H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
xylH
D-xylose ABC transporter, permease
|
HS_0584
|
no
|
HI1109
|
xylG
D-xylose ABC transporter, ATP-binding protein
|
HS_0585
|
no
|
HI1110
|
xylF
D-xylose ABC transporter, periplasmic sugar-binding protein
|
HS_0586
|
no
|
HI1111
|
xylA
xylose isomerase
|
HS_0587
|
no
|
HI1112
|
xylB
xylulokinase
|
HS_0588
|
no
|
HI1113
|
xylR
|
HS_0794
|
no
|
HI1106
|
L. Xylulose
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
NAD(P)H-dependent xylose reductase
|
no
|
no
|
no
|
xdh
xylitol dehydrogenase
|
no
|
no
|
no
|
zinc-binding xylitol/sorbitol dehydrogenase
|
no
|
no
|
no
|
xylitol (sorbitol) dehydrogenase
|
no
|
no
|
no
|
D-xylulose reductase (EC 1.1.1.9) (Xylitol dehydrogenase) (XDH)
|
no
|
no
|
no
|
L-xylulose reductase (EC 1.1.1.10) (XR)
|
no
|
no
|
no
|
sgbK/lyxK
L-xylulokinase
|
HS_0770
|
no
|
HI1027
|
sgbH
3-hexulose-6-phosphate synthase
|
HS_0771
|
HD1857
|
HI1024
|
sgbU
hexulose-6-phosphate isomerase
|
HS_0772
|
HD1864
|
HI1026
|
L-arabinitol 4-dehydrogenase (LAD1)
|
no
|
no
|
no
|
araD
ribulose phosphate 4-epimerase
|
HS_0773
|
HD1866
|
HI1025
|
M. Trehalose (pathways from MetaCyc (8))
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
trehalose degradation I
|
|
|
|
treC
trehalose 6-P hydrolase
|
no
|
no
|
no
|
trehalose degradation II
|
|
|
|
treA
trehalase, periplasmic
|
no
|
no
|
no
|
treF
trehalase, cytoplasmic
|
no
|
no
|
no
|
trehalose degradation III
|
|
|
|
trePP/otsB
trehalose-6-phosphate phosphatase
|
no
|
no
|
no
|
trehalose degradation IV and V
|
|
|
|
trehalose phosphorylase 2.4.1.64
|
no
|
no
|
no
|
synthesis
|
|
|
|
otsA
trehalose-6-phosphate synthase
|
no
|
no
|
no
|
transport
|
|
|
|
treB/treP
PTS family enzyme IIBC, trehalose(maltose)-specific
|
no
|
no
|
no
|
regulation
|
|
|
|
treR
repressor of treA,B,C
|
no
|
no
|
no
|
N. Fructose
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
mak
Cryptic manno(fructo)kinase
|
HS_1041
|
no
|
HI0182
|
pfkB
6-phosphofructokinase II
|
no
|
no
|
no
|
pfkA
6-phosphofructokinase I
|
HS_0485
|
HD0465
|
HI0982
|
fbaA
fructose-bisphosphate aldolase, class II
|
HS_0206
|
HD0864
|
HI0524
|
fbaB
fructose-bisphosphate aldolase class I
|
possibly HS_0055
|
no
|
no
|
fruA
PTS system, fructose-specific IIBC component
|
no
|
no
|
HI0446
|
fruK
1-phosphofructokinase
|
no
|
no
|
HI0447
|
fruB
PTS system, fructose-specific IIA/FPr component
|
no
|
no
|
HI0448
|
O. Maltose
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
malT
transcriptional regulator necessary for transcription of mal genes except malIXY
|
no
|
no
|
no
|
malQ
amylomaltase
|
HS_0890
|
no
|
HI1356
|
malE
|
no
|
no
|
no
|
malF
maltose transport protein (ABC superfamily, membrane)
|
no
|
no
|
no
|
malG
maltose transport protein (ABC superfamily, membrane)
|
no
|
no
|
no
|
malK
|
no
|
no
|
no
|
malP
maltodextrin phosphorylase
|
no
|
no
|
no
|
malS
alpha-amylase
|
no
|
no
|
no
|
lamB
maltodextrin pore
|
no
|
no
|
no
|
malX
PTS family enzyme IIC (N-terminal); enzyme IIB (C-terminal)
|
no
|
no
|
no
|
malZ
maltodextrin glucosidase
|
no
|
no
|
no
|
maltose phosphorylase
|
no
|
no
|
no
|
Beta-phosphoglucomutase
|
no
|
no
|
no
|
Table S6. Amino acid metabolism
A. Arginine and polyamine biosynthesis
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
argA
N-acetylglutamate synthase
|
no
|
HD1384
|
no
|
argB
N-acetylglutamate kinase
|
no
|
HD0891
|
no
|
argC
N-acetylglutamyl phosphate reductase
|
no
|
HD0890
|
no
|
argD
acetylornithine transaminase
|
no
|
HD0892
|
no
|
argE
acetylornithine deacetylase
|
no
|
HD0566
|
no
|
astC
acetylornithine transaminase, catabolic
|
no
|
no
|
no
|
argI
ornithine carbamoyltransferase
|
no
|
HD0232
|
HI0596
|
argF
ornithine carbamoyltransferase
|
no
|
no
|
no
|
argG
arginosuccinate synthase
|
HS_1362
|
HD1204
|
HI1727
|
argH
arginosuccinate lyase
|
HS_0692
|
HD1033
|
HI0811
|
argJ
Glutamate N-acetyltransferase (Ornithine acetyltransferase)
|
no
|
no
|
no
|
argR
arginine repressor
|
HS_1056
|
HD0262
|
HI1209
|
speA
arginine decarboxylase, biosynthetic
|
no
|
no
|
no
|
adiA
arginine decarboxylase, degradative
|
no
|
no
|
no
|
speB
agmatinase
|
no
|
no
|
no
|
speC
ornithine
decarboxylase, biosynthetic
|
HS_1573
|
no
|
HI0591
|
speF
ornithine
decarboxylase, degradative
|
HS_1573
|
no
|
HI0591
|
speD
S-adenosylmethionine decarboxylase
|
no
|
no
|
no
|
speE
spermidine synthase
|
no
|
no
|
no
|
carB
carbamoyl phosphate synthetase
|
no
|
HD0233
|
no
|
carA
carbamoyl phosphate synthetase
|
no
|
HD0235
|
no
|
B. Cysteine biosynthesis and sulfate assimilation
Gene
|
H. somnus 129Pt
|
H. ducreyi 35000HP
|
H. influenzae Rd
|
cysE
serine acetyltransferase
|
HS_0154
|
HD0659
|
HI0606
|
cysM
O-acetylserine (thiol)-lyase B
|
no
|
no
|
no
|
cysK
O-acetylserine (thiol)-lyase A
|
HS_0369
|
HD0896
|
HI1103
|
cysZ
cysteine biosynthesis protein
|
HS_0370
|
HD0832
|
HI1102
|
cysQ
|
HS_1650
|
HD0840
|
HI0559
|
cysA
ATP-binding component of sulfate permease A protein; chromate resistance
|
no
|
no
|
no
|
cysC
adenosine 5'-phosphosulfate kinase
|
no
|
no
|
no
|
cysD
ATP-sulfurylase, subunit 2
|
no
|
no
|
no
|
cysG
siroheme synthase
|
no
|
no
|
no
|
cysH
3'-phosphoadenosine 5'-phosphosulfate (PAPS) reductase
|
no
|
no
|
no
|
cysI
sulfite reductase, alpha subunit
|
no
|
no
|
no
|
cysJ
sulfite reductase (NADPH), flavoprotein beta subunit
|
no
|
no
|
no
|
cysN
ATP-sulfurylase (ATP:sulfate
adenylyltransferase), subunit 1, probably a GTPase
|
no
|
no
|
no
|
C. Glutamate, Glutamine, Aspartate and Asparagine biosynthesis
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