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acacc acaac tagtc tggat tattc ccttg gtcag gcttg agtct gaaat gaaag tatgc ctttg gagcg agcta tgtgg tgttg atcag accta ataag ggaac cagtc cgaac tcaga cttta ctttc atacg gaaac ctcgc tcgat catcc ttcat ccttg ctgtg aacag aatag ct tctct gtgcc attct ctaag ttaag tcgtg agtgc cagta gtagg aagta ggaac gacac ttgtc ttatc ga agaga cacgg taaga gattc aattc agcac tcacg gtcat IVS 15 tctcc ctgaa ataac tgcca gagcc agttt gcagg caggt gaaga tcatt aggtt tcttc ctgat ccagt tggga agagg gactt tattg acggt ctcgg tcaaa cgtcc gtcca cttct agtaa tccaa agaag gacta ggtca accct tagct gttct ctaga tcata gctct tcctc accac agatc ctagg cttca cctac aacag tctca agctg ccctt atcga caaga gatct agtat cgaga aggag tggtg tctag gatcc gaagt ggatg ttgtc agagt tcgac gggaa 2370 2385 2400 ttcct caatc catga ccaac atctt tccag TTC AGA TCG GAG TCT TGG GAA CCT CAG AAC GAG CTG TGG aagga gttag gtact ggttg tagaa aggtc AAG TCT AGC CTC AGA ACC CTT GGA GTC TTG CTC GAC ACC Phe Arg Ser Glu Ser Trp Glu Pro Gln Asn Glu Leu Trp F R S E S W E P Q N E L W 790 795 800 A=His (17) T=Ile (17) | T=Leu (17) 2415 | 2430 | | 2445 2460 ATT GAA ATC ACC AAG TGC TGT GGC CTC CGG AGT CGA TGG CTG GGA ACT CAA CCC AGT CCA TAT GCT TAA CTT TAG TGG TTC ACG ACA CCG GAG GCC TCA GCT ACC GAC CCT TGA GTT GGG TCA GGT ATA CGA Ile Glu Ile Thr Lys Cys Cys Gly Leu Arg Ser Arg Trp Leu Gly Thr Gln Pro Ser Pro Tyr Ala I E I T K C C G L R S R W L G T Q P S P Y A 805 810 815 820 G=Gly (17,25) T=Leu (4,9) | G=Val (17) A=Thr (17) 2475 | 2490 2505 | | 2520 | 2535 GTG TAC CGC TTC TTC ACC TTT TCT GAC CAT GAC ACT GCC ATC ATT CCA GCC AGT AAC AAC CCC TAC CAC ATG GCG AAG AAG TGG AAA AGA CTG GTA CTG TGA CGG TAG TAA GGT CGG TCA TTG TTG GGG ATG Val Tyr Arg Phe Phe Thr Phe Ser Asp His Asp Thr Ala Ile Ile Pro Ala Ser Asn Asn Pro Tyr V Y R F F T F S D H D T A I I P A S N N P Y 825 830 835 840 845 T=ter (5) |A=Gln (17,25,10)dup (1,5) G=ter (18) 2550 || 2565 || 2580 |2595 TTT AGA GAC CAG GCT CGA TTC CCA GTG CTT GTG ACC TCT GAC CTG GAC CAT TAT CTG AGA CGG GAG AAA TCT CTG GTC CGA GCT AAG GGT CAC GAA CAC TGG AGA CTG GAC CTG GTA ATA GAC TCT GCC CTC Phe Arg Asp Gln Ala Arg Phe Pro Val Leu Val Thr Ser Asp Leu Asp His Tyr Leu Arg Arg Glu F R D Q A R F P V L V T S D L D H Y L R R E 850 855 860 865 (22,5,15,2) ter=T (20,25) ter=T | insA (16,25) G=Gly (2) A=Asp (17) | | | 2625 | 2640 | 2655 | | GCC TTG TCT ATA CAT GTT TTT GAT GAT GAA GAC TTA GAG CCT GGC TCG TAT CTT GGC CGA GCC CGA CGG AAC AGA TAT GTA CAA AAA CTA CTA CTT CTG AAT CTC GGA CCG AGC ATA GAA CCG GCT CGG GCT Ala Leu Ser Ile His Val Phe Asp Asp Glu Asp Leu Glu Pro Gly Ser Tyr Leu Gly Arg Ala Arg A L S I H V F D D E D L E P G S Y L G R A R 870 875 880 885 890
2685 2700 2710 | GTG CCT TTA CTG CCT CTT GCA AAA AAT GAA TCT ATC AAA G gtggg agttc gaggt tatta catct CAC GGA AAT GAC GGA GAA CGT TTT TTA CTT AGA TAG TTT C gaccc tcaag ctcca ataat gtaga Val Pro Leu Leu Pro Leu Ala Lys Asn Glu Ser Ile Lys Gly V P L L P L A K N E S I K G 895 900 904
agtgc gggag aaggg tcaca acaga gggac aggac taaga tgaaa agaaa ctaat gaacg aactt tgtca gagag ttaaa acctg aagat aaagg attta gaata ttgtc aagag caaca gagca gaaga cttag agcct cacta cttgt aattt tggac ttcta tttcc taaat cttat aacag ttctc gttgt ctcgt cttct gaatc tcgga gtgat gaaca gtgga aacac tggct tcttc tgctt ctttt cagcc acaaa gacaa cattc ctaag tgggt agagc cagca acctg cacct ttgtg accga agaag acgaa gaaaa gtcgg tgttt ctgtt gtaag gattc accca tctcg gtcgt tggac aattc tatac ctctg tatct gaata aactt ctttg ttttt tgaga ttaag atatg gagac ataga cttat ttgaa gaaac aaaaa actct IVS 16 cactt gaggg tagag gtaac agttt tcttg gtaca actaa ggcac agtaa gcatt tgata atagt aataa taatg gtgaa ctccc atctc cattg tcaaa agaac catgt tgatt ccgtg tcatt cgtaa actat tatca ttatt attac cagcc ttgtt cattg gctgg atgac tgatg acaag caagc tgtac tcctt ttcat acacc cttca ctatc tcttc gtcgg aacaa gtaac cgacc tactg actac tgttc gttcg acatg aggaa aagta tgtgg gaagt gatag agaag ctgaa tccta gagat aaccc atctt ccctg attaa tattc taact gcact gctgt ttgat tttac ttctg agtgt gactt aggat ctcta ttggg tagaa gggac taatt ataag attga cgtga cgaca aacta aaatg aagac tcaca atcat catcg taatt attta atgga tgtta attaa ttgct gataa aatat gttga aatta aaaat gggaa ggaag tagta gtagc attaa taaat tacct acaat taatt aacga ctatt ttata caact ttaat tttta ccctt ccttc tagat aaggt gctga caaat gctca cttgc ttatt tcatg tgatc aggtc ttatt aatat ctgtt tgttt ctcag atcta ttcca cgact gttta cgagt gaacg aataa agtac actag tccag aataa ttata gacaa acaaa gagtc dup (2) 2711 2730 2745 | 2775 GT GAT TTT AAC CTC ACT GAC CCT GCA GAG AAA CCC AAC GGA TCT ATT CAA GTG CAA CTG GAT TGG CA CTA AAA TTG GAG TGA CTG GGA CGT CTC TTT GGG TTG CCT AGA TAA GTT CAC GTT GAC CTA ACC Gly Asp Phe Asn Leu Thr Asp Pro Ala Glu Lys Pro Asn Gly Ser Ile Gln Val Gln Leu Asp Trp G D F N L T D P A E K P N G S I Q V Q L D W 904 905 910 915 920 925
AAG TTT CCC TAC ATA CCC CCT GAG AGC TTC CTG AAA CCA GAA GCT CAG ACT AAG GGG AAG GAT ACC TTC AAA GGG ATG TAT GGG GGA CTC TCG AAG GAC TTT GGT CTT CGA GTC TGA TTC CCC TTC CTA TGG Lys Phe Pro Tyr Ile Pro Pro Glu Ser Phe Leu Lys Pro Glu Ala Gln Thr Lys Gly Lys Asp Thr K F P Y I P P E S F L K P E A Q T K G K D T 930 935 940 945 2850 2865 2880 2895 AAG GAC AGT TCA AAG ATC TCA TCT GAA GAG GAA AAG GCT TCA TTT CCT TCC CAG gtaac tctcc aggac TTC CTG TCA AGT TTC TAG AGT AGA CTT CTC CTT TTC CGA AGT AAA GGA AGG GTC cattg agagg tcctg Lys Asp Ser Ser Lys Ile Ser Ser Glu Glu Glu Lys Ala Ser Phe Pro Ser Gln K D S S K I S S E E E K A S F P S Q 950 955 960 965 tccac aggta gcaga tctct gccaa tccta tggag cagat ttgaa ggaga cagta ttata gttga agtag gtgca aggtg tccat cgtct agaga cggtt aggat acctc gtcta aactt cctct gtcat aatat caact tcatc cacgt gtggc tcacg cctgt aatcc cagca ctttg ggagg ccatg gcagg cgaat tacct gaggt cagga gttca agacc caccg agtgc ggaca ttagg gtcgt gaaac cctcc ggtac cgtcc gctta atgga ctcca gtcct caagt tctgg agcct gacca acatg gggaa accct gcctc tacta aaaat acaaa aaatt agctg ggcgt ggtgg cacat gcctg tcgga ctggt tgtac ccctt tggga cggag atgat tttta tgttt tttaa tcgac ccgca ccacc gtgta cggac taatc ccagc tactg ggagg ctgag gcagg agaat cactt gaacc tagga ggtgg aggtt gcggc gagcc gagat attag ggtcg atgac cctcc gactc cgtcc tctta gtgaa cttgg atcct ccacc tccaa cgccg ctcgg ctcta cacgc cattg cactc tggcc tgggc aacaa gagca gaact ctgtc tcaaa aaaaa aaaga aaaag aaatt ccctc gtgcg gtaac gtgag accgg acccg ttgtt ctcgt cttga gacag agttt ttttt tttct ttttc tttaa gggag IVS 17 t gtgag tgtca tgtgt cctgt gaact taata tatat ccctc ataat gccat gagac tactg atgga gcgaa a cactc acagt acaca ggaca cttga attat atata gggag tatta cggta ctctg atgac tacct cgctt agcct gggtt ttact gcgga aaaga gagag aaata gcatt tctca gctcc atgag gagag aaatg aagtc taaca tcgga cccaa aatga cgcct tttct ctctc tttat cgtaa agagt cgagg tactc ctctc tttac ttcag attgt ctagt tccca aatcc ctttc ttgtg tttct aggtt gttaa actac cagct tgtaa tgcta tctct gatct ttcta gatca agggt ttagg gaaag aacac aaaga tccaa caatt tgatg gtcga acatt acgat agaga ctaga aagat 2896 2910 2925 2940 2955 ttcag GAT CAG ATG GCA TCT CCT GAG GTT CCC ATT GAA GCT GGC CAG TAT CGA TCT AAG AGA AAA CCT aagtc CTA GTC TAC CGT AGA GGA CTC CAA GGG TAA CTT CGA CCG GTC ATA GCT AGA TTC TCT TTT GGA Asp Gln Met Ala Ser Pro Glu Val Pro Ile Glu Ala Gly Gln Tyr Arg Ser Lys Arg Lys Pro D Q M A S P E V P I E A G Q Y R S K R K P 966 970 975 980 985 2970 2985 3000 3015 CCT CAT GGG GGA GAA AGA AAG GAG AAG GAG CAC CAG GTT GTG AGC TAC TCA AGA AGA AAA CAT GGC GGA GTA CCC CCT CTT TCT TTC CTC TTC CTC GTG GTC CAA CAC TCG ATG AGT TCT TCT TTT GTA CCG Pro His Gly Gly Glu Arg Lys Glu Lys Glu His Gln Val Val Ser Tyr Ser Arg Arg Lys His Gly P H G G E R K E K E H Q V V S Y S R R K H G 990 995 1000 1005 3030 3045 3060 3075 3090 AAA AGA ATA GGT GTT CAA GGA AAG AAT AGA ATG GAG TAT CTT AGC CTT AAC ATC TTA AAT GGA AAT TTT TCT TAT CCA CAA GTT CCT TTC TTA TCT TAC CTC ATA GAA TCG GAA TTG TAG AAT TTA CCT TTA Lys Arg Ile Gly Val Gln Gly Lys Asn Arg Met Glu Tyr Leu Ser Leu Asn Ile Leu Asn Gly Asn K R I G V Q G K N R M E Y L S L N I L N G N 1010 1015 1020 1025 1030 Glu (2,14) | 3099
ACA CCA CAG gtaag acctt aaaaa ctctg aagca ctaaa ttgtg ggttg tagtg tcccc agatg tatta ttctc TGT GGT GTC cattc tggaa ttttt gagac ttcgt gattt aacac ccaac atcac agggg tctac ataat aagag Thr Pro Gln T P Q
1033 agagg tagaa gcaga agcag aagca gacac acaag ataag cacta atcgg ccggg catgg tggct tcggc ctgta tctcc atctt cgtct tcgtc ttcgt ctgtg tgttc tattc gtgat tagcc ggccc gtacc accga agccg gacat atccc agcac tttgg gcagt tgagg tgggc agatc acctc aggtc agcct ggcca acacg gtgaa ctcct atctc taggg tcgtg aaacc cgtca actcc acccg tctag tggag tccag tcgga ccggt tgtgc cactt gagga tagag tgcta aaaat acaaa atgag gcctg gtgca gtggc tcacg cctgt aatcc caaca ctttg ggagg ccgag gtggg acgat tttta tgttt tactc cggac cacgt caccg agtgc ggaca ttagg gttgt gaaac cctcc ggctc caccc tggat cacct gaggt cagga gttcg agacc agctt gacca acatg gtgaa accct gtctc tacta aaaat acaaa accta gtgga ctcca gtcct caagc tctgg tcgaa ctggt tgtac cactt tggga cagag atgat tttta tgttt aatta gccag gcatg gtggt gtgtg cctgt aatcc cagtt actcg ggagg ctgag gaagg agaat cacct ttaat cggtc cgtac cacca cacac ggaca ttagg gtcaa tgagc cctcc gactc cttcc tctta gtgga IVS 18 ttggg aggct gaggc atgcg gatca catga ggtca ggagt tcgag accag cctgg ccaac atggt gaaac cccat aaccc tccga ctccg tacgc ctagt gtact ccagt cctca agctc tggtc ggacc ggttg tacca ctttg gggta ctcta ctaaa aatag aaaaa ttagt caggt gtggt gacgg gctcc tgtaa tccca gctac tcagg aggct gaggc gagat gattt ttatc ttttt aatca gtcca cacca ctgcc cgagg acatt agggt cgatg agtcc tccga ctccg aggag aattg cttga accca ggagg cgaag gttgc agtga gccga gatgg tgcca ctgca ctctg gcctg agtga tcctc ttaac gaact tgggt cctcc gcttc caacg tcact cggct ctacc acggt gacgt gagac cggac tcact cagag ggaga ctctg tctca aaaaa ataat aataa taaaa attaa aaaaa taaaa agagc taata tttaa aaaga gtctc cctct gagac agagt ttttt tatta ttatt atttt taatt ttttt atttt tctcg attat aaatt tttct aggca ggaag gaagg aatga agaaa gaaaa ccaag atatt accag ctatg tagta ttgtt gttct tattc tgaag tccgt ccttc cttcc ttact tcttt ctttt ggttc tataa tggtc gatac atcat aacaa caaga ataag acttc 3102 3120 3135 3150 3165 CAG GTG AAT TAC ACT GAG TGG AAG TTC TCA GAG ACT AAC AGC TTC ATA GGT GAT GGC TTT AAA AAT GTC CAC TTA ATG TGA CTC ACC TTC AAG AGT CTC TGA TTG TCG AAG TAT CCA CTA CCG AAA TTT TTA Gln Val Asn Tyr Thr Glu Trp Lys Phe Ser Glu Thr Asn Ser Phe Ile Gly Asp Gly Phe Lys Asn Q V N Y T E W K F S E T N S F I G D G F K N 1034 1040 1045 1050 1055 T=Leu (23) | 3180 3195 3210 3225 CAG CAC GAG GAA GAG GAA ATG ACA TTA TCC CAT TCA GCA CTG AAA CAG AAG GAA CCT CTA CAT CCT GTC GTG CTC CTT CTC CTT TAC TGT AAT AGG GTA AGT CGT GAC TTT GTC TTC CTT GGA GAT GTA GGA Gln His Glu Glu Glu Glu Met Thr Leu Ser His Ser Ala Leu Lys Gln Lys Glu Pro Leu His Pro Q H E E E E M T L S H S A L K Q K E P L H P 1060 1065 1070 1075
GTA AAT G gtatt gtctt ttaaa atcta ttttt tttcc tagca ctttg ggagg ccgag gtggg cagat cacga CAT TTA C cataa cagaa aattt tagat aaaaa aaagg atcgt gaaac cctcc ggctc caccc gtcta gtgct Val Asn Asp V N D 1080
ctagt ccgaa agttc tcgtc ggacc ggttg tacta ctttg ggcag agatg atttt tatgt tttta atcgg cccat tggtg gcagg cgcct gtaat cccag ctacg tgggc ggcgg aggca ggaga attgc ttgaa cccag gagga ggagg accac cgtcc gcgga catta gggtc gatgc acccg ccgcc tccgt cctct taacg aactt gggtc ctcct cctcc ttgca gtgag ccgag attgc accac tgcac tcctc cagcc tgggc gacag agcga gactc catct caaaa aaaag aacgt cactc ggctc taacg tggtg acgtg aggag gtcgg acccg ctgtc tcgct ctgag gtaga gtttt ttttc aaaaa aatat atatt ttttc tgttt aatca tttaa ttgtt ttgcc aagct agtta tttac ttttc tcctt cacct ttttt ttata tataa aaaag acaaa ttagt aaatt aacaa aacgg ttcga tcaat aaatg aaaag aggaa gtgga tagaa tgcta aagtt ttcat ggaaa attag tatgt aagac ctgag gccca gtttt gtgtt acaag tgtga tggtt atctt acgat ttcaa aagta ccttt taatc ataca ttctg gactc cgggt caaaa cacaa tgttc acact accaa IVS 19 catct ttgga aaata caatc tgccc caccc aattg cacag cttta cctca agctt ggcca ttttc ttcag ccccc gtaga aacct tttat gttag acggg gtggg ttaac gtgtc gaaat ggagt tcgaa ccggt aaaag aagtc ggggg acaaa aggac ttcct ttctt ccttc cttac tctca ccctt ccttc ctgtc ttcct tcctt tcttc ctttc tgttt tgttt tcctg aagga aagaa ggaag gaatg agagt gggaa ggaag gacag aagga aggaa agaag gaaag acaaa ttcct tcttt ccctt tcttt ttttg agaag tgaat cctgt atgtt tggca agctt ctgaa taagt gtacc tttga aagga agaaa gggaa agaaa aaaac tcttc actta ggaca tacaa accgt tcgaa gactt attca catgg aaact aaaag agggt ttgat tctta gtaag tgaag gcaaa atcta gacac tcgga actag tgacc agaca gtgga ttgga ttttc tccca aacta agaat cattc acttc cgttt tagat ctgtg agcct tgatc actgg tctgt cacct aacct gatgt gtgtg ctggg tcttt tcttg ggcta aagtg ctttg aaaca gttct ataac tgcaa cctct tctct agcag ctaca cacac gaccc agaaa agaac ccgat ttcac gaaac tttgt caaga tattg acgtt ggaga agaga tcgtc 3239 3255 3270 3285 3300 AC AAA GAA TCC TCT GAA CAA GGT TCT GAA GTC AGT GAA GCA CAA ACT ACC GAC AGT GAT GAT GTC TG TTT CTT AGG AGA CTT GTT CCA AGA CTT CAG TCA CTT CGT GTT TGA TGG CTG TCA CTA CTA CAG Asp Lys Glu Ser Ser Glu Gln Gly Ser Glu Val Ser Glu Ala Gln Thr Thr Asp Ser Asp Asp Val D K E S S E Q G S E V S E A Q T T D S D D V 1080 1085 1090 1095 1100 A=ter (20,24) 3315 | 3339 ATA GTG CCA CCC ATG TCT CAG AAA TAT CCT AAG GCA gtaag tacac tggag taatc attgc atacg agata TAT CAC GGT GGG TAC AGA GTC TTT ATA GGA TTC CGT cattc atgtg acctc attag taacg tatgc tctat Ile Val Pro Pro Met Ser Gln Lys Tyr Pro Lys Ala I V P P M S Q K Y P K A 1105 1110 1113
tctgc tattt attac tgtca ccggt cagta ccccc gagtg cggac attag ggtcg tggaa ccctc cggct ccgtc gcaga tcacc taagg tcggg agttc gagac cagcc tgacc aacat ggaga aaccc catct ctact aaaaa tacaa cgtct agtgg attcc agccc tcaag ctctg gtcgg actgg ttgta cctct ttggg gtaga gatga ttttt atgtt aaaaa attag ccagg catgg tggag cgtcc ttgta atccc agcta ctcag gaggc tgagg cagga gaatt gcttg ttttt taatc ggtcc gtacc acctc gcagg aacat taggg tcgat gagtc ctccg actcc gtcct cttaa cgaac aaccc gggag gcaga ggttg cagtg agcca agatc acgcc attgc actcc ggcct gggca acaag agcaa aactc ttggg ccctc cgtct ccaac gtcac tcggt tctag tgcgg taacg tgagg ccgga cccgt tgttc tcgtt ttgag tgtct caaaa aaaaa aaaaa aaaaa aaaaa agcaa taatg acagt gtgct tagtg gccac acaag tgaag ggcaa acaga gtttt ttttt ttttt ttttt ttttt tcgtt attac tgtca cacga atcac cggtg tgttc acttc ccgtt IVS 20 gcgac gcaca ttgtt cccac caagc aacct cccat catcc accct ccccg ccgct ccgaa tcaga cattt ttttt cgctg cgtgt aacaa gggtg gttcg ttgga gggta gtagg tggga ggggc ggcga ggctt agtct gtaaa aaaaa tattc tttct atatg tggag atgac tgaga aaggc tgtcc tggag aaatg atcca ctgga ctgtg agaga gaaga ataag aaaga tatac acctc tactg actct ttccg acagg acctc tttac taggt gacct gacac tctct cttct gctgg gttct cttta taaat ttcct atcaa ttaac tatgg caatt aagtc aagtt gtctt ttgat gccag tttta cgacc caaga gaaat attta aagga tagtt aattg atacc gttaa ttcag ttcaa cagaa aacta cggtc aaaat cctat aaaag gattc tcagg gaata atata gtaga tagat tatac ctatg gttga tttct agaga gtacc gtaat ggata ttttc ctaag agtcc cttat tatat catct atcta atatg gatac caact aaaga tctct catgg catta gggtt aattg gatgg cgtat aagca cttgg agcct cacta acctt tagga actaa ataaa cattt tcctt atcag cccaa ttaac ctacc gcata ttcgt gaacc tcgga gtgat tggaa atcct tgatt tattt gtaaa aggaa tagtc G=Gly (1,5,7,14,15,7,10) | G=Leu(10) G=Gln (21) | 3345 | 3375 | 3405 GAT TCA GAG AAG ATG TGC ATT GAA ATT GTC TCC CTG GCC TTC TAC CCA GAG GCA GAA GTG ATG TCT CTA AGT CTC TTC TAC ACG TAA CTT TAA CAG AGG GAC CGG AAG ATG GGT CTC CGT CTT CAC TAC AGA Asp Ser Glu Lys Met Cys Ile Glu Ile Val Ser Leu Ala Phe Tyr Pro Glu Ala Glu Val Met Ser D S E K M C I E I V S L A F Y P E A E V M S 1115 1120 1125 1130 1135 3420 3435 3450 3465 GAT GAG AAC ATA AAA CAG GTG TAT GTG GAG TAC AAA TTC TAC GAC CTA CCC TTG TCG GAG ACA GAG CTA CTC TTG TAT TTT GTC CAC ATA CAC CTC ATG TTT AAG ATG CTG GAT GGG AAC AGC CTC TGT CTC Asp Glu Asn Ile Lys Gln Val Tyr Val Glu Tyr Lys Phe Tyr Asp Leu Pro Leu Ser Glu Thr Glu D E N I K Q V Y V E Y K F Y D L P L S E T E 1140 1145 1150 1155 del (12) 3480 | 3495 3510 3525 3532 ACT CCA GTG TCC CTA AGG AAG CCT AGG GCA GGA GAA GAA ATC CAC TTT CAC TTT AGC AAG G gtgag TGA GGT CAC AGG GAT TCC TTC GGA TCC CGT CCT CTT CTT TAG GTG AAA GTG AAA TCG TTC C cactc Thr Pro Val Ser Leu Arg Lys Pro Arg Ala Gly Glu Glu Ile His Phe His Phe Ser Lys Val T P V S L R K P R A G E E I H F H F S K V 1160 1165 1170 1175 1178 gcatc ctgtg tggtt actgg ggtga ggaag tctga tgaac attga gactg agggt cagaa ttact ctgga ttttt cgtag gacac accaa tgacc ccact ccttc agact acttg taact ctgac tccca gtctt aatga gacct aaaaa
caccc cactt aggtc ggtaa agtga aataa taaaa taaca agttt cacaa cacac gtaca ccaaa ttttt gtagc aatgg ggcta aacat tttac atgaa gcagg ccttt gtccc agctc ttcac agatc acttc gcctg ttccc accct ttacc ccgat ttgta aaatg tactt cgtcc ggaaa caggg tcgag aagtg tctag tgaag cggac aaggg tggga tcctc aatcc acggc ttccc acatt tcagc tatat ttatt tttac ttttt gaggt ggagt ctcgc tctgt tgccc aggag ttagg tgccg aaggg tgtaa agtcg atata aataa aaatg aaaaa ctcca cctca gagcg agaca acggg aggct agaat gcagt ggtgt gatct tggct cactg ccacc tctga ctccg agatt caagc gattc acgtg actca tccga tctta cgtca ccaca ctaga accga gtgac ggtgg agact gaggc tctaa gttcg ctaag tgcac tgagt IVS 21 aagtt ggaga ccagc ctggc caacg tggca aaacc ctgtc tctac taaaa ataca aaaat tagcc gggca tggtg ttcaa cctct ggtcg gaccg gttgc accgt tttgg gacag agatg atttt tatgt tttta atcgg cccgt accac gggtg cacct gtaat cccaa ctact cggga ggctg aggca ggaga atcgc ttgaa cttgg gagat ggaga ctgcg cccac gtgga catta gggtt gatga gccct ccgac tccgt cctct tagcg aactt gaacc ctcta cctct gacgc gtgaa ccaag atcac gccac tgcac tctag cctga cacag taaga atctg tcaca cacac acaca cacaa atgat cactt ggttc tagtg cggtg acgtg agatc ggact gtgtc attct tagac agtgt gtgtg tgtgt gtgtt tacta tttca aagca gttgg tccat gttat tctag atcca ggcaa ggagt ctaat ctttt tatga aaact accat gaata aaagt ttcgt caacc aggta caata agatc taggt ccgtt cctca gatta gaaaa atact tttga tggta cttat ccact aatga aagtc ttggg gctca cactg caaca gtata tgatt ctttg ctttt ttctc ttacc cttaa tacag ggtga ttact ttcag aaccc cgagt gtgac gttgt catat actaa gaaac gaaaa aagag aatgg gaatt atgtc T=ter (24,25,19) T=Asp (2,14) |-------|del (6) 3534 3540 | 3555 | 3570 | 3585 TA ATA GAC CTG GAC CCA CAG GAG CAG CAA GGC CGA AGG CGG TTT CTG TTC GAC ATG CTG AAT GGA AT TAT CTG GAC CTG GGT GTC CTC GTC GTT CCG GCT TCC GCC AAA GAC AAG CTG TAC GAC TTA CCT Val Ile Asp Leu Asp Pro Gln Glu Gln Gln Gly Arg Arg Arg Phe Leu Phe Asp Met Leu Asn Gly V I D L D P Q E Q Q G R R R F L F D M L N G 1178 1180 1185 1190 1195 del (2) 3600 | 3617 CAA GAT CCT GAT CAA GGA CA gtaag catct gcttt ccact ttgaa acaaa ggaga tattg agaca gaaat GTT CTA GGA CTA GTT CCT GT cattc gtaga cgaaa ggtga aactt tgttt cctct ataac tctgt cttta Gln Asp Pro Asp Gln Gly His Q D P D Q G H 1200 1206
agttt tcaaa ctcaa accaa aacac gacta cgact tataa aatta ttgaa aaaac tcaat taaat gagaa ttact atttc ctatg tactt gagta taatt tatat ttgtg actac ctaat ccatt accta atctt atagg ttatt tattt taaag gatac atgaa ctcat attaa atata aacac tgatg gatta ggtaa tggat tagaa tatcc aataa ataaa attta tttat ttatt tattt tcgag acagg gtctc actct gtcgt ccagg ctaga gtgca gtggt gcgat cttgg taaat aaata aataa ataaa agctc tgtcc cagag tgaga cagca ggtcc gatct cacgt cacca cgcta gaacc ctcac tgcaa cctcc acctc cccag gctca aggga ttctt gtgcc tctgc ctccc aagta gctag ggtta taggc gagtg acgtt ggagg tggag gggtc cgagt tccct aagaa cacgg agacg gaggg ttcat cgatc ccaat atccg atgtg ccacc atgcc tggct aattt tttgt gtttg tagta gagat agggt tttgc cgtgt tgctc atgtc tggtc tacac ggtgg tacgg accga ttaaa aaaca caaac atcat ctcta tccca aaacg gcaca acgag tacag accag IVS 22 cagcc cactg catcc tcgac ctcct gggct caagt gatct cacct cagcc ttcca agtag ctggg actat aggtg gtcgg gtgac gtagg agctg gagga cccga gttca ctaga gtgga gtcgg aaggt tcatc gaccc tgata tccac tgtgc cacca tgccc ggcta atttt ttatt ttttt tgtag agacg gggtg ttcct atgtt accca ggctg gtctt acacg gtggt acggg ccgat taaaa aataa aaaaa acatc tctgc cccac aagga tacaa tgggt ccgac cagaa gaact catgg gcaca tccca tgatg ttccc tcttc taaaa ggact gttac tgctt aaatt atacc aattc ctgac cttga gtacc cgtgt agggt actac aaggg agaag atttt cctga caatg acgaa tttaa tatgg ttaag gactg ttttt tgctt attgt cattt tgtaa aatgg aggca aggga aaagt gattc agaga agacg ttgta ttgtt tatga aaaaa acgaa taaca gtaaa acatt ttacc tccgt tccct tttca ctaag tctct tctgc aacat aacaa atact ttact tttat cctta tttta ttttt gaagc attaa gagta tcaac agtgc tgaat taaat gcaat ttctt tttag aatga aaata ggaat aaaat aaaaa cttcg taatt ctcat agttg tcacg actta attta cgtta aagaa aaatc ins G (1,5) G=ter (9) | A=Glu (11) 3618 | | | 3645 3660 3675 T TTA AAG TTT ACA GTG GTA AGT GAT CCT CTG GAT GAA GAA AAG AAA GAA TGT GAA GAA GTG GGA A AAT TTC AAA TGT CAC CAT TCA CTA GGA GAC CTA CTT CTT TTC TTT CTT ACA CTT CTT CAC CCT His Leu Lys Phe Thr Val Val Ser Asp Pro Leu Asp Glu Glu Lys Lys Glu Cys Glu Glu Val Gly H L K F T V V S D P L D E E K K E C E E V G 1206 1210 1215 1220 1225 T=ter (22) 3690 | 3720 3735 3748 TAT GCA TAT CTT CAA CTG TGG CAG ATC CTG GAG TCA GGA AGA GAT ATT CTA GAG CAA GAG CTA GAC A ATA CGT ATA GAA GTT GAC ACC GTC TAG GAC CTC AGT CCT TCT CTA TAA GAT CTC GTT CTC GAT CTG T Tyr Ala Tyr Leu Gln Leu Trp Gln Ile Leu Glu Ser Gly Arg Asp Ile Leu Glu Gln Glu Leu Asp I Y A Y L Q L W Q I L E S G R D I L E Q E L D I 1230 1235 1240 1245 1249
cactc agtaa aaaaa aagtc aagat taata aaggt tcctt tagta ggatt atcac ttata taaaa tagaa gttat cataa ttatt actat gaagt tgata agaca caaag tggat tgaaa tctta tccct acaac tgtat ttatt tctgg gtatt aataa tgata cttca actat tctgt gtttc accta acttt agaat aggga tgttg acata aataa agacc atcca acatt aaagt agtca gttgt gtatt tttac cccca tatac ctgat tacaa ctaga attga ttttg aatct taggt tgtaa tttca tcagt caaca cataa aaatg ggggt atatg gacta atgtt gatct taact aaaac ttaga acaat gtttg aaaag gagat tttta aaaag acaag ttatt ttcat ttcaa attta tacat cagaa ttttg gacct tgtta caaac ttttc ctcta aaaat ttttc tgttc aataa aagta aagtt taaat atgta gtctt aaaac ctgga Yüklə 230,17 Kb. Dostları ilə paylaş:
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