The 20th International Taurine Meeting Taurine and Brain Health program and abstracts may 23-27, 2016 The Plaza Hotel Seoul, korea by the Organizing Committee of the 20

Effects of Taurine on Obesity, Diabetes and Nutrition

Chairperson: Stephen Schaffer (University of South Alabama, USA) & Kyung Ja Chang (Inha University, Korea)

9:00 - 9:25 Oral Presentation 11

Is the lower taurine levels in the white adipose tissue of the obese mice ameliorated by endurance training?

Ohmori H¹, Yamamoto D¹, Ebina K¹, Ishikura K², Komine S¹, Miyazaki T³, Ono T¹, Miyakawa S<sup>1

1</sup>University of Tsukuba, Japan; ²Sojo University, Japan; ³Tokyo Medical University Ibaraki Medical Center, Japan

9:25 - 9:50 Oral Presentation 12

Taurine intake with magnesium reduces cardiometabolic risks

Yukio Yamori¹, Miki Sagara², Yoshimi Arai³, Hitomi Kobayashi³, Kazumi Kishimoto³, Ikuko Matsuno³, Hideki Mori¹, Mari Mori¹

¹Institute for World Health Development, Mukogawa Women’s University, Nishinomiya, Japan; ²Laboratory of Preventive Nutritional Medicine, Research Institute for Production and Development, Kyoto, Japan; ³Hyogo Prefecture Health Promotion Association, Kobe, Japan

9:50 – 10:15 Oral Presentation 13

Comparison of toxicity of taurine and GABA in combination with alcohol in 7-day-old mice

Andrey G. Taranukhin¹, Pirjo Saransaari¹, Kalervo Kiianmaa², Teemu Gunnar³ and Simo S. Oja¹

¹Medical School, University of Tampere, Tampere, Finland, ²Department of Alcohol, Drugs and Addiction, National Institute for Health and Welfare, Helsinki, Finland, ³Alcohol and Drug Analytics Unit, National Institute for Health and Welfare, Helsinki, Finland

10:15 – 10:35 Coffee Break

10:35 - 12:00 Session IX

Taurine for Energy Production and Muscle

Chairperson Shigeru Murakami (Fukui Prefectural University, Japan) & Kyung Soon Choi (Sahmyook University, Korea)

10:35 - 11:10 Lecture 10

The taurine deficient heart is energy deficient

Stephen Schaffer¹, Kayoko Shimada-Takaura¹, Chian Ju Jong¹, Takashi Ito², Kyoko Takahashi³

¹Department of Pharmacology, University of South Alabama College of Medicine, Mobile, AL, USA
²School of Pharmacy, Hyogo University of Health Sciences, Kobe, Japan
³Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan

11:10 - 11:35 Oral Presentation 14

The role of N-acetyltaurine on the normalization of energy metabolism balance in the skeletal muscle after endurance exercise

Teruo Miyazaki¹, YuhoNakamura², KeiEbina², TakakiMizushima², Song-GyuRa³, KeisukeIshikura⁴, YasushiMatsuzaki¹, HajimeOhmori², Akira Honda<sup>1

1</sup>Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan, ²University of Tsukuba, Tsukuba, Ibaraki, Japan, ³Fukuoka University, Fukuoka, Japan, and ⁴Sojo University, Kumamoto, Japan.

11:35 - 12:00 Oral Presentation 15

The effect of maternal taurine supplementation on gestational protein restriction in newborn skeletal muscle in Wistar rats

Lea Hüche Larsen, Sofie Sandø-Pedersen, Laura Kofoed Hvidsten Ørstrup, Niels Grunnet, Bjørn Quistorff and Ole Hartvig Mortensen

Department of Biomedical Sciences, University of Copenhagen, Denmark

12:00 – 13:00 Lunch at Maple Hall

13:00 – 17:30 Dong-A Socio Holdings &Suwon Hwaseong

Visiting Dong-A Socio Holdings Research Institute (1 hr)

Tour in Suwon: Suwon Hwaseong (UNESCO Culture, 40 min)

17:30 – 20:00 Farewell Party at Han River Restaurant (Chavit Cuisine)

Friday, May 27 (Maple Hall, 4F)

9:00 - 10:00 Session X

Taurine and Brain Health IV

Chairperson: Eunkyue Park (NYS Institute for Basic Research in DD, USA) & Sung Hoon Kim (Konkuk University, Korea)

9:00 – 9:35 Lecture 11

Ethanol, taurine and dopamine – a rewarding relationship

Mia Ericson, Lisa Ulenius, Louise Adermark, Bo Söderpalm

Addiction Biology Unit, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Sweden

9:35 – 10:00 Oral Presentation 16

Antenatal taurine improves neural axon development in featl rats with intrauterine growth restriction by inhibiting the activity of Rho-ROCK signaling pathway

Jing Liu, Zu-Lin Lu, Wei Fu

Department of Neonatology & NICU of Bayi Children’s Hospital, Beijing Military General Hospital. Beijing 100700, China

10:00 – 10:20 Coffee Break

10:20 - 12:25 Session XI

Taurine and Brain Health V

Chairperson: Mia Ericson (University of Gothenburg, Sweden) & KyoungSoo Kim (Kyung Hee University Hospital, Korea)

10:20 – 10:55 Lecture 12

Taurine as a treatment in neurodegenerative diseases and other neurological disorders

Annette K Offringa-Hup

Vitamine B12 Institute NL, Westervoort, The Netherlands

10:55 – 11:20 Oral Presentation 17

GABAA receptor activation by maternally-derived taurine underlies the temporal regulation of cellular properties of the neural stem cells in the mouse developing cortex

Shiro Tochitani^1,2,3,4,5, Tomonori Furukawa^6,7, Ryo Bando^4,5, Shigeaki Kondo^4,5, Takashi Ito⁸, Yoshitaka Matsushima⁹, Toshio Kojima¹⁰, Hideo Matsuzaki^1,2,3, Atsuo Fukuda<sup>6

1</sup>Division of Development of Mental Functions, Research Center for Child Mental Development, University of Fukui, Fukui 910-1193, Japan; ²Division of Developmental Higher Brain Functions, United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka 565-0871, Japan; ³Research and Education Program for Life Science, University of Fukui, Fukui910-8507, Japan; ⁴Department of Anatomy and Developmental Neurobiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima770-8503, Japan; ⁵Student Lab, The University of Tokushima Faculty of Medicine, Tokushima770-8503, Japan; ⁶Department of Neurophysiology, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan; ⁷Department of Neurophysiology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan; ⁸SchoolofPharmacy, Hyogo University of Health Sciences, Kobe 650-8530, Japan; ⁹Department of Applied Biology and Chemistry, Tokyo University of Agriculture, Tokyo156-8502, Japan; ¹⁰Health Care Center, Toyohashi University of Technology, Toyohashi 441-8580, Japan

11:20 – 11:45 Oral Presentation 18

Taurine recovery of learning deficits induced by developmental Pb2+ exposure

Lorenz S. Neuwirth^1-6, Nicholas P. Volpe^4-5, Chuyon Corwin^4-6, Simon Ng³, Navita Madan³, Alyssa M. Ferraro³, Yevgeniy Furman³ and Abdeslem El Idrissi<sup>4-6

1</sup>Department of Psychology, SUNY Old Westbury, NY, USA
²SUNY Neuroscience Research Institute, SUNY Old Westbury, NY, USA
³DepartmentofPsychology, The College of Staten Island CUNY, NY, USA
⁴DepartmentofBiology, The College of Staten Island CUNY, NY, USA
⁵The Center for Developmental Neuroscience, The College of Staten Island CUNY, NY, USA
⁶Department of Biology The CUNY Graduate Center, NY, USA

11:45– 12:05 Closing Remarks by Stephen Schaffer (University of South Alabama, USA)

12:05 – 12:25 Announcement for Next International Taurine Meeting

Dr. Fengyuan Piao (Dalian Medical University, China)

Dr. Jianmin Hu (Shenyang Agricultural University, China)

12:25 – 14:00 Lunch at Maple Hall

14:00 – 18:00 Seoul City Tour (Gyeongbokgung, Folklore Museum, Bukchon Hanok Village and Insa-dong street for foreigners)

18:00 – 20:00 Dinner at Korean Restaurant (Kejeol Babsang Restaurant at Insa-dong)

Poster Session I

May 24, Tuesday (09:00-18:00)

*Standing Time: 17:15 – 18:00
P1-1 Taurine protection effort on cisplatin-induced nephrotoxicity by decreasing oxidative DNA damage and inflammation: an immunocytochemical study

Masahiro Tsunekawa1, Shumin Wang¹, Toshihiro Kato², Takenori Yamashita³, Ning Ma<sup>1

1</sup>Faculty of Nursing Science, Suzuka University of Medical Science, Suzuka 513-8670, Mie, Japan
²Sport Medical Center, Suzukakaisei Hospital, Suzuka 513-0836, Mie, Japan
³Faculty of Health Science, Suzuka University of Medical Science, Suzuka 510-0293, Mie, Japan
P1-2 Effects of taurine on Down syndrome model of Caenorhabditis elegans

Youn Jung Ko¹, Dong Hee Lee²

Department of Life Science, University of Seoul, 163 Siripdaegil, Dongdaemun-Gu, Seoul, Korea
P1-3 Perinatal taurine supplementation alters renal function via renin-angiotensin system overactivity in adult female rats

Sanya Roysommuti¹ and Wichaporn Lerdweeraphon¹^,²

¹Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
²Faculty of Veterinary Medicine, Mahasarakham University, Mahasarakham 44000, Thailand.
P1-4 Taurine supplementation improves sugar-increased renal sympathetic nerve activity related to renin release in adult male rats

Sasipa Rakmanee¹, Supaporn Kulthinee¹^,², and Sanya Roysommuti¹

¹Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
²Department of Community Public Health, Faculty of Science and Technology, Rajabhat Mahasarakham University, Mahasarakarm 44000, Thailand
P1-5 Taurine Attenuates Epithelial-Mesenchymal Transition-related Genes in Human Prostate Cancer Cells

Yujiao Tang¹,², Eun-Ju Choi³, Young Joung Hwang⁴, Pyo-Jam Park⁵, Sang-Ho Moon¹,², Eun-Kyung Kim¹,²,*

¹Division of Food Bio Science and ²Korea Nokyong Research Center, Konkuk University, Chungju, Korea;
³Division of Sport Science, Konkuk University, Chungju, Korea;
⁴Department of Food Science & Culinary, International University of Korea, Jinju, Korea;
⁵Department of Biotechnology, Konkuk University, Chungju, Korea
P1-6 Inhibitory Effects of Taurine on Migration in Human Lung Cancer Cells

Yujiao Tang¹,², Eun-Ju Choi³, Pyo-Jam Park⁴, Sang-Ho Moon¹,², Eun-Kyung Kim¹,²*

¹Division of Food Bio Science and ²Korea Nokyong Research Center, Konkuk University, Chungju, Korea
³Division of Sport Science, Konkuk University, Chungju, Korea
⁴Department of Biotechnology, Konkuk University, Chungju, Korea
P1-7 The Effect of Radiation on the Expression of Taurine Transporter in Mouse

Takenori Yamashita¹, Toshihiro Kato^1,2, Masahiro Tunekawa¹, Yeunhwa Gu³, Ning Ma<sup>1

1</sup>Faculty of Health Science, Suzuka University of Medical Science, Kishioka, Suzuka, Mie, 510-0293, Japan.
²Sport Medical Center, Suzukakaisei Hospital, Koucho, Suzuka, Mie, 513-0836, Japan.
³Faculty of Health Seience, Junshin Gakuen University, Chikushigaoka, Minamiku, Fukuoka, 815-8510, Japan.
P1-8 Investigation of the role of a supplementation with taurine on the effects of hypoglycemic-hypotensive therapy against diabetes-induced nephropathy in rats

Kashyap Pandya, Cesar A. Lau-Cam

Department of Pharmaceutical Sciences, St. John’s University, College of Pharmacy and Health Sciences, Jamaica, New York 11439, USA
P1-9 The effect of metformin and taurine, alone and in combination, on the oxidative stress caused by diabetes in the brain of rats

George J. Clark, Kashyap Pandya,Cesar A. Lau-Cam

Department of Pharmaceutical Sciences, St. John’s University, College of Pharmacy and Health Sciences, Jamaica, New York 11439, USA
P1-10 The effect of taurine and its immediate homologs on diabetes-induced oxidative stress in the brain and spinal cord of rats

Sanket N. Patel, Cesar A. Lau-Cam

Department of Pharmaceutical Sciences, St. John's University, College of Pharmacy and Health Professions, Jamaica, New York 11439, USA
P1-11 Taurine inhibits the activation of Kupffer cells induced by Lipopolysaccharide in Alcoholic liver damaged rats

Gaofeng Wu, Riyi Tang, Jiancheng Yang, Yang Yu, Shumei Lin, Qunhui Yang, Qiufeng Lv, Jianmin Hu*

College of Animal Science & Veterinary, Shenyang Agricultural University, Shenyang, China
P1-12 Taurine inhibits oxidative stress and apoptosis of hepatocytes induced by alcohol in rats

Riyi Tang, Gaofeng Wu , Wenying Jing, Jiancheng Yang, Shumei Lin, Qunhui Yang, Qiufeng Lv, Jianmin Hu*

College of Animal Science & Veterinary, Shenyang Agricultural University, Shenyang, China
P1-13 Effect of taurine supplement on metabolomics profiling of dyslipidemia in high-fat diet induced-rat model by ¹H-NMR MS spectroscopy

Kyoung Soo Kim¹,Hyung-In Yang¹, Eun Jung Bang²

¹East-West Bone and Joint Disease research Institute, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea
²Integrated Metabolomics Research Group, Western Seoul Center, Korea Basic Science Institute, Seoul, Republic of Korea.


P1-14 Antioxidant effects of short-neck clam (Tapes philippinarum) water extract containing taurine against AAPH-induced oxidative stress in zebrafish embryos

Dong-Sung Lee¹, Ki Han Kwon², Sun Hee Cheong³

¹College of Pharmacy, Chosun University, Dong-gu, Gwangju, 61452, Republic of Korea; ²Department of Food Science and Nutrition, College of Health, Welfare, and Education, Gwangju University, Gwangju 61743, South Korea and ³Department of Marine Bio Food Science, College of Fisheries and Ocean Science, Chonnam National University, Yeosu 550-749, Republic of Korea
P1-15 Mussel (Mytilus coruscus) water extract containing taurine prevents LPS-induced inflammatory responses in zebrafish model

Sun Hee Cheong¹, Ki Woong Kim¹, Ki Han Kwon², Dong-Sung Lee³

¹Department of Marine Bio Food Science, College of Fisheries and Ocean Science, Chonnam National University, Yeosu 550-749, Republic of Korea; ²Department of Food Science and Nutrition, College of Health, Welfare, and Education, Gwangju University, Gwangju 61743, South Korea and ³College of Pharmacy, Chosun University, Dong-gu, Gwangju, 61452, Republic of Korea
P1-16 Taurine provides neuroprotection against oxidative stress-induced mouse hippocampal HT22 cell damage through the Nrf2 and MAPK pathways

Dong-Sung Lee¹, Sun Hee Cheong²

¹College of Pharmacy, Chosun University, Dong-gu, Gwangju, 61452, Republic of Korea and ²Department of Marine Bio Food Science, College of Fisheries and Ocean Science, Chonnam National University, Yeosu 550-749, Republic of Korea
P1-17 Taurine chloramine inhibits lipopolysaccharide-induced neuroinflammatory responses through Nrf2-mediated heme oxygenase-1 expression in mouse BV2 microglia cells

Dong-Sung Lee¹, Ki Woong Kim², Sun Hee Cheong²

¹College of Pharmacy, Chosun University, Dong-gu, Gwangju, 61452, Republic of Korea and ²Department of Marine Bio Food Science, College of Fisheries and Ocean Science, Chonnam National University, Yeosu 550-749, Republic of Korea
P1-18 Effects of Taurine on Endurance Capacity and Physical Fatigue in Trained Mice

Eun-Kyung Kim¹,², Yujiao Tang¹,², Young-Jin Choi¹, Eun-Ju Choi³

¹Division of Food Bio Science and ²Korea Nokyong Research Center, Konkuk University, Chungju, Korea
³Division of Sport Science, Konkuk University, Chungju, Korea
P1-19 Antioxidative Effects of Taurine on Hepatic System and Muscle Fatigue after High Intensity Workout in Mice

Eun-Kyung Kim¹^,², Yujiao Tang¹,², Young-Jin Choi¹, Eun-Ju Choi³

¹Division of Food Bio Science and ²Korea Nokyong Research Center, Konkuk University, Chungju, Korea
³Division of Sport Science, Konkuk University, Chungju, Korea
P1-20 Effect of taurine on iNOS-mediated DNA damage in drug-induced renal injury

Toshihiro Kato¹, Masahiro Tsunekawa², Shumin Wang², Takenori Yamashita³, Ning Ma<sup>2

1</sup>Sport Medical Center, Suzukakaisei Hospital, Suzuka 513-0836, Mie, Japan
²Faculty of Nursing Science, Suzuka University of Medical Science, Suzuka 513-8670, Mie, Japan
³Faculty of Health Science, Suzuka University of Medical Science, Suzuka 510-0293, Mie, Japan

P1-21 Effects of taurine on spermioteleosis in rats

Jiancheng Yang, Gaofeng Wu, Shu zhang, Qiufeng Lv, Shumei Lin and Jianmin Hu

College of Animal Science & Veterinary Medicine, University of Shenyang Agricultural University, Shenyang, Liaoning Province, P.R.China
P1-22 Effects of taurine on hyperuricemic rats with kidney injury

Ying Feng, Jiancheng Yang, Yongchao Gao, Gaofeng Wu, Shumei Lin，Jianmin Hu

College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, P.R.China
P1-23 Effects of taurine on spermatogenesis in rats

Jiancheng Yang, Gaofeng Wu, Meng zhang, Qiufeng Lv, Shumei Lin and Jianmin Hu

College of Animal Science & Veterinary Medicine, University of Shenyang Agricultural University, Shenyang, Liaoning Province, P.R.China
P1-24 Is Taurine a Biomarker in Autism?

Eunkyue Park¹, Ira Cohen², Maripaz Gonzalez², Mario Castellano³, Michael Flory⁴, Edmund C. Jenkins⁵, W. Ted Brown⁵, and Georgia Schuller-Levis¹

Departments of Developmental Neurobiology¹, Psychology², Infant Development⁴, and Human Genetics⁵, NY State Institute for Basic Research in Developmental Disabilities, Staten Island NY 10314, United States, ³Division of Hematology/Oncology, Department of Medicine, Staten Island University Hospital, Staten Island, NY 10305, United States
P1-25 Taurine normalizes the essential trace elements levels in mouse liver and kidney subchronic exposure to arsenic

Cong Zhang¹, Shuangyue Li², Fengyuan Piao<sup>2

1</sup>Department of Nutrition and Food Safety, Dalian Medical University, PR China
²Department of Occupational and Environmental of Health, Dalian Medical University, PR China
P1-26 Taurine content in Japanese seaweed

Azusa Kawasaki¹, Ayuko Ono¹, Shoshi Mizuta², Mitsunobu Kamiya², Shigeru Murakami¹

¹Department of Bioscience, Fukui Prefectural University, Fukui, Japan
²Department of Marine Bioscience, Fukui Prefectural University, Obama, Japan
P1-27 Taurine reduced the duration of AF induced by CaCl2- Ach in rats through inhibiting the atrial electrical remodeling

Qunhui Yang , Man Feng, Jiancheng Yang, Gaofeng Wu, Ying Feng, Qiufeng Lu, Shumei Lin, Jianmin Hu

College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, China
P1-28 A Study on Blood Lipid and Leptin Change of a White Rat in a High-fat Diet with Taurine 10%

Kyung-Soon Choi¹, Kyung-Ok Shin²

¹²Dept. of Food and Nutrition, Sahmyook University, Seoul 01795, Korea
P1-29 The effect on blood lipid concentration and liver-function improvement of a white rat in a high-fat diet with taurine 20%

Kyung-Soon Choi¹, Kyung-Ok Shin¹, Ha Won Kim²

¹Dept. of Food and Nutrition, Sahmyook University, Seoul 01795, Korea; ²Dept. of Life Science, University of Seoul, Seoul 02504, Korea
P1-30 Taurine supplementation in perinatal period on maternal diabetes mellitus prevents development of diabetes mellitus (DM) and hypertension in the offspring during adulthood.

Punyaphat Teangphuck¹, Rungrudee Srisawat¹, Sanya Roysommuti², Atcharaporn Thaeomor<sup>1

1</sup>School of Preclinic, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, 30000, Thailand.²Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40000, Thailand
P1-31 Sex dependent effects of taurine supplementation in maternal diabetic mellitus on developments diabetic mellitus and hypertension in adult offspring

Atcharaporn Thaeomor¹, Janeyuth Chaisakul², Suphaket Seanthaweesuk³, Nuntiya Somparn³, Sanya Roysommutti<sup>4

1</sup>School of Preclinic, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, 30000, Thailand.²Department of Pharmacology, Phramongkutklao College of Medicine, Bangkok, 10400, Thailand.³Department of Preclinic Science, Faculty of Medicine, Thammasat University, Rangsit Campus, Khlong Luang, Pathum Thani, 12120, Thailand.