Supplementary Online Material


S1: Metabolic network in C. necator with butyric acid as carbon source



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S1: Metabolic network in C. necator with butyric acid as carbon source



S2: Anabolic network

1 Ammonia + 1 NADH + 1 Pyruvate



1 alanine

4 Ammonia + 5 ATP + 3 NADH + 1 NADPH + 1 Acetyl CoA + 1 -ketoglutarate + 1 Oxaloacetate + 1 CO2



1 Fumarate + 1 Acetate + 1 CoA-SH + 1 arginine

2 Ammonia + 2 ATP + 1 NADH + 1 Oxaloacetate



1 asparagine

1 Ammonia + 1 NADH + 1 Oxaloacetate



1 aspartate

1 Soufre + 1 Ammonia + 3 ATP + 4 NADPH + 1 Acetyl CoA + 1 Glycerate-P



1 Acetate + 1 CoA-SH + 1 cysteine

1 Ammonia + 1 NADH + 1 - ketoglutarate



1 glutamate

2 Ammonia + 1 ATP + 1 NADH + 1-ketoglutarate



1 glutamine

1 THF + 1 Ammonia + 1 Glycerate-P



1 Methylene-THF + 1 glycine

1 Methenyl-THF + 3 Ammonia + 3 ATP + 1 Oxaloacetate + 1 Pentose-P



1 THF + 1 NADH+ 1 Fumarate + 1 histidine

1 Ammonia + 2 ATP + 5 NADPH + 1 Oxaloacetate + 1 Pyruvate



1 CO2 + 1 isoleucine

1 Ammonia + 1 NADPH + 1 Acetyl CoA + 2 Pyruvate



2 CO2 + 1 CoA-SH + 1 leucine

2 Ammonia + 1 ATP + 2 NADH+ 2 NADPH+ 1 Oxaloacetate + 1 Pyruvate + 1 SuccinylCoA



1 CO2 + 1 Succinate + 1 CoA-SH + 1 lysine

1 Methyl-THF + 1 Sulfur + 1 Ammonia + 4 ATP + 1 NADH + 6 NADPH + 1 Acetyl CoA + 1 Oxaloacetate + 1 Glycerate-P + 1 SuccinylCoA



1 THF + 1 Pyruvate + 1 Acetate + 1 Succinate + 2 CoA-SH + 1 methionine

1 Ammonia + 1 ATP + 1 NADH + 1 NADPH + 1 Erythrose-P + 2 PEP



1 CO2 + 1 phenylalanine

1 Ammonia + 1 ATP + 3 NADPH + 1-ketoglutarate



1 proline

1 Ammonia + 1 Glycerate-P



1 serine

1 Ammonia + 2 ATP + 2 NADH + 1 NADPH + 1 Oxaloacetate



1 threonine

2 Ammonia + 4 ATP + 1 NADH + 1 NADPH + 1 Erythrose-P + 1 Pentose-P + 2 PEP + 1 Glycerate-P



1 Pyruvate + 1 CO2 + 1 Glycerol-P + 1 tryptophane

1 Ammonia + 1 ATP + 1 NADPH + 1 Erythrose-P + 2 PEP



1 CO2 + 1 tyrosine

0.1009 alanine + 0.0446 arginine + 0.0455 asparagine + 0.0455 aspartate + 0.0677 cysteine + 0.0386 glutamate + 0.0386 glutamine + 0.0992 glycine + 0.0449 histidine + 0.0333 isoleucine + 0.0579 leucine + 0.0457 lysine + 0.0175 methionine + 0.0256 phenylalanine + 0.1373 proline + 0.0325 serine + 0.0444 threonine + 0.0106 tryptophane + 0.0192 tyrosine + 4.324 ATP



1 PROTEIN

2 Formyl-THF + 5 Ammonia + 11 ATP + 4 NADH + 2 Oxaloacetate + 1 Pentose-P + 1 Glycerate-P + 1 CO2



1 THF + 1 Methyl-THF + 2 Fumarate + 1 ATP

2 Formyl-THF + 5 Ammonia + 12 ATP + 2 NADH + 1 Oxaloacetate + 1 Pentose-P + 1 Glycerate-P + 1 CO2



1 THF + 1 Methyl-THF + 1 Fumarate + 1 GTP

3 Ammonia + 10 ATP + 1 NADH + 1 Oxaloacetate + 1 Pentose-P + 0.5 Oxygen



1 CTP

2 Ammonia + 7 ATP + 1 NADH + 1 Oxaloacetate + 1 Pentose-P + 0.5 Oxygen



1 UTP

0.18 ATP + 0.3264 GTP + 0.3201 CTP + 0.1691 UTP + 0.4 ATP



1 RNA

2 Formyl-THF + 5 Ammonia + 11 ATP + 4 NADH + 2 Oxaloacetate + 1 Pentose-P + 1 Glycerate-P + 1 CO2



1 THF + 1 Methyl-THF + 1 NADPH+ 2 Fumarate + 1 dATP

2 Formyl-THF + 5 Ammonia + 12 ATP + 2 NADH + 1 Oxaloacetate + 1 Pentose-P + 1 Glycerate-P + 1 CO2



1 THF + 1 Methyl-THF + 1 NADPH + 1 Fumarate + 1 dGTP

3 Ammonia + 10 ATP + 1 NADH + 1 Oxaloacetate + 1 Pentose-P + 0.5 Oxygen



1 NADPH+ 1 dCTP

1 Methylene-THF + 2 Ammonia + 8 ATP + 1 NADH + 1 Oxaloacetate + 1 Pentose-P + 0.5 Oxygen



1 THF + 1 NADPH + 1 dTTP

0.1691 dATP + 0.3201 dGTP + 0.3264 dCTP + 0.1844 dTTP + 1.4161 ATP



1 DNA

1 ATP + 1 Glycerol-P



1 glycerolP

1 Ammonia + 1 Glycerate-P



1 serine

7 ATP + 15 NADPH + 8 Acetyl CoA



8 CoA-SH + 1 C16:0

7 ATP + 15 NADPH + 8 Acetyl CoA + 0.5 Oxygen



8 CoA-SH + 1 C16:1

8 ATP + 16 NADPH + 9 Acetyl CoA + 0.5 Oxygen



9 CoA-SH + 1 C18:1

1 Glucose-P



1 inositol

1 Ammonia + 1 Glycerate-P



1 CO2 + 1 Ethanolamine

1 glycerolP + 0.6 serine + 0.666667 C16:0 + 0.66666666666 C16:1 + 0.66666666666 C18:1 + 0.2 inositol + 0.2 Ethanolamine + 2 ATP



1 PHOSPHOLIPIDS

1 ATP + 1 Glucose-P



1 Equiv glucose

1 Equiv glucose



1 POLYSACCHARIDES

1 Glycerol-P



1 glycerolP

7 ATP + 15 NADPH + 8 Acetyl CoA



8 CoA-SH + 1 C16:33%

7 ATP + 15 NADPH + 8 Acetyl CoA + 0.5 Oxygen



8 CoA-SH + 1 C16:1 33%

8 ATP + 16 NADPH + 9 Acetyl CoA + 0.5 Oxygen



9 CoA-SH + 1 C18:1 33%

1 glycerolP + 1 C16:33% + 1 C16:1 33% + 1 C18:1 33% + 2. ATP



1 TRIGLYCERIDES

1 Ammonia + 1 ATP + 1 NADH + 1 Acetyl CoA + 1 Fructose-P



1 CoA-SH + 1 UDP-N-acetylglucosamine

1 Ammonia + 2 ATP + 1 NADH + 1 NADPH + 1 Acetyl CoA + 1 Fructose-P + 1 PEP



1 CoA-SH + 1 UDP-N-amuramic

1 Ammonia + 1 NADH + 1 Pyruvate



1 Alanine

2 Ammonia + 1 ATP + 4 NADPH + 1 Oxaloacetate + 1 Pyruvate + 1 SuccinylCoA



1 Succinate + 1 CoA-SH + 1 diaminopimelate

1 Ammonia + 1 NADH + 1 -ketoglutarate



1 glutamate

1 UDP-N-acetylglucosamine + 1 UDP-N-amuramic + 2 Alanine + 1 diaminopimelate + 1 glutamate + 5 ATP



1 PEPTYDOGLYCANE

1 ATP + 1 Glucose-P



1 UDP-glucose

1 Ammonia + 1 Glycerate-P



1 CO2 + 1 CDP-ethanolamine

6 ATP + 11 NADPH + 7 Acetyl CoA



7 CoA-SH + 1 OH-Myristique

2 ATP + 1 Pentose-P + 1 PEP



1 CMP KDO

1 ATP + 2 Glucose-P



4 NADPH + 2 CO2 + 1 Glycerol-P + 1 NDP Heptose

1 Ammonia + 2 ATP + 1 Fructose-P



1 TDP glucosamine

5 UDP-glucose + 2 CDP-ethanolamine + 6 OH-Myristique + 3 CMP KDO + 3 NDP Heptose + 3 TDP glucosamine



1 LPS

2 Ammonia + 2 ATP + 3 NADPH + 1 Acetyl CoA + 1-ketoglutarate



1 Acetate + 1 CoA-SH + 1 ornithine

1 ornithine



1 POLYAMINE

Composition data for E. coli (Ingraham et al., 1983) was used wherever specific data was unavailable for C. necator.


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