Traditional Posters: Body Imaging
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| Riikka J. Immonen1, Smaragda Lamprianou2, Laurent Vinet2, Paolo Meda2, Rolf Gruetter1,3
1Laboratory for functional and metabolic imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, CH-1015, Switzerland; 2Department of Cell Physiology and Metabolism, University of Geneva, Geneva, CH-1210, Switzerland; 3Department of Radiology, University of Geneva and Lausanne, Geneva and Lausanne, CH-1210 and CH-1015, Switzerland In diabetes the gradual loss of pancreatic β–cells leads to impaired regulation of blood glucose levels. β–cell islets, 30-600μm in diameter, are sparsely located accross the pancreas. We utilized for the first time ultra high field of 14.1T in combination of manganese- and iron-oxide nanoparticle-enhanced MRI to assess pancreatic structures ex vivo. We were able to distinguish all the main pancreatic structures, including lobules and branching duct tree with terminal acini. The manganese with glucose stimulus, without and together with the infusion of iron oxide particles, also delineated structures which are likely to correspond to individual pancreatic islets. 2636. Could Obesity Possibly Be Harmless Lidia S. Szczepaniak1, Jaime L. Legendre2, Edward W. Szczepaniak1, Angela L. Price2, Ildiko Lingvay2 1The Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States; 2Endocrinology, UT Southwestern Medical Center, Dallas, TX, United States There is no doubt that obesity is associated with diabetes, increased cardiovascular risk factors, not to mention arthritis and cancers. Sixty to 90% of patients with diabetes are obese but not all obese individuals present metabolic and cardiovascular diseases. This leads to a notion that certain individuals tolerate obesity well and without metabolic consequences. We present clinical evidence that given enough time the so called "healthy obesity" eventually becomes harmful with full spectrum of metabolic consequences. 2637. Beneficial Effects of Diethylnorspermine in Obesity and Its Cardiac Complications MingMing Li1, Beau Pontre2, Stephen Pickup3, Hong Xu4, Anthony Philips2, Garth Cooper2, Jun Lu2,5 1School of Biological Sciences, Auckland University, Auckland, New Zealand; 2School of Biological Sciences, Auckland University, New Zealand; 3Department of Radiology, University of Pennsylvania, Philadelphia, United States; 4College of Chemistry and Chemical Engineering, Shen Zhen University, Shenzhen, Guangdong, China; 5NCIECP, Auckland University of Technology, Auckland, New Zealand We hypothesise that chemically induced Spermidine/spermine acetyl transferase (SSAT) activity, which stimulates polyamine catabolism and in turn enhances fat/glucose metabolism, would decrease fat content and improve cardiac function in obese mice. C57Bl/6 and matched leptin deficiency (ob/ob) mice were treated with a potent SSAT inducer, N1, N11-diethylnorspermine (DENS), through i.p. injection. Results showed that DNES not only can significantly reduce body fat percentages in both mice models, but also can control ob/ob’s body weight. Moreover, DENS can prevent the development of cardiac hypertrophy in obese mice. Therefore, SSAT is a potential target for the development of pharmacotherapy in obesity. 2638. Patient Specific T2 correction in Hepatic Fat Content Measurement in Obese Patients Annie M. Tang1, Kelvin K. Wong1, Kathleen Wyne2,3, Dikoma C. Shungu4, Willa Hsueh2,5, Stephen T. Wong1 1Center for Bioengineering and Informatics and Department of Radiology, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, TX, United States; 2Diabetes Research Center, The Methodist Hospital Research Institute, Houston, TX, United States; 3Division of Diabetes, Obesity & Lipids, The Methodist Hospital, Weill Cornell Medical College, Houston, TX, United States; 4Department of Radiology, Weill Cornell Medical College, Cornell University, New York, NY, United States; 5Division of Diabetes, Obesity & Lipids , The Methodist Hospital, Weill Cornell Medical College, Houston, TX, United States 1H-MRS is used for quantifying liver fat content in patients with NAFLD. T2 corrections of hepatic fat/water are usually done using T2 values obtained in literature. However, these T2 values of depends a lot on the concentration of iron in the liver. In patients with NAFLD, different degree of iron concentration was observed depending on the patient sex and diabetes status. We are conducting an ongoing pilot trial to study the hepatic fat content in obese patients before and during diet/weight management. The hepatic water and fat T2 relaxation values were measured and its effects in hepatic fat content measurements were explored. 2639. Triglyceride Composition Measured by 1H MRS at Clinical Field Strengths Gavin Hamilton1, Michael S. Middleton1, Takeshi Yokoo1, Mark Bydder1, Michael E. Schroeder1, Claude B. Sirlin1 1Department of Radiology, University of California, San Diego, San Diego, CA, United States The multi-peak structure of the fat 1H MR spectrum allows the triglyceride composition in adipose tissue to be estimated non-invasively. We assess the ability of 1H MR spectroscopy to reproducibly provide information about triglyceride composition in adipose tissue in vivo at clinical field strengths. 2640. In Vivo Repeatability of Liver Fat Measurement Using 1H MR Spectroscopy Yüklə 458,11 Kb. Dostları ilə paylaş:
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