Supplementary material 1

Nucleotide synthesis

Purines

56. 
    prpp + 2*glum + gly + 7*atp + asp + 3*eau + 3*co + 4*h = imp + 7*adp + 9*p + 2*glut + fum
    
57. 
    imp + gtp + asp + atp = 2*adp + gdp + fum + p
    
58. 
    imp + nad + 3*atp + glum + 3*eau = gdp + nadh + glut + 3*adp + 2*p + h
    
59. 
    gdp + atp + nadph + h = dgtp + nadp + adp + eau
    
60. 
    gdp + atp = gtp + adp
    
61. 
    atp + nadph + h = datp + nadp + eau
    

Pyrimidines

62. 
    carp + asp + (1/2)*o + prpp + atp = udp + co + 3*p + eau + adp
    
63. 
    udp + atp = utp + adp
    
64. 
    utp + glum + atp + eau = ctp + adp + glut + p
    
65. 
    ctp + nadph + h = dctp + nadp + eau
    
66. 
    udp + 3*nadph + 4*atp + co + 5*h = dttp + 3*nadp + 4*adp + 3*p