Traditional Posters: Body Imaging

Yongming Dai¹, Daoying Gen², Jiani Hu³, E.M. Haacke<sup>3

1</sup>Siemens Ltd China, Healthcare, Magnetic Resonance Imaging, Shanghai, China; ²Fudan University affiliated Huashan Hospital, Shanghai, China; ³Wayne State University, United States

In this study, susceptibility weighted imaging has been extended from human brain to abdomen for iron deposition research of hepatic diseases. From the inital result, susceptibility weighted imaging could correlate the degree of hepatic iron overloaded of patients with their clinical examination results well. It seems that susceptibility weighted imaging will be a promising method alternative to conventional T2, T2star methods for iron deposition research.

2607. T1_rho Dispersion MR Imaging for the Diagnosis and Characetrizaton of Different Liver Pathologies

Dania Daye¹, Kejia Cai², Mohammad Haris², Anup Singh², Santosh Gaddam², Rebecca Wells^3,4, Emma Furth, Ravinder Reddy<sup>2

1</sup>Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States; ²Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; ³Department of Medicine, University of Pennsylvania, Philadelphia, PA; ⁴Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, United States

It has been previously shown that T1ρ weighted MR imaging has significant potential to provide for a non-invasive assessment of liver disease, specifically in fibrosis. In T1ρ weighted imaging, nuclear spins are locked with a radiofrequency locking field, yielding a longitudinal relaxation time (T1ρ) in the rotating frame. By varying the strength of the locking field (B1), it is possible to make the T1ρ relaxation time changes sensitive to different contrast mechanisms in tissues. Here, we show that that T1 ρ dispersion technique has significant potential to differentiate between different liver pathologies as well al further characterize certain pathologies, such as fibrosis.

2608. Quantitative Assessment of Iron Overload in Liver of Patients with Thalassemia Major Using Ultra-Short T2*

azza abdelrahim ahmed¹, Taigang He², Dudley Pennell², David Firmin<sup>2

1</sup>CMR, imperial college london, London, Kensignton and Chelsea, United Kingdom; ²Imperial college london

Attempts were made in measuring ultra-short T2*(<1ms) for accurate assessment of iron in the liver of patients with thalassemia major. A new sequence was developed by minimizing duration of RF pulse and shortening the ramp times and duration of field gradients. The sequence tested in phantom involved an initial echo time was reduced to 0.8ms and echo spacing to 0.6ms. For liver imaging, an echo spacing of 1.9ms was used. The developed sequence was later compared with conventional one. Results show a feasibility of measuring ultra-short T2* values in phantoms and in liver of patients using the improved sequence.

2609. Clinical Application for Cirrhosis with Susceptibility Weighted Imaging

Yongming Dai¹, Daoying Gen², Wei Cheng³, E.M. Haacke<sup>4

1</sup>Siemens Ltd China, Healthcare, Magnetic Resonance Imaging, Shanghai, China; ²Fudan University affiliated Huashan Hospital; ³The Third Military Medical University affiliated SouthWest hospital; ⁴Wayne State University, United States

In this study we extended clinical application for hepatic disease (Cirrhosis)with susceptibility weighted imaging (SWI). The results showed promising future for SWI application in human abdomen.

2610. A Software Phantom Generator System for Quality Control (QA) of MRI Iron Overload Assessment Software