5.2Population
A cohort was defined of patients newly diagnosed with primary hypertension, excluding those with pre-existing CVDs, HF or DM. According to Burke’s retrospective cohort study, which observed 109,454 patients newly diagnosed with hypertension between 1991 and 2001 in the UK, it was assumed that the mean age of the cohort of newly diagnosed primary hypertensive patients was 60.6 years old (standard deviation (SD) 13.4) and the initial SBP was 173.5 mmHg (SD 21.1)[283]. The raw dataset of the Health Survey England (HSE) was analysed to get the mean total cholesterol (TC), high-density lipoprotein cholesterol (HDL) and body mass index (BMI) of the patients with hypertension in the UK (see Table 5.)[284].
Table 5.. The mean TC, HDL, BMI of the hypertensive patients in the UK[221]
|
Age groups
|
Men
|
Women
|
TC (mg/dl)
|
55-64
|
199.96
|
207.68
|
65-74
|
185.33
|
206.80
|
75-84
|
179.36
|
197.63
|
85+
|
159.59
|
185.97
|
HDL (mg/dl)
|
55-64
|
50.55
|
60.61
|
65-74
|
50.94
|
60.39
|
75-84
|
55.46
|
64.35
|
85+
|
66.92
|
63.06
|
BMI
|
55-64
|
32.18
|
31.33
|
65-74
|
30.07
|
30.24
|
75-84
|
29.01
|
30.75
|
85+
|
27.27
|
27.30
|
The patients included in the base-case had the following characteristics:
-
60.6 years old white men.
-
SBP 173.5 mmHg (SD 21.1).
-
Average TC, HDL, BMI of the patients with hypertension in the UK.
-
Non-smoker.
-
No CVD family history.
-
No chronic renal disease (CRD), atrial fibrillation (AF) or RA.
To test whether the costs and effectiveness of sequential treatment strategies were sensitive depending on the patient’s characteristics, sensitivity analyses were conducted for female, different age groups with mean ages of 50 and 70 years old and the patients having a different SBP (153.5 and 163.5 mmHg) at the initial stage.
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