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fMRI Fluctuations & Connectivity
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fMRI Fluctuations & Connectivity Hall B Monday 14:00-16:00 1167. Comparison of BOLD Response Modulation During Pain Stimulation and Resting-State Conditions Under Intravenous (0.2 Mg/70kg) or Sublingual (2 Mg) Buprenorphine Treatment Jaymin Upadhyay1,2, Julie Anderson1,2, Adam J. Schwarz1,3, Richard Baumgartner1,4, Alexandre Coimbra1,5, Lauren Nutile1,2, James Bishop1,2, Ed George1,6, Brigitte Robertson1,7, Smriti Iyengar1,3, David Bleakman1,3, Richard Hargreaves1,5, Lino Becerra1,2, David Borsook1,2 1Imaging Consortium for Drug Development, Harvard Medical School, Belmont, MA, United States; 2P.A.I.N. Group; Brain Imaging Center, McLean Hospital, Belmont, MA, United States; 3Lilly Research Department, Eli Lilly and Company, Indianapolis, IN, United States; 4Biometrics Research Department, Merck Research Laboratories, Rahway, NJ, United States; 5Imaging Department, Merck Research Laboratories, West Point, PA, United States; 6Department of Anesthesiology and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States; 7Sepracor, Inc., Marlborough, MA, United States Buprenorphine is commonly prescribed to treat pain. We implemented blood oxygenated-level dependent (BOLD) functional MRI to characterize and compare the effects of 2.0 mg (sublingual), 0.1 mg/70kg (intravenous) and 0.2 mg/70kg (intravenous) doses of buprenorphine on the central nervous system during pain processing and during the resting state. During pain processing, the 2.0 mg (sublingual) and 0.2 mg/70kg (intravenous) doses significantly (p<0.01) potentiated the BOLD response in regions such as the striatum, while attenuated the BOLD response in somatosensory cortices. Furthermore, the resting-state connectivity for sublingual and intravenous doses of buprenorphine were also altered among structures that mediate pain processing. 1168. Depth-Resolved Laminar Analysis of Resting-State Fluctuation Amplitude in High-Resolution 7T FMRI Jonathan Rizzo Polimeni1, Douglas N. Greve1, Bruce Fischl1,2, Lawrence L. Wald1,3 1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, United States; 2Computer Science and AI Lab (CSAIL), Massachusetts Institute of Technology, Cambridge, MA, United States; 3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States While voxels as small as 0.75 mm isotropic provide sufficient SNR for high-field fMRI, voxels falling within cortical gray matter voxels are still influenced by partial-volume contamination with white matter and CSF, which contribute different levels of physiological noise. Here we characterize the impact of partial-volume effects as a function of cortical depth on the resting-state fluctuation amplitudes at 7T. Even after partial-volume effects are taken into account, the magnitude of resting state fluctuations increases with proximity to the pial surface. This suggests that laminar differences in the resting-state fluctuations exist and may reflect increasing dominance of extravascular BOLD signal changes surrounding large pial vessels. 1169. Functional Connectivity During Memory Consolidation: A Resting-State FMRI Study Chia-Wei Li1, Ke-Hsin Chen2, Tai-Li Chou2,3, Keng-Chen Liang2,3, Ya-Chih Yu1, Chang-Wei Wu1, Jy-Horng Chen1,3 1Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan, Taiwan; 2Department of Psychology, National Taiwan University, Taipei, Taiwan; 3Center for Neurobiology and Cognitive Science, National Taiwan University, Taipei, Taiwan Memory consolidation is a process which stabilizes a short-term memory into a long-term memory. Consolidation occurs after the initial learning lasting for a period of time. In this study, we employed resting-state experiment design to reveal the functional connectivity among hippocampus, PCC, and MTG during consolidation of memorizing easy and difficult words that would result in good and poor memory respectively. As seeds set at three ROIs, we detected increase connection with cuneus in the hard condition, implying the engagement of visual analysis; increment in connection with cerebellum and frontal cortex in the easy condition, reflecting the on-going consolidated activity. 1170. Assessing Functional Connectivity Measures at 3T and 7T Joanne Rachel Hale1, Matthew Jon Brookes1, Emma Louise Hall1, Susan T. Francis1, Peter Gordon Morris1 1SPMMRC, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom Functional connectivity, implied by inter-region correlation, has been reported in resting state BOLD activity. It is well known that as magnetic field strength is increased, BOLD contrast to noise is improved, implying that a move to high field would benefit functional connectivity measurement. However, fMRI signals are affected by non-neuronal artifacts which increase with field strength making the advantage of 7T questionable. Here, we assess non-neuronal physiological artifacts in 3T and 7T resting state data. Results show that sensorimotor cortex connectivity can be measured accurately and at high spatial resolution at 7T with little contribution from non-neuronal physiological artifact. 1171. Prediction of Functional Connectivity from Structural Brain Connectivity Fani Deligianni1, Emma C. Robinson1, Christian F. Beckmann1, David Sharp1, A. David Edwards1, Daniel Rueckert1 1Imperial College London, London, United Kingdom Studies that examine the relationship of functional and structural connectivity are important in interpreting neurophysiological data. Although, a linear relationship between functional and structural connectivity has been demonstrated, there is no explicit attempt to quantitatively measure how well functional data can be predicted from structural data. Here, we predict functional connectivity from structural connectivity by utilizing a predictive model based on principal component analysis (PCA) and canonical correlation analysis (CCA). 1172. Resting-State Functional Connectivity Strength Depends on the Magnitude of Resting BOLD Fluctuations and Not Differences in CBF Anna Leigh Rack-Gomer1,2, Joy Liau3, Thomas T. Liu1,2 1Bioengineering, UC San Diego, La Jolla, CA, United States; 2Center for Functional MRI, UC San Diego, La Jolla, CA, United States; 3School of Medicine , UC San Diego, La Jolla, CA, United States Interpretation of inter-subject differences in resting-state functional connectivity is complicated by the BOLD signal’s dependence on vascular factors. We found functional connectivity strength to be correlated with resting-state fluctuation amplitude (RSFA) across healthy subjects, where RSFA has previously been shown to correspond to vascular reactivity within subjects. However, we did not find RSFA to be related to either the task-related cerebral blood flow (CBF) response or baseline CBF, suggesting that RSFA does not indicate vascular differences across subjects. Instead, RSFA may reflect true differences in spontaneous neural activity, which contribute to the normal variability found in resting-state functional connectivity. 1173. Spontaneous Increase in Neuronal Activity in the Resting State Is Associated with Increase in Blood Oxygenation Shmuel Na'aman1, Sebastien Thomas1, Mirza Baig1, Peter O'Connor1, Amir Shmuel1,2 1MNI, Dept. of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada; 2Center for MR Research, U. of Minnesota, Minneapolis, MN, United States Recent studies have demonstrated large amplitude spontaneous slow (< 0.1 Hz) fluctuations in functional-MRI (fMRI) signals in humans in the resting state. Despite the large body of human imaging literature on spontaneous activity and functional-connectivity in the resting state, the link to underlying neural activity remains tenuous. We show that spontaneous neurophysiological activity in rat S1FL includes events in which changes in local field potentials across cortical layers resemble the corresponding changes in response to sensory stimulation. These spontaneous neurophysiological events are accompanied by increases in blood oxygenation that peak approximately 5 s following the events. 1174. Resting-State FMRI After Experimental Hemispherectomy in Rats: Changes in Functional Connectivity and Network Synchronization Willem M. Otte1,2, Rick M. Dijkhuizen2, Peter C. van Rijen1, Peter H. Gosselaar1, Maurits P.A. van Meer1,2, Onno van Nieuwenhuizen1, Kees P.J. Braun1 1Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, Netherlands; 2Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands Hemispherectomy is a last resort treatment for catastrophic hemispheric epilepsy. The remarkable motor recovery after hemispherectomy reflects the plastic capacities of the brain. We studied the remaining brain in hemispherectomized rats, 7 and 49 days post surgery using resting-state fMRI, graph analysis and interregional connectivity. The sensorimotor cortex and striatum in the healthy contralesional hemisphere exhibited significantly increased functional connectivity after surgery. The graph analysis results assume a shift toward a more regular network organization. We have shown that rs-fMRI, connectivity analyses and specific network measures can provide unique insights into functional reorganization in the remaining brain after experimental hemispherectomy. fMRI: Neuroscience Hall B Tuesday 13:30-15:30 1175. The Non-Linear Dynamic Characteristics of Olfactory BOLD ResponseΞ Christopher W. Weitekamp1, Jianli Wang1, Paul J. Eslinger2,3, Jeffrey Vesek1, Xiaoyu Sun1, James R. Connor4, Qing X. Yang1,4, Jianzhong Yin1, Martin A. Lindquist5 1Radiology, Penn State University College of Medicine, Hershey, PA, United States; 2Neurology, Penn State University College of Medicine, Hershey, PA, United States; 3Neural & Behavioral Sciences, Penn State University College of Medicine, Hershey, PA, United States; 4Neurosurgery, Penn State University College of Medicine, Hershey, PA, United States; 5Statistics, Columbia University, New York, NY, United States This study examined the dynamic nonlinear BOLD response pattern in the primary olfactory cortex (POC) and associated brain structures during an olfactory fMRI paradigm. An intricate relationship among perception threshold, sensitivity, and habituation of the human olfactory system challenges the fundamental assumption of linearity in BOLD response. The goal of this study was to emphasize an unconventional nonlinear model of BOLD response through the use of olfactory fMRI and to suggest that such dynamic characteristics may extend to other neuronal systems with a feedback mechanism, profoundly impacting fMRI data acquisition/analysis and its clinical applications. 1176. The Dependency of Age-Related Change of Brain Activation on the Visual Stimuli - Demand-Reservation Balance Toshiharu Nakai1, Makoto Miyakoshi1, Epifanio Bagarinao1, Masaki Yoshida2, Chikako Nakai3, Kayako Matsuo4 1Functional Brain Imaging Lab, National Center for Geriatrics and Gerontology, Ohbu, Aichi, Japan; 2Ophthalmology, The Jikei University, Tokyo, Japan; 3School of Health Sciences, Toyoshashi Sozo University, Toyohashi, Aichi; 4Psychology, National Taiwan University, Taipei, Taiwan We evaluated the effect task demand for visual processing on the age-related change of the brain activation in healthy subjects. In the elderly subjects, the % HRF in V1 was reduced by the flickering checkerboard stimuli. By a visuo-motor translation task the % HRF in BA19/7/39 was increased in the elderly, while no significant difference of % HRF was detected between the two age groups in V1. HRF analysis suggested that age-related change of % HRF may depend on the existence of neuronal network to compensate the potential functional decline according to aging. 1177. Acute Vs. Tonic Muscular Pain: Changes in Cerebral Blood Flow as Imaged by Arterial Spin Labeling Daron Gordon Owen1,2, Collin Franklin Clarke3, Sugantha Ganapathy3, Frank S. Prato1,4, Keith S. St. Lawrence1,2 1Imaging Program, Lawson Health Research Institute, London, Ontario, Canada; 2Medical Biophysics, The University of Western Ontario, London, Ontario, Canada; 3Anesthesia and Perioperative Medicine, The University of Western Ontario, London, Ontario, Canada; 4Imaging, St. Joseph's Hospital, London, Ontario, Canada The cerebral representation of acute pain is well established, whereas that of tonic pain is not due to difficulties in applying functional imaging to prolonged stimuli. We used arterial spin labeling (ASL) to investigate the neural activation associated with tonic muscular pain. The use of ASL allows direct comparison between studies. Compared to our previous study incorporating both acute and tonic phases, we observed smaller CBF changes, and only in bilateral insula and frontal gyrus, despite similar pain levels. A likely explanation is that the acute phase of the previous study induced anxiety and distress, whereas our tonic pain stimulus did not. 1178. Age and Gender Effects on Whole Brain Cerebral Blood Flow in Adolescents Ai-Ling Lin1, Timothy Q. Duong1, Peter T. Fox1, Douglas E. Williamson2 1Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States; 2Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States Both gender and have long been assumed to have effects on brain function and cerebral blood flow (CBF). However, the effects of gender and age on CBF have not well explored in adolescents. To increase our knowledge in this area, MRI techniques were employed to measure global CBF with 267 adolescents. Our result shows that significant difference in CBF was observed between 12 and 15 years of age. However, no significant main effects of gender were found in the study. The results provide better understanding of brain functions for adolescent across age and gender. 1179. A FMRI Study of Temporary Hearing Threshold Shift Piotr Bogorodzki1, Tomasz Wolak2, Krzysztof Kochanek2, Ewa Piatkowska-Janko1, Piotr Skarzynski2, Adam Pilka2, Jozef Kotus3, Andrzej Czyzewski3 1Institute of Radioelectronics, Warsaw University of Technology, Warsaw, Poland; 2Institute of Physiology and Pathology of Hearing; 3Gdansk University of Technology, Gdansk, Poland Several empirical studies have shown, that long lasting acoustic noise exposure causes on humans effect called Temporary Hearing Threshold Shift (TTS). This work presents results from 15 healthy subjects participating in a fMRI study of TTS consisting of two runs: ⣣pre⣣ with silent GE EPI scanning and ⣣post⣣ identical to ⣣⣣pre⣣, but after 15min high volume noise exposure (causing a mean 12 dB TTS effect). Group level analysis showed activations in auditory cortex (T=13.3 in lh, and 10.45 in rh). A two-sample T-test fails for post>pre contrast, however detailed ROI analysis shows differences in sub-auditory areas. 1180. Functional Imaging of Observation of Action in Elite Archers Using Video of Western-Style Archery Task Hui-jin Song1, Joo-hyun Kim1, Jeehye Seo1, Moon-jung Hwang2, Young-ju Lee2, Kyung Jin Suh3, Sung Woo Kim3, Young Hwan Lee4, Dong Soo Yoo5, Yongmin Chang1,6 1Medical & Biological Engineering, Kyungpook National University, Daegu, Korea, Republic of; 2GE healthcare, Seoul; 3Dongguk University, Gyungju; 4Radiology, College of Medicine, Catholic University, Daegu; 5Radiology, College of Medicine, Dankook University, Chunan; 6Diagnostic Radiology, Kyungpook National University, Daegu, Korea, Republic of Although the mirror neuron system has been extensively studied, no functional imaging data are currently available to gain insight in the possible difference of the mirror system between experts and novices. Therefore, the aim of the present study is to investigate the differences of activation in the mirror neuron system during viewing tool use familiar to experts between expert archers and novice subjects. Our results demonstrated that expert archers showed strong activation in the mirror neuron system during viewing videos of Western-style archery relative to inexpert control subjects. Taken together, our data consistent with previous reports suggest that human mirror neuron system could contain representations of tool use and expand motor repertoire with tool use experiences. 1181. Localization of the Hand Motor Area Using BOLD and ASL FMRI Marco Pimentel1, Pedro Vilela2, Inês Sousa3,4, Patricia Figueiredo3 1Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Lisbon, Portugal; 2Imaging Department, Hospital da Luz, Lisbon, Portugal; 3Instituto Superior Técnico, Lisbon, Portugal; 4Healthcare Sector, Siemens, S.A., Portugal Previous studies have shown that ASL-based fMRI exhibits better spatial specificity than the most commonly used BOLD contrast. Here, we compared the localization of the hand motor area obtained by simultaneous ASL-BOLD fMRI and standard BOLD fMRI at 3T with well established anatomical landmarks, in a group of 15 healthy subjects. Our results indicate that the localization of the hand motor area obtained using ASL fMRI is significantly less variable and closer to the hand motor cortex anatomical landmarks than the one produced by BOLD fMRI. This supports the notion that ASL may more accurately localize brain activation than BOLD. 1182. Understanding Consciousness from Information and Integration Within the Thalamocortical System Xiaolin Liu1, Jingsheng Zhou2, Anthony G. Hudetz3, Shi-Jiang Li1 1Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States; 2Rehabilitation Department, Xuanwu Hospital Capital Medical University, Beijing, China; 3Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, United States Understanding the neural mechanisms of consciousness requires identification of the nature of contributions from each of the potential neural correlates, which together generate a complete cognitive experience. We examined the specific and nonspecific thalamic connections in the brain based on the neuroanatomical findings implicating their respective functional roles in sustaining information and integration, which are essential to consciousness. Our results endorse the view that the thalamocortical system is essential to consciousness, and support the hypothesis that the nonspecific thalamic connections largely reflect brain regions that are responsible for information integration, potentially sustaining various awareness functions. 1183. Examining Structure and Function in a Cognitive Task Jeffrey Thomas Duda1, Corey McMillan, Murray Grossman, James Gee 1Bioengineering, University of Pennsylvania, Philadelphia, PA, United States Structure and function are examined in the language network with DT-MRI and BOLD fMRI during a cognitive task. Activated cortical regions are identified and used to determine activation levels in each subject. Additionally, the regions are used to identify fiber tracts of interest. Canonical correlation analysis is used to identify correlations between functional activation and average fractional anisotropy in the fiber tracts. For each correlation found, the highest weightings are found for cortical regions and a tract that connects to that region. 1184. Effects of FMRI Acoustic Scanner Noise on Neural Processing Networks During Task Performance and Rest Dave Langers1, Pim van Dijk1 1Otorhinolaryngology, University Medical Center Groningen, Groningen, Netherlands Scanner acoustic noise may detrimentally affect stimulus/task-evoked neural responses in fMRI. This has been reported for the unimodal and associative auditory systems, but also for the default mode network and other brain systems. In the current experiment, the effects of scanner noise in resting state fMRI are studied. We find that similar independent components may be extracted with and without background scanner noise, both during active and resting states. However, the overall strength, spatial extent, and temporal dynamics of various neural components are affected by the presence of background noise. Our results both corroborate and extend previous findings in literature. More detailed specific findings for various brain systems will be presented.
Can we use patterns of brain activity to detect when someone is feigning a hearing loss? To answer this question, we asked 15 adult participants to respond to pure tones and simple words correctly, incorrectly, randomly, or with the intent to feign a hearing loss. 1186. An FMRI Study of Memory Performance in Type 2 Diabetes Mellitus: A Twin Study Amanda Wood1, Jian Chen2,3, Thanh G. Phan2, Kimberlea Cooper2, Stacey Litras2, Srikanth Velandai2 1Developmental and Functional Brain Imaging,Critical Care and Neuroscience, Murdoch Childrens Research Institute, Melbourne, VIC, Australia; 2Stroke and Ageing Research Group, Department of Medicine, Monash University, Melbourne, VIC, Australia; 3Developmental and Functional Brain Imaging,Critical Care and Neuroscience , Murdoch Childrens Research Institute, Melbourne, VIC, Australia Type 2 Diabetes mellitus (DM) is linked to a greater risk of dementia, but the underlying mechanisms and brain regions involved are unknown. We conducted a co-twin (DM/non DM) case-control study of fMRI activation during a visual memory task. Non DM twins showed greater activation of temporal, parietal and occipital cortices suggesting involvement of these areas in DM pathology. Yüklə 4,25 Mb. Dostları ilə paylaş:
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