Stefan Weick1, Philipp Ehses2, Martin Blaimer2, F. A. Breuer2, P. M. Jakob1,2
1Department of Experimental Physics 5, University of Wuerzburg, Wuerzburg, Bavaria, Germany; 2Research Center for Magnetic Resonance Bavaria (MRB)
In this work, 3D Flash examinations of the human lung were performed during free respiration using the DC signal for self-gating. Short echo times (TE) are required to provide sufficiently SNR because of the short T2* of the lung tissue. It is shown that the DC signal can be acquired after the actual imaging module still providing enough quality for respiratory gating and simultaneously providing very short echo times. The maxima and minima of the DC signal were used to define threshold values for data rejection and high resolution images were reconstructed retrospectively.
2526. Dynamic MR Perfusion Imaging Vs. Time-Resolved MR Angiography Vs. MDCT: Disease Extent Assessment and Outcome Prediction for Patients with Acute Pulmonary Thromboembolism
Keiko Matsumoto1, Yoshiharu Ohno1, Hisanobu Koyama1, Yumiko Onishi1, Daisuke Takenaka1, Munenobu Nogami1, Nobukazu Aoyama2, Hideaki Kawamitsu2, Tsutomu Araki3, Kazuro Sugimura1
1Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan; 2Division of Radiology, Kobe University Hospital, Kobe, Japan; 3Department of Radiology, University of Yamanashi, Japan
MDCT has become the first imaging examination in suspected APTE patients. As well as technical advances of CT, technical advances of magnetic resonance (MR) imaging make it possible to obtain time-resolved MR angiography or perfusion MR imaging (perfusion MRI) in APTE patients. We hypothesized that quantitatively assessed pulmonary perfusion parameters from contrast-enhanced perfusion MRI have potential for disease extent assessment and have predictive capability of patient outcome in APTE patients. The aim of our study was therefore to directly compare the capability for disease severity assessment and patient outcome prediction of MDCT and MR techniques in APTE patients.
2527. Exploration of Gas Flow During High Frequency Oscillated Ventilation by 19F-Gas-MRI
Janet Friedrich1, Julien Rivoire1, Alexander Wiegbert Scholz2, Maxim Terekhov1, Rainer Köbrich2, Lars Krenkel3, Claus Wagner3, Laura Maria Schreiber1
1Section of Medical Physics, Department of Diagnostic and Interventional Radiology, Johannes Gutenberg University Medical Center, Mainz, Germany; 2Department of Anesthesiology, Johannes Gutenberg University Medical Center, Mainz, Germany; 3German Aerospace Center, Göttingen, Germany
To detect convective gas flow inside the large airways during high frequency oscillated ventilation (HFOV) the fluorinated contrast gas Heptafluoropropane was used for 19F-MRI. In a first study the comparison between constant flow measurements and Computational Fluid Dynamics (CFD) simulations provided a good agreement. In a following experiment oscillated flow was applied to a lung phantom consisting of ventilation bag and long pipe. The pressure wave inside the pipe was explored point-by-point and corresponding velocities were determined. With these experiments it could be shown for the first time that flow measurement during HFOV using fluorinated contrast gas is feasible.
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