| The Effect Of Tetrodotoxin On The Rat Prostate Cancer
In vitro studies show that voltage gated sodium channels are expressed in rat and human prostatic cell lines play important roles in both cell proliferation and metastases. This voltage gated sodium channels in cell zares are blocked by tetrodotoxin which is a neurotoxin.
In this study, it was aimed to investigate the role of sodium channel blocker terodotoxin on primary prostate tumors which formed in rats using Mat-LyLu cell line. The effects of tetrodotoxin on primary tumors were evaluated by the kinetic parameters including tumor weight, labelling index and mitotic index. Besides, the effect of tetrodotoxin on secondary tumors were examined by the number of metastases in the lungs.
At first, the primary prostate tumor formed in adult male Copenhagen rats by subcutaneously injection of 2x105 Mat-LyLu cells. At the seventh, tenth, fifth, twenty first and twenty fifth days after the cell inoculation primary tumors were removed from the control group and animals treated with 200 nM tetrodotoxin and then, kinetic parameters were determined. In addition, the effect of tetrodotoxin on secondary tumors were assessed by the number of metastases in the lungs which were removed from rats at the twenty first and twenty fifth days.
This study shows that tetrodotoxin inhibits prostate tumor growth and reduces the number of metastases in vivo.
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