Traditional Posters: Miscellaneous
Other Spectroscopy Methodology
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| Other Spectroscopy Methodology
Hall B Thursday 13:30-15:30 929. SPECIAL-COSY at 7T Alexander Fuchs1, Anke Henning1, Peter Boesiger1 1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland The ability of 2D spectroscopy to spread spectral information that is otherwise hard to detect into a second frequency dimension makes these type of techniques very interesting. On ultra-high field strength the short relaxation time of interesting metabolite signals makes commonly used localized sequneces like L-COSY or PRESS localized COSY impractical. Hence a suitable localized COSY sequence at 7T was implemented using the SPECIAL sequence. The successful application of SPECIAL for localized COSY at 7T is demonstrated in a phantom and in-vivo measurements. 930. SPECIAL-J-Resolved Spectroscopy at 7T Alexander Fuchs1, Anke Henning1, Peter Boesiger1 1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland Unambiguous detection of coupled spin systems like Glutamate, Glutamine or GABA can be a quite challeging task with regular one dimensional spectroscopy. 2D J-resolved spectroscopy can be used to decrease the spectral overlap by encoding the phase evolution behaviour of coupled spin systems in second frequency dimension. At ultra-high fields typical localization schemes can often limit the minimum achievable echo times and therefor hampering the actual 2D experiment. To circumvent this problem SPECIAL was implemented on a Philips 7T system and j-resolved spectra were acquired in a phantom and a healthy volunteer.
We have implemented and validated the LCT-PRESS technique in healthy rat brain. This sequence clearly demonstrates superior resolution and permits reliable detection of several brain metabolites that overlap in conventional techniques. The LCT-PRESS sequence performs this separation due to its incorporation of constant-time evolution, resulting in spin-spin decoupling along the F1 dimension. 932. The Benefits of Higher Order B0 Shimming of the Human Brain at 7T Hoby Patrick Hetherington1, Kai-Ming Lo2, William Punchard2, Piotr Starewicz2, Jullie W. Pan1 1Neurosurgery, Yale University, New Haven, CT, United States; 2Resonance Research Inc., Billerica, MA, United States With the advent of ultrahigh field systems, 7T, significant improvements in spectroscopic imaging studies of the human brain have been anticipated. However, these gains are dependent upon the achievable B0 homogeneity, both globally (over the entire ROI or slice) and locally (the linewidths of individual SI voxels within the ROI). Our 7T human brain data demonstrates that substantial improvements in both global and local homogeneity can be achieved using 1st-3rd and higher order shims. The required strengths to achieve higher order terms (4th and 5th orders) can be obtained using a shim insert and modest strength power supplies. 933. Early Metabolic Changes of Mild Traumatic Brain Injury Revealed by 3D MRSI at 3T Duan Xu1,2, Natalie Charlton1, Srivathsa Veeraraghavan1, Geoffrey T. Manley3, Pratik Mukherjee1,2 1Dept of Radiology, UCSF, San Francisco, CA, United States; 2UCSF/UC Berkeley Joint Graduate Group in Bioengineering, San Francisco and Berkeley, CA, United States; 3Dept of Neurosurgery, UCSF, San Francisco, CA, United States Conventional MR imaging does not accurately predict outcome in mild TBI, but MR diffusion and proton spectroscopy has shown promise as potential biomarkers for injury severity and long-term neurocognitive and functional outcome. In this study, we utilized 3D MRSI at 3T with wide anatomic coverage to assess TBI in specific association, commissural, and projection white matter tracts. 934. Constant-TE Difference Editing of Serine at 3T: Simulation and Phantom Study Yüklə 355,76 Kb. Dostları ilə paylaş:
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