H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
Glutamate and glutamine
|
|
|
|
gltB
glutamate synthase, large subunit
|
no
|
no
|
no
|
gltD
glutamate synthase, small subunit
|
no
|
no
|
no
|
gdhA
glutamate dehydrogenase, NADP-specific
|
HS_1339
|
no
|
HI0189
|
glnA
glutamine synthetase
|
HS_0418
|
HD0750
|
HI0865
|
glnB
nitrogen regulatory protein p-II
|
HS_1355
|
HD0062
|
HI0337
|
glnD
uridylyltransferase
|
HS_0829
|
HD1497
HD1496
|
HI1719
|
glnE
glutamate-ammonia-ligase adenylyltransferase
|
HS_1218
|
HD1709
|
HI0069
|
Aspartate and asparagine
|
|
|
|
aspA
aspartate ammonia-lyase
|
HS_0466
|
HD0564
|
HI0534
|
asnA
asparagine synthetase
|
HS_1440
|
HD1913
|
HI0564
|
asnB
asparagine synthetase B
|
no
|
no
|
no
|
aspC
aspartate aminotransferase
|
HS_0838
|
HD1419
|
HI1617
|
ansB
periplasmic L-asparaginase II
NP_417432
|
no
|
HD0372
|
no
|
ansA
cytoplasmic L-asparaginase I
|
no
|
no
|
no
|
asparaginase
|
no
|
no
|
no
|
rpoN
RNA polymerase, sigma(54 or 60) factor
|
no
|
no
|
no
|
ntrB
histidine protein kinase sensor for GlnG regulator
|
no
|
no
|
no
|
ntrC
response regulator for gln
|
no
|
no
|
no
|
serC
phosphoserine aminotransferase
|
HS_0611
|
HD1382
|
HI1167
|
D. Lysine, Threonine, Methionine biosynthesis
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
Lysine
|
|
|
|
lysC
aspartokinase III
|
no
|
HD1375
|
no
|
thrA
aspartate kinase I
bifunctional: aspartokinase I (N-terminal); homoserine dehydrogenase I (C-terminal)
|
HS_1214
|
no
|
HI0089
|
metL
aspartate kinase II
bifunctional: aspartokinase II and homoserine dehydrogenase II
|
no
|
no
|
no
|
asd
aspartate semialdehyde dehydrogenase
|
HS_1552
|
HD0847
|
HI0646
|
dapA
dihydrodipicolinate synthase
|
HS_0492
|
HD1107
|
HI0255
|
dapB
dihydrodipicolinate reductase
|
HS_0835
|
HD1398
|
HI1308
|
dapD
tetrahydrodipicolinate synthase
|
HS_0785
|
HD0630
|
HI1634
|
dapC
N-succinyldiaminopimelate-aminotransferase
|
HS_0926
|
no
|
no
|
dapE
N-succinyl-L-diaminopimelic acid desuccinylase
|
HS_0578
|
HD0642
|
HI0102
|
dapF
diaminopimelate epimerase
|
HS_1610
|
HD0026
|
HI0750
|
lysA
diaminopimelate decarboxylase
|
HS_1713
|
HD0036
|
HI0727
|
Threonine
|
|
|
|
thrA
homoserine dehydrogenase
|
HS_1214
|
no
|
HI0089
|
thrB
homoserine kinase
|
HS_1213
|
no
|
HI0088
|
thrC
threonine synthase
|
HS_1212
|
no
|
HI0087
|
Methionine
|
|
|
|
metA
homoserine O-succinyltransferase
|
no
|
no
|
no
|
metB
O-succinylhomoserine lyase
|
HS_1345
|
no
|
HI0086
|
malY
cystathionine beta-lyase
|
no
|
no
|
no
|
metC
L-cysteine desulfhydrase / cystathionine-beta-lyase
|
HS_0475
|
no
|
HI0122
|
metH
Cobalamin-dependent homocysteine transmethylase
|
no
|
no
|
no
|
metE
Cobalamin-independent homocysteine transmethylase
|
HS_1226
HS_0824
|
no
no
|
HI1702
|
metK
methionine adenosyltransferase I
|
HS_1623
|
HD0569
|
HI1172
|
metF
5,10-methylenetetrahydrofolate reductase
|
HS_1130
|
no
|
HI1444
|
metX
homoserine O-acetyltransferase
|
HS_1076
|
no
|
HI1263
|
metJ
met repressor
|
HS_0469
|
HD0675
|
HI0294
|
met2
Homoserine O-acetyltransferase (EC 2.3.1.31)
|
no
|
no
|
no
|
E. Leucine, Isoleucine and Valine biosynthesis
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
ilvA
threonine ammonia-lyase (threonine dehydratase, threonine deaminase)
|
HS_0183
|
no
|
HI0738.1
|
ilvB
acetolactate synthase I, large subunit, valine-sensitive
|
no
|
no
|
no
|
ilvC
ketol-acid reductoisomerase
|
HS_1671
|
no
|
HI0682
|
ilvD
dihydroxy-acid dehydratase (DAD)
|
HS_0342
|
no
|
HI0738
|
ilvE
branched-chain amino acid transaminase
|
HS_0494
|
no
|
HI1193
|
ilvG
acetohydroxy acid synthase II, large subunit
|
HS_0147
|
no
|
N-terminal of HI0737
|
ilvH
acetolactate synthase III, small subunit
|
no
|
no
|
HI1584
|
ilvI
acetolactate synthase III, valine sensitive, large subunit
|
no
|
no
|
HI1585
|
ilvM
acetohydroxy acid synthase II, small subunit
|
HS_0148
|
no
|
C-terminal of HI0737
|
ilvN
acetolactate synthase I, small subunit
|
no
|
no
|
no
|
leuA
2-isopropylmalate synthase (alpha-isopropylmalate synthetase)
|
HS_0392
|
no
|
HI0986
|
leuB
3-isopropylmalate dehydrogenase
|
HS_0391
|
no
|
HI0987
|
leuC
3-isopropylmalate dehydratase, large subunit
|
HS_0390
|
no
|
HI0988
|
leuD
3-isopropylmalate dehydratase, small subunit
|
HS_0389
|
no
|
HI0989
|
avtA
alanine-alpha-ketoisovalerate (or valine-pyruvate) transaminase, transaminase C
|
no
|
no
|
no
|
tdcB
threonine deaminase, catabolic, PLP-dependent
NP_417587
|
no
|
no
|
no
|
sdaA
L-serine deaminase I
|
no
|
HD1142
|
HI0288
|
sdaB
L-serine deaminase 2
|
no
|
no
|
no
|
tyrB
tyrosine aminotransferase, tyrosine-repressible,
PLP-dependent
|
no
|
no
|
no
|
F. Histidine, Glycine, Serine, Alanine, Proline, Phenylalanine, Tyrosine, Trptophan biosynthesis
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
Histidine
|
|
|
|
hisG
ATP phosphoribosyltransferase
|
no
|
no
|
HI0468
|
hisI
bifunctional: phosphoribosyl-AMP cyclohydrolase (N-terminal); phosphoribosyl-ATP pyrophosphatase (C-terminal)
|
no
|
no
|
HI0475
|
hisA
N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'- phosphoribosyl)-4-imidazolecarboxamide isomerase
|
no
|
no
|
HI0473
|
hisF
imidazole glycerol phosphate synthase subunit in heterodimer with HisH = imidazole glycerol pHS_phate synthase holoenzyme
|
no
|
no
|
HI0474
|
hisH
glutamine amidotransferase subunit of heterodimer with HisF = imidazole glycerol phosphate synthase holoenzyme
|
no
|
no
|
HI0472
|
hisB
bifunctional: histidinol-phosphatase (N-terminal); imidazoleglycerol-phosphate dehydratase (C-terminal)
|
no
|
no
|
HI0471
|
hisC
histidinol phosphate aminotransferase
|
HS_0612
|
no
|
HI0470
|
hisD
L-histidinal:NAD+ oxidoreductase; L-histidinol:NAD+ oxidoreductase
|
no
|
no
|
HI0469
|
Glycine and serine
|
|
|
|
glyA
glycine/serine hydroxymethyltransferase
|
HS_1627
|
no
|
HI0889
|
serA
phosphoglycerate dehydrogenase (D-3-phosphoglycerate dehydrogenase)
|
HS_0122
|
no
|
HI0465
|
serC
phosphoserine transaminase (phosphoserine aminotransferase)
|
HS_0611
|
HD1382
|
HI1167
|
serB
phosphoserine phosphatase
|
HS_0687
|
HD0207
|
HI1033
|
Alanine
|
|
|
|
ilvE
branched-chain amino acid transaminase
|
HS_0494
|
no
|
HI1193
|
avtA
alanine-alpha-ketoisovalerate (or valine-pyruvate) transaminase, transaminase C
|
no
|
no
|
no
|
dadX
alanine racemase 2, PLP-binding, catabolic
|
HS_0939
|
HD0624
|
HI1575
|
alr
alanine racemase
|
HS_0939
|
HD0624
|
HI1575
|
Proline
|
|
|
|
gdhA
NADP-specific glutamate dehydrogenase
|
HS_1339
|
no
|
HI0189
|
proA
glutamate-5-semialdehyde dehydrogenase
|
HS_0408
|
no
|
HI1239
|
proB
glutamate 5-kinase (gamma-glutamyl kinase)
|
HS_0192
|
no
|
HI0900
|
proC
pyrroline-5-carboxylate reductase
|
HS_1285
|
no
|
HI0307
|
Phenylalanine and tyrosine
|
|
|
|
pheA
bifunctional P-protein: chorismate mutase; prephenate dehydratase
|
HS_0365
|
HD0873
|
HI1145
|
tyrA
bifunctional protein: chorismate mutase; prephenate dehydrogenase
|
HS_0671
|
HD0443
|
HI1290
|
tyrB
tyrosine aminotransferase, tyrosine repressible
|
no
|
no
|
no
|
Tryptophan
|
|
|
|
trpE
anthranilate synthase component I
|
no
|
no
|
HI1387
|
trpD/ trpGD
anthranilate synthase component II, glutamine amidotransferase and phosphoribosylanthranilate transferase
|
no
|
no
|
HI1389
|
trpG
anthranilate synthase component II (para-aminobenzoate synthase component II)
|
HS_0130
|
HD0406
|
HI1171
HI1388
|
trpC
N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase
|
no
|
no
|
HI1389.1
|
trpA
tryptophan synthase, alpha protein
|
no
|
no
|
HI1432
|
trpB
tryptophan synthase, beta
|
no
|
no
|
HI1431
|
G. Arginine degradation
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
E. coli ast pathway (arginine degradation VI)
|
|
|
|
astA
arginine succinyltransferase
|
no
|
no
|
no
|
astB
succinylarginine dihydrolase
|
no
|
no
|
no
|
astC
acetylornithine delta-aminotransferase
|
no
|
no
|
no
|
astD
succinylglutamic semialdehyde dehydrogenase
|
no
|
no
|
no
|
astE
succinylglutamate desuccinylase
|
no
|
no
|
no
| | |
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