Traditional Posters: Body Imaging

Matt Smith¹, Krishna Kurpad², Catherine Moran¹, Xu Zhai¹, Walter Block^1,3, Sean Fain<sup>1,3

1</sup>Medical Physics, University of Wisconsin, Madison, WI, United States; ²Radiology, University of Wisconsin, Madison, WI, United States; ³Biomedical Engineering, University of Wisconsin, Madison, WI, United States

Regardless of the sampling technique, the volume of interest is degraded by excited signal energy outside the FOV. With 3D non-Cartesian acquisitions, the effect is incoherent streaking with noise-like appearance. Commercial receive only breast coils require slice/slab excitation from the body coil, exciting tissue outside the FOV. A local transmit/receive breast coil based on a solenoid design is compared with a commercial receive-only coil to demonstrate that local excitation minimizes the unwanted signal energy contaminating the FOV for non-Cartesian breast MR. Measurements of contrast are higher and more consistent using a 3DPR SSFP sequence with a local transmit/receive breast coil.

2499. Adaptive 3D Radial MRI Based on Multidimensional Golden Means for Supine Breast Imaging

Peter Siegler¹, Rachel W.-C. Chan², Elizabeth A. Ramsay¹, Donald B. Plewes<sup>1

1</sup>Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; ²Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

Dynamic contrast-enhanced breast MRI shows a high sensitivity for breast cancer but is commonly done in prone position which complicates its use for image-aided strategies. Recently, supine unilateral breast MRI with compensation for respiratory motion was successfully implemented. However, standard Cartesian sampling has no isotropic spatial resolution, which is desirable for image-aided applications. Here, 3D projection reconstruction based on multidimensional golden means was tested for use in supine breast MRI. The technique allowed post-processed compensation for respiratory motion, which is intrinsic in a supine position of the patient, without the need to choose any motion-compensation settings prior to the scan.

2500. Towards a Microspectroscopy Catheter for Early-Stage Breast Cancer Detection

Debra Strick Rivera¹, Jack W. Judy², W Gilbert Clarke², Dixie J. Mills³, Allen C. Chu², Mark S. Cohen<sup>2

1</sup>Neurophysics, Max Planck Institute, Leipzig, Saxony, Germany; ²University of California, Los Angeles; ³Dr. Susan Love Research Foundation

Early-detection of breast cancer is unreliable, and of increased importance due to encouraging results of intraductal application of chemotherapy. We present a prototype radio-frequency transceiver for intraductal microspectroscopy, including soak-tests and heating studies. We demonstrate that the microcoil prototype is capable of resolving fat and water spectra in a sample with 5000-fold fewer spins than a state of the art matrix coil.

2501. Breast Perfusion Imaging Using Arterial Spin Labeling

Misung Han^1,2, Brian A. Hargreaves¹, Bruce L. Daniel¹, David C. Alsop^3,4, Philip M. Robson, ^4,5, Eric Han⁶, Pauline W. Worters¹, Ajit Shankaranarayanan<sup>6

1</sup>Radiology, Stanford University, Stanford, CA, United States; ²Electrial Engineering, Stanford University, Stanford, CA, United States; ³Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States; ⁴Radiology, Harvard Medical School, Boston, MA, United States; ⁵Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA, United States; ⁶Applied Science Lab, GE Healthcare, Menlo Park, CA, United States

Malignant breast tumors induce high level angiogenesis, resulting in increased vascularity and perfusion. For breast MRI, dynamic contrast-enhanced MRI is most widely used to detect and characterize tumors; on the other hand, arterial spin labeling (ASL) technique is very challenging due to low baseline flow in breasts. Here, we show our experience in 2D breast ASL using FAIR labeling and background suppression in both volunteers and patients. With our technique, higher perfusion signal was depicted in tumor.

2502. Improved Fat Suppression with High Resolution Balanced Steady State Imaging in the Breast

Dorothee Barbara Engel¹, Catherine Judith Moran², Fred Kelcz³, Stephan O. Schoenberg¹, Walter Block<sup>2

1</sup>Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Mannheim, Germany; ²Department of Medical Physics, University of Wisconsin, Madison, WI, United States; ³Department of Radiology, University of Wisconsin, Madison, WI, United States

While the Dynamic Contrast Enhanced (DCE) acquisition remains the centerpiece of breast MRI, both signal intensity and the depiction of lesion morphology in T2-weighted images can help to distinguish malignant versus benign lesions. With TRs on the order of seconds, T2-weighted acquisitions are generally inefficient and most often acquired with high in-plane resolution but low through plane resolution. A radial bSSFP acquisition termed 3DPR-SSFP has been shown to provide improved depiction of lesion morphology in comparison to conventional T2-weighed acquisitions. We evaluate the performance of two methods for improving fat suppression of 3DPR-SSFP while retaining the advantage of clear depiction of fine morphological details in the breast.

2503. Resolving Arterial Phase in Dynamic Breast MRI Using a Fast TWIST Acquisition During Injection Delay

Karl-Heinz Herrmann¹, Pascal A. Baltzer, Ines Krumbein, Christian Geppert², Werner A. Kaiser, Jürgen R. Reichenbach<sup>1

1</sup>Medical Physics Group, Department of Diagnostic and Interventional Radiology, University Hospital Jena, Jena, Thüringen, Germany; ²MR Oncology, Siemens Healthcare, Erlangen

In MR Mammography pathologic vascularisation is utilized for the diagnosis of tumors. Many standard dynamic MRM protocols contain a delay of 35s, during which the contrast agent is applied, between the native scan and the following multiple post-CA scans. This injection delay can be efficiently used to acquire additional dynamic data sets with both high temporal (5.7s) and spatial resolution (0.9x0.9x1.5mm) using a 3D gradient echo view sharing sequence with stochastic trajectories (TWIST). This allows to resolve the arterial phase of the contrast agents first pass and helps to detect anomalous arterial supply vessels to suspect lesions.