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agcat ttgct caaaa cttcc taaga gtatt cttct agcat gtgtg aggtg atgag atata acaaa gttgt tgcag tcgta aacga gtttt gaagg attct cataa gaaga tcgta cacac tccac tactc tatat tgttt caaca acgtc gtatt ctcag atggt cttaa atatt tggcc ctatt cacca ctgtg agtgg gctgc atgtg aagct aggtg aatgt cataa gagtc tacca gaatt tataa accgg gataa gtggt gacac tcacc cgacg tacac ttcga tccac ttaca IVS 7 c tgtgc ttaag aatca ccact aagac agagt tccaa acgag accac ccagc tgtgc ctcac cagag gagtc g acacg aattc ttagt ggtga ttctg tctca aggtt tgctc tggtg ggtcg acacg gagtg gtctc ctcag cgcca gaaac acaca cagaa cttct ggagt taaca tgtca cttgt ctagg tacaa acgta gtcat cataa aaaag gcggt ctttg tgtgt gtctt gaaga cctca attgt acagt gaaca gatcc atgtt tgcat cagta gtatt ttttc cagtc aaata gctta gaaag tgaag gcagc tttgg aaggt ggcaa ctaat ttaaa gctag ggatt aattt gaacc gtcag tttat cgaat ctttc acttc cgtcg aaacc ttcca ccgtt gatta aattt cgatc cctaa ttaaa cttgg ttgag aaaat taagg ctcaa gggcc aggcg cggtg gctca cgcct gtaat cccag cactt gggga ggcgg aggcg aactc tttta attcc gagtt cccgg tccgc gccac cgagt gcgga catta gggtc gtgaa cccct ccgcc tccgc ggtgg atgac ctaag gtcag gagtt cgaga ccagc ctggc caaca tggag aaacc ctgtc tctat taaaa ataca ccacc tactg gattc cagtc ctcaa gctct ggtcg gaccg gttgt acctc tttgg gacag agata atttt tatgt aaaat tagct gggcg tggtg gctca tgcct gtaat cccag ctact cagga ggctg aggca ggaga attgc ttgaa tttta atcga cccgc accac cgagt acgga catta gggtc gatga gtcct ccgac tccgt cctct taacg aactt cccgg taggc agagg ttgca gtgag ccaag cacta ttgca ctcca gcctg ggcaa cagag cgaga ctgtc tcaat gggcc atccg tctcc aacgt cactc ggttc gtgat aacgt gaggt cggac ccgtt gtctc gctct gacag agtta aaata aataa ataaa taaat acaag aaaag aaaat taaag ctcaa atgat gaact acaat tgccc agaat ggaaa tttat ttatt tattt attta tgttc ttttc tttta atttc gagtt tacta cttga tgtta acggg tctta ccttt cccta cctac caggg aaatt atact tccag agaaa tgcta gggtg aaaaa caagg ttaac gaaca gtaca aaggt gggat ggatg gtccc tttaa tatga aggtc tcttt acgat cccac ttttt gttcc aattg cttgt catgt ttcca aataa gctat taatc aaagt cattc tttgt gacat ctgtt agaga atgct agggt tgctg gtgtc tggag accac ttatt cgata attag tttca gtaag aaaca ctgta gacaa tctct tacga tccca acgac cacag acctc tggtg 931 945 tcgtg ctgag tgata tgacc attcc cagag gtact ttcct tttga cccag AAT CAG GGA ATC CTG AGT GCA agcac gactc actat actgg taagg gtctc catga aagga aaact gggtc TTA GTC CCT TAG GAC TCA CGT Asn Gln Gly Ile Leu Ser Ala N Q G I L S A 311 315
| 960 975 990 1005 GCC CAT GAG GCC CTC CTC AAG CAA GTG AAT GAG CTC AGG GCA GAG CTG AAG GAA GAA AGC AAG AAG CGG GTA CTC CGG GAG GAG TTC GTT CAC TTA CTC GAG TCC CGT CTC GAC TTC CTT CTT TCG TTC TTC Ala His Glu Ala Leu Leu Lys Gln Val Asn Glu Leu Arg Ala Glu Leu Lys Glu Glu Ser Lys Lys A H E A L L K Q V N E L R A E L K E E S K K 320 325 330 335 (5) g 1020 1035 1050 1065 1077 | GCT GTG AGC TTG AAG AGC CAA CTG GAA GAT GTG TCT ATC TTG CAG ATG ACT CTG AAG GAG gtaaa CGA CAC TCG AAC TTC TCG GTT GAC CTT CTA CAC AGA TAG AAC GTC TAC TGA GAC TTC CTC cattt Ala Val Ser Leu Lys Ser Gln Leu Glu Asp Val Ser Ile Leu Gln Met Thr Leu Lys Glu A V S L K S Q L E D V S I L Q M T L K E 340 345 350 355 359
attat tatca acttt ctatg gtaga tgtaa agttg aagtc cctac aatct tacac ataga atcgt tgtta tactc tattg cattt tttca aatga caaaa acgaa gctcc gagta gttaa atcat ttgct taaga ttaca ccatt agagg ataac gtaaa aaagt ttact gtttt tgctt cgagg ctcat caatt tagta aacga attct aatgt ggtaa tctcc gaaag cttgg atttg tactt atgtc tgttt ttcaa agtcc ttgct ctttc ataat gtttt gctgc ttccc tagca ctttc gaacc taaac atgaa tacag acaaa aagtt tcagg aacga gaaag tatta caaaa cgacg aaggg atcgt IVS 8 gtaga aaccc agaaa cagtg aagac ttatt ttgga aaatc ctcat taatc ccaat acaag tttct agccg acctt catct ttggg tcttt gtcac ttctg aataa aacct tttag gagta attag ggtta tgttc aaaga tcggc tggaa ca attgg ttcaa gtctt tctag ttgga tggct tctca gacac tggag atggt gatag aaagc ctctc accca gt taacc aagtt cagaa agatc aacct accga agagt ctgtg acctc tacca ctatc tttcg gagag tgggt cgccc ctccc tgcca tggac agggg aaatc ctgtg caggg gaata gattt taaca tttta tctca agggc tacta gcggg gaggg acggt acctg tcccc tttag gacac gtccc cttat ctaaa attgt aaaat agagt tcccg atgat C=Thr (17) del |dup (27) del (2,20,24,25) |- 1078 ||- 1095 |1110 1125 | tcact cttag TTT CAG GAG AGA GTT GAA GAT TTG GAA AAA GAA CGA AAA TTG CTG AAT GAC AAT TAT agtga gaatc AAA GTC CTC TCT CAA CTT CTA AAC CTT TTT CTT GCT TTT AAC GAC TTA CTG TTA ATA Phe Gln Glu Arg Val Glu Asp Leu Glu Lys Glu Arg Lys Leu Leu Asn Asp Asn Tyr F Q E R V E D L E K E R K L L N D N Y 360 365 370 375 (15) -| | 1140 1151 GAC AAA CTC TTA GAA AG gtgag tacca cattt gggtc ccaga gcagt gttac tatga aagac attat agaaa CTG TTT GAG AAT CTT TC cactc atggt gtaaa cccag ggtct cgtca caatg atact ttctg taata tcttt Asp Lys Leu Leu Glu Ser D K L L E S 380 384
caagt aagga ttatg gatcg taatt attta tatac ccctt taacc atgag ttata acaat cactc ttata attag ggcag tcttt tggaa gggaa tttga cacta ttaaa atgtt aaatg tgcat atcct ctttt ttttt ttttt gagat ccgtc agaaa acctt ccctt aaact gtgat aattt tacaa tttac acgta tagga gaaaa aaaaa aaaaa ctcta ggagt ctcgc tctgc tgccc aggct ggagt gcagt ggtgc gatct tggct cactg caacc tctac ctccc gggtt cctca gagcg agacg acggg tccga cctca cgtca ccacg ctaga accga gtgac gttgg agatg gaggg cccaa caaac gattc tcctg actct tcttc ctttt tattt tttta accag caatt ccttt tttct ttttt tgaga tgtag gtttg ctaag aggac tgaga agaag gaaaa ataaa aaaat tggtc gttaa ggaaa aaaga aaaaa actct acatc tttct ctctg tcacc caggc tggaa aacag tggca ttcta ggctt actgc agccc cagtc tccca ggctc aagca aaaga gagac agtgg gtccg acctt ttgtc accgt aagat ccgaa tgacg tcggg gtcag agggt ccgag ttcgt IVS 9 cttca gcata gtaat ttata atcta ggtca aagac aaata ttctc taaac tcacc gttgg tgaag gtaga tggag gaagt cgtat catta aatat tagat ccagt ttctg tttat aagag atttg agtgg caacc acttc catct acctc gcatg gggtt tgaga aaagg aagat tttgt tcctc atttc taatc cggca ggcct gagaa ggtct tgata catag cgtac cccaa actct tttcc ttcta aaaca aggag taaag attag gccgt ccgga ctctt ccaga actat gtatc ttccc tgact aaaga aagcc atcat ggtgg agaag ttcct tggga aatgg atatg acttg gggtg tttgc tcagt aaggg actga tttct ttcgg tagta ccacc tcttc aagga accct ttacc tatac tgaac cccac aaacg agtca cagat atctg agacc taaac agaaa tggta ctgag caata actca gtagg actca aaagt tccaa ggcag ttggt gtcta tagac tctgg atttg tcttt accat gactc gttat tgagt catcc tgagt tttca aggtt ccgtc aacca aaatg acagt tatga ataaa gcaag ggcag aaaaa aacat gtagg ggaga gaatg aggaa ctagg tccag gagat tttac tgtca atact tattt cgttc ccgtc ttttt ttgta catcc cctct cttac tcctt gatcc aggtc ctcta gctga aactg gataa taaag acgtc atatc acacc ccttg gggta tccat ctgag agctt gcttt ccatt gccag cgact ttgac ctatt atttc tgcag tatag tgtgg ggaac cccat aggta gactc tcgaa cgaaa ggtaa cggtc T=ter (9) 1155 1070 | 1085 1200 1215 C ATG CTG GAC AGC AGT GAC AGC TCC AGT CAG CCC CAC TGG AGC AAC GAG CTC ATA GCG GAA CAG G TAC GAC CTG TCG TCA CTG TCG AGG TCA GTC GGG GTG ACC TCG TTG CTC GAG TAT CGC CTT GTC Ser Met Leu Asp Ser Ser Asp Ser Ser Ser Gln Pro His Trp Ser Asn Glu Leu Ile Ala Glu Gln S M L D S S D S S S Q P H W S D E L I A E Q 384 385 390 395 400 405 RRR
CTA CAG CAG CAA GTC TCT CAG CTG CAG GAT CAG CTG GAT GCT GAG CTG GAG GAC AAG AGA AAA GTT GAT GTC GTC GTT CAG AGA GTC GAC GTC CTA GTC GAC CTA CGA CTC GAC CTC CTG TTC TCT TTT CAA Leu Gln Gln Gln Val Ser Gln Leu Gln Asp Gln Leu Asp Ala Glu Leu Glu Asp Lys Arg Lys Val L Q Q Q V S Q L Q D Q L D A E L E D K R K V 410 415 420 425
1290 | 1306 TTA CTT GAG CTG TCC AGG GAG AAA G gtagg ctgga ccttg aagag ctctc tcaaa tgtgg catcc tctac AAT GAA CTC GAC AGG TCC CTC TTT C catcc gacct ggaac ttctc gagag agttt acacc gtagg agatg Leu Leu Glu Leu Ser Arg Glu Lys Ala L L E L S R E K A 430 435 436
gagac caaac cctct tctat tgaac tcggt agtaa agaaa ttagg ggagt gaact aggat aagaa aacac ccaac taggt aacta gaatg agaac actag caata gatca gatct acaat cagga aaaca tgaca cttac ctacc tctca atcca ttgat cttac tcttg tgatc gttat ctagt ctaga tgtta gtcct tttgt actgt gaatg gatgg agagt tgtat acttt ttcct atata atgtc tttcc atttg agaag atgct agttt ttgtt tgttt gtttg tttgt ttgtt acata tgaaa aagga tatat tacag aaagg taaac tcttc tacga tcaaa aacaa acaaa caaac aaaca aacaa tttga ggtgg agttt cgctc ttgtt gctca ggctc gagtg caatg gcacg atttc agctc actgc aacct tcacc aaact ccacc tcaaa gcgag aacaa cgagt ccgag ctcac gttac cgtgc taaag tcgag tgacg ttgga agtgg tccca ggtac aagcg attct cctat ctcag cctcc caagt agctc ggatt acaag catgc actac cacgc ctggc agggt ccatg ttcgc taaga ggata gagtc ggagg gttca tcgag cctaa tgttc gtacg tgatg gtgcg gaccg IVS 10 acaga gagct agtaa cctag aagtc agaat ggagt ggggg tggag ttggt gagat actgg tttcg atgct gctgt tgtct ctcga tcatt ggatc ttcag tctta cctca ccccc acctc aacca ctcta tgacc aaagc tacga cgaca caaaa agttt ggatt accct agtca agtga ttccc tttct gtttt gtgtt gttat tgtta ttcca ctttc cactc gtttt tcaaa cctaa tggga tcagt tcact aaggg aaaga caaaa cacaa caata acaat aaggt gaaag gtgag tacca ttctg caggt gtctt ttgtt ttcgg agtgc aagta gtatc acctc agttt actga gtcaa taagc tagag atggt aagac gtcca cagaa aacaa aagcc tcacg ttcat catag tggag tcaaa tgact cagtt attcg atctc tcctc ctctg tagaa ataat agaga attgc ttctc aaatt tataa catta attaa acctt agtgg gaaga ttaaa aggag gagac atctt tatta tctct taacg aagag tttaa atatt gtaat taatt tggaa tcacc cttct aattt ttcac acttg atcca actct gacca tggtg ataaa taact acaga atttc acatt tctgg attat ttttc cccag aagtg tgaac taggt tgaga ctggt accac tattt attga tgtct taaag tgtaa agacc taata aaaag gggtc T=ter (17) 1307 | 1320 1335 1350 1365 CC CAA AAT GAG GAT CTG AAG CTT GAA GTC ACC AAC ATA CTT CAG AAG CAT AAA CAG GAA GTA GAG GG GTT TTA CTC CTA GAC TTC GAA CTT CAG TGG TTG TAT GAA GTC TTC GTA TTT GTC CTT CAT CTC Ala Gln Asn Glu Asp Leu Lys Leu Glu Val Thr Asn Ile Leu Gln Lys His Lys Gln Glu Val Glu A Q N E D L K L E V T N I L Q K H K Q E V E 436 440 445 450 455
CTC CTC CAA AAT GCA GCC ACA ATT TCC CAA CCT CCT GAC AGG CAA TCT GAA CCA GCC ACT CAC CCA GAG GAG GTT TTA CGT CGG TGT TAA AGG GTT GGA GGA CTG TCC GTT AGA CTT GGT CGG TGA GTG GGT Leu Leu Gln Asn Ala Ala Thr Ile Ser Gln Pro Pro Asp Arg Gln Ser Glu Pro Ala Thr His Pro L L Q N A A T I S Q P P D R Q S E P A T H P 460 465 470 475 1440 1455 1467 GCT GTA TTG CAA GAG AAC ACT CAG ATC GAG gtaag agcct cttta aacaa actag tccac tctgc agaga CGA CAT AAC GTT CTC TTG TGA GTC TAG CTC cattc tcgga gaaat ttgtt tgatc aggtg agacg tctct Ala Val Leu Gln Glu Asn Thr Gln Ile Glu A V L Q E N T Q I E 480 485 489 gatct ctggc aaata tctct aggga agatg atgag attag aaaac taact aaata atatt ttgtc ctgac tgagg ctaga gaccg tttat agaga tccct tctac tactc taatc ttttg attga tttat tataa aacag gactg actcc acact ctttt ttttt ttgag acaga gtctc gctgt cgccc aggct ggagt gcagt ggcgc gatct cggct cactg tgtga gaaaa aaaaa aactc tgtct cagag cgaca gcggg tccga cctca cgtca ccgcg ctaga gccga gtgac caggc tccgc cccct ggggt tcacg ccgtt ctcct gcctc agcct tccga gtagc tggga ctaca ggcac ccgcc gtccg aggcg gggga cccca agtgc ggcaa gagga cggag tcgga aggct catcg accct gatgt ccgtg ggcgg acctc gcccg gttaa ttttt ttgta ttttt agtag agacg gggtt tcacc gtgtt agcca ggatg gtctc gatct tggag cgggc caatt aaaaa aacat aaaaa tcatc tctgc cccaa agtgg cacaa tcggt cctac cagag ctaga cctga cctcg tgatc cgccc acctc ggcct cccaa agtgc tggga ttaca ggcgt aagcc accgc gcccg gccca ggact ggagc actag gcggg tggag ccgga gggtt tcacg accct aatgt ccgca ttcgg tggcg cgggc cgggt IVS 11 c tcttt ttttt ttttt ttttt tttga gatgg agttt tgctc ttgtt tccca ggctg gagtg caatg gcgcg g agaaa aaaaa aaaaa aaaaa aaact ctacc tcaaa acgag aacaa agggt ccgac ctcac gttac cgcgc atctc ggctc actac agtct ttgcc tccca ggttt aagca attct ccttc ctcag cctcc cgagt agctg ggatt tagag ccgag tgatg tcaga aacgg agggt ccaaa ttcgt taaga ggaag gagtc ggagg gctca tcgac cctaa acagg tgctt gccac cacag ccggc taatt ttttg tattt ttagt agaga caggg tttcg ccatt ttggc caggc tgtcc acgaa cggtg gtgtc ggccg attaa aaaac ataaa aatca tctct gtccc aaagc ggtaa aaccg gtccg tggtc tcgaa ctcct gacct ctggt gatcc gccca actca gcctc ccaaa gtgct gggat tacag gcacg tgcca accag agctt gagga ctgga gacca ctagg cgggt tgagt cggag ggttt cacga cccta atgtc cgtgc acggt ctgtg ccctg cttga ggaca ctttt tggaa aactg tgaga aggca gagcg tagag aactt catga gctcc accca gacac gggac gaact cctgt gaaaa acctt ttgac actct tccgt ctcgc atctc ttgaa gtact cgagg tgggt tttct tccac tcttt gcagc tcata aaatt tagaa tcttt ttcag atgag gactt gaaaa gatct gtgga agagc aaaga aggtg agaaa cgtcg agtat tttaa atctt agaaa aagtc tactc ctgaa ctttt ctaga cacct tctcg aaaca gccat tagtg gctgt atcat ctccc ttcac tgctg ctact gaaca tgaga actag gggaa agagc acttg tttgt cggta atcac cgaca tagta gaggg aagtg acgac gatga cttgt actct tgatc ccctt tctcg tgaac tgaag tcata caggt ccttg tttac atttt ggagt agttt ctgct gctgg cattt tacta ctacc aacaa ctgtt acttc agtat gtcca ggaac aaatg taaaa cctca tcaaa gacga cgacc gtaaa atgat gatgg ttgtt gacaa 1468 ttatg gagaa tcatt attac tttac ctgtc atatt tatac tccct tttac caatg cgttt ccctc tacag CCA aatac ctctt agtaa taatg aaatg gacag tataa atatg aggga aaatg gttac gcaaa gggag atgtc GGT Pro
P 490
1485 1500 |---| 1515 | 1530 AGT GAA CCC AAA AAC CAA GAA GAA AAG AAA CTG TCC CAG GTG CTA AAT GAG TTG CAA GTA TCA CAC TCA CTT GGG TTT TTG GTT CTT CTT TTC TTT GAC AGG GTC CAC GAT TTA CTC AAC GTT CAT AGT GTG Ser Glu Pro Lys Asn Gln Glu Glu Lys Lys Leu Ser Gln Val Leu Asn Glu Leu Gln Val Ser His S E P K N Q E E K K L S Q V L N E L Q V S H 495 500 505 510 1545 1560 1575 1590 GCA GAG ACC ACA TTG GAA CTA GAA AAG ACC AGG GAC ATG CTT ATT CTG CAG CGC AAA ATC AAC GTG CGT CTC TGG TGT AAC CTT GAT CTT TTC TGG TCC CTG TAC GAA TAA GAC GTC GCG TTT TAG TTG CAC Ala Glu Thr Thr Leu Glu Leu Glu Lys Thr Arg Asp Met Leu Ile Leu Gln Arg Lys Ile Asn Val A E T T L E L E K T R D M L I L Q R K I N V 515 520 525 530 1611 TGT TAT CAG gtgca aggaa agatg gtaca ggaag gggat ggata acagg aacgt gggaa ccact cacag gactg ACA ATA GTC cacgt tcctt tctac catgt ccttc cccta cctat tgtcc ttgca ccctt ggtga gtgtc ctgac Cys Tyr Gln C Y Q 537
cctta cttcg ttctg gattc aaagg tcccg actat ggtcc actac acgat aggac tcgtt tgtgt gttac cgaca ccttt gaaga acttg aggac tcaca catgc ccacg gcacc ttggc actag gagcc agtga tgggg ccagc ccatg ggaaa cttct tgaac tcctg agtgt gtacg ggtgc cgtgg aaccg tgatc ctcgg tcact acccc ggtcg ggtac IVS 12 c caatg gcaag cgtaa ggctt ctggg ttcaa atttt gccag tccta ggaac caccc tacct caatg atagc g gttac cgttc gcatt ccgaa gaccc aagtt taaaa cggtc aggat ccttg gtggg atgga gttac tatcg acaac tagtc ttgga ggggt ctgca aggaa atcaa acctt cttct agtgg gtgaa cctgc ccagc taagg atagc tgttg atcag aacct cccca gacgt tcctt tagtt tggaa gaaga tcacc cactt ggacg ggtcg attcc tatcg agtct tcttg accta gccag tgcca cattt tttat gctct ttggt tttag gccac tgaga tagaa aagtt cagac tcaga agaac tggat cggtc acggt gtaaa aaata cgaga aacca aaatc cggtg actct atctt ttcaa gtctg |--del (14)-| T=Ser (2,14,4,19) 1612 | 1620 | 1635 | 1650 1665 attat tttgt ttcag GAG GAA CTG GAG GCA ATG ATG ACA AAA GCT GAC AAT GAT AAT AGA GAT CAC AAA taata aaaca aagtc CTC CTT GAC CTC CGT TAC TAC TGT TTT CGA CTG TTA CTA TTA TCT CTA GTG TTT Glu Glu Leu Glu Ala Met Met Thr Lys Ala Asp Asn Asp Asn Arg Asp His Lys E E L E A M M T K A D N D N R D H K 538 540 545 550 555
GAA AAG CTG GAG AGG TTG ACT CGA CTA CTA GAC CTC AAG AAT AAC CGT ATC AAG CAG CTG GAA GGT CTT TTC GAC CTC TCC AAC TGA GCT GAT GAT CTG GAG TTC TTA TTG GCA TAG TTC GTC GAC CTT CCA Glu Lys Leu Glu Arg Leu Thr Arg Leu Leu Asp Leu Lys Asn Asn Arg Ile Lys Gln Leu Glu Gly E K L E R L T R L L D L K N N R I K Q L E G 560 565 570 575 T=Ser (17) 1740 | 1762 ATT TTA AGA AGC CAT GAC CTT CCA ACA TCT G gcaag tctta gtcct ttgtt ctcct cactt cggga ccctt TAA AAT TCT TCG GTA CTG GAA GGT TGT AGA C cgttc agaat cagga aacaa gagga gtgaa gccct gggaa Ile Leu Arg Ser His Asp Leu Pro Thr Ser Glu I L R S H D L P T S E 580 585 588
ggtgt cgatt gcgga cacaa ggtga gacac atgaa cagtt cttcc cacgg agagt atggg aatcg tatac tgaat tcctt cttgt tcttt atcct atcat ttttg ttgtt ttttt ttgct tgttt gcttt tgaga tggag tcttg ctctg aggaa gaaca agaaa tagga tagta aaaac aacaa aaaaa aacga acaaa cgaaa actct acctc agaac gagac tcact caggc tggag tgcag tggtg cgatc ttggc tcact gcaac ctctg ccttc caggt tcaag cgatt ctcct agtga gtccg acctc acgtc accac gctag aaccg agtga cgttg gagac ggaag gtcca agttc gctaa gagga gcctc agcct cccaa gtagc tggga tgaca gttgt ccacc accat gcctg gctaa ttttt tgtat tttta gtaga cggag tcgga gggtt catcg accct actgt caaca ggtgg tggta cggac cgatt aaaaa acata aaaat catct gatgg ggttt cacca tgttg gccag gttgg tctgg aactt ctgac ctcag gtgat ccacc tgcct cagcc tccca ctacc ccaaa gtggt acaac cggtc caacc agacc ttgaa gactg gagtc cacta ggtgg acgga gtcgg agggt IVS 13 agaaa tattc atgtt tttgt gtttc tagta cttct cttat ggaat tacca gttaa tcata gggcc acgat gtaca tcttt ataag tacaa aaaca caaag atcat gaaga gaata cctta atggt caatt agtat cccgg tgcta catgt ccaaa acaat gtcat atata agata aaatg tgccc ccagt gtttt cctaa gttta gcatc tactt tccag tcact ggttt tgtta cagta tatat tctat tttac acggg ggtca caaaa ggatt caaat cgtag atgaa aggtc agtga ccttt tgtac cttct cccta aagct ggcat tggat tattt ggcta tcgga attca atgct cctgg ttgtc cttct ggaaa acatg gaaga gggat ttcga ccgta accta ataaa ccgat agcct taagt tacga ggacc aacag gaaga gttgc ttttc ctttt gaatc acgtg gtttc ttgaa ataat cacaa cttgg acttc cacca tgtgt tttat atttc caacg aaaag gaaaa cttag tgcac caaag aactt tatta gtgtt gaacc tgaag gtggt acaca aaata taaag del (4) |---------| ttttg tccac cctcc tctac cctaa gaaag agctc cctac ccttt aacgg atagg cagct ttctt tcccc tctag aaaac aggtg ggagg agatg ggatt ctttc tcgag ggatg ggaaa ttgcc tatcc gtcga aagaa agggg agatc A=Gln (17,25) | A=Pro (2) | | G=Trp (23) T=His (2,10) | | | C=Ser (17) 1763 |1770 1785 | |1800 | | 1815 AA CAG CTC AAA GAT GTT GCT TAT GGC ACC CGA CCG TTG TCG TTA TGT TTG GAA ACA CTG CCA GCC TT GTC GAG TTT CTA CAA CGA ATA CCG TGG GCT GGC AAC AGC AAT ACA AAC CTT TGT GAC GGT CGG Glu Gln Leu Lys Asp Val Ala Tyr Gly Thr Arg Pro Leu Ser Leu Cys Leu Glu Thr Leu Pro Ala E Q L K D V A Y G T R P L S L C L E T L P A 588 590 595 600 605 (6) Pro=T 1830 1845 1860 1875 1890 | CAT GGA GAT GAG GAT AAA GTG GAT ATT TCT CTG CTG CAT CAG GGT GAG AAT CTT TTT GAA CTG CAC GTA CCT CTA CTC CTA TTT CAC CTA TAA AGA GAC GAC GTA GTC CCA CTC TTA GAA AAA CTT GAC GTG His Gly Asp Glu Asp Lys Val Asp Ile Ser Leu Leu His Gln Gly Glu Asn Leu Phe Glu Leu His H G D E D K V D I S L L H Q G E N L F E L H 610 615 620 625 630
| | 1920 1935 1950 ATC CAC CAG GCC TTC CTG ACA TCT GCC GCC CTA GCT CAG GCT GGA GAT ACC CAA CCT ACC ACT TTC TAG GTG GTC CGG AAG GAC TGT AGA CGG CGG GAT CGA GTC CGA CCT CTA TGG GTT GGA TGG TGA AAG Ile His Gln Ala Phe Leu Thr Ser Ala Ala Leu Ala Gln Ala Gly Asp Thr Gln Pro Thr Thr Phe I H Q A F L T S A A L A Q A G D T Q P T T F 635 640 645 650
1965 1980 | 1995 2010 2025 TGC ACC TAT TCC TTC TAT GAC TTT GAA ACC CAC TGT ACC CCA TTA TCT GTG GGG CCA CAG CCC CTC ACG TGG ATA AGG AAG ATA CTG AAA CTT TGG GTG ACA TGG GGT AAT AGA CAC CCC GGT GTC GGG GAG Cys Thr Tyr Ser Phe Tyr Asp Phe Glu Thr His Cys Thr Pro Leu Ser Val Gly Pro Gln Pro Leu C T Y S F Y D F E T H C T P L S V G P Q P L 655 660 665 670 675
TAT GAC TTC ACC TCC CAG TAT GTG ATG GAG ACA GAT TCG CTT TTC TTA CAC TAC CTT CAA GAG GCT ATA CTG AAG TGG AGG GTC ATA CAC TAC CTC TGT CTA AGC GAA AAG AAT GTG ATG GAA GTT CTC CGA Tyr Asp Phe Thr Ser Gln Tyr Val Met Glu Thr Asp Ser Leu Phe Leu His Tyr Leu Gln Glu Ala Y D F T S Q Y V M E T D S L F L H Y L Q E A 680 685 690 695 2100 2115 2130 2145 TCA GCC CGG CTT GAC ATA CAC CAG GCC ATG GCC AGT GAA CAC AGC ACT CTT GCT GCA GGA TGG ATT AGT CGG GCC GAA CTG TAT GTG GTC CGG TAC CGG TCA CTT GTG TCG TGA GAA CGA CGT CCT ACC TAA Ser Ala Arg Leu Asp Ile His Gln Ala Met Ala Ser Glu His Ser Thr Leu Ala Ala Gly Trp Ile S A R L D I H Q A M A S E H S T L A A G W I 700 705 710 715 2150 2175 2190 2205 2215 TGC TTT GAC AGG GTG CTA GAG ACT GTG GAG AAA GTC CAT GGC TTG GCC ACA CTG ATT G gtaag tgccg ACG AAA CTG TCC CAC GAT CTC TGA CAC CTC TTT CAG GTA CCG AAC CGG TGT GAC TAA C cattc acggc Cys Phe Asp Arg Val Leu Glu Thr Val Glu Lys Val His Gly Leu Ala Thr Leu Ile Gly C F D R V L E T V E K V H G L A T L I G 720 725 730 735 739 ttggc ttcct gcggc tccta a gcacc aatgc agaat ttccc aaagc ctaca gttgc ttttc tggtg gtttc aaccg aagga cgccg aggat t cgtgg ttacg tctta aaggg tttcg gatgt caacg aaaag accac caaag Ivs 14 ttatt ttctt ccttt gtctt gttct tgatc cttgc cacac catct gtatt ccccc tgctt tcaca ctttc tgcta aataa aagaa ggaaa cagaa caaga actag gaacg gtgtg gtaga cataa ggggg acgaa agtgt gaaag acgat A=Glu (1,5,20) 2216 2235 | 2250 2265 cccag GA GCT GGT GGA GAA GAG TTC GGG GTT CTA GAG TAC TGG ATG AGG CTG CGT TTC CCC ATA AAA gggtc CT CGA CCA CCT CTT CTC AAG CCC CAA GAT CTC ATG ACC TAC TCC GAC GCA AAG GGG TAT TTT Gly Ala Gly Gly Glu Glu Phe Gly Val Leu Glu Tyr Trp Met Arg Leu Arg Phe Pro Ile Lys G A G G E E F G V L E Y W M R L R F P I K 739 740 745 750 755 T=Val (17) |A=Ala (14) 2280 ||2295 2310 2325 2340 CCC AGC CTA CAG GCG TGC AAT AAA CGA AAG AAA GCC CAG GTC TAC CTG TCA ACC GAT GTG CTT GGA GGG TCG GAT GTC CGC ACG TTA TTT GCT TTC TTT CGG GTC CAG ATG GAC AGT TGG CTA CAC GAA CCT Pro Ser Leu Gln Ala Cys Asn Lys Arg Lys Lys Ala Gln Val Tyr Leu Ser Thr Asp Val Leu Gly P S L Q A C N K R K K A Q V Y L S T D V L G 760 765 770 775 780
2355 2367 | GGC CGG AAG GCC CAG GAA GAG GAG gtgag aaaaa agatg tgccg aggca tctca gagga gcctc agcca CCG GCC TTC CGG GTC CTT CTC CTC cactc ttttt tctac acggc tccgt agagt ctcct cggag tcggt Gly Arg Lys Ala Gln Glu Glu Glu G R K A Q E E E 785 789
ttgtc gagta ctcgt gtcaa gtcag aaggt gagag ttatt cacaa acaac ttaca cttac tttct ctttt gacag Yüklə 230,17 Kb. Dostları ilə paylaş:
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