| Arginine metabolism
Like H. influenzae Rd (43), H. somnus 129Pt was missing the genes encoding the enzymes for five initial steps of arginine biosynthesis (argA, argB, argC, argD, and argE), and in addition was missing argI, which is present in H. influenzae Rd (43). H. ducreyi 35000HP had all of the genes necessary for arginine biosynthesis (Table S6). Also like H. influenzae Rd (43), both H. somnus 129Pt and H. ducreyi 35000HP were missing the spe genes, speA, speB, speC, speD and speE, which are involved in polyamine biosynthesis from arginine and S-adenosyl methionine. We could not find any genes for arginine degradation in the genome of H. somnus 129Pt; however, it did contain speF encoding ornithine decarboxylase (HS_1573), which converts ornithine to putrescene. H. influenzae Rd also had a speF homolog, but H. ducreyi did not. In fact, none of these organisms contained a complete pathway for arginine degradation.
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