Sequential drug decision problems in long-term medical conditions: a case Study of Primary Hypertension Eunju Kim ba, ma, msc

Appendix 8. Simulated annealing results depending on the size of the neighbourhood

Table A8.1. Computational results from SA depending on the definition of the neighbourhood

Definition of the neighbourhood	Size of the neighbourhood	Total iteration number	Time (h)	Time per iteration (s)	Optimal policy number	Total net benefit of the solution	Search rate
25	50	2,400	6.59	9.88	625*	330,150	19.58
50	100	1,600	4.45	10.02	3721*	330,090	24.99
100	200	2,350	6.62	10.14	3721*	330,100	30.12

1) It was assumed that the initial temperature is 1 and the cooling rate is 0.7.

2) The solution numbers with * are included in the top eight policies identified from the enumeration in Table ‎7..

Figure A8.1. Convergence depending on the definition of the neighbourhood

1^ Most of the description in this section is based on Current Medical Diagnosis and Treatment^[228] and Applied Therapeutics: The Clinical Use of Drugs^[229].