Sequential drug decision problems in long-term medical conditions: a case Study of Primary Hypertension Eunju Kim ba, ma, msc

(4) Angiotensin-Converting Enzyme Inhibitors

Angiotensin-Converting Enzyme Inhibitors (ACEIs) directly inhibit angiotensin-converting enzyme and block the conversion of angiotensin I to angiotension II. This action reduces angiotensin II mediated vasoconstriction and aldosterone secretion, and hence lowers blood pressure.

ACEIs are a drug of choice in persons with DM renal dysfunction by delaying the progression to end-stage RD; and in patients with congestive HF and asymptomatic patients by reducing ejection fractions whether due to MI or to other causes. An advantage of the ACEIs is less AEs, but a chronic dry cough is common, seen in 10% of patients or more, and may require stopping the drug.