studies of raw materials and products, manufacturing studies of different dosage forms, the studies of sales and marketing units, studies of approval file preparation for licensed and generic products, studies concerned with GMP/GLP will be performed in the pharmaceutical industry.
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PHR501
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Graduation Project I
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The student will prepare a project on specific topic under the supervision of an academic advisor will gain skills in writing a project report
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PHR502
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Graduation Project II
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The student will continue on the same project specific topic under the supervision of an academic advisor will gain skills in writing a project report with the data obtained and be able to present the project as a poster or oral presentation in a scientific meeting.
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PHR503
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Oxidation and Antioxidation
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Free radicals, generation mechanims of free radicals, free radical-induced tissue and organ injury, the role of free radicals in physiological functions, free radical-induced diseases, the role of free radicals in aging, free radicals and cancer, antioxidant systems and exercise, endogenous antioxidants, exogenous antioxidants, experimental methods for oxidative tissue injury methods for antioxidants will be covered. Core Textbook: Course package
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PHR504
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Training V
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Industry Training: Formulation designing studies, quality control and quality assurance studies of raw materials and products, manufacturing studies of different dosage forms, the studies of sales and marketing units, studies of approval file preparation for licensed and generic products, studies concerned with GMP/GLP will be performed in the pharmaceutical industry. Drug Analysis and Control Laboratories Training: Analysis of quality control API and of pharmaceutical product (method, materials and equipment, application, evaluation of data) will be performed. Parenteral Solution Laboratory Training: Organisation and management, working system, methods for the production of parenteral solutions and flow chart, quality control of raw materials and finished product are the main topics. State Organizations Training: Working systems, knowledge on the programmes used in this center will be covered.
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PHR505
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Perfume and Perfume's Chemistry
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Definition of perfume, history of perfume, series of perfume, types of perfume, notes of perfume, chemical structure of perfume, perfume ingredients, aroma chemicals, fragrant molecules, making perfume, application of perfume (food, cosmetics and pharmaceutical industry) are the main topics. Core Textbook: Pybus, D., Sell, C. (1999). The chemistry of fragrances, Royal Society of Chemistry (Great Britain), ISBN: 085404528; 9780854045280
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PHR509
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Patient Education and Monitoring
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Patient education and it's importance for clinical pharmacist, communication and patient counseling techniques, therapeutic drug monitoring, narrow therapeutic index drugs in monitoring and patient education, role of patient education in rational antibiotic use, patient counseling for antibiotics of different dosage forms, adherence issues and patient education in elderly patients, patient education in diabetes, patient counseling session for antidiabetic drugs, for different inhaler dosage forms, dosage forms with special usage instructions and patient education, patient education for OTC Drugs, patient education for antihypertansive drugs and general evaluation will be covered. Core Textbook: Navanno, R. P. (2008). Managed Care Pharmacy Practice, 2nd Edition, Bartlett Learning, ISBN-10; 0763732400
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PHR511
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Drug Design
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Historical background of drug design and discovery, drug-receptor interactions and bond types involved in these interactions, the role of water/lipid solubility in binding, distribution and metabolism of drugs, importance of stereochemistry in drug action, conformational flexibility, rigid analogues, importance of structure-activity relationships for new drug design and the role of acidity-basicity in drug effect, approaches used for the definition of lead compounds, design based on target macromolecules, endogenous molecules, analogue design, combinatorial chemistry, pharmacophore definition, lead compound modification and optimization, prediction of lipophilicity, ionization and steric parameters, pro-drug design, drug targetting and soft drug design, the drug design based on enzymes, enzyme inhibitors, toxic effects due to the functional groups and their corrections, examples of succesful applications for rational drug design are the main topics. Core Textbook: Course package
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PHR513
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Drug Licence and Patent
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Drug license process and problems, safety evaluation during drug licensing, laws and regulations in drug licensing, documents required for application in drug licensing, preparation of a CTD file, CTD format for generics drug licensing, pharmaceutical dosage forms and quality control methods in drug licensing, bioavailability and bioequivalence studies in the CTD files, pharmaceutical dosage forms and quality control methods in drug licensing, importance of packaging materials in drug licensing, stability studies in drug licensing, general information about intellectual property rights and patents, patent and legal processes in the pharmaceutical sector are the main topics. Core Textbook: Course package
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PHR515
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Phytotherapy Applied
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Methods of preparing herbal teas, phytotherapeutics for mouth and throat disorders, for respiratory tract disorders, for cardiovascular disorders, hepatoprotective and choleretic phytotherapeutics, for central nervous system, gynecological, dermatological and rheumatism disorders herbal medicines, for gastrointestinal tract disorders, herbal medicines for urinary system, herbal dietary products, analysis of phyto-pharmaceuticals in market, herbal monographs are the main topics. Core Textbook: Course package
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